Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence.

abstract：:Large cell/anaplastic (LC/A) medulloblastoma (MB) is a recently recognized variant of medulloblastoma known to be associated with an advanced stage and a poor prognosis. Although Eberhart et al. suggested histopathologic grading of medulloblastoma in 2002, no consensus has been reached in terms of determining the crit...

journal_title：Acta neuropathologica

authors： Min HS,Lee YJ,Park K,Cho BK,Park SH

更新日期：2006-07-01 00:00:00

abstract：:Separation of pilocytic astrocytoma from diffuse astrocytomas frequently poses problems mostly related to small sample size. Precise classification and grading are essential due to different therapeutic strategies prompted by diagnoses of pilocytic astrocytoma WHO grade I, diffuse astrocytomas WHO grade II or anaplast...

journal_title：Acta neuropathologica

authors： Korshunov A,Meyer J,Capper D,Christians A,Remke M,Witt H,Pfister S,von Deimling A,Hartmann C

更新日期：2009-09-01 00:00:00

abstract：:Accumulation of the tau protein in fibrillar intracellular aggregates is a defining feature of multiple neurodegenerative diseases collectively referred to as tauopathies. Despite intensive study of tau, there is limited information on the formation and clearance dynamics of tau inclusions. Using rAAV vectors to media...

journal_title：Acta neuropathologica

authors： Croft CL,Goodwin MS,Ryu DH,Lessard CB,Tejeda G,Marrero M,Vause AR,Paterno G,Cruz PE,Lewis J,Giasson BI,Golde TE

更新日期：2021-01-26 00:00:00

abstract：:Several cases of progressive multifocal leukoencephalopathy (PML) have been associated with simian virus 40 (SV40), rather than with JC virus (JCV), the polyomavirus originally isolated from PML tissue. PML has, therefore, been defined as a demyelinating syndrome with possible multiple viral etiologies. Tissues from t...

journal_title：Acta neuropathologica

authors： Stoner GL,Ryschkewitsch CF

更新日期：1998-09-01 00:00:00

abstract：:The quadriceps femoris muscles of experimental allergic myositis, in strain 13 guinea pigs immunised with rabbit myosin B fraction, were subjected to histochemical, immunohistochemical and electron microscopic studies. They demonstrated a variety of degenerative changes of muscle fibres, infiltration of lymphocytes an...

journal_title：Acta neuropathologica

authors： Matsubara S,Takamori M

更新日期：1987-01-01 00:00:00

abstract：:Hyper- and hypothyroidism repercussions on soma, nucleus and cytoplasm increases were studied by electron microscopy on 7-, 14-, 21-, and 35-day-old rats. Adult normal animals were compared with adult ones made hypothyroid until they were 35 days old. Also heat value restriction of food intake effects were compared wi...

journal_title：Acta neuropathologica

authors： Rebière A,Dainat J

更新日期：1978-09-15 00:00:00

abstract：:We described a new type of cytoplasmic inclusion in the choroidal epithelial cells of humans. The inclusions usually appeared as brown, round or elongated bodies with or without an inner core, ranging in size from 1.3 to 7.0 micron. Histochemically, they contained polysaccharides, proteins and compound lipids. Ultrast...

journal_title：Acta neuropathologica

authors： Ohama E,Takeda S,Ikuta F

更新日期：1988-01-01 00:00:00

abstract：:We have studied microtubule-associated protein 2 (MAP2) expression in anterior horn neurons in the cervical and lumbar spinal cords of 19 cases of adult-onset sporadic amyotrophic lateral sclerosis (ALS) using immunohistochemistry. Specimens from 7 patients without neurological disease served as controls. MAP2 express...

journal_title：Acta neuropathologica

authors： Kikuchi H,Doh-ura K,Kawashima T,Kira J,Iwaki T

更新日期：1999-01-01 00:00:00

abstract：:Four melanin pigment-containing intracranial tumors were found in three Long-Evans rats in the course of experimental oncogenesis by transplacental ethylnitrosourea (ENU). One of them was a leptomeningeal melanoma. Aside from the presence of scattered melanin-pigmented cells, the other three had the typical histologic...

journal_title：Acta neuropathologica

authors： Spence AM,Rubinstein LJ,Conley FK,Herman MM

更新日期：1976-05-18 00:00:00

abstract：:Abnormal TDP-43 aggregation is a prominent feature in the neuropathology of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Mutations in TARDBP, the gene encoding TDP-43, cause some cases of ALS. The normal function of TDP-43 remains incompletely understood. To better understand TDP-43 biolo...

journal_title：Acta neuropathologica

authors： Kraemer BC,Schuck T,Wheeler JM,Robinson LC,Trojanowski JQ,Lee VM,Schellenberg GD

更新日期：2010-04-01 00:00:00

abstract：:A cerebral biopsy was performed in a 39-year-old male patient with subacute paraparesis who later developed severe dementia and moderate cerebellar involvement. The histological examination showed a marked neuronal loss, severe neurofibrillary degeneration, and a great number of senile plaques. No PAS-positive plaques...

journal_title：Acta neuropathologica

authors： Ferrer I,Aymami A,Rovira A,Grau Veciana JM

更新日期：1983-01-01 00:00:00

abstract：:The hemizygote of the macular mutant mice, which is clinically and neuropathologically considered to be a model of Menkes kinky hair disease (MKHD), were injected intraperitoneally four times with 10, 20, 20 and 30 micrograms of cupric chloride on days 4, 6, 8 and 10 after birth, respectively. Their cerebral and cereb...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Onaga A,Kawasaki H,Iwane S,Ono K,Nishimura M

更新日期：1988-01-01 00:00:00

abstract：:The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences in t...

journal_title：Acta neuropathologica

authors： Ritzel RM,Lai YJ,Crapser JD,Patel AR,Schrecengost A,Grenier JM,Mancini NS,Patrizz A,Jellison ER,Morales-Scheihing D,Venna VR,Kofler JK,Liu F,Verma R,McCullough LD

更新日期：2018-07-01 00:00:00

abstract：:To clarify the role of prostaglandins in peripheral nerve demyelination, we examined the expression of cyclooxygenase-2 (COX-2) using selected nerve specimens from patients with chronic inflammatory demyelinating polyneuropathy. COX-2 protein was up-regulated in macrophages causing active demyelination. In situ hybrid...

journal_title：Acta neuropathologica

authors： Kawasaki T,Oka N,Akiguchi I,Miyamoto K,Kaji R,Shibasaki H

更新日期：2001-02-01 00:00:00

abstract：:A 64-year-old woman developed septicemia and a generalized peripheral neuropathy while being ventilated postoperatively. No cause for the neuropathy could be found during life. At autopsy she was found to have infective endocarditis and multifocal inflammatory lesions in the central and peripheral nervous systems, con...

journal_title：Acta neuropathologica

authors： Pamphlett R,Walsh J

更新日期：1989-01-01 00:00:00

abstract：:In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs). The mechanisms responsible for this selective degeneration are largely unknown, but the molecular signatures of ...

journal_title：Acta neuropathologica

authors： Nizzardo M,Taiana M,Rizzo F,Aguila Benitez J,Nijssen J,Allodi I,Melzi V,Bresolin N,Comi GP,Hedlund E,Corti S

更新日期：2020-05-01 00:00:00

abstract：:Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) represent pathological hallmark lesions of Alzheimer's disease (AD). Both lesions develop in parallel in the human brain throughout the pre...

journal_title：Acta neuropathologica

authors： Gomes LA,Hipp SA,Rijal Upadhaya A,Balakrishnan K,Ospitalieri S,Koper MJ,Largo-Barrientos P,Uytterhoeven V,Reichwald J,Rabe S,Vandenberghe R,von Arnim CAF,Tousseyn T,Feederle R,Giudici C,Willem M,Staufenbiel M,Thal DR

更新日期：2019-12-01 00:00:00

abstract：:The ontogenesis of Fc gamma receptors (FcR) and C3b/C4b receptors (CR1) was studied in peripheral nerves from ten fetuses aged from 20 to 38 weeks using immunohistochemical and functional assays. Monoclonal antibodies (mAbs) against FcR and CR1 stained nerve fibers at 10 weeks of gestation and the staining intensity i...

journal_title：Acta neuropathologica

authors： Vedeler CA,Scarpini E,Beretta S,Doronzo R,Matre R

更新日期：1990-01-01 00:00:00

abstract：:We report an experimental model of Creutzfeldt-Jakob's disease (CJD) in mice leading to the formation of giant autophagic vacuoles (AV) in neurons of the cerebral cortex. These AV appear at the end of the incubation period (4-6 months postinoculation), together with spongy changes and clinical symptoms. Autophagy, a p...

journal_title：Acta neuropathologica

authors： Boellaard JW,Schlote W,Tateishi J

更新日期：1989-01-01 00:00:00

abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...

journal_title：Acta neuropathologica

authors： Takahashi N,Iwatsubo T,Nakano I,Machinami R

更新日期：1992-01-01 00:00:00

abstract：:Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and 'adult-type' diffuse gliomas, are largely established, those of uncommon LGNTs remain to be define...

journal_title：Acta neuropathologica

authors： Qaddoumi I,Orisme W,Wen J,Santiago T,Gupta K,Dalton JD,Tang B,Haupfear K,Punchihewa C,Easton J,Mulder H,Boggs K,Shao Y,Rusch M,Becksfort J,Gupta P,Wang S,Lee RP,Brat D,Peter Collins V,Dahiya S,George D,Konomos

更新日期：2016-06-01 00:00:00

abstract：:HTLV-III-like particles were observed within a cell process surrounded by a myelin sheath, in the brain of a 4-year-old boy with AIDS encephalopathy. Similar particles were also observed in the mononuclear macrophage-like cells. ...

journal_title：Acta neuropathologica

authors： Kato T,Dembitzer HM,Hirano A,Llena JF

更新日期：1987-01-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild impact traumatic brain injury from contact sports. Recently, a consensus panel defined the pathognomonic lesion for CTE as accumulations of abnormally hyperphosphorylated tau (p-tau) in neurons (neurofibrillary tangle...

journal_title：Acta neuropathologica

authors： Shively SB,Edgerton SL,Iacono D,Purohit DP,Qu BX,Haroutunian V,Davis KL,Diaz-Arrastia R,Perl DP

更新日期：2017-03-01 00:00:00

abstract：:Emerging evidence has demonstrated the neuroprotection of estrogen in Alzheimer's disease (AD). The hippocampus, an important target of estrogen action, is severely affected in the Alzheimer process. The aim of present study was to detect the distribution of estrogen receptor-alpha (ER-alpha) and the relationship betw...

journal_title：Acta neuropathologica

authors： Hu XY,Qin S,Lu YP,Ravid R,Swaab DF,Zhou JN

更新日期：2003-09-01 00:00:00

abstract：:Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the other hand is less frequent and neuropathologically should only be diagnosed if criteria for more than one full blown disease are met. We quantitatively measured ...

journal_title：Acta neuropathologica

authors： Walker L,McAleese KE,Thomas AJ,Johnson M,Martin-Ruiz C,Parker C,Colloby SJ,Jellinger K,Attems J

更新日期：2015-05-01 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of a number of diseases including Alzheimer's disease (AD). The oxidative stress hypothesis of AD pathogenesis, in part, is based on beta-amyloid peptide (Abeta)-induced oxidative stress in both in vitro and in vivo studies. Oxidative modification of the protein...

journal_title：Acta neuropathologica

authors： Sultana R,Perluigi M,Butterfield DA

更新日期：2009-07-01 00:00:00

abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...

journal_title：Acta neuropathologica

authors： Mann DM,Iwatsubo T,Fukumoto H,Ihara Y,Odaka A,Suzuki N

更新日期：1995-01-01 00:00:00

abstract：:In the cytoplasm of Schwann cells of a sural nerve biopsy from a 21-year-old female patient with chronic neuropathy we noted numerous unique, usually double membrane-bound, osmiophilic, granular or globular inclusions, approximately 30-600 microm in diameter. Some of these membrane-bound vesicular or tubular structure...

journal_title：Acta neuropathologica

authors： Schröder JM,Wang JF,Sindern E,Malin JP

更新日期：1999-10-01 00:00:00

abstract：:The gastrocnemius muscles of 3 groups of 10 rats, sacrified 5, 7, and 12 days respectively, following tenotomy, were submitted to different types of fixation, fixative and embedding. The occurrence of target fibres is shown not to be an artefact due to the histological procedures. Further examination demonstrates that...

journal_title：Acta neuropathologica

authors： De Reuck J,De Coster W,vander Eecken H

更新日期：1978-05-24 00:00:00

abstract：:In hereditary myopathy of the diaphragmatic muscles in Holstein-Friesian cattle, the largest number of acidophilic intracytoplasmic inclusions was found in the myocardium. These inclusions, which were oval and measured 12-15 microm in the transverse sections, were characterized by a dense, amorphous zone, and a relati...

journal_title：Acta neuropathologica

authors： Furuoka H,Murakami A,Doi T,Kobayashi Y,Matsui T,Nakamura N

更新日期：1999-02-01 00:00:00