Abstract:
:Emerging evidence has demonstrated the neuroprotection of estrogen in Alzheimer's disease (AD). The hippocampus, an important target of estrogen action, is severely affected in the Alzheimer process. The aim of present study was to detect the distribution of estrogen receptor-alpha (ER-alpha) and the relationship between ER-alpha-containing neurons and the pretangles stained by Alz-50 in the hippocampus of AD patients. The results showed that more than half of hippocampal neurons expressed ER-alpha. The number of cytoplasmic ER-alpha-positive neurons was significantly decreased in the CA1 and CA2 subfields of AD hippocampus, but the ratio of these ER-alpha-expressing neurons to the nucleolated neuronal profiles stained by thionin was not different between the two groups. Interestingly, the number of nuclear ER-alpha-staining neurons was also markedly decreased in the CA1 and CA2 subfields of AD hippocampus, and the percentage of these nuclear staining neurons was also significantly decreased in the same subfields. Furthermore, some double-labeled neurons containing ER-alpha and Alz-50 were found in AD patients. However, in these double-labeled neurons, ER-alpha was only located in the cytoplasm. Thus, we hypothesize that the nuclear ER-alpha may play more important roles of neuroprotection during the process of AD.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Hu XY,Qin S,Lu YP,Ravid R,Swaab DF,Zhou JNdoi
10.1007/s00401-003-0720-3subject
Has Abstractpub_date
2003-09-01 00:00:00pages
213-20issue
3eissn
0001-6322issn
1432-0533journal_volume
106pub_type
杂志文章abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product...
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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