Abstract：
:Central pontine myelinolysis (CPM) is an uncommon complication in sick patients with severe underlying disorders such as chronic alcoholism, malignancy, malnutrition and hyponatraemia. We report two patients with advanced HIV infection who developed CPM. In one case the diagnosis was not suspected in life, in the other the diagnosis was made just before death, on the basis of magnetic resonance (MR) imaging appearances. At post mortem there was a close correlation between the MR abnormalities and the anatomic changes in the pons.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Miller RF,Harrison MJ,Hall-Craggs MA,Scaravilli Fdoi
10.1007/s004010050931subject
Has Abstractpub_date
1998-11-01 00:00:00pages
537-40issue
5eissn
0001-6322issn
1432-0533journal_volume
96pub_type
杂志文章abstract：:Alpha-synuclein (alphaS) and ubiquitin (Ub) are shared constituents of glial cytoplasmic inclusions (GCIs) and Lewy bodies (LBs), both composed of fibrillary structures. Staining profiles of GCIs were investigated with triple immunofluorescence involving immunostaining for alphaS and Ub, both amplified with catalyzed ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1066-9
更新日期：2005-10-01 00:00:00
abstract：:In adult mice, administration of the anticonvulsive drug phenytoin caused focal swellings along the Purkinje cell axon correlated with ataxia and incoordination of movements. In our model, we used murine cerebellar slice cultures to study the influence of phenytoin on postnatal Purkinje cell axon differentiation. Almo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050844
更新日期：1998-06-01 00:00:00
abstract：:Autopsy findings of a patient, with sialidosis type I phenotype carrying V217M/G243R mutations in the lysosomal sialidase gene and biochemically defined isolated sialidase deficiency, who died of intractable lymphoma at the age of 32 years, are described. Perikaryal expansion of cytoplasm was evident, mostly in motor ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-009-0544-x
更新日期：2010-01-01 00:00:00
abstract：:Various parts of the central and peripheral nervous system of the mutant hamster with hind leg paralysis were studied in the electron microscope. A number of alterations involving the myelin sheath, the axon and certain neuronal perikarya were observed. Anterior horn cells were apparently well preserved. This conditio...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691701
更新日期：1977-08-31 00:00:00
abstract：:We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and duration of disease. Sections of middle frontal and inferior parie...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0162-9
更新日期：2007-01-01 00:00:00
abstract：:Axons of the peripheral nervous system (PNS) are reduced in caliber in response to the experimental diabetic state. The cause of this reduced axonal size is disputed. Various theories include (a) axonal dwindling, (b) inhibition of growth, and (c) shrinkage due to serum hyperosmolarity. This study was designed to dire...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688637
更新日期：1985-01-01 00:00:00
abstract：:Localization of organ-specific brain antigens in the central nervous system of the rat has been studied by means of indirect immunofluorescence. Rabbit antiserum against homogenate of rat brain, previously absorbed with normal serum and homogenates of rat organs (kidney, liver, spleen), reacted with the water-soluble ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703316
更新日期：1977-08-16 00:00:00
abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00307646
更新日期：1995-01-01 00:00:00
abstract：:Entorhinal cortex displays a distinctive organization in layer II and forms small elevations on its surface called entorhinal verrucae. In Alzheimer's disease, the verrucae disappear due to neurofibrillary tangle formation and neuronal death. Isosurface models were reconstructed from high-resolution ex vivo MRI volume...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-011-0929-5
更新日期：2012-01-01 00:00:00
abstract：:We have developed a functional vegetative model by an 18-min clamping of the ascending aorta combined with a bypass formation between the aorta to right atrium and the aorta to femoral vein. Complete global brain ischemia (CGBI) induced for 18 min with this model provided the following distinct advantages: cardiopulmo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294614
更新日期：1990-01-01 00:00:00
abstract：:Considering the possibility of a paracellular pathway for edema resolution, we studied the intracerebral movement of proteins and ionic lanthanum in rats with experimental hydrocephalus. Hydrocephalus was induced by injection of kaolin suspension into the cisterna magna. After induction of hydrocephalus, horseradish p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687004
更新日期：1985-01-01 00:00:00
abstract：:Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050960
更新日期：1999-01-01 00:00:00
abstract：:Pelizaeus-Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model of PMD with perturbed blood-brain barrier integrity, cholesterol supplementation promotes myelin membrane growth. Here, we show that in contrast to the mouse model, dietary cholesterol in two PMD patients did not lead to a major ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-019-01985-2
更新日期：2019-07-01 00:00:00
abstract：:Evidence of misfolded wild-type superoxide dismutase 1 (SOD1) has been detected in spinal cords of sporadic ALS (sALS) patients, suggesting an etiological relationship to SOD1-associated familial ALS (fALS). Given that there are currently a number of promising therapies under development that target SOD1, it is of cri...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1623-4
更新日期：2016-12-01 00:00:00
abstract：:Amyloid-beta (Abeta) peptide pathology in Alzheimer's disease (AD) comprises extracellular plaques and cerebral amyloid angiopathy (CAA). In Parkinson's disease (PD), alpha-synuclein forms intraneuronal Lewy bodies (LBs), and cortical LBs are thought to play a major role in cognitive decline designated as PD with deme...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0336-0
更新日期：2008-04-01 00:00:00
abstract：:The evolvement of amyloid beta (Abeta) deposition in the frontal cerebral cortex of 24 patients of increasing age with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D) was studied using end-specific monoclonal antibodies to Abetax-42 (Abeta42) or Abetax-40 (Abeta40) and markers for degenerating neu...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051143
更新日期：2000-04-01 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:A desmoplastic primary cerebral neuroblastoma originating in the frontal lobe of a boy who died at the age of 6 years contained dense core vesicles within the cytoplasm of neoplastic cells as evidence of neuronal differentiation. Sarcomatous transformation had occurred at the time of recurrence. At autopsy, he also ha...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688540
更新日期：1980-01-01 00:00:00
abstract：:The regional distribution of the postsynaptic microtubule-associated protein 2 (MAP2) and the presynaptic marker protein synaptophysin was investigated by immunohistochemistry in brains of rats submitted to 30-min forebrain ischemia by four-vessel occlusion. The following brain temperature profiles during ischemia wer...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00230493
更新日期：1993-01-01 00:00:00
abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687402
更新日期：1989-01-01 00:00:00
abstract：:Abundant proliferation of cells having the histologic and tinctorial features of microglia, were seen in the brain of 34-year old man who suffered cardiac arrest 10 days before death and whose bone marrow was nearly totally depleted of white-blood-cell precursors. It is suggested, that in adult human brains there are ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691588
更新日期：1978-09-15 00:00:00
abstract：:Presence and distribution of S-100 protein (S-100), neuron-specific enolase (NSE), cytokeratin polypeptides, glial fibrillary acidic protein (GFAP), vimentin, actin, lysozyme and pituitary hormones (prolactin, hGH, ACTH, beta-FSH, beta-LH, beta-TSH, alpha subunit) in folliculo-stellate cells (FSC) were studied in seve...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00689825
更新日期：1984-01-01 00:00:00
abstract：:The present study used cocultures of rat dorsal root ganglia (DRG) and peritoneal macrophages to define the role of activated complement components during demyelination. The complement cascade was activated in vitro by treatment of the cultures with natural rat serum and lipopolysaccharides. Complement activation was ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00318572
更新日期：1995-01-01 00:00:00
abstract：:Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer's disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in the forms of extrace...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1546-0
更新日期：2016-04-01 00:00:00
abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1021-9
更新日期：2005-07-01 00:00:00
abstract：:The neuropathological staging model of Alzheimer's disease proposed by Braak and Braak [Acta Neuropathol (1991) 82:259] requires that the evolution of neurofibrillary pathology follows a predictable pattern that can be ordered in a regular regional hierarchy. We have operationalized the neuropathological staging syste...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050780
更新日期：1998-02-01 00:00:00
abstract：:Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1800-0
更新日期：2018-02-01 00:00:00
abstract：:Progression of neuritic dystrophy is a histological hallmark of Alzheimer's disease (AD) in addition to amyloid deposition and neurofibrillary tangle formation. Dystrophic neurites (DNs) are abnormal neurites, and are closely associated with amyloid deposits. To clarify the process of DN formation, we immunohistochemi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0907-2
更新日期：2004-11-01 00:00:00
abstract：:Spinal cord of the rat was investigated immunohistochemically to detect signs of extravasation of fibronectin in animals in which the cord was subjected to different degrees of compression trauma. Immunohistochemistry was performed after survival periods of 4 and 24 h and parallel sections were incubated for albumin i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227738
更新日期：1992-01-01 00:00:00
abstract：:Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of non-demented elderly people. However, several studies...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-016-1562-0
更新日期：2016-09-01 00:00:00
