Abstract：
:The finding of novel fibroblastic onion bulb-like structures in peripheral nerves is reported for the first time in avian riboflavin deficiency. Day old broiler meat chickens were fed a riboflavin deficient diet (1.8 mg/kg) and were killed on postnatal days 6, 11, 16, 21 and 31, whereas control chickens were fed a conventional diet containing 5.0 mg/kg riboflavin. The fibroblastic onion bulb-like structures were found in sciatic and brachial nerves from day 11 onwards and consisted of long cytoplasmic processes of hypertrophied fibroblasts surrounding demyelinated, remyelinated and normally myelinated axons. The fibroblast cytoplasmic processes often enveloped more than one nerve fibre to produce a unique compound-like onion bulb structure. These onion bulb-like structures occurred early in the course of segmental demyelination at the same time as tomacula formation and became increasingly more prominent in the later stages of demyelination and remyelination. The molecular basis of formation of these unique structures requires further study as to the basis of the attraction of the fibroblast processes to nerve fibres associated with myelinating Schwann cells. The model may also be useful in investigating the role of endoneurial fibroblasts in endoneurial fibrosis as the early fibroblastic response in the onion bulbs is distinct from the more usual fibroblastic deposition of collagen in end-stage peripheral nerve disease.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Cai Z,Blumbergs PC,Finnie JW,Manavis J,Thompson PDdoi
10.1007/s00401-007-0215-8subject
Has Abstractpub_date
2007-08-01 00:00:00pages
187-94issue
2eissn
0001-6322issn
1432-0533journal_volume
114pub_type
杂志文章abstract：:A woman of 36 was admitted to hospital because of griping abdominal pain which occurred especially during the night when turning in bed. She had a history of constipation and bloating since birth. Irrigoscopy revealed megacolon extending from the middle of the transverse colon to the rectum. A rectal biopsy excluded H...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688193
更新日期：1987-01-01 00:00:00
abstract：:Immunohistochemical studies of monoamine neurons were performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with those of their offspring. Mice, 9-11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) duri...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294662
更新日期：1989-01-01 00:00:00
abstract：:Twenty necropsy cases of the association of fetal encephalitis with porencephaly, hydranencephaly or polymicrogyria were reviewed including 5 from the authors' material. The latter include a basket brain, a porencephalic necrosis of recent date and a polymicrogyria in the formative state. The supratentorial lesions ar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685011
更新日期：1978-08-07 00:00:00
abstract：:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00693778
更新日期：1987-01-01 00:00:00
abstract：:Neuroaxonal spheroids became evident microscopically after the autopsy of a 45-year-old woman with pigmentation of the globus pallidus suggesting Hallervorden-Spatz disease. In our opinion the fine floccular pigment seen electron-microscopically in many of the axonal spheroids is melanin, an end product of catecholami...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691981
更新日期：1983-01-01 00:00:00
abstract：:A 64-year-old woman developed septicemia and a generalized peripheral neuropathy while being ventilated postoperatively. No cause for the neuropathy could be found during life. At autopsy she was found to have infective endocarditis and multifocal inflammatory lesions in the central and peripheral nervous systems, con...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687409
更新日期：1989-01-01 00:00:00
abstract：:Emerging evidence has demonstrated the neuroprotection of estrogen in Alzheimer's disease (AD). The hippocampus, an important target of estrogen action, is severely affected in the Alzheimer process. The aim of present study was to detect the distribution of estrogen receptor-alpha (ER-alpha) and the relationship betw...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0720-3
更新日期：2003-09-01 00:00:00
abstract：:The fine structure of an intracerebellar "fibroma" has been examined. The tumor consists of irregularly-shaped cells connected by well developed junctional complexes. Unusual, fenestrated capillaries with extremely narrow and irregular lumens are frequent. Collagen fibers are not common but the wide extracellular spac...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00696567
更新日期：1975-08-27 00:00:00
abstract：:A patient with mixed gonadal dysgenesis showed glove and stocking-type sensory impairment and slowing of motor and sensory nerve conduction. Sural nerve biopsy revealed minifascicular formation with decreased density of myelinated fibers. As far as we are aware, this is the first report of polyneuropathy with minifasc...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051085
更新日期：1999-09-01 00:00:00
abstract：:The spinal cord of 20 patients with amyotrophic lateral sclerosis (ALS) and 5 patients with lower motor neuron disease (LMND) were investigated immunohistochemically using anti-human excitatory amino acid transporter 1 (EAAT1) and EAAT2 antibodies which are the astrocytic transporters. The purpose of the study was to ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004019900159
更新日期：2000-08-01 00:00:00
abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00307635
更新日期：1990-01-01 00:00:00
abstract：:A cerebral biopsy was performed in a 39-year-old male patient with subacute paraparesis who later developed severe dementia and moderate cerebellar involvement. The histological examination showed a marked neuronal loss, severe neurofibrillary degeneration, and a great number of senile plaques. No PAS-positive plaques...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703200
更新日期：1983-01-01 00:00:00
abstract：:A significant reduction in the myelinated nerve fiber population was observed during quantitative electron-microscopic examination of peripheral nerves in chronic alloxan diabetic rats. Dystrophic axonal abnormalities and regenerating fibers were more numerous in diabetics than age-matched controls. Schwann cells show...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690466
更新日期：1984-01-01 00:00:00
abstract：:We studied three siblings and one unrelated patient with cerebrotendinous xanthomatosis (CTX). Of two unrelated patients, we examined biopsies of sural nerve, soleus muscle, and achilles tendon. We also performed neurophysiologic investigations. Another patient died, and a postmortem examination of both brain and spin...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688117
更新日期：1984-01-01 00:00:00
abstract：:Several missense mutations within exons 1, 2, 4 and 5 of the gene for Cu/Zn-binding superoxide dismutase (SOD1) have been discovered to be involved in the development of chromosome 21q-linked familial amyotrophic lateral sclerosis (FALS). We describe here an autopsied patient with FALS, in whom we have recently identi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294513
更新日期：1994-01-01 00:00:00
abstract：:Pilocytic astrocytomas are the most common astrocytic tumors of childhood and differ clinically and histopathologically from those astrocytomas that affect adults. Studies of adult astrocytic tumors have revealed allelic losses on chromosomes 10, 17p, 19q and alterations in the epidermal growth factor receptor (EGFR) ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00454903
更新日期：1993-01-01 00:00:00
abstract：:Healthy nodes of Ranvier are crucial for action potential propagation along myelinated axons, both in the central and in the peripheral nervous system. Surprisingly, the node of Ranvier has often been neglected when describing CNS disorders, with most pathologies classified simply as being due to neuronal defects in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-014-1305-z
更新日期：2014-08-01 00:00:00
abstract：:CD44 antigen (CD44), the principle cell surface receptor for hyaluronate, is up-regulated in the human demyelinating disease multiple sclerosis on fibrous astrocytes. As astrocytes are the main target cell of canine distemper virus (CDV), the consequences of a CDV infection on the CD44 expression and distribution in b...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007417
更新日期：2000-02-01 00:00:00
abstract：:Paired helical filaments (PHF) were isolated from autopsied brain of cases of Alzheimer dementia, and their polypeptides were identified with monoclonal antibodies to PHF by Western blots. The PHF polypeptide profile consisted of several bands with a size difference of less than 5 kilodalton (kDa) between adjacent ban...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690830
更新日期：1985-01-01 00:00:00
abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687402
更新日期：1989-01-01 00:00:00
abstract：:Experimental brain tumors were produced in rats by stereotactical implantation of various neoplastic cell lines (RG 2, RG1 2.2, G 13/11, F 98, RN 6, B 104, and E 367). Using autoradiographic, bioluminescence, and fluoroscopic methods, the following regional hemodynamic and metabolic parameters were measured on intact ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687050
更新日期：1986-01-01 00:00:00
abstract：:Changes in immature rats in motor neurones after axotomy were studied by enzyme-histochemical methods. Increased activity of dehydrogenases in these neurones demonstrates enhanced metabolism and there was also increase of acid phosphatases. Decreased activity of acetylcholinesterase and indoxylacetate esterase in the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686163
更新日期：1975-12-30 00:00:00
abstract：:We described a new type of cytoplasmic inclusion in the choroidal epithelial cells of humans. The inclusions usually appeared as brown, round or elongated bodies with or without an inner core, ranging in size from 1.3 to 7.0 micron. Histochemically, they contained polysaccharides, proteins and compound lipids. Ultrast...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687675
更新日期：1988-01-01 00:00:00
abstract：:This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer's disease: mechanisms of amyloid formation, neurotoxicity, pathways involved ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-010-0691-0
更新日期：2011-01-01 00:00:00
abstract：:Peroxiredoxin-ll (Prxll) and glutathione peroxidase-l (GPxl) are regulators of the redox system that is one of the most crucial supporting systems in neurons. This system is an antioxidant enzyme defense system and is synchronously linked to other important cell supporting systems. To clarify the common self-survival ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1019-3
更新日期：2005-08-01 00:00:00
abstract：:The expression of glial fibrillary acidic protein (GFAP) in continuous glioma and non-glioma cell lines was evaluated by molecular hybridization and immunocytochemistry. RNA transcripts from the GFAP gene were detected in two of six cell lines by Northern blot analysis of cellular RNAs using a cloned mouse GFAP cDNA p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688264
更新日期：1987-01-01 00:00:00
abstract：:Separation of pilocytic astrocytoma from diffuse astrocytomas frequently poses problems mostly related to small sample size. Precise classification and grading are essential due to different therapeutic strategies prompted by diagnoses of pilocytic astrocytoma WHO grade I, diffuse astrocytomas WHO grade II or anaplast...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-009-0550-z
更新日期：2009-09-01 00:00:00
abstract：:The thoracic sympathetic preganglionic outflow is important in the maintenance of postural normotension in man. Normative data on the intermediolateral column (ILC) neuron cell bodies is lacking. Counts and measurements on the right ILC cytons have been performed on the T6, T7 and T8 segments of 12 spinal cords of man...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688573
更新日期：1977-09-26 00:00:00
abstract：:To clarify the role of prostaglandins in peripheral nerve demyelination, we examined the expression of cyclooxygenase-2 (COX-2) using selected nerve specimens from patients with chronic inflammatory demyelinating polyneuropathy. COX-2 protein was up-regulated in macrophages causing active demyelination. In situ hybrid...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000279
更新日期：2001-02-01 00:00:00
abstract：:A histochemical study is reported of regional differences of the lipid storage in a case of Niemann-Pick disease (NPD) type C. Besides tissues known to be affected (reticulo-endothelium, hepatocytes, nervous system), storage was demonstrated in adrenal cortical spongiocytes, sweat glands, renal glomerular and tubular ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688393
更新日期：1975-12-19 00:00:00
