Regional metabolism of experimental brain tumors.

abstract：:In hereditary myopathy of the diaphragmatic muscles in Holstein-Friesian cattle, the largest number of acidophilic intracytoplasmic inclusions was found in the myocardium. These inclusions, which were oval and measured 12-15 microm in the transverse sections, were characterized by a dense, amorphous zone, and a relati...

journal_title：Acta neuropathologica

authors： Furuoka H,Murakami A,Doi T,Kobayashi Y,Matsui T,Nakamura N

更新日期：1999-02-01 00:00:00

abstract：:We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mea...

journal_title：Acta neuropathologica

authors： Heinsen H,Rüb U,Bauer M,Ulmar G,Bethke B,Schüler M,Böcker F,Eisenmenger W,Götz M,Korr H,Schmitz C

更新日期：1999-06-01 00:00:00

abstract：:This report concerns an immunocytochemical and ultrastructural study of the motor cortices of 11 patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 normal individuals served as controls. Antibodies against phosphorylated neurofilament (PNF; 200 kDa), ubiquitin, glial fibrillary acidic protein (GFAP) ...

journal_title：Acta neuropathologica

authors： Sasaki S,Maruyama S

更新日期：1994-01-01 00:00:00

abstract：:The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spi...

journal_title：Acta neuropathologica

authors： Kelly DF,Gaskell CJ

更新日期：1976-06-15 00:00:00

abstract：:Abnormal TDP-43 aggregation is a prominent feature in the neuropathology of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Mutations in TARDBP, the gene encoding TDP-43, cause some cases of ALS. The normal function of TDP-43 remains incompletely understood. To better understand TDP-43 biolo...

journal_title：Acta neuropathologica

authors： Kraemer BC,Schuck T,Wheeler JM,Robinson LC,Trojanowski JQ,Lee VM,Schellenberg GD

更新日期：2010-04-01 00:00:00

abstract：:Microglia are long-living resident immune cells of the brain, which secure a stable chemical and physical microenvironment necessary for the proper functioning of the central nervous system (CNS). These highly dynamic cells continuously scan their environment for pathogens and possess the ability to react to damage-in...

journal_title：Acta neuropathologica

authors： Dudvarski Stankovic N,Teodorczyk M,Ploen R,Zipp F,Schmidt MHH

更新日期：2016-03-01 00:00:00

abstract：:Excitotoxicity is considered a major cell death inductor in neurodegeneration. Yet the mechanisms involved in cell death and cell survival following excitotoxic insults are poorly understood. Expression of active, phosphorylation-dependent mitogen-activated extracellular signal-regulated kinases (MAPK/ERKs), stress-ac...

journal_title：Acta neuropathologica

authors： Ferrer I,Blanco R,Carmona M,Puig B,Domínguez I,Viñals F

更新日期：2002-04-01 00:00:00

abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...

journal_title：Acta neuropathologica

authors： Delacourte A,Flament S,Dibe EM,Hublau P,Sablonnière B,Hémon B,Shérrer V,Défossez A

更新日期：1990-01-01 00:00:00

abstract：:The immunohistochemical distribution of alpha and beta subunits of S-100 protein (S-100 alpha, S-100 beta, respectively) in 138 cases of human brain tumors was investigated by the avidin-biotin immunoperoxidase method. Brain tumors can be divided into four groups: group 1 [S-100 alpha (+) and/or S-100 beta (+)]; astro...

journal_title：Acta neuropathologica

authors： Hayashi K,Hoshida Y,Horie Y,Takahashi K,Taguchi K,Sonobe H,Ohtsuki Y,Akagi T

更新日期：1991-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is a prevalent neurodegenerative disease of heterogeneous histopathology. Neuropathological subtypes are identified on the basis of the presence or absence of tau- or ubiquitin-positive neuronal inclusions. Our recent work has established four disease stages that are independent of neurop...

journal_title：Acta neuropathologica

authors： Kersaitis C,Halliday GM,Kril JJ

更新日期：2004-12-01 00:00:00

abstract：:In adult mice, administration of the anticonvulsive drug phenytoin caused focal swellings along the Purkinje cell axon correlated with ataxia and incoordination of movements. In our model, we used murine cerebellar slice cultures to study the influence of phenytoin on postnatal Purkinje cell axon differentiation. Almo...

journal_title：Acta neuropathologica

authors： Tauer U,Knoth R,Volk B

更新日期：1998-06-01 00:00:00

abstract：:Fifteen cases of Down syndrome between age 25-59 years were examined neuropathologically. A variety of histological methods were used to identify plaques and neurofibrillary tangles (NFT). All cases had some plaques or NFT, but their density was generally not high before the age of 40 years. Plaques and NFT tended to ...

journal_title：Acta neuropathologica

authors： Motte J,Williams RS

更新日期：1989-01-01 00:00:00

abstract：:An ultrastructural study was performed on normal and Benzo(a)-pyrene(B(a)P)-transformed fetal mouse brain cells. Early subcultures of a strain initiated from whole brain presented three cell types in vitro: astroglial, poorly differentiated glial, and spongioblastic types. After B(a)P-treatment, there was an exclusive...

journal_title：Acta neuropathologica

authors： Tripier MF,Markovits P,Papadopoulo D,Toga M

更新日期：1979-08-01 00:00:00

abstract：:A series of 50 human primary intracranial tumors were cultivated in vitro in an attempt to establish cell lines with the trypsinization technique. During the in vitro adaptation period, cultures were maintained at high cell density to avoid rapid over-growth by connective tissue. Five lines were established from 5 tum...

journal_title：Acta neuropathologica

authors： Maunoury R

更新日期：1977-07-15 00:00:00

abstract：:Circumscribed pink areas 0.3-1.0 cm in diameter seen in deeper parts of otherwise well-fixed brains are usually ascribed to inadequate fixation. Twenty-three patients with pink areas in their fixed brains had evidence of inflammation in at least one organ. Blood vessels in the pink areas contained bacteria. Postmortem...

journal_title：Acta neuropathologica

authors： Hedley-Whyte ET

更新日期：1985-01-01 00:00:00

abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...

journal_title：Acta neuropathologica

authors： Mizukami K,Kosaka K

更新日期：1989-01-01 00:00:00

abstract：:We report the case of an 11-year-old male who developed subacute diffuse polyradiculoneuropathy, associated with digestive symptoms and Epstein-Barr virus infection. Parental consanguinity was present. The laboratory findings including bone marrow smear were consistent with hemophagocytic lymphohistiocytosis (HLH). El...

journal_title：Acta neuropathologica

authors： De Armas R,Sindou P,Gelot A,Routon MC,Ponsot G,Vallat JM

更新日期：2004-10-01 00:00:00

abstract：:To clarify the role of prostaglandins in peripheral nerve demyelination, we examined the expression of cyclooxygenase-2 (COX-2) using selected nerve specimens from patients with chronic inflammatory demyelinating polyneuropathy. COX-2 protein was up-regulated in macrophages causing active demyelination. In situ hybrid...

journal_title：Acta neuropathologica

authors： Kawasaki T,Oka N,Akiguchi I,Miyamoto K,Kaji R,Shibasaki H

更新日期：2001-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product...

journal_title：Acta neuropathologica

authors： Blokhuis AM,Groen EJ,Koppers M,van den Berg LH,Pasterkamp RJ

更新日期：2013-06-01 00:00:00

abstract：:Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of non-demented elderly people. However, several studies...

journal_title：Acta neuropathologica

authors： Köhler C

更新日期：2016-09-01 00:00:00

abstract：:We have studied microtubule-associated protein 2 (MAP2) expression in anterior horn neurons in the cervical and lumbar spinal cords of 19 cases of adult-onset sporadic amyotrophic lateral sclerosis (ALS) using immunohistochemistry. Specimens from 7 patients without neurological disease served as controls. MAP2 express...

journal_title：Acta neuropathologica

authors： Kikuchi H,Doh-ura K,Kawashima T,Kira J,Iwaki T

更新日期：1999-01-01 00:00:00

abstract：:Neuregulins belong to a family of multipotent growth-promoting proteins, and have been shown to have a crucial role in accumulating acetylcholine receptor at neuromuscular junctions. A functional role of neuregulins in muscle regeneration has not yet been identified. Using reverse transcription (RT)-PCR, Western blot ...

journal_title：Acta neuropathologica

authors： Hirata M,Sakuma K,Okajima S,Fujiwara H,Inashima S,Yasuhara M,Kubo T

更新日期：2007-04-01 00:00:00

abstract：:Altered levels of cerebrospinal fluid (CSF) peptides related to Alzheimer's disease (AD) are associated with pathologic AD diagnosis, although cognitively normal subjects can also have abnormal levels of these AD biomarkers. To identify novel CSF biomarkers that distinguish pathologically confirmed AD from cognitively...

journal_title：Acta neuropathologica

authors： Hu WT,Chen-Plotkin A,Arnold SE,Grossman M,Clark CM,Shaw LM,Pickering E,Kuhn M,Chen Y,McCluskey L,Elman L,Karlawish J,Hurtig HI,Siderowf A,Lee VM,Soares H,Trojanowski JQ

更新日期：2010-06-01 00:00:00

abstract：:In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in Alzheimer's disease (AD). In this study, we used TR as a potential diagnostic marker of AD in frozen...

journal_title：Acta neuropathologica

authors： Luna-Muñoz J,Peralta-Ramirez J,Chávez-Macías L,Harrington CR,Wischik CM,Mena R

更新日期：2008-11-01 00:00:00

abstract：:Marinesco-Sjögren syndrome (MSS) features cerebellar ataxia, mental retardation, cataracts, and progressive vacuolar myopathy with peculiar myonuclear alterations. Most MSS patients carry homozygous or compound heterozygous SIL1 mutations. SIL1 is a nucleotide exchange factor for the endoplasmic reticulum resident cha...

journal_title：Acta neuropathologica

authors： Roos A,Buchkremer S,Kollipara L,Labisch T,Gatz C,Zitzelsberger M,Brauers E,Nolte K,Schröder JM,Kirschner J,Jesse CM,Goebel HH,Goswami A,Zimmermann R,Zahedi RP,Senderek J,Weis J

更新日期：2014-05-01 00:00:00

abstract：:Recent studies have documented carbonyl stress involvement in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The aim of the present study was to assess a role for carbonyl stress in motor neuron degeneration associated with superoxide dismutase-1 (SOD1) mutant familial ALS and its transgenic mouse m...

journal_title：Acta neuropathologica

authors： Shibata N,Hirano A,Hedley-Whyte ET,Dal Canto MC,Nagai R,Uchida K,Horiuchi S,Kawaguchi M,Yamamoto T,Kobayashi M

更新日期：2002-08-01 00:00:00

abstract：:The contribution of leukocyte apoptosis to the resolution of meningeal inflammation in bacterial meningitis was studied in the cerebrospinal fluid (CSF) and in meningeal infiltrates of humans and rabbits by in situ tailing, flow cytometry, agarose gel electrophoresis, and electron microscopy. In humans, the rate of ap...

journal_title：Acta neuropathologica

authors： Nau R,Zettl U,Gerber J,Trostdorf F,Michel U,Böttcher T,Schmidt H,Adler S,Brück W

更新日期：1998-11-01 00:00:00

abstract：:The accumulation of calcium in the hippocampal and thalamic vascular endothelium and the perivascular space was detected histochemically by means of the pyroantimonate technique 30, 60 and 120 min after systemic kainic acid administration. An increased number of calcium pyroantimonate deposits was found in the endothe...

journal_title：Acta neuropathologica

authors： Sztriha L,Joo F

更新日期：1986-01-01 00:00:00

abstract：:In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...

journal_title：Acta neuropathologica

authors： von Cramon D

更新日期：1975-01-01 00:00:00

abstract：:Newborn rats were exposed to daily intraperitoneal injections of 10 mg lead nitrate per kg body weight for the first 15 postnatal days. The growth and mortality of the lead-exposed animals did not differ from their control litter-mates, injected with vehicle only. In our previous studies, focal hemorrhages and spongy ...

journal_title：Acta neuropathologica

authors： Sundström R,Kalimo H

更新日期：1987-01-01 00:00:00