Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.

abstract：:Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have rem...

journal_title：Acta neuropathologica

authors： Fekete R,Cserép C,Lénárt N,Tóth K,Orsolits B,Martinecz B,Méhes E,Szabó B,Németh V,Gönci B,Sperlágh B,Boldogkői Z,Kittel Á,Baranyi M,Ferenczi S,Kovács K,Szalay G,Rózsa B,Webb C,Kovacs GG,Hortobágyi T,West BL,Kö

更新日期：2018-09-01 00:00:00

abstract：:The present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus Calmette-Guerin (BCG). Three days following injection of BCG (0.5 - 4.0 X 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. ...

journal_title：Acta neuropathologica

authors： Merchant RE

更新日期：1979-08-01 00:00:00

abstract：:Two cases of Central neurocytoma arising in the lateral ventricles are presented. Both patients had well-circumscribed masses in the right lateral ventricle causing hydrocephalus. The tumors were composed of small round cells forming Homer Wright rosettes against a fine fibrillary background. In one patient surgical r...

journal_title：Acta neuropathologica

authors： Townsend JJ,Seaman JP

更新日期：1986-01-01 00:00:00

abstract：:The morphology of toxoplasma and its interaction with the cellular elements of the brain were studied in a patient who dies of extensive cerebral toxoplasmosis superimposed on Hodgkin's disease. The cerebral lesions were devoid of inflammatory cellular response and contained numerous organisms mostly in isolated multi...

journal_title：Acta neuropathologica

authors： Ghatak NR,Sawyer DR

更新日期：1978-06-30 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, and 6 more RBPs showing abnormal expression/distribution in ALS albeit...

journal_title：Acta neuropathologica

authors： Bakkar N,Kovalik T,Lorenzini I,Spangler S,Lacoste A,Sponaugle K,Ferrante P,Argentinis E,Sattler R,Bowser R

更新日期：2018-02-01 00:00:00

abstract：:Large cell/anaplastic (LC/A) medulloblastoma (MB) is a recently recognized variant of medulloblastoma known to be associated with an advanced stage and a poor prognosis. Although Eberhart et al. suggested histopathologic grading of medulloblastoma in 2002, no consensus has been reached in terms of determining the crit...

journal_title：Acta neuropathologica

authors： Min HS,Lee YJ,Park K,Cho BK,Park SH

更新日期：2006-07-01 00:00:00

abstract：:The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic coun...

journal_title：Acta neuropathologica

authors： Dulai MS,Park CY,Howell WD,Smyth LT,Desai M,Carter DM,Vogel H

更新日期：2008-03-01 00:00:00

abstract：:Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...

journal_title：Acta neuropathologica

authors： Dux E,Oschlies U,Uto A,Kusumoto M,Hossmann KA

更新日期：1996-12-01 00:00:00

abstract：:Spinal cord-notochord relationship was analyzed histologically and immunohistochemically in normal human conceptuses between the 4-8 developmental weeks and in a 8-week embryo with double spinal cord. In the early 4-week embryo, the gradual closure of the neural tube along the cranio-caudal body axis was paralleled by...

journal_title：Acta neuropathologica

authors： Saraga-Babić M,Stefanović V,Wartiovaara J,Lehtonen E

更新日期：1993-01-01 00:00:00

abstract：:In adult mice, administration of the anticonvulsive drug phenytoin caused focal swellings along the Purkinje cell axon correlated with ataxia and incoordination of movements. In our model, we used murine cerebellar slice cultures to study the influence of phenytoin on postnatal Purkinje cell axon differentiation. Almo...

journal_title：Acta neuropathologica

authors： Tauer U,Knoth R,Volk B

更新日期：1998-06-01 00:00:00

abstract：:Changes in immature rats in motor neurones after axotomy were studied by enzyme-histochemical methods. Increased activity of dehydrogenases in these neurones demonstrates enhanced metabolism and there was also increase of acid phosphatases. Decreased activity of acetylcholinesterase and indoxylacetate esterase in the ...

journal_title：Acta neuropathologica

authors： Maślińska D,Thomas E

更新日期：1975-12-30 00:00:00

abstract：:Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We hypothesized that the failu...

journal_title：Acta neuropathologica

authors： Nagano S,Jinno J,Abdelhamid RF,Jin Y,Shibata M,Watanabe S,Hirokawa S,Nishizawa M,Sakimura K,Onodera O,Okada H,Okada T,Saito Y,Takahashi-Fujigasaki J,Murayama S,Wakatsuki S,Mochizuki H,Araki T

更新日期：2020-11-01 00:00:00

abstract：:A system is presented for the classification of chronic herniations of the cerebellar tonsils in the absence of space-occupying intracranial lesions, based on a survey of the literature and 13 own cases. The Arnold-Chiari malformation in adults typically involves herniation of the cerebellar tonsils instead of herniat...

journal_title：Acta neuropathologica

authors： Friede RL,Roessmann U

更新日期：1976-03-30 00:00:00

abstract：:The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...

journal_title：Acta neuropathologica

authors： Seilhean D,Kobayashi K,He Y,Uchihara T,Rosenblum O,Katlama C,Bricaire F,Duyckaerts C,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:In the cytoplasm of Schwann cells of a sural nerve biopsy from a 21-year-old female patient with chronic neuropathy we noted numerous unique, usually double membrane-bound, osmiophilic, granular or globular inclusions, approximately 30-600 microm in diameter. Some of these membrane-bound vesicular or tubular structure...

journal_title：Acta neuropathologica

authors： Schröder JM,Wang JF,Sindern E,Malin JP

更新日期：1999-10-01 00:00:00

abstract：:A 25-year-old homosexual AIDS patient presented with progressive cognitive, motor and behavioral disturbances consistent with HIV encephalopathy. CT scans demonstrated progressive diffuse brain atrophy. Neuropathology showed predominant cortical changes including severe neuronal loss corroborated by morphometry. Only ...

journal_title：Acta neuropathologica

authors： Gray F,Haug H,Chimelli L,Geny C,Gaston A,Scaravilli F,Budka H

更新日期：1991-01-01 00:00:00

abstract：:We described the first two unrelated Polish families with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). In the morphological examination with light microscopy, two kinds of changes were observed: (1). panarteritis nodosa-like changes with eosinophilic fibrinoid n...

journal_title：Acta neuropathologica

authors： Rafalowska J,Fidziańska A,Dziewulska D,Podlecka A,Szpak GM,Kwieciński H

更新日期：2003-12-01 00:00:00

abstract：:To investigate the relationship between cerebral amyloid angiopathy and subcortical (lobar) hemorrhage, we examined the severity of amyloid deposition in the leptomeningeal, cortical and subcortical arteries in 28 autopsied elderly patients with cerebral amyloid angiopathy with subcortical hemorrhage, deep cerebral he...

journal_title：Acta neuropathologica

authors： Iwamoto N,Ishihara T,Ito H,Uchino F

更新日期：1993-01-01 00:00:00

abstract：:In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease. This finding sparked interest in this member of the sialic acid-binding immunoglobulin-type lectin family which is linked to innate immunity. Subsequent studies found that CD33 is expressed in...

journal_title：Acta neuropathologica

authors： Estus S,Shaw BC,Devanney N,Katsumata Y,Press EE,Fardo DW

更新日期：2019-08-01 00:00:00

abstract：:Monosodium-L-glutamate given subcutaneously to pregnant rats caused acute necrosis of the acetylcholinesterase-positive neurons in the area postrema. The same effect has been observed in the area postrema of fetal rats. The process of neuronal cell death and the elimination of debris by microglia cells proved to be si...

journal_title：Acta neuropathologica

authors： Tóth L,Karcsu S,Feledi J,Kreutzberg GW

更新日期：1987-01-01 00:00:00

abstract：:We have developed a functional vegetative model by an 18-min clamping of the ascending aorta combined with a bypass formation between the aorta to right atrium and the aorta to femoral vein. Complete global brain ischemia (CGBI) induced for 18 min with this model provided the following distinct advantages: cardiopulmo...

journal_title：Acta neuropathologica

authors： Sato M,Hashimoto H,Kosaka F

更新日期：1990-01-01 00:00:00

abstract：:The distribution of apolipoprotein E (ApoE) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam, locally known as lytico bodig disease (LB), and compared with cases of Alzheimer's disease (AD) and normal brain tissue. In both LB and AD, strong ApoE immuno...

journal_title：Acta neuropathologica

authors： Schwab C,Steele JC,Akiyama H,McGeer PL

更新日期：1996-10-01 00:00:00

abstract：:Three weeks after inoculation of 24-day-old gnotobiotic dogs with Snyder-Hill canine distemper virus, white matter samples were taken from the primary predilection sites for canine distemper virus-associated demyelination. The plasmalogenase activity in extracts was nearly 6-fold greater than control values for a dog ...

journal_title：Acta neuropathologica

authors： Fu SC,Mozzi R,Krakowka S,Higgins RJ,Horrocks LA

更新日期：1980-01-01 00:00:00

abstract：:Surgical specimens of 4 intracranial saccular aneurysms were studied by scanning electron microscopy. The internal surface of the aneurysms showed crater-like defects and cytoplasmic bridges. In some areas the endothelium was preserved, but its longitudinal convolutions were higher and thicker than those found in unch...

journal_title：Acta neuropathologica

authors： Scanarini M,Mingrino S,Zuccarello M,Trincia G

更新日期：1978-11-15 00:00:00

abstract：:Although it is known that deletions or mutations of the SMN1 gene on chromosome 5 cause decreased levels of the SMN protein in subjects with proximal autosomal recessive spinal muscular atrophy (SMA), the exact sequence of pathological events leading to selective motoneuron cell death is not fully understood yet. In t...

journal_title：Acta neuropathologica

authors： Simic G

更新日期：2008-09-01 00:00:00

abstract：:An unusual tumor of the pituitary gland is reported. The most characteristic finding of the present tumor was the presence of numerous "colloid" and mucoid secretions. The cells were stellate in shape and there were intra- or intercellular lumina which were lined by many microvilli and occasional cilia. There were als...

journal_title：Acta neuropathologica

authors： Yagishita S,Itoh Y,Nakazima S,Suzuki N,Hirata K,Yamashita T

更新日期：1984-01-01 00:00:00

abstract：:Prions cause scrapie and Creutzfeldt-Jakob disease (CJD); these infectious pathogens are composed largely, if not entirely, of protein molecules. No prion-specific polynucleotide has been identified. Purified preparations of scrapie prions contain high titers (greater than or equal to 10(9.5) ID50/ml), one protein (Pr...

journal_title：Acta neuropathologica

authors： Prusiner SB,Gabizon R,McKinley MP

更新日期：1987-01-01 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1 B (CMT1B) is a demyelinating neuropathy caused by mutations in the myelin protein zero (P0) gene (MPZ). A few cases of CMT1B were recently found to be characterized by focally folded myelin sheaths in nerve biopsy specimens; the significance of this association is unknown. Here, we d...

journal_title：Acta neuropathologica

authors： Fabrizi GM,Taioli F,Cavallaro T,Rigatelli F,Simonati A,Mariani G,Perrone P,Rizzuto N

更新日期：2000-09-01 00:00:00

abstract：:An autopsy case of unclassifiable presenil dementia is reported. The outstanding pathological findings were as follows; 1. presence of senile plaques, neurofibrillary changes, Pick bodies, Hirano bodies, granulovacuolar degeneration of neurons, etc. 2. numerous Lewy bodies in the brain stem and diencephalon, 3. peculi...

journal_title：Acta neuropathologica

authors： Kosaka K,Oyanagi S,Matsushita M,Hori A

更新日期：1976-11-15 00:00:00

abstract：:Pilocytic astrocytomas (PAs) are the most common brain tumors in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating alterations in the mitogen-activated protein kinase pathway, but little else is known about their development. To ma...

journal_title：Acta neuropathologica

authors： Lambert SR,Witt H,Hovestadt V,Zucknick M,Kool M,Pearson DM,Korshunov A,Ryzhova M,Ichimura K,Jabado N,Fontebasso AM,Lichter P,Pfister SM,Collins VP,Jones DT

更新日期：2013-08-01 00:00:00