Abstract:
:The distribution of apolipoprotein E (ApoE) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam, locally known as lytico bodig disease (LB), and compared with cases of Alzheimer's disease (AD) and normal brain tissue. In both LB and AD, strong ApoE immunostaining was observed in association with pathological lesions. In LB, these were mainly extracellular neurofibrillary tangles (eNFTs) which were intensely immuno-positive for ApoE. Occasional diffuse beta-amyloid protein (beta AP) deposits appear in this disorder and they were moderately immunopositive. In AD, senile plaques and diffuse beta AP deposits were intensely immunopositive, while eNFTs were only moderately immunopositive. The reason for the strong association of ApoE with the pathological entities in LB and AD is unknown, but may be related to a scavenger function which does not involve lipid metabolism. In both LB and AD, subpial and layer I diffuse deposits were ApoE negative but beta AP positive. Intracellular NFTs were mostly ApoE negative. A few showed weak positive staining. These data suggest that ApoE appears in LB and AD pathological lesions only after they are well established. In all controls, as well as all LB and AD cases, strong ApoE immunoreactivity was observed in unidentifiable structures in capillaries. Weak staining in a few neurons and very weak staining of an occasional astrocyte was observed. The source of ApoE which is deposited on extracellular pathological structures in LB and AD is unknown.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Schwab C,Steele JC,Akiyama H,McGeer PLdoi
10.1007/s004010050533subject
Has Abstractpub_date
1996-10-01 00:00:00pages
378-85issue
4eissn
0001-6322issn
1432-0533journal_volume
92pub_type
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