Nerve cell loss in the thalamic mediodorsal nucleus in Huntington's disease.

Abstract:

:We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mean age 53.6 +/- 12.1 years) by means of a stereological protocol. The mean total neurone number (N(T)) in the MD of controls was 2,985,188 +/- 174,710, the mean glial number (G(T); astrocytes, oligodendrocytes) 21,785,008 +/- 2,986,678, and the glial index 7.29 +/- 0.88. In HD, the average neurone number was decreased by 23.8% to 2,275,321 +/- 247,162 (Mann-Whitney U-test P < 0.05), the mean glial number by 29.7% to 15,318,895 +/- 1,722,524 (Mann-Whitney U-test P < 0.05), the glial index was slightly reduced to 6.81 +/- 1.06. Gallyas' impregnation for the demonstration of fibrous astroglia gave strongly positive results in all cases with HD and negative results in the controls. The morpho-functional correlation of the results is complicated because individual variability, presence of segregated and parallel neuronal circuits, and plasticity of the adult human CNS must be considered.

journal_name

Acta Neuropathol

journal_title

Acta neuropathologica

authors

Heinsen H,Rüb U,Bauer M,Ulmar G,Bethke B,Schüler M,Böcker F,Eisenmenger W,Götz M,Korr H,Schmitz C

doi

10.1007/s004010051037

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

613-22

issue

6

eissn

0001-6322

issn

1432-0533

journal_volume

97

pub_type

杂志文章
  • Subcortical afferent projection systems in Huntington's chorea.

    abstract::The number and nucleolar volume of nerve cells within the nucleus basalis of Meynert, locus caeruleus, substantia nigra and dorsal raphe were examined in five patients with Huntington's chorea. No significant changes in nerve cell number were noted in any area in any patient and, although nucleolar volume was reduced ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00687718

    authors: Mann DM

    更新日期:1989-01-01 00:00:00

  • TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.

    abstract::Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We hypothesized that the failu...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-020-02205-y

    authors: Nagano S,Jinno J,Abdelhamid RF,Jin Y,Shibata M,Watanabe S,Hirokawa S,Nishizawa M,Sakimura K,Onodera O,Okada H,Okada T,Saito Y,Takahashi-Fujigasaki J,Murayama S,Wakatsuki S,Mochizuki H,Araki T

    更新日期:2020-11-01 00:00:00

  • Neuronal loss in the basal nucleus of Meynert in progressive supranuclear palsy.

    abstract::A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00697397

    authors: Tagliavini F,Pilleri G,Gemignani F,Lechi A

    更新日期:1983-01-01 00:00:00

  • Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.

    abstract::Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild impact traumatic brain injury from contact sports. Recently, a consensus panel defined the pathognomonic lesion for CTE as accumulations of abnormally hyperphosphorylated tau (p-tau) in neurons (neurofibrillary tangle...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-016-1649-7

    authors: Shively SB,Edgerton SL,Iacono D,Purohit DP,Qu BX,Haroutunian V,Davis KL,Diaz-Arrastia R,Perl DP

    更新日期:2017-03-01 00:00:00

  • Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies.

    abstract::The cholinergic basal forebrain is divided into four subregions (Ch1-4), and cholinergic neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive impairments in both Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). However, the Ch1-2 regions, which provide the major choline...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-005-0004-1

    authors: Fujishiro H,Umegaki H,Isojima D,Akatsu H,Iguchi A,Kosaka K

    更新日期:2006-02-01 00:00:00

  • Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration.

    abstract::Neuronal and glial cytoplasmic inclusions (NCIs and GCIs), which contain alpha-synuclein as a major component, are characteristic cytopathological features of multiple system atrophy (MSA). We report MSA of 19 years' duration in a 73-year-old woman. Her initial symptom was parkinsonism, with dementia appearing about 8...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s004010000292

    authors: Piao YS,Hayashi S,Hasegawa M,Wakabayashi K,Yamada M,Yoshimoto M,Ishikawa A,Iwatsubo T,Takahashi H

    更新日期:2001-03-01 00:00:00

  • Unmyelinated fibers in sural nerve biopsies of chronic inflammatory demyelinating polyneuropathy.

    abstract::Seven patients aged 29 to 76 years with various clinical subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP) were investigated. Sural nerve biopsies were performed between 7 months and 19 years after onset of disease. Quantitative electron microscopy revealed involvement of primary unmyelinated fibers...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00307700

    authors: Gibbels E,Kentenich M

    更新日期:1990-01-01 00:00:00

  • Histopathological effects of intracerebral injections of human recombinant tumor necrosis factor-alpha in the rat.

    abstract::Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals received a single injection of either 6 x 10(4) U rTNF-alpha or excipient in their right parietal lobe. Others received three consecutive daily injections of eithe...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00304638

    authors: Wright JL,Merchant RE

    更新日期:1992-01-01 00:00:00

  • Pericapillary rosettes in the human spinal cord.

    abstract::We have found large eosinophilic bodies in the pericapillary regions of the gray and white matter in the human spinal cord. These are entirely different from the previously reported pericapillary inclusion bodies (PIB). We have designated them pericapillary rosettes (PR), since they consist of clusters of round or ovo...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00299408

    authors: Sasaki S,Maruyama S

    更新日期:1992-01-01 00:00:00

  • Characteristic inclusions in the kidney of canine globoid cell leukodystrophy.

    abstract::The kidney of a 7-month-old male Cairn terrier with globoid cell leukodystrophy (GLD) was investigated with light and electron microscopes. A few tubular epithelial cells in the inner medulla as well as some exfoliated cells in the lumina revealed PAS-positive cytoplasm in which needle-like structures were to be seen ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00687036

    authors: Suzuki K

    更新日期:1986-01-01 00:00:00

  • Abnormalities of muscle fibers in maple syrup urine disease.

    abstract::Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00685251

    authors: Ferrière G,de Castro M,Rodriguez J

    更新日期:1984-01-01 00:00:00

  • Immunohistochemical study of utrophin and dystrophin at the motor end-plate in myasthenia gravis.

    abstract::We studied the densities of utrophin and dystrophin at the motor end-plates of patients with myasthenia gravis (MG) using immunohistochemical analysis. The densities were compared with those found in patients with amyotrophic lateral sclerosis, Lambert-Eaton myasthenic syndrome and normal controls. Utrophin was reduce...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s004010050483

    authors: Ito H,Yoshimura T,Satoh A,Takino H,Tsujihata M,Nagataki S

    更新日期:1996-07-01 00:00:00

  • Doublecortin immunoreactivity in giant cells of tuberous sclerosis and focal cortical dysplasia.

    abstract::Cerebral cortical lesions of tuberous sclerosis (TSC) and focal cortical dysplasia (FCD) show disturbances in laminar architecture and cellular differentiation. We immunohistochemically studied the expression of doublecortin, a fetal neuronal protein that regulates neuronal migration, in the surgical specimens of five...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-002-0575-z

    authors: Mizuguchi M,Yamanouchi H,Becker LE,Itoh M,Takashima S

    更新日期:2002-10-01 00:00:00

  • Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease: diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and Aβ42 levels.

    abstract::The differential diagnosis of Creutzfeldt-Jakob disease (CJD) from other, sometimes treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity of the disease. Real-time quaking-induced prion conversion (RT-QuIC) is a novel ultrasensitive in vitro assay, which, at variance with surroga...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-017-1683-0

    authors: Lattanzio F,Abu-Rumeileh S,Franceschini A,Kai H,Amore G,Poggiolini I,Rossi M,Baiardi S,McGuire L,Ladogana A,Pocchiari M,Green A,Capellari S,Parchi P

    更新日期:2017-04-01 00:00:00

  • "Pink spots" in formalin-fixed brains--poor fixation or bacterial byproduct?

    abstract::Circumscribed pink areas 0.3-1.0 cm in diameter seen in deeper parts of otherwise well-fixed brains are usually ascribed to inadequate fixation. Twenty-three patients with pink areas in their fixed brains had evidence of inflammation in at least one organ. Blood vessels in the pink areas contained bacteria. Postmortem...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00687020

    authors: Hedley-Whyte ET

    更新日期:1985-01-01 00:00:00

  • Inflammatory myopathy with abundant macrophages and dermatomyositis: two stages of one disorder or two distinct entities?

    abstract::Inflammatory myopathy with abundant macrophages (IMAM) and dermatomyositis (DM) are considered to represent related disorders, since they share inflammatory infiltrates and skin alterations. In order to get more insight into these disorders, we addressed the cellular composition of the inflammatory infiltrates in musc...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-009-0570-8

    authors: Brunn A,Hans VJ,Vogelgesang S,Deckert M

    更新日期:2009-12-01 00:00:00

  • Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence.

    abstract::Double immunofluorescence for paired helical filament (PHF)-tau (AT8) and ubiquitin, enhanced by catalyzed reporter deposition amplification, was combined with thiazin red (TR), a fluorochrome, which has an affinity to fibrillary structures such as neurofibrillary tangles (NFTs). After recording these triple-fluoresce...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s004010000306

    authors: Uchihara T,Nakamura A,Yamazaki M,Mori O

    更新日期:2001-06-01 00:00:00

  • Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.

    abstract::The microtubule-associated protein tau accumulates as cytoplasmic inclusions in Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We investigated the immunoreactivity of tau-positive structures using a panel of antibodies to epitopes spanning the ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-003-0671-8

    authors: Arai T,Ikeda K,Akiyama H,Tsuchiya K,Iritani S,Ishiguro K,Yagishita S,Oda T,Odawara T,Iseki E

    更新日期:2003-05-01 00:00:00

  • Do human intracranial arteries lack vasa vasorum? A comparative immunohistochemical study of intracranial and systemic arteries.

    abstract::Vasa vasorum are adventitial vessels that play a role in pathogenesis of atherosclerosis, aneurysm, vasculitides, and graft vascular disease. The existence of vasa vasorum in human intracranial arteries is not yet well defined. The specific aims of this study are to determine whether the human intracranial arteries ha...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s004010050856

    authors: Aydin F

    更新日期:1998-07-01 00:00:00

  • "Reducing body"-like inclusions in skeletal muscle in childhood-onset acid maltase deficiency.

    abstract::Unusual inclusions with some of the features of "reducing bodies" were encountered in the skeletal muscle biopsy of a 2.5-year-old boy with childhood-onset acid maltase deficiency. The biopsy revealed a vacuolar myopathy with lysosomal storage of glycogen and eosinophilic refractile inclusions in myofibers, which appe...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00304641

    authors: Jay V,Christodoulou J,Mercer-Connolly A,McInnes RR

    更新日期:1992-01-01 00:00:00

  • Depopulation of the ventromedial hypothalamic nucleus in the diabetic Chinese hamster.

    abstract::The relationship between diabetes and the size, density and area of the ventromedial hypothalamic nucleus (VMH) was studied in the genetically diabetic Chinese hamster. Matched diabetic and non-diabetic control chinese hamsters were perfused, the hypothalamus collected, sectioned and stained for light microscopy. The ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00691183

    authors: Garris DR,Diani AR,Smith C,Gerritsen GC

    更新日期:1982-01-01 00:00:00

  • Disentangling the pathology of schizophrenia and paraphrenia.

    abstract::With increasing longevity, the number of older schizophrenic patients is growing. Previous criteria used the age of symptom onset to differentiate between the late manifestations of early-onset schizophrenia and late-onset schizophreniform disorders. Current DSM-IV or ICD 10 nomenclatures do not differentiate between ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-001-0468-6

    authors: Casanova MF,Stevens JR,Brown R,Royston C,Bruton C

    更新日期:2002-04-01 00:00:00

  • Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with hypertrophic spinal radiculopathy mimicking neurofibromatosis.

    abstract::This report illustrates a case of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) masquerading as neurofibromatosis due to multifocal enlargements of spinal nerve roots. The patient initially complained of intermittent numbness of the hands and leg weakness at age 62. Nerve conduction velocities were ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-002-0616-7

    authors: Pytel P,Rezania K,Soliven B,Frank J,Wollmann R

    更新日期:2003-02-01 00:00:00

  • New ultrastructural evidence for a protein transport system in endothelial cells of gerbil brains.

    abstract::Pathways for transfer of horseradish peroxidase (HRP) across the cerebral microvasculature were studied in Mongolian gerbils after inducing either unilateral carotid-artery ligation or intracarotid air embolism. Electron microscopy on samples from both ipsilateral and contralateral brain hemispheres showed the reactio...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00717032

    authors: Lossinsky AS,Garcia JH,Iwanowski L,Lightfoote WE Jr

    更新日期:1979-07-13 00:00:00

  • Distinct pathological subtypes of FTLD-FUS.

    abstract::Most cases of frontotemporal lobar degeneration (FTLD) are characterized by abnormal intracellular accumulation of either tau or TDP-43 protein. However, in ~10% of cases, composed of a heterogenous collection of uncommon disorders, the molecular basis remains to be uncertain. We recently discovered that the pathologi...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-010-0764-0

    authors: Mackenzie IR,Munoz DG,Kusaka H,Yokota O,Ishihara K,Roeber S,Kretzschmar HA,Cairns NJ,Neumann M

    更新日期:2011-02-01 00:00:00

  • Immunochemistry of ethylnitrosourea-induced rat neurinomas, the RN6 neurinoma cell line and their transplantation tumors.

    abstract::The expression of glial fibrillary acidic protein (GFAP), vimentin, S-100 protein (S-100), HNK-1, myelin basic protein (MBP) and fibronectin was investigated immunohistochemically in 51 ethylnitrosourea (ENU)-induced neurinomas of the rat. Additionally, 90 transplantation tumors derived from ENU-induced neurinomas and...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00310927

    authors: Vogeley KT,Bilzer T,Reifenberger G,Wechsler W

    更新日期:1991-01-01 00:00:00

  • Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.

    abstract::Evidence of misfolded wild-type superoxide dismutase 1 (SOD1) has been detected in spinal cords of sporadic ALS (sALS) patients, suggesting an etiological relationship to SOD1-associated familial ALS (fALS). Given that there are currently a number of promising therapies under development that target SOD1, it is of cri...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s00401-016-1623-4

    authors: Ayers JI,Diamond J,Sari A,Fromholt S,Galaleldeen A,Ostrow LW,Glass JD,Hart PJ,Borchelt DR

    更新日期:2016-12-01 00:00:00

  • Glial fibrillary acidic protein expression in a new human glioma cell line in culture before and after xenogenic transplantation into nude mice.

    abstract::A human glioma cell line, SA146, was initiated on precoated extracellular matrix from a stereotactic biopsy of a glioblastoma. We report modulation in the expression of glial fibrillary acidic protein (GFAP) by SA146 passed in vitro before or after xenogenic transplantation into nude mice. Immunofluorescence data show...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/s004010050722

    authors: Gomès D,de Néchaud B,Maunoury R,Moura Neto V,Brigaudeau C,Labrousse F,Dupouey P

    更新日期:1997-10-01 00:00:00

  • Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients.

    abstract::We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showe...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00294174

    authors: Doi-Yi R,Kitamoto T,Ogomori K,Mehraein P,Tateishi J

    更新日期:1994-01-01 00:00:00

  • Neuropathological study on the nucleus basalis of Meynert in Pick's disease.

    abstract::The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章

    doi:10.1007/BF00687402

    authors: Mizukami K,Kosaka K

    更新日期:1989-01-01 00:00:00