Transplacental effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopaminergic neurons in the mouse. An immunohistochemical study.


:Immunohistochemical studies of monoamine neurons were performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with those of their offspring. Mice, 9-11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) during pregnancy on Day 9 and 12 of gestation (G9 and G12) miscarried and were examined at 13 weeks of age. Conversely, mice treated during pregnancy with sequential low dose of MPTP (2.8 mg/kg per day at G9-G17 for 8 days) successfully delivered their babies and were examined at the age of 15 weeks. Baby mice were examined at 1 and 6 weeks of age. The tyrosine hydroxylase-, aromatic L-amino acid decarboxylase- and dopamine (DA)-immunoreactive density of caudoputamen was reduced in 13-week-old mice treated with high dose of MPTP but not in the 15-week-old mothers exposed to a low dose of MPTP as compared to their respective controls. The DA-immunoreactive density of the caudoputamen was the only staining that was reduced in both 1- and 6-week-old baby mice. In conclusion, these results demonstrate that MPTP injected to pregnant mice causes a DA depletion in the striatum of their offspring indicating a transplacental effect of MPTP. The findings also indicate that fetal brain is more susceptible to MPTP toxicity than the brain of young pregnant mice.


Acta Neuropathol


Acta neuropathologica


Furune S,Miura K,Watanabe K,Nagao S,Takahashi H,Sakai M,Spatz M,Nagatsu I




Has Abstract


1989-01-01 00:00:00












  • Ultrastructure of muscle and sensory nerve in Fabry's disease.

    abstract::A study of a muscle biopsy has provided evidence of storage involvement of the skeletal muscle fibres in Fabry's disease. In the endothelial cells of the capillaries, the inclusions were more abundant and pleomorphic. Muscle satellite cells were spared. In the sensory nerve biopsy, the perineurial and endothelial cell...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Tomé FM,Fardeau M,Lenoir G

    更新日期:1977-06-15 00:00:00

  • Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

    abstract::Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer's disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in the forms of extrace...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Kumar S,Wirths O,Stüber K,Wunderlich P,Koch P,Theil S,Rezaei-Ghaleh N,Zweckstetter M,Bayer TA,Brüstle O,Thal DR,Walter J

    更新日期:2016-04-01 00:00:00

  • Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis.

    abstract::Axonal degeneration contributes to the transient and permanent neurological deficits seen in multiple sclerosis, an inflammatory disease of the central nervous system. To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats an...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Aboul-Enein F,Weiser P,Höftberger R,Lassmann H,Bradl M

    更新日期:2006-06-01 00:00:00

  • The effects of 2,5-hexanedione on axonal regeneration after nerve crush in the rat.

    abstract::The pattern of recovery of myelinated axons in the posterior tibial nerve after crushing was studied in rats chronically intoxicated with 2,5-hexanedione. It was given for 2 weeks before crushing (200 mg/kg i.p. 5 times a week) or additionally for two further weeks after the nerve crush. Two animals were examined from...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Simonati A,Rizzuto N,Cavanagh JB

    更新日期:1983-01-01 00:00:00

  • Congenital muscular dystrophy. A study on the variability of morphological changes and dystrophin distribution in muscle biopsies.

    abstract::Histomorphological and histochemical variability was studied in muscle specimens from 30 patients with congenital muscular dystrophy (CMD). We found involvement of the central nervous system in 8 patients (Fukuyama CMD, F-CMD), involvement of the brain and the eyes in 5 patients (muscle, eye and brain disease, MEB-D) ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Leyten QH,ter Laak HJ,Gabreëls FJ,Renier WO,Renkawek K,Sengers RC

    更新日期:1993-01-01 00:00:00

  • Immunocytochemical and ultrastructural studies of the motor cortex in amyotrophic lateral sclerosis.

    abstract::This report concerns an immunocytochemical and ultrastructural study of the motor cortices of 11 patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 normal individuals served as controls. Antibodies against phosphorylated neurofilament (PNF; 200 kDa), ubiquitin, glial fibrillary acidic protein (GFAP) ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Sasaki S,Maruyama S

    更新日期:1994-01-01 00:00:00

  • Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72.

    abstract::The most common cause of familial frontotemporal lobar degeneration with TAR DNA-binding protein-43 pathology (FTLD-TDP) has been found to be an expansion of a hexanucleotide repeat (GGGGCC) in a noncoding region of the gene C9ORF72. Hippocampal sclerosis (HpScl) is a common finding in FTLD-TDP. Our objective was to s...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Murray ME,Bieniek KF,Banks Greenberg M,DeJesus-Hernandez M,Rutherford NJ,van Blitterswijk M,Niemantsverdriet E,Ash PE,Gendron TF,Kouri N,Baker M,Goodman IJ,Petrucelli L,Rademakers R,Dickson DW

    更新日期:2013-10-01 00:00:00

  • A new neurophysiological/neuropathological ex vivo model localizes the origin of glioma-associated epileptogenesis in the invasion area.

    abstract::Seizures commonly occur in glioma patients, but their pathogenesis is poorly understood, in part due to a lack of valid and versatile experimental models. We have established a new model that enables comprehensive neuropathological and neurophysiological analysis on identical tissue preparations. Rat C6 glioma cells s...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Senner V,Köhling R,Püttmann-Cyrus S,Straub H,Paulus W,Speckmann EJ

    更新日期:2004-01-01 00:00:00

  • Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.

    abstract::Paired helical filaments (PHF) were isolated from autopsied brain of cases of Alzheimer dementia, and their polypeptides were identified with monoclonal antibodies to PHF by Western blots. The PHF polypeptide profile consisted of several bands with a size difference of less than 5 kilodalton (kDa) between adjacent ban...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Grundke-Iqbal I,Wang GP,Iqbal K,Tung YC,Wisniewski HM

    更新日期:1985-01-01 00:00:00

  • Simultaneous visualization of vascular permeability change and leukocyte egress in the central nervous system during autoimmune encephalomyelitis.

    abstract::An unresolved issue in the study of demyelinating disease is whether blood-brain barrier damage is dependent upon the migration of inflammatory cells into the central nervous system (CNS). In a study of experimental autoimmune encephalomyelitis (EAE) in rabbits, a freeze-dried, paraffin-embedded tissue technique was e...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Simmons RD,Buzbee TM,Linthicum DS,Mandy WJ,Chen G,Wang C

    更新日期:1987-01-01 00:00:00

  • Exertional rhabdomyolysis and exercise intolerance revealing dystrophinopathies.

    abstract::Exercise intolerance associated with myalgias, muscle cramps or myoglobinuria may be associated with a dystrophinopathy. A search for abnormal dystrophin expression (using immunohistochemistry, immunoblot and DNA analysis) was carried out in a series of 15 patients. They were selected because they presented exercise i...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Figarella-Branger D,Baeta Machado AM,Putzu GA,Malzac P,Voelckel MA,Pellissier JF

    更新日期:1997-07-01 00:00:00

  • Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells.

    abstract::We have recently shown that glioma cell lines, as well as cells of human malignant gliomas in situ, synthesize tropoelastin. In addition, glioma cells degrade tropoelastin using metalloproteinase(s), and the resulting peptides, incapable of assembling in the extracellular fibers, interact with the 67-kDa cell surface ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Hinek A,Jung S,Rutka JT

    更新日期:1999-04-01 00:00:00

  • Neuropathology and general autopsy findings in AIDS during the last 15 years.

    abstract::A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of tr...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Jellinger KA,Setinek U,Drlicek M,Böhm G,Steurer A,Lintner F

    更新日期:2000-08-01 00:00:00

  • The origin, fate, and contribution of macrophages to spinal cord injury pathology.

    abstract::Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia a...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Milich LM,Ryan CB,Lee JK

    更新日期:2019-05-01 00:00:00

  • Perinuclear leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) as prognostic indicators in astrocytic tumors.

    abstract::We have previously characterized three human leucine-rich repeats and immunoglobulin-like domains (LRIG) genes and proteins, named LRIG1-3 and proposed that they may act as suppressors of tumor growth. The LRIG1 transmembrane protein antagonizes the activity of epidermal growth factor receptor family receptor tyrosine...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Guo D,Nilsson J,Haapasalo H,Raheem O,Bergenheim T,Hedman H,Henriksson R

    更新日期:2006-03-01 00:00:00

  • Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease.

    abstract::The transmissible spongiform encephalopathies (TSEs) or prion diseases of animals are characterised by CNS spongiform change, gliosis and the accumulation of disease-associated forms of prion protein (PrP(d)). Particularly in ruminant prion diseases, a wide range of morphological types of PrP(d) depositions are found ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Jeffrey M,McGovern G,Sisó S,González L

    更新日期:2011-01-01 00:00:00

  • The unfolded protein response in neurodegenerative diseases: a neuropathological perspective.

    abstract::The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins is a common characte...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Scheper W,Hoozemans JJ

    更新日期:2015-09-01 00:00:00

  • Distributions of amyloid plaques in four regions of the brains of mice infected with scrapie by intracerebral and intraperitoneal routes of injection.

    abstract::VM mice were inoculated by intracerebral and intraperitoneal routes with brain homogenates containing the 87V strain of scrapie. The distribution and numbers of plaques were found for the parietal cortex, cingulate cortex, corpus callosum and hippocampus/dentate in coronal sections cut at the level of the thalamus and...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Gibson PH

    更新日期:1986-01-01 00:00:00

  • Spinal and cranial motor nerve roots in amyotrophic lateral sclerosis and X-linked recessive bulbospinal muscular atrophy: morphometric and teased-fiber study.

    abstract::Amyotrophic lateral sclerosis (ALS) and adult onset X-linked recessive bulbospinal muscular atrophy (SPMA), constituting the category of adult onset form of motor neuron disease, were analyzed on motor nerve roots. The results of morphometric analysis on ventral spinal roots (VSR) of all spinal segments from ALS and S...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Sobue G,Matsuoka Y,Mukai E,Takayanagi T,Sobue I,Hashizume Y

    更新日期:1981-01-01 00:00:00

  • FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.

    abstract::In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we examined an associati...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Brand F,Förster A,Christians A,Bucher M,Thomé CM,Raab MS,Westphal M,Pietsch T,von Deimling A,Reifenberger G,Claus P,Hentschel B,Weller M,Weber RG

    更新日期:2020-01-01 00:00:00

  • The lateral corticospinal tract and spinal ventral horn in X-linked recessive spinal and bulbar muscular atrophy: a quantitative study.

    abstract::A quantitative study was performed on spinal cord lesions in seven patients with X-linked recessive spinal and bulbar muscular atrophy. The myelinated fiber density of the lateral corticospinal tracts at the T7 cord level was well preserved for both large and small myelinated fibers. On the other hand, neurons in the ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Terao S,Sobue G,Li M,Hashizume Y,Tanaka F,Mitsuma T

    更新日期:1997-01-01 00:00:00

  • Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?

    abstract::In this study, we used immunohistochemistry to screen for alpha-synuclein pathology in the brains of 241 individuals without clinical evidence of neurologic disease, and discovered 36 cases (15%) with incidental Lewy bodies (LBs) and one case, a 96-year-old woman (0.4%), with inclusions similar to those seen in multip...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Fujishiro H,Ahn TB,Frigerio R,DelleDonne A,Josephs KA,Parisi JE,Eric Ahlskog J,Dickson DW

    更新日期:2008-09-01 00:00:00

  • Neuronopathic juvenile glucosylceramidosis due to sap-C deficiency: clinical course, neuropathology and brain lipid composition in this Gaucher disease variant.

    abstract::Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

    更新日期:1999-01-01 00:00:00

  • Immunohistochemical expression of nestin in the non-tumorous hypophysis and in pituitary neoplasms.

    abstract::The aim of the present work was to investigate whether nestin, a member of the intermediate filament family, is immunohistochemically expressed in the non-tumoral human hypophysis and pituitary neoplasms. Twenty-three normal pituitaries and 125 pituitary neoplasms were included. The tissues were formalin-fixed and par...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Rotondo F,Kovacs K,Horvath E,Bell CD,Lloyd RV,Scheithauer BW

    更新日期:2006-03-01 00:00:00

  • Inclusion bodies in cerebral cortical astrocytes: a new change of astrocytes.

    abstract::A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Minagawa M,Shioda K,Shimizu Y,Isshiki T

    更新日期:1992-01-01 00:00:00

  • Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis.

    abstract::Multiple sclerosis (MS) is the most frequent demyelinating disease in young adults and despite significant advances in immunotherapy, disease progression still cannot be prevented. Promotion of remyelination, an endogenous repair mechanism resulting in the formation of new myelin sheaths around demyelinated axons, rep...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Starost L,Lindner M,Herold M,Xu YKT,Drexler HCA,Heß K,Ehrlich M,Ottoboni L,Ruffini F,Stehling M,Röpke A,Thomas C,Schöler HR,Antel J,Winkler J,Martino G,Klotz L,Kuhlmann T

    更新日期:2020-11-01 00:00:00

  • The temporal evolution of hypoglycemic brain damage. III. Light and electron microscopic findings in the rat caudoputamen.

    abstract::The caudate nucleus and putamen belong to the selectively vulnerable brain regions which incur neuronal damage in clinical and experimental settings of both hypoglycemia and ischemia. We have previously documented the density and distribution of the hypoglycemic damage in rat caudoputamen, but the evolution of the inj...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Kalimo H,Auer RN,Siesjö BK

    更新日期:1985-01-01 00:00:00

  • Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms.

    abstract::Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have rem...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Fekete R,Cserép C,Lénárt N,Tóth K,Orsolits B,Martinecz B,Méhes E,Szabó B,Németh V,Gönci B,Sperlágh B,Boldogkői Z,Kittel Á,Baranyi M,Ferenczi S,Kovács K,Szalay G,Rózsa B,Webb C,Kovacs GG,Hortobágyi T,West BL,Kö

    更新日期:2018-09-01 00:00:00

  • Pontocerebellar hypoplasia type 2: a neuropathological update.

    abstract::Pontocerebellar hypoplasia type 2 (PCH-2; MIM 277470), an autosomal recessive neurodegeneration with fetal onset, was studied in six autopsies with ages at death ranging between 1 and 22 years. Three patients were distantly related. A case of olivopontocerebellar hypoplasia (OPCH; MIM 225753) was studied for compariso...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Barth PG,Aronica E,de Vries L,Nikkels PG,Scheper W,Hoozemans JJ,Poll-The BT,Troost D

    更新日期:2007-10-01 00:00:00

  • Wolfram syndrome: a clinicopathologic correlation.

    abstract::Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is a neurodegenerative disorder characterized by diabetes mellitus and optic atrophy as well as diabetes insipidus and deafness in many cases. We report the post-mortem neuropathologic findings of a patient with Wolfram syn...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Hilson JB,Merchant SN,Adams JC,Joseph JT

    更新日期:2009-09-01 00:00:00