Transplacental effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopaminergic neurons in the mouse. An immunohistochemical study.


:Immunohistochemical studies of monoamine neurons were performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with those of their offspring. Mice, 9-11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) during pregnancy on Day 9 and 12 of gestation (G9 and G12) miscarried and were examined at 13 weeks of age. Conversely, mice treated during pregnancy with sequential low dose of MPTP (2.8 mg/kg per day at G9-G17 for 8 days) successfully delivered their babies and were examined at the age of 15 weeks. Baby mice were examined at 1 and 6 weeks of age. The tyrosine hydroxylase-, aromatic L-amino acid decarboxylase- and dopamine (DA)-immunoreactive density of caudoputamen was reduced in 13-week-old mice treated with high dose of MPTP but not in the 15-week-old mothers exposed to a low dose of MPTP as compared to their respective controls. The DA-immunoreactive density of the caudoputamen was the only staining that was reduced in both 1- and 6-week-old baby mice. In conclusion, these results demonstrate that MPTP injected to pregnant mice causes a DA depletion in the striatum of their offspring indicating a transplacental effect of MPTP. The findings also indicate that fetal brain is more susceptible to MPTP toxicity than the brain of young pregnant mice.


Acta Neuropathol


Acta neuropathologica


Furune S,Miura K,Watanabe K,Nagao S,Takahashi H,Sakai M,Spatz M,Nagatsu I




Has Abstract


1989-01-01 00:00:00












  • Investigation on the expression of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1-positive patients.

    abstract::Among the various mechanisms proposed to explain the pathogenesis of cerebral lesions in human immunodeficiency virus (HIV)-induced encephalitis, a cytokine-mediated action has found most favour. Indeed, elevated expression of cytokines such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha), thought to...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: An SF,Ciardi A,Giometto B,Scaravilli T,Gray F,Scaravilli F

    更新日期:1996-01-01 00:00:00

  • Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.

    abstract::Paired helical filaments (PHF) were isolated from autopsied brain of cases of Alzheimer dementia, and their polypeptides were identified with monoclonal antibodies to PHF by Western blots. The PHF polypeptide profile consisted of several bands with a size difference of less than 5 kilodalton (kDa) between adjacent ban...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Grundke-Iqbal I,Wang GP,Iqbal K,Tung YC,Wisniewski HM

    更新日期:1985-01-01 00:00:00

  • Infective endocarditis with inflammatory lesions in the peripheral nervous system.

    abstract::A 64-year-old woman developed septicemia and a generalized peripheral neuropathy while being ventilated postoperatively. No cause for the neuropathy could be found during life. At autopsy she was found to have infective endocarditis and multifocal inflammatory lesions in the central and peripheral nervous systems, con...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Pamphlett R,Walsh J

    更新日期:1989-01-01 00:00:00

  • GM1-gangliosidosis in a cross-bred dog confirmed by detection of GM1-ganglioside using electrospray ionisation-tandem mass spectrometry.

    abstract::The post-mortem diagnosis of lysosomal storage diseases can be confounded by the unavailability of suitable material. Here we report the diagnosis of GM1-gangliosidosis in a cross-bred dog, from which only formalin-fixed brain was available, by a combination of electron microscopy and the detection of elevated levels ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Whitfield P,Johnson AW,Dunn KA,Delauche AJ,Winchester BG,Franklin RJ

    更新日期:2000-10-01 00:00:00

  • Hirano body in extraocular muscle.

    abstract::Thirty-three rectus superior extraocular muscles from 23 autopsy cases, all over 60 years, were examined. Eosinophilic inclusions (Hirano bodies) were observed in all the muscles; they were stained deep red by Masson's trichrome stain and were positive for protein stain. They consisted of a collection of filamentous s...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Tomonaga M

    更新日期:1983-01-01 00:00:00

  • An electron and light microscopic study of the numbers of dystrophic neurites and vacuoles in the hippocampus of mice infected intracerebrally with scrapie.

    abstract::Numbers of dystrophic neurites, seen with the electron microscope, in CA1 of the hippocampus of either C3H mice infected with 22C or 79A strains of scrapie, or LM mice infected with strain ME7 were greater than in age-matched control mice. Vacuolation, seen by light microscopy in CA1 of the hippocampus of mice infecte...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Gibson PH,Liberski PP

    更新日期:1987-01-01 00:00:00

  • Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys.

    abstract::Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Garruto RM,Shankar SK,Yanagihara R,Salazar AM,Amyx HL,Gajdusek DC

    更新日期:1989-01-01 00:00:00

  • The function of the cellular prion protein in health and disease.

    abstract::The essential role of the cellular prion protein (PrPC) in prion disorders such as Creutzfeldt-Jakob disease is well documented. Moreover, evidence is accumulating that PrPC may act as a receptor for protein aggregates and transduce neurotoxic signals in more common neurodegenerative disorders, such as Alzheimer's dis...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Watts JC,Bourkas MEC,Arshad H

    更新日期:2018-02-01 00:00:00

  • Neuronopathic juvenile glucosylceramidosis due to sap-C deficiency: clinical course, neuropathology and brain lipid composition in this Gaucher disease variant.

    abstract::Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

    更新日期:1999-01-01 00:00:00

  • Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains.

    abstract::PICALM, a clathrin adaptor protein, plays important roles in clathrin-mediated endocytosis in all cell types. Recently, genome-wide association studies identified single nucleotide polymorphisms in PICALM gene as genetic risk factors for late-onset Alzheimer disease (LOAD). We analysed by western blotting with several...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Ando K,Brion JP,Stygelbout V,Suain V,Authelet M,Dedecker R,Chanut A,Lacor P,Lavaur J,Sazdovitch V,Rogaeva E,Potier MC,Duyckaerts C

    更新日期:2013-06-01 00:00:00

  • Paranodal structure in diabetic sensory polyneuropathy.

    abstract::Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Thomas PK,Beamish NG,Small JR,King RH,Tesfaye S,Ward JD,Tsigos C,Young RJ,Boulton AJ

    更新日期:1996-12-01 00:00:00

  • Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.

    abstract::Accumulation of amyloid-β (Aβ) and neurofibrillary tangles in the brain, inflammation and synaptic and neuronal loss are some of the major neuropathological hallmarks of Alzheimer's disease (AD). While genetic mutations in amyloid precursor protein and presenilin-1 and -2 (PS1 and PS2) genes cause early-onset familial...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Wahlster L,Arimon M,Nasser-Ghodsi N,Post KL,Serrano-Pozo A,Uemura K,Berezovska O

    更新日期:2013-02-01 00:00:00

  • The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.

    abstract::Synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) aggregates throughout the nervous system but diverge from one another with regard to their clinical and pathological phenotype. The recent generatio...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Van der Perren A,Gelders G,Fenyi A,Bousset L,Brito F,Peelaerts W,Van den Haute C,Gentleman S,Melki R,Baekelandt V

    更新日期:2020-06-01 00:00:00

  • Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system: an immunohistochemical investigation.

    abstract::This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive con...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Kato S,Hirano A,Kato M,Herz F,Ohama E

    更新日期:1992-01-01 00:00:00

  • Immunohistochemical observations on rat radial glia: relationship with the origin of ethylnitrosourea-induced tumors.

    abstract::Gliomas induced in the rat by transplacental administration of ethylnitrosourea (ENU) are intensely immunoreactive for vimentin and scarcely for glial fibrillary acidic protein (GFAP). Since tumoral transformation takes place during the late fetal and early postnatal period, the sequential expression of the two glial ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Giordana MT,Migheli A,Mocellini C,Villare F,Schiffer D

    更新日期:1992-01-01 00:00:00

  • Experimental cerebral ischemia in Mongolian gerbils. IV. Behaviour of biogenic amines.

    abstract::Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin through...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Mrsulja BB,Mrsulja BJ,Spatz M,Ito U,Walker JT Jr,Klatzo I

    更新日期:1976-09-15 00:00:00

  • The distribution of degenerative changes in INH neuropathy. Further evidence for focal axonal lesions.

    abstract::Rats were given isoniazid either in a single large dose or continuously in drinking water and killed 5--105 days later. The distribution of degenerating fibres in various nerves (sensory and mixed) and in various sites along nerves and spinal roots was studied by light and electron microscopy. It was found that sensor...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Jacobs JM,Miller RH,Cavanagh JB

    更新日期:1979-10-01 00:00:00

  • Neuronal loss in the basal nucleus of Meynert in progressive supranuclear palsy.

    abstract::A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Tagliavini F,Pilleri G,Gemignani F,Lechi A

    更新日期:1983-01-01 00:00:00

  • Synaptotagmin 13 is neuroprotective across motor neuron diseases.

    abstract::In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs). The mechanisms responsible for this selective degeneration are largely unknown, but the molecular signatures of ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Nizzardo M,Taiana M,Rizzo F,Aguila Benitez J,Nijssen J,Allodi I,Melzi V,Bresolin N,Comi GP,Hedlund E,Corti S

    更新日期:2020-05-01 00:00:00

  • Examination of the validity of the hierarchical model of neuropathological staging in normal aging and Alzheimer's disease.

    abstract::The neuropathological staging model of Alzheimer's disease proposed by Braak and Braak [Acta Neuropathol (1991) 82:259] requires that the evolution of neurofibrillary pathology follows a predictable pattern that can be ordered in a regular regional hierarchy. We have operationalized the neuropathological staging syste...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Gertz HJ,Xuereb J,Huppert F,Brayne C,McGee MA,Paykel E,Harrington C,Mukaetova-Ladinska E,Arendt T,Wischik CM

    更新日期:1998-02-01 00:00:00

  • Late-onset malignant astrocytoma in a case of multiple sclerosis. Clinical, neuropathological, virological, and tissue culture studies.

    abstract::An unusual case of concurrent MS and anaplastic astrocytoma is presented. MS was diagnosed in a female patient at the age of 22 years. A left side thalamotomy was performed for relief of severe intention tremor at age 28 and at age 32 she received immunosuppressive therapy for 1 year. At the age of 36 after a severe e...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Kalimo H,Frey H,Raine CS,Törmä T,Röyttä M

    更新日期:1979-05-15 00:00:00

  • Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas.

    abstract::Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing rev...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Reis RM,Nakamura M,Masuoka J,Watanabe T,Colella S,Yonekawa Y,Kleihues P,Ohgaki H

    更新日期:2001-04-01 00:00:00

  • Changes in the cytoskeletal proteins, sarcoplasmic reticulum, and capillaries in acute relaxant-steroid myopathy (ARSM) in contrast to the corticosteroid myopathy.

    abstract::Since we reported a case of acute relaxant-steroid myopathy (ARSM) in 1994, we continued histological studies and compared the findings with those in a case of corticosteroid myopathy (CM). It was revealed that (1) dystrophin, spectrin, beta dystroglycan, and sarcoglycans on the cell surface were decreased, (2) regula...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Matsubara S,Kitaguchi T,Isozaki E,Miyamoto K,Hirai S

    更新日期:1999-05-01 00:00:00

  • Niemann-Pick disease type C. Study on the nature of the cerebral storage process.

    abstract::A complex neuropathological study of two cases of Niemann-Pick disease (NPD) type C (NPDC) revealed some novel features in the chemical pathology of the neuronal storage. Lipid histochemistry showed the presence of a lipid which met the criteria of a neuronal glycosphingolipid. Sphingomyelin (SM) was not detected in t...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Elleder M,Jirásek A,Smíd F,Ledvinová J,Besley GT

    更新日期:1985-01-01 00:00:00

  • Expression of serine proteases and metalloproteinases in human pituitary adenomas and anterior pituitary lobe tissue.

    abstract::Data on the dural invasiveness of pituitary adenomas have been correlated to the expression of matrix metalloproteinases (e.g. MMP-9). Serine proteases have not yet been investigated in human pituitary adenomas. In this study, paraffin-embedded material from 84 human pituitary adenomas (acromegaly n=18, Cushing's dise...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Knappe UJ,Hagel C,Lisboa BW,Wilczak W,Lüdecke DK,Saeger W

    更新日期:2003-11-01 00:00:00

  • The perineurium modifies the effects of phenol and glycerol in rat sciatic nerve.

    abstract::Endoneurial cell response and type of nerve fibre damage were studied after perineural injections of 7% phenol-aqua and pure glycerol. Our previous studies have shown that phenol and glycerol induce different types of nerve fibre degeneration after intraneural injections: phenol dissolves axons and Schwann cells insid...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Westerlund T,Vuorinen V,Röyttä M

    更新日期:2004-10-01 00:00:00

  • Evaluation of CD33 as a genetic risk factor for Alzheimer's disease.

    abstract::In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease. This finding sparked interest in this member of the sialic acid-binding immunoglobulin-type lectin family which is linked to innate immunity. Subsequent studies found that CD33 is expressed in...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Estus S,Shaw BC,Devanney N,Katsumata Y,Press EE,Fardo DW

    更新日期:2019-08-01 00:00:00

  • Intranuclear inclusions in a case of Creutzfeldt-Jakob disease: an ultrastructural study.

    abstract::Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranculear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Payne CM,Sibley WA

    更新日期:1975-01-01 00:00:00

  • Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.

    abstract::Accumulation of the tau protein in fibrillar intracellular aggregates is a defining feature of multiple neurodegenerative diseases collectively referred to as tauopathies. Despite intensive study of tau, there is limited information on the formation and clearance dynamics of tau inclusions. Using rAAV vectors to media...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Croft CL,Goodwin MS,Ryu DH,Lessard CB,Tejeda G,Marrero M,Vause AR,Paterno G,Cruz PE,Lewis J,Giasson BI,Golde TE

    更新日期:2021-01-26 00:00:00

  • Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex.

    abstract::The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...

    journal_title:Acta neuropathologica

    pub_type: 临床试验,杂志文章


    authors: Seilhean D,Kobayashi K,He Y,Uchihara T,Rosenblum O,Katlama C,Bricaire F,Duyckaerts C,Hauw JJ

    更新日期:1997-05-01 00:00:00