Transplacental effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopaminergic neurons in the mouse. An immunohistochemical study.

abstract：:Seven patients with the typical clinical picture and muscle biopsy findings of classical Werdnig-Hoffmann disease showed Wallerian degeneration in their biopsied sural nerves. In dorsal root ganglia of one patient there were residual nodules and several chromatolytic neurons. By electron microscopy the changes of chro...

journal_title：Acta neuropathologica

authors： Carpenter S,Karpati G,Rothman S,Watters G,Andermann F

更新日期：1978-05-24 00:00:00

abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...

journal_title：Acta neuropathologica

authors： Ma KC,Chang ZH,Shih H,Zhu JH,Wu JY

更新日期：1991-01-01 00:00:00

abstract：:Alpha-synuclein (alphaS) and ubiquitin (Ub) are shared constituents of glial cytoplasmic inclusions (GCIs) and Lewy bodies (LBs), both composed of fibrillary structures. Staining profiles of GCIs were investigated with triple immunofluorescence involving immunostaining for alphaS and Ub, both amplified with catalyzed ...

journal_title：Acta neuropathologica

authors： Sakamoto M,Uchihara T,Nakamura A,Mizutani T,Mizusawa H

更新日期：2005-10-01 00:00:00

abstract：:Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord...

journal_title：Acta neuropathologica

authors： Higgins RJ,Vandevelde M,Hoff EJ,Jagar JE,Cork LC,Silberman MS

更新日期：1977-01-31 00:00:00

abstract：:The effects of ageing, cachexia and neoplasms on striated muscle were examined in histological sections of an autopsy material. Paraffin sections were examined from four separate muscles of 30 previously healthy subjects who died suddenly, from eight cases with cachexia and from 16 cases with cachexia and neoplasms. I...

journal_title：Acta neuropathologica

authors： Lindboe CF,Torvik A

更新日期：1982-01-01 00:00:00

abstract：:An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...

journal_title：Acta neuropathologica

authors： Goto S,Korematsu K,Nagahiro S,Ushio Y

更新日期：1993-01-01 00:00:00

abstract：:This report illustrates a case of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) masquerading as neurofibromatosis due to multifocal enlargements of spinal nerve roots. The patient initially complained of intermittent numbness of the hands and leg weakness at age 62. Nerve conduction velocities were ...

journal_title：Acta neuropathologica

authors： Pytel P,Rezania K,Soliven B,Frank J,Wollmann R

更新日期：2003-02-01 00:00:00

abstract：:The relationship between diabetes and the size, density and area of the ventromedial hypothalamic nucleus (VMH) was studied in the genetically diabetic Chinese hamster. Matched diabetic and non-diabetic control chinese hamsters were perfused, the hypothalamus collected, sectioned and stained for light microscopy. The ...

journal_title：Acta neuropathologica

authors： Garris DR,Diani AR,Smith C,Gerritsen GC

更新日期：1982-01-01 00:00:00

abstract：:A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...

journal_title：Acta neuropathologica

authors： Tokuda T,Ikeda S,Yanagisawa N,Ihara Y,Glenner GG

更新日期：1991-01-01 00:00:00

abstract：:Immunohistochemical analysis of inflammatory cell density and infiltrate subpopulations in 42 meningiomas was performed. Evaluation of infiltrating cell density was carried out by cell counting. Meningothelial and fibroblastic meningiomas contained an average of 3% mononuclear cells; the few lymphocytes were localized...

journal_title：Acta neuropathologica

authors： Becker I,Roggendorf W

更新日期：1989-01-01 00:00:00

abstract：:Pregnant rats were administered a liquid diet containing 5% (w/v) ethanol between gestational days 10 and 21, and the brains of nine offspring were examined at 8 weeks of age. Two ethanol-treated offspring showed obvious hydrocephalus characterized by markedly enlarged lateral ventricles. Most of the other ethanol-tre...

journal_title：Acta neuropathologica

authors： Sakata-Haga H,Sawada K,Ohnishi T,Fukui Y

更新日期：2004-11-01 00:00:00

abstract：:The E200K mutation is the most frequent prion protein gene (PRNP) mutation detected worldwide that is associated with Creutzfeldt-Jakob disease (CJD) and thought to have overlapping features with sporadic CJD, yet detailed neuropathological studies have not been reported. In addition to the prion protein, deposition o...

journal_title：Acta neuropathologica

authors： Kovacs GG,Seguin J,Quadrio I,Höftberger R,Kapás I,Streichenberger N,Biacabe AG,Meyronet D,Sciot R,Vandenberghe R,Majtenyi K,László L,Ströbel T,Budka H,Perret-Liaudet A

更新日期：2011-01-01 00:00:00

abstract：:Mutations in the sarcomeric protein titin, encoded by TTN, are emerging as a common cause of myopathies. The diagnosis of a TTN-related myopathy is, however, often not straightforward due to clinico-pathological overlap with other myopathies and the prevalence of TTN variants in control populations. Here, we present a...

journal_title：Acta neuropathologica

authors： Rees M,Nikoopour R,Fukuzawa A,Kho AL,Fernandez-Garcia MA,Wraige E,Bodi I,Deshpande C,Özdemir Ö,Daimagüler HS,Pfuhl M,Holt M,Brandmeier B,Grover S,Fluss J,Longman C,Farrugia ME,Matthews E,Hanna M,Muntoni F,Sarkozy

更新日期：2021-01-15 00:00:00

abstract：:Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of non-demented elderly people. However, several studies...

journal_title：Acta neuropathologica

authors： Köhler C

更新日期：2016-09-01 00:00:00

abstract：:Adult white rats were injected daily for 1 month with aluminum chloride and killed. Aluminum was identified, quantitated, and localized in the brains of these rats. The only detectable anomalies were crystals of aluminum and phosphorus in lysosomes and lipofuscin granules in the cytoplasm of neurons. ...

journal_title：Acta neuropathologica

authors： Galle P,Berry JP,Duckett S

更新日期：1980-01-01 00:00:00

abstract：:Neurological signs were observed in 3 lambs at approximately 1 month of age, in a flock of 1 ram and 29 ewes with 43 lambs. Deterioration occurred such that the lambs had either died or been killed by 4 months of age. Necropsies of two of these lambs revealed a diffuse encephalopathy in which the most prominent featur...

journal_title：Acta neuropathologica

authors： Skelly BJ,Jeffrey M,Franklin RJ,Winchester BG

更新日期：1995-01-01 00:00:00

abstract：:Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these ...

journal_title：Acta neuropathologica

authors： Dickson DW,Yen SH,Suzuki KI,Davies P,Garcia JH,Hirano A

更新日期：1986-01-01 00:00:00

abstract：:A Schwann cell can form only one internode of myelin around an axon. However, we observed the formation by a single Schwann cell of myelin around two axons of different diameters in the sural nerve of a 45-year-old man with mononeuritis multiplex. Schwann cell processes spiraled in the same direction around each axon,...

journal_title：Acta neuropathologica

authors： Kusaka H,Imai T,Matsumoto S,Ito H,Yamasaki M

更新日期：1992-01-01 00:00:00

abstract：:In addition to motor neurone degeneration, up to 50% of amyotrophic lateral sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, as cognitively impaired patients exhibit a shorter survival time from symptom onset. Given the ...

journal_title：Acta neuropathologica

authors： Henstridge CM,Sideris DI,Carroll E,Rotariu S,Salomonsson S,Tzioras M,McKenzie CA,Smith C,von Arnim CAF,Ludolph AC,Lulé D,Leighton D,Warner J,Cleary E,Newton J,Swingler R,Chandran S,Gillingwater TH,Abrahams S,Spires-

更新日期：2018-02-01 00:00:00

abstract：:In this study, we used immunohistochemistry to screen for alpha-synuclein pathology in the brains of 241 individuals without clinical evidence of neurologic disease, and discovered 36 cases (15%) with incidental Lewy bodies (LBs) and one case, a 96-year-old woman (0.4%), with inclusions similar to those seen in multip...

journal_title：Acta neuropathologica

authors： Fujishiro H,Ahn TB,Frigerio R,DelleDonne A,Josephs KA,Parisi JE,Eric Ahlskog J,Dickson DW

更新日期：2008-09-01 00:00:00

abstract：:A large series of central and peripheral nervous system tumors was studied for the presence of glial fibrillary acidic protein (GFAP) and gamma-enolase (neuron-specific enolase, NSE), using specific monoclonal antibodies (mAbs). Occurrence in and specificity of GFAP to glial and mixed tumors was confirmed and depended...

journal_title：Acta neuropathologica

authors： Cras P,Martin JJ,Gheuens J

更新日期：1988-01-01 00:00:00

abstract：:It was demonstrated that New Zealand Albino rabbits sensitized to galactocerebroside had high levels of anti-galactocerebroside antibody and of immune complexes. The rabbits was high titers of immune complexes developed demyelination in the peripheral nerves. Lesion were produced in the peripheral nerves of mice by th...

journal_title：Acta neuropathologica

authors： Tsukada N,Koh CS,Yanagisawa N,Taketomi T,Behan PO

更新日期：1985-01-01 00:00:00

abstract：:Two cases of Central neurocytoma arising in the lateral ventricles are presented. Both patients had well-circumscribed masses in the right lateral ventricle causing hydrocephalus. The tumors were composed of small round cells forming Homer Wright rosettes against a fine fibrillary background. In one patient surgical r...

journal_title：Acta neuropathologica

authors： Townsend JJ,Seaman JP

更新日期：1986-01-01 00:00:00

abstract：:The current classification of human sporadic prion diseases recognizes six major phenotypic subtypes with distinctive clinicopathological features, which largely correlate at the molecular level with the genotype at the polymorphic codon 129 (methionine, M, or valine, V) in the prion protein gene and with the size of ...

journal_title：Acta neuropathologica

authors： Parchi P,de Boni L,Saverioni D,Cohen ML,Ferrer I,Gambetti P,Gelpi E,Giaccone G,Hauw JJ,Höftberger R,Ironside JW,Jansen C,Kovacs GG,Rozemuller A,Seilhean D,Tagliavini F,Giese A,Kretzschmar HA

更新日期：2012-10-01 00:00:00

abstract：:Research efforts during the last decade have deciphered the basic molecular mechanisms governing mitochondrial fusion and fission. We now know that in mammalian cells mitochondrial fission is mediated by the large GTPase dynamin-related protein 1 (Drp1) acting in concert with outer mitochondrial membrane (OMM) protein...

journal_title：Acta neuropathologica

authors： Oettinghaus B,Licci M,Scorrano L,Frank S

更新日期：2012-02-01 00:00:00

abstract：:Cavernous malformations (CVMs) and arteriovenous malformations (AVMs) were immunostained for three smooth muscle cell (SMC)-specific protein markers (smooth muscle alpha-actin, SM1 and SM2). Smooth muscle alpha-actin, a widely used marker of SMCs, is reportedly one of the earliest proteins expressed during differentia...

journal_title：Acta neuropathologica

authors： Hoya K,Asai A,Sasaki T,Kimura K,Kirino T

更新日期：2001-09-01 00:00:00

abstract：:Clinical and morphological findings in an 8-year-old Jewish girl with spongy leukodystrophy are presented. Ultrastructural changes indicated that this may be a form of Canavan's disease with some atypical features. Biochemical measurements indicated that synaptosomal membranes prepared from the striatum but not from t...

journal_title：Acta neuropathologica

authors： Boehme DH,Marks N

更新日期：1981-01-01 00:00:00

abstract：:Excitotoxicity is considered a major cell death inductor in neurodegeneration. Yet the mechanisms involved in cell death and cell survival following excitotoxic insults are poorly understood. Expression of active, phosphorylation-dependent mitogen-activated extracellular signal-regulated kinases (MAPK/ERKs), stress-ac...

journal_title：Acta neuropathologica

authors： Ferrer I,Blanco R,Carmona M,Puig B,Domínguez I,Viñals F

更新日期：2002-04-01 00:00:00

abstract：:A 65-year-old woman was admitted to our hospital for forgetfulness, depression and eccentric behavior that had been first noticed 2 years prior to admission. She showed memory impairment, perseveration and repeated violent actions, but no limb-kinetic apraxia. She died 12 years after the onset of symptoms. At autopsy,...

journal_title：Acta neuropathologica

authors： Mizuno Y,Ozeki M,Iwata H,Takeuchi T,Ishihara R,Hashimoto N,Kobayashi H,Iwai K,Ogasawara S,Ukai K,Shibayama H

更新日期：2002-03-01 00:00:00

abstract：:Synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) aggregates throughout the nervous system but diverge from one another with regard to their clinical and pathological phenotype. The recent generatio...

journal_title：Acta neuropathologica

authors： Van der Perren A,Gelders G,Fenyi A,Bousset L,Brito F,Peelaerts W,Van den Haute C,Gentleman S,Melki R,Baekelandt V

更新日期：2020-06-01 00:00:00