Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?

abstract：:The character of the silver positive reticulin network was analyzed with immunofluorescence and immunoperoxidase methods in an intra vitam diagnosed case of primary brain lymphoma. The network was shown to contain connective tissue proteins rich in hexose-sugars, such as type III collagen (classical "reticulin"), basa...

journal_title：Acta neuropathologica

authors： Kalimo H,Lehto M,Näntö-Salonen K,Jalkanen M,Risteli L,Risteli J,Narva EV

更新日期：1985-01-01 00:00:00

abstract：:A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secreted beta-human chorionic gonadotropin (beta-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), alpha-fetoprotein (alpha-FP), and beta-HCG showed a mixed pop...

journal_title：Acta neuropathologica

authors： Aguzzi A,Hedinger CE,Kleihues P,Yaşargil MG

更新日期：1988-01-01 00:00:00

abstract：:The cytoskeletal properties and endogenous degradation of intermediate filaments in cultured human glioma cells (U-251MG) were studied using monoclonal antibodies in immunohistochemical and immunochemical methods. Both glial fibrillary acidic protein (GFAP)- and vimentin-antibodies gave a fibrillar cytoplasmic stainin...

journal_title：Acta neuropathologica

authors： Paetau A,Virtanen I

更新日期：1986-01-01 00:00:00

abstract：:Histochemical and electron microscopic studies of the brains inclusive of the leptomeninges containing large blood vessels from 7 patients with mucopolysaccharidosis (MPS) I, II, IIIA and V showed marked increase in mesenchymal elements and the generalized presence of characteristic lesions around cerebral veins and a...

journal_title：Acta neuropathologica

authors： Dekaban AS,Constantopoulos G

更新日期：1977-07-15 00:00:00

abstract：:Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic exami...

journal_title：Acta neuropathologica

authors： Pollanen MS,Onzivua S,Robertson J,McKeever PM,Olawa F,Kitara DL,Fong A

更新日期：2018-11-01 00:00:00

abstract：:Adult rabbits were subjected to 4.5 Gy of whole-blody or brain alone gamma-irradiation, and their hippocampus was examined with the light and electron microscope. Pycnotic cells were found at the base of the granular layer of the dentate gyrus in the so-called subgranular zone, as soon as 3 h after irradiation, and we...

journal_title：Acta neuropathologica

authors： Guéneau G,Drouet J,Privat A,Court L

更新日期：1979-12-01 00:00:00

abstract：:SNAP-25 (a synaptosomal-associated protein of 25 kDa) has been shown to be involved both in synaptic vesicle exocytosis and in axonal outgrowth. In the present study, we investigated the changes in SNAP-25 immunoreactivity in the hippocampus of the Mongolian gerbil (Meriones unguiculatus) at different time points afte...

journal_title：Acta neuropathologica

authors： Martí E,Ferrer I,Ballabriga J,Blasi J

更新日期：1998-03-01 00:00:00

abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...

journal_title：Acta neuropathologica

authors： Schröder JM,Sommer C

更新日期：1991-01-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition (CARASIL) have emerged as important genetic model diseases for studying the molecular pathomechanisms of cerebral small vessel disease (SVD). CADASIL, the most frequent ...

journal_title：Acta neuropathologica

authors： Zellner A,Scharrer E,Arzberger T,Oka C,Domenga-Denier V,Joutel A,Lichtenthaler SF,Müller SA,Dichgans M,Haffner C

更新日期：2018-07-01 00:00:00

abstract：:Round granulated body (RGB) and eosinophilic hyaline droplets (EHDs) have been described as cytoplasmic inclusions of certain astrocytic tumors. In the previous literature, however, these inclusions have been described using various terms or regarded as nosologically the same entity. Light microscopically, RGB appeare...

journal_title：Acta neuropathologica

authors： Hitotsumatsu T,Iwaki T,Fukui M,Tateishi J

更新日期：1994-01-01 00:00:00

abstract：:The binding of carbon disulphide sulphur was studied in the spinal cord and its axons of four control and four phenobarbitone pretreated adult rats 3 and 6 h after an intraperitoneal injection of 650 mumol of CS2 in olive oil. The binding of CS2 carbon was measured in the same fractions of two adult control rats 4.5 h...

journal_title：Acta neuropathologica

authors： Savolainen H,Vainio H

更新日期：1976-11-15 00:00:00

abstract：:Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focused on adult glioblastoma multiforme (GBM) with phase III trials target...

journal_title：Acta neuropathologica

authors： Smith SJ,Tilly H,Ward JH,Macarthur DC,Lowe J,Coyle B,Grundy RG

更新日期：2012-07-01 00:00:00

abstract：:Massive GGGGCC repeat expansion in the first intron of the gene C9orf72 is the most common known cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Despite its intronic localization and lack of an ATG start codon, the repeat region is translated in all three reading fra...

journal_title：Acta neuropathologica

authors： Mori K,Arzberger T,Grässer FA,Gijselinck I,May S,Rentzsch K,Weng SM,Schludi MH,van der Zee J,Cruts M,Van Broeckhoven C,Kremmer E,Kretzschmar HA,Haass C,Edbauer D

更新日期：2013-12-01 00:00:00

abstract：:The IgM fraction of normal swine serum (NSS) was found to adhere to human peripheral nerve myelin sheaths from randomly selected neuropathies and control nerves in electron microscopic immunocytochemical assays. The reaction could be blocked by preincubation with undiluted fetal calf serum (FCS), whereas endoneurial b...

journal_title：Acta neuropathologica

authors： Sommer C,Schröder JM

更新日期：1988-01-01 00:00:00

abstract：:We investigated whether the brainstem is affected by the pathologic process of sporadic Creutzfeldt-Jakob disease (sCJD), with particular attention to brainstem atrophy, neuronal loss, pyramidal tract degeneration, and prion protein (PrP) deposition, in 33 patients with sCJD. Brainstem atrophy, particularly in the pon...

journal_title：Acta neuropathologica

authors： Iwasaki Y,Hashizume Y,Yoshida M,Kitamoto T,Sobue G

更新日期：2005-06-01 00:00:00

abstract：:Silver-staining methods are helpful for histological identification of pathological deposits. In spite of some ambiguities regarding their mechanism and interpretation, they are widely used for histopathological diagnosis. In this review, four major silver-staining methods, modified Bielschowsky, Bodian, Gallyas (GAL)...

journal_title：Acta neuropathologica

authors： Uchihara T

更新日期：2007-05-01 00:00:00

abstract：:The gastrocnemius muscles of 3 groups of 10 rats, sacrified 5, 7, and 12 days respectively, following tenotomy, were submitted to different types of fixation, fixative and embedding. The occurrence of target fibres is shown not to be an artefact due to the histological procedures. Further examination demonstrates that...

journal_title：Acta neuropathologica

authors： De Reuck J,De Coster W,vander Eecken H

更新日期：1978-05-24 00:00:00

abstract：:Sera from guinea pigs with acute or chronic relapsing experimental allergic encephalomyelitis (EAE) were injected into lumbosacral subarachnoid space of normal recipient rats. Seventeen of 37 sera induced demyelination in the CNS, and 27 of 37 sera caused demyelinated peripheral nerve fibers in the roots. The highest ...

journal_title：Acta neuropathologica

authors： Lassmann H,Kitz K,Wisniewski HM

更新日期：1981-01-01 00:00:00

abstract：:We investigated clinicopathologically pyramidal signs, including hyperreflexia, Babinski sign, and spasticity, and the involvement of the primary motor cortex and pyramidal tract, in eight Japanese autopsy cases of amyotrophic lateral sclerosis (ALS) with dementia. Pyramidal signs were observed in seven (88%) of the e...

journal_title：Acta neuropathologica

authors： Tsuchiya K,Ikeda K,Mimura M,Takahashi M,Miyazaki H,Anno M,Shiotsu H,Akabane H,Niizato K,Uchihara T,Tominaga I,Nakano I

更新日期：2002-09-01 00:00:00

abstract：:A study of a muscle biopsy has provided evidence of storage involvement of the skeletal muscle fibres in Fabry's disease. In the endothelial cells of the capillaries, the inclusions were more abundant and pleomorphic. Muscle satellite cells were spared. In the sensory nerve biopsy, the perineurial and endothelial cell...

journal_title：Acta neuropathologica

authors： Tomé FM,Fardeau M,Lenoir G

更新日期：1977-06-15 00:00:00

abstract：:This report presents the largest series of consecutive, neuropathologically confirmed cases of frontotemporal degeneration (FTD). Prior studies have found dementia lacking distinctive histology (DLDH) to be the most common pathology underlying the clinical diagnosis of FTD. In this series of 76 cases, 29 (38%) were fo...

journal_title：Acta neuropathologica

authors： Lipton AM,White CL 3rd,Bigio EH

更新日期：2004-11-01 00:00:00

abstract：:Medulloblastoma (MB) represents approximately 4% of adult brain tumours, and as such is a poorly studied disease. Although many adult MB are treated using paediatric MB protocols, the reported outcomes are inferior to those observed in children. It remains unclear whether biologic differences underlie these clinical o...

journal_title：Acta neuropathologica

authors： Al-Halabi H,Nantel A,Klekner A,Guiot MC,Albrecht S,Hauser P,Garami M,Bognar L,Kavan P,Gerges N,Shirinian M,Roberge D,Muanza T,Jabado N

更新日期：2011-02-01 00:00:00

abstract：:We studied the densities of utrophin and dystrophin at the motor end-plates of patients with myasthenia gravis (MG) using immunohistochemical analysis. The densities were compared with those found in patients with amyotrophic lateral sclerosis, Lambert-Eaton myasthenic syndrome and normal controls. Utrophin was reduce...

journal_title：Acta neuropathologica

authors： Ito H,Yoshimura T,Satoh A,Takino H,Tsujihata M,Nagataki S

更新日期：1996-07-01 00:00:00

abstract：:Stereological estimates of mean volumes, surface areas, and cortical thicknesses were obtained on formalin-fixed brains from 19 men with AIDS and 19 controls. Volumes of neocortex, white matter, central brain nuclei, ventricles and archicortex were estimated using point counting and Cavalieri's unbiased principle for ...

journal_title：Acta neuropathologica

authors： Oster S,Christoffersen P,Gundersen HJ,Nielsen JO,Pakkenberg B,Pedersen C

更新日期：1993-01-01 00:00:00

abstract：:The neuropathological staging model of Alzheimer's disease proposed by Braak and Braak [Acta Neuropathol (1991) 82:259] requires that the evolution of neurofibrillary pathology follows a predictable pattern that can be ordered in a regular regional hierarchy. We have operationalized the neuropathological staging syste...

journal_title：Acta neuropathologica

authors： Gertz HJ,Xuereb J,Huppert F,Brayne C,McGee MA,Paykel E,Harrington C,Mukaetova-Ladinska E,Arendt T,Wischik CM

更新日期：1998-02-01 00:00:00

abstract：:In spite of several cases reported in the literature, the exact pathogenetic mechanism of neuropathic changes in porphyric neuropathy remains uncertain. Various authors have ascribed the neuropathologic findings to either a dying-back axonal degeneration or segmental demyelination. In recent years, the hypothesis of a...

journal_title：Acta neuropathologica

authors： Di Trapani G,Casali C,Tonali P,Topi GC

更新日期：1984-01-01 00:00:00

abstract：:Electron microscopy revealed the presence of cytoplasmic tubular aggregates in the capillary endothelium of a sparsely granulated growth hormone cell adenoma removed surgically from a 25-year-old female patient with acromegaly. To our knowledge, this is the second publication describing these structures in hypophysial...

journal_title：Acta neuropathologica

authors： Kovacs K,Horvath E,Pritzker KP,Schwartz ML

更新日期：1977-01-31 00:00:00

abstract：:Ubiquitin-positive Lewy neurites and Lewy bodies are found in idiopathic Parkinson's disease (PD) and diffuse Lewy body disease (DLBD). We found that, in three patients with PD and one with DLBD, microtubule-associated protein 5 (MAP5) immunostaining was consistently present in both Lewy neurites and Lewy bodies throu...

journal_title：Acta neuropathologica

authors： Gai WP,Blumbergs PC,Blessing WW

更新日期：1996-01-01 00:00:00

abstract：:Transient forebrain ischemia produces a spatially and temporally selective pattern of neuronal degeneration in the hippocampal formation of the Mongolian gerbil. Ischemic neuronal death has been suggested to depend on the activation of excitatory hippocampal pathways that project to the vulnerable neurons. This idea w...

journal_title：Acta neuropathologica

authors： Kaplan TM,Lasner TM,Nadler JV,Crain BJ

更新日期：1989-01-01 00:00:00

abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...

journal_title：Acta neuropathologica

authors： Hinokuma K,Ohama E,Ikuta F,Tanimura K,Kameyama S

更新日期：1990-01-01 00:00:00