Deletions on the long arm of chromosome 17 in pilocytic astrocytoma.

abstract：:In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of Alzheimer's disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebr...

journal_title：Acta neuropathologica

authors： Braak H,Zetterberg H,Del Tredici K,Blennow K

更新日期：2013-11-01 00:00:00

abstract：:Cystic necrosis in the cerebellar white matter was found in three premature infants. The necrosis was characteristically localized in the center of the white matter of the superficial cerebellar folia, sparing the overlying cortex. The patients were aged between 28 and 34 gestational weeks, and had a clinical history ...

journal_title：Acta neuropathologica

authors： Tsuru A,Mizuguchi M,Takashima S

更新日期：1995-01-01 00:00:00

abstract：:In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...

journal_title：Acta neuropathologica

authors： von Cramon D

更新日期：1975-01-01 00:00:00

abstract：:Most cases of frontotemporal lobar degeneration (FTLD) are characterized by abnormal intracellular accumulation of either tau or TDP-43 protein. However, in ~10% of cases, composed of a heterogenous collection of uncommon disorders, the molecular basis remains to be uncertain. We recently discovered that the pathologi...

journal_title：Acta neuropathologica

authors： Mackenzie IR,Munoz DG,Kusaka H,Yokota O,Ishihara K,Roeber S,Kretzschmar HA,Cairns NJ,Neumann M

更新日期：2011-02-01 00:00:00

abstract：:Immunohistochemical techniques were employed to examine the changes in free ubiquitin within the hippocampus 1, 3, 7, 14, and 30 days after a unilateral perforant pathway lesion occurred in the rat brain. Immunoreactivity for ubiquitin was remarkably decreased in the cell body and proximal dendrites of neurons through...

journal_title：Acta neuropathologica

authors： Mizukami K,Ishikawa M,Iwakiri M,Hidaka S,Kato N,Asada T

更新日期：2002-05-01 00:00:00

abstract：:We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...

journal_title：Acta neuropathologica

authors： Nishiyama A,Onda K,Washiyama K,Kumanishi T,Kuwano R,Sakimura K,Takahashi Y

更新日期：1989-01-01 00:00:00

abstract：:The presence and distribution of human immunodeficiency virus (HIV) were examined in the CNS of two children with severe HIV encephalitis and myelitis. Using polymerase chain reaction-mediated DNA amplification and subsequent Southern analysis, proviral HIV gag sequences were identified in brain tissue of both patient...

journal_title：Acta neuropathologica

authors： Brüstle O,Spiegel H,Leib SL,Finn T,Stein H,Kleihues P,Wiestler OD

更新日期：1992-01-01 00:00:00

abstract：:An autopsy case of unclassifiable presenil dementia is reported. The outstanding pathological findings were as follows; 1. presence of senile plaques, neurofibrillary changes, Pick bodies, Hirano bodies, granulovacuolar degeneration of neurons, etc. 2. numerous Lewy bodies in the brain stem and diencephalon, 3. peculi...

journal_title：Acta neuropathologica

authors： Kosaka K,Oyanagi S,Matsushita M,Hori A

更新日期：1976-11-15 00:00:00

abstract：:The mechanism of antibody-mediated central nervous system (CNS) demyelination in vivo was studied using rabbit eyes. Injection of anti-galactocerebroside (Gal C) antiserum alone into the normal rabbit vitreous body induced demyelination in the epiretinal myelinated fibers. This activity of the antiserum disappeared af...

journal_title：Acta neuropathologica

authors： Ozawa K,Saida T,Saida K,Nishitani H,Kameyama M

更新日期：1989-01-01 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of a number of diseases including Alzheimer's disease (AD). The oxidative stress hypothesis of AD pathogenesis, in part, is based on beta-amyloid peptide (Abeta)-induced oxidative stress in both in vitro and in vivo studies. Oxidative modification of the protein...

journal_title：Acta neuropathologica

authors： Sultana R,Perluigi M,Butterfield DA

更新日期：2009-07-01 00:00:00

abstract：:Gliomatosis cerebri (GC), a rare and deadly CNS neoplasm characterized by involvement of at least three cerebral lobes, predominantly affects adults. While a few small series have reported its occurrence in children, little is known about the molecular characteristics of pediatric GC. We reviewed clinical, radiologica...

journal_title：Acta neuropathologica

authors： Broniscer A,Chamdine O,Hwang S,Lin T,Pounds S,Onar-Thomas A,Shurtleff S,Allen S,Gajjar A,Northcott P,Orr BA

更新日期：2016-02-01 00:00:00

abstract：:We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient wit...

journal_title：Acta neuropathologica

authors： Crain BJ,McPhatter L,Croom DW 2nd,Hulette CM

更新日期：1995-01-01 00:00:00

abstract：:Patients with von Hippel-Lindau disease carry a germline mutation of the Von Hippel-Lindau (VHL) tumor-suppressor gene. We discuss the molecular consequences of loss of VHL gene function and their impact on the nervous system. Dysfunction of the VHL protein causes accumulation and activation of hypoxia inducible facto...

journal_title：Acta neuropathologica

authors： Vortmeyer AO,Falke EA,Gläsker S,Li J,Oldfield EH

更新日期：2013-03-01 00:00:00

abstract：:Aberrant peripheral nerve fiber bundles, i.e., masses of peripheral nerve fibers without perineural sheath cells, are found in the perivascular spaces of some spinal cords. The 514 spinal cords examined for these structures were separated into two groups; 507 spinal cords without definite necrotic lesions (group 1) an...

journal_title：Acta neuropathologica

authors： Kamiya M,Hashizume Y

更新日期：1989-01-01 00:00:00

abstract：:Seizures commonly occur in glioma patients, but their pathogenesis is poorly understood, in part due to a lack of valid and versatile experimental models. We have established a new model that enables comprehensive neuropathological and neurophysiological analysis on identical tissue preparations. Rat C6 glioma cells s...

journal_title：Acta neuropathologica

authors： Senner V,Köhling R,Püttmann-Cyrus S,Straub H,Paulus W,Speckmann EJ

更新日期：2004-01-01 00:00:00

abstract：:Little information is available regarding the morphological changes in the mitochondria in amyotrophic lateral sclerosis (ALS). In particular, mitochondrial changes in dorsal root ganglion cells have not yet been examined. We therefore conducted an electron microscopic examination of the mitochondria in dorsal root ga...

journal_title：Acta neuropathologica

authors： Sasaki S,Horie Y,Iwata M

更新日期：2007-12-01 00:00:00

abstract：:This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer's disease: mechanisms of amyloid formation, neurotoxicity, pathways involved ...

journal_title：Acta neuropathologica

authors： Reiniger L,Lukic A,Linehan J,Rudge P,Collinge J,Mead S,Brandner S

更新日期：2011-01-01 00:00:00

abstract：:In order to further evaluate the parameters whereby intracerebral administration of recombinant α-synuclein (αS) induces pathological phenotypes in mice, we conducted a series of studies where αS fibrils were injected into the brains of M83 (A53T) and M47 (E46K) αS transgenic (Tg) mice, and non-transgenic (nTg) mice. ...

journal_title：Acta neuropathologica

authors： Sacino AN,Brooks M,Thomas MA,McKinney AB,McGarvey NH,Rutherford NJ,Ceballos-Diaz C,Robertson J,Golde TE,Giasson BI

更新日期：2014-05-01 00:00:00

abstract：:A case of progressive polyneuropathy associated with Waldenström's macroglobulinaemia is reported. A monoclonal IgM-lambda gradient was detected in the serum and cerebro-spinal fluid. By electro-immunoblot analysis antibodies against myelin-associated glycoprotein were found in the serum and cerebro-spinal fluid. The ...

journal_title：Acta neuropathologica

authors： Meier C,Roberts K,Steck A,Hess C,Miloni E,Tschopp L

更新日期：1984-01-01 00:00:00

abstract：:The presence of many neurofibrillary tangles (NFTs) in the central nervous system is a hallmark of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) in people living in the Kii peninsula of Japan and in the island of Guam. To determine whether or not ALS and PDC are on a spectrum of a single ...

journal_title：Acta neuropathologica

authors： Mimuro M,Kokubo Y,Kuzuhara S

更新日期：2007-06-01 00:00:00

abstract：:We studied the distribution pattern of pathology and cholinergic deficits in the subnuclei of the amygdaloid complex (AC) in five patients with Alzheimer's disease (AD), eight with dementia with Lewy bodies (DLB) and five normal controls. In controls, the basal nucleus contained the highest choline acetyltransferase a...

journal_title：Acta neuropathologica

authors： Sahin HA,Emre M,Ziabreva I,Perry E,Celasun B,Perry R

更新日期：2006-02-01 00:00:00

abstract：:A quantitative technique involving serial sectioning and semiautomatic morphometric analysis was used to assess the severity of the reduction in size of the major brain structures in cerebral hemispheres of children congenitally infected with HIV-1. Cerebral hemispheres from 12 children (18-48 months of age) who died ...

journal_title：Acta neuropathologica

authors： Kozlowski PB,Brudkowska J,Kraszpulski M,Sersen EA,Wrzolek MA,Anzil AP,Rao C,Wisniewski HM

更新日期：1997-02-01 00:00:00

abstract：:Excitotoxicity is considered a major cell death inductor in neurodegeneration. Yet the mechanisms involved in cell death and cell survival following excitotoxic insults are poorly understood. Expression of active, phosphorylation-dependent mitogen-activated extracellular signal-regulated kinases (MAPK/ERKs), stress-ac...

journal_title：Acta neuropathologica

authors： Ferrer I,Blanco R,Carmona M,Puig B,Domínguez I,Viñals F

更新日期：2002-04-01 00:00:00

abstract：:This report presents the largest series of consecutive, neuropathologically confirmed cases of frontotemporal degeneration (FTD). Prior studies have found dementia lacking distinctive histology (DLDH) to be the most common pathology underlying the clinical diagnosis of FTD. In this series of 76 cases, 29 (38%) were fo...

journal_title：Acta neuropathologica

authors： Lipton AM,White CL 3rd,Bigio EH

更新日期：2004-11-01 00:00:00

abstract：:This paper examines the neuropathology of oxygen-glucose deprivation uncomplicated by stagnant conditions. Rabbit vagus nerves were pulled into a multi-compartment perfusion chamber, stimulated five times per second and deprived of energy by substituting nitrogen and deoxyglucose for oxygen and glucose in the Locke's ...

journal_title：Acta neuropathologica

authors： Dahl NA,Looney GA,Black WH

更新日期：1982-01-01 00:00:00

abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...

journal_title：Acta neuropathologica

authors： Mizukami K,Kosaka K

更新日期：1989-01-01 00:00:00

abstract：:The suprascapular nerve from 14 horses, which had no clinical evidence of spinatus muscle atrophy, were obtained to determine whether the nerve was sub-clinically compressed at the scapular edge. The nerves were divided into three portions, proximal and distal to the scapular edge and as it reflected around it. In nin...

journal_title：Acta neuropathologica

authors： Duncan ID,Schneider RK,Hammang JP

更新日期：1987-01-01 00:00:00

abstract：:Spinal cord-notochord relationship was analyzed histologically and immunohistochemically in normal human conceptuses between the 4-8 developmental weeks and in a 8-week embryo with double spinal cord. In the early 4-week embryo, the gradual closure of the neural tube along the cranio-caudal body axis was paralleled by...

journal_title：Acta neuropathologica

authors： Saraga-Babić M,Stefanović V,Wartiovaara J,Lehtonen E

更新日期：1993-01-01 00:00:00

abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...

journal_title：Acta neuropathologica

authors： Sasaki S,Warita H,Abe K,Iwata M

更新日期：2005-07-01 00:00:00

abstract：:In our recent ultrastructural studies on synapses of the nucleus dorsalis, central cervical nucleus, and anterior horn of the spinal cord of the normal cat we happened to find spheroids and several types of axonal alterations. These spheroids were up to 39 micrometer in diameter. They were found in myelinated and unmy...

journal_title：Acta neuropathologica

authors： Saito K

更新日期：1980-01-01 00:00:00