Abstract：
:The character of the silver positive reticulin network was analyzed with immunofluorescence and immunoperoxidase methods in an intra vitam diagnosed case of primary brain lymphoma. The network was shown to contain connective tissue proteins rich in hexose-sugars, such as type III collagen (classical "reticulin"), basal lamina constituents type IV collagen and laminin, pericellular type V collagen, as well as fibronectin (protein involved in cell adhesion). On the other hand, very little of the fibrous type I collagen was discernible. Similarly as the silver positive network, the immunohistochemically demonstrable reticulum seemed to hold the cells in the perivascular location, and once it was broken diffuse spread into the tissue occurred. Since malignant cells of B-lymphocyte origin are not known to synthesize so-called reticulin, it is suggested that the network in primary brain lymphomas is produced by cells in the brain parenchyma (possibly pericytes or astrocytes) as a protective attempt to restrict the spread of foreign cells into the brain.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Kalimo H,Lehto M,Näntö-Salonen K,Jalkanen M,Risteli L,Risteli J,Narva EVdoi
10.1007/BF00690962subject
Has Abstractpub_date
1985-01-01 00:00:00pages
299-305issue
4eissn
0001-6322issn
1432-0533journal_volume
66pub_type
杂志文章abstract：:Among the various mechanisms proposed to explain the pathogenesis of cerebral lesions in human immunodeficiency virus (HIV)-induced encephalitis, a cytokine-mediated action has found most favour. Indeed, elevated expression of cytokines such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha), thought to...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050457
更新日期：1996-01-01 00:00:00
abstract：:The pro-inflammatory and blood-brain barrier (BBB) effects of intratumoral (IT) injection of human recombinant tumor necrosis factor-alpha (rTNF-alpha) were studied in the Fischer rat RT-2 glioma model. Animals received a single stereotaxic injection of either 6 x 10(4) U rTNF-alpha or excipient (vehicle) into the cen...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007398
更新日期：1997-01-01 00:00:00
abstract：:Circumscribed pink areas 0.3-1.0 cm in diameter seen in deeper parts of otherwise well-fixed brains are usually ascribed to inadequate fixation. Twenty-three patients with pink areas in their fixed brains had evidence of inflammation in at least one organ. Blood vessels in the pink areas contained bacteria. Postmortem...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687020
更新日期：1985-01-01 00:00:00
abstract：:The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arterial press...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00305878
更新日期：1991-01-01 00:00:00
abstract：:We report a patient who showed pathological features of both multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) at autopsy. The clinical features included severe cerebellar ataxia, autonomic failure, and rigid-akinetic parkinsonism. The clinical diagnosis was MSA. Pathological examination showed se...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100433
更新日期：2002-01-01 00:00:00
abstract：:Old age is associated with a deficient recovery from stroke, but the cellular mechanisms underlying such phenomena are poorly understood. To address this issue, focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 3- and 20-month-old male Sprague-Dawley rats. Aged rats sh...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0164-7
更新日期：2007-03-01 00:00:00
abstract：:Recent studies of genetic abnormalities in pediatric low-grade gliomas (LGGs) have focused on activation of the ERK/MAPK pathway by KIAA1549-BRAF gene fusions in the majority of pilocytic astrocytomas (PAs) and by rare mutations in elements of the pathway across histopathologically diverse LGGs. This study reports tha...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0763-1
更新日期：2010-12-01 00:00:00
abstract：:Continuous intrathecal infusion of N-methyl-D-aspartate (NMDA) at the level of the lumbar enlargement of the spinal cord in middle-aged rats produced dose-dependent toxicity of spinal cord neuronal systems. Toxicity was enhanced by coadministration of glycine, but was significantly reduced when NMDA was co-administere...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00662631
更新日期：1990-01-01 00:00:00
abstract：:It is conventionally accepted that during the early stages of Wallerian degeneration of myelinated peripheral nerve fibres Schmidt-Lanterman incisures represent the sites at which the myelin sheath, together with enclosed axoplasm, is segmented into myelin ovoids. This mechanism is considered by some authors to be fac...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:The activities of three enzymes of the hexose monophosphate pathway (HMP) were measured in frozen samples of rat cerebral cortex and ethylnitrosourea-induced tumors of the rat nervous system. Results show that in most tumors, adequate amounts of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogena...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690440
更新日期：1978-03-15 00:00:00
abstract：:This report presents the largest series of consecutive, neuropathologically confirmed cases of frontotemporal degeneration (FTD). Prior studies have found dementia lacking distinctive histology (DLDH) to be the most common pathology underlying the clinical diagnosis of FTD. In this series of 76 cases, 29 (38%) were fo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0900-9
更新日期：2004-11-01 00:00:00
abstract：:Acetylcholinesterase and butyrylcholinesterase have been associated with structures undergoing neurofibrillary degeneration, as well as with all types of senile plaques, in non-demented aged and Alzheimer's brains. At the electron microscope level, the reaction product of both enzymes, appeared to decorate paired heli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296744
更新日期：1994-01-01 00:00:00
abstract：:An unusual tumor of the pituitary gland is reported. The most characteristic finding of the present tumor was the presence of numerous "colloid" and mucoid secretions. The cells were stellate in shape and there were intra- or intercellular lumina which were lined by many microvilli and occasional cilia. There were als...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687617
更新日期：1984-01-01 00:00:00
abstract：:Chronic wasting disease (CWD), a progressive neurological disorder of captive mule deer, black-tailed deer, hybrids of mule deer and white-tailed deer and Rocky Mountain elk, is characterized neuropathologically by widespread spongiform change of the neuropil, intracytoplasmic vacuolation in neuronal perikarya and ast...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310125
更新日期：1991-01-01 00:00:00
abstract：:The caudate nucleus and putamen belong to the selectively vulnerable brain regions which incur neuronal damage in clinical and experimental settings of both hypoglycemia and ischemia. We have previously documented the density and distribution of the hypoglycemic damage in rat caudoputamen, but the evolution of the inj...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688122
更新日期：1985-01-01 00:00:00
abstract：:Histological, immunohistochemical and ultrastructural sural nerve and skin biopsy findings in a case of cryoglobulinemia secondary to an IgM-kappa-producing non-Hodgkin lymphoma are described. The main finding was an occlusive microangiopathy present in both the sural nerve and the skin. Widespread cryoglobulin deposi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00713536
更新日期：1992-01-01 00:00:00
abstract：:Olfactory dysfunction is a frequent and early feature of patients with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) and is very uncommon in patients with frontotemporal dementia (FTD). Mechanisms underlying this clinical manifestation are poorly understood but the premature...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-011-0830-2
更新日期：2011-07-01 00:00:00
abstract：:In the present study we assessed the neuroprotective effects of the pan-caspase inhibitor z-VAD.fmk [N-benzyloxycarbony-valine-alanine-aspartate-(OMe)-fluoromethylketone], and the caspase-3 inhibitor Ac-DEVD.CHO (acetyl-aspartate-chloromethylketone) in the double-lesion rat model of striatonigral degeneration (SND), t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0931-2
更新日期：2005-02-01 00:00:00
abstract：:The contribution of leukocyte apoptosis to the resolution of meningeal inflammation in bacterial meningitis was studied in the cerebrospinal fluid (CSF) and in meningeal infiltrates of humans and rabbits by in situ tailing, flow cytometry, agarose gel electrophoresis, and electron microscopy. In humans, the rate of ap...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050921
更新日期：1998-11-01 00:00:00
abstract：:The choroid plexus is an epithelial-endothelial vascular convolute within the ventricular system of the vertebrate brain. It consists of epithelial cells, fenestrated blood vessels, and the stroma, dependent on various physiological or pathological conditions, which may contain fibroblasts, mast cells, macrophages, gr...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-009-0627-8
更新日期：2010-01-01 00:00:00
abstract：:The immunoreactivity to the free radical-related enzymes, nitric oxide synthase (NOS) and superoxide dismutase (SOD), was examined in brain tissue in progressive supranuclear palsy (PSP). To determine the relationship between the immunoexpression of these enzymes and tau-positive, argyrophilic cytoplasmic inclusions, ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050808
更新日期：1998-04-01 00:00:00
abstract：:Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685251
更新日期：1984-01-01 00:00:00
abstract：:Immunofluorescence and immunogold labelling were used to localise the 43-kDa dystrophin-associated glycoprotein (43DAG) of the dystrophin-glycoprotein complex in control and Duchenne muscular dystrophy (DMD) biopsies. In control muscle 43DAG was localised by immunofluorescence to the periphery of the fibre and, by imm...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00313603
更新日期：1994-01-01 00:00:00
abstract：:Adult rabbits were subjected to 4.5 Gy of whole-blody or brain alone gamma-irradiation, and their hippocampus was examined with the light and electron microscope. Pycnotic cells were found at the base of the granular layer of the dentate gyrus in the so-called subgranular zone, as soon as 3 h after irradiation, and we...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690520
更新日期：1979-12-01 00:00:00
abstract：:A 40-year-old man suffering from amyotrophic lateral sclerosis with symmetrical degeneration of the thalamus and the substantia nigra is reported. The distribution pattern of the thalamic degeneration in the present case was characteristic in that the Nucleus centralis was the severest affected of the thalamic nuclei...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691074
更新日期：1978-12-15 00:00:00
abstract：:The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic coun...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0338-y
更新日期：2008-03-01 00:00:00
abstract：:The spinal cord of 20 patients with amyotrophic lateral sclerosis (ALS) and 5 patients with lower motor neuron disease (LMND) were investigated immunohistochemically using anti-human excitatory amino acid transporter 1 (EAAT1) and EAAT2 antibodies which are the astrocytic transporters. The purpose of the study was to ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004019900159
更新日期：2000-08-01 00:00:00
abstract：:To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohistochemistry employing the monoclonal antibody 6E10, which is specific ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050735
更新日期：1997-11-01 00:00:00
abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294808
更新日期：1995-01-01 00:00:00
abstract：:The cholinergic basal forebrain is divided into four subregions (Ch1-4), and cholinergic neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive impairments in both Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). However, the Ch1-2 regions, which provide the major choline...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-0004-1
更新日期：2006-02-01 00:00:00
