Abstract：
:Leukocyte adhesion molecules to endothelium plays an important role in the pathogenesis of inflammatory diseases, including HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). To help define the role of adhesion molecules in HAM/TSP, we studied the expression of lymphocyte function-associated antigen-1 (LFA-1), Mac-1, very late antigen-4 (VLA-4), Sialyl Lewisx (SLex), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1) and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions of HAM/TSP. The results indicate that spinal cord lesions of HAM/TSP have greater VCAM-1 expression on endothelium compared with those of controls. Infiltrating mononuclear cells, especially perivascular lesions, expressed VLA-4. Although the expression of ICAM-1 in the spinal cords was not distinctive between HAM/TSP and controls, infiltrating mononuclear cells in the spinal cords of HAM/TSP strongly expressed LFA-1 and Mac-1. ELAM-1 was expressed on endothelium in the inactive-chronic lesions from three of five HAM/HAM/TSP, but was not detectable in the spinal cords of controls. SLex reactions was detectable on occasional perivascular cells in the spinal cord of HAM/TSP, but not in those controls. MCP-1 was detectable on perivascular infiltrating cells and vascular endothelium in active-chronic lesions. This study suggest that VLA-4/VCAM-1 interaction may play an important role for lymphocyte migration into the central nervous system (CNS) and MCP-1 may also be involved in inflammatory cell recruitment to the CNS in HAM/TSP.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Umehara F,Izumo S,Takeya M,Takahashi K,Sato E,Osame Mdoi
10.1007/s004010050435subject
Has Abstractpub_date
1996-01-01 00:00:00pages
343-50issue
4eissn
0001-6322issn
1432-0533journal_volume
91pub_type
杂志文章abstract：:In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293469
更新日期：1991-01-01 00:00:00
abstract：:Spinal cord-notochord relationship was analyzed histologically and immunohistochemically in normal human conceptuses between the 4-8 developmental weeks and in a 8-week embryo with double spinal cord. In the early 4-week embryo, the gradual closure of the neural tube along the cranio-caudal body axis was paralleled by...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00228587
更新日期：1993-01-01 00:00:00
abstract：:Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD is even considered to be a pre-NFT stage in the disease process of AD. Currently, the composition of GVD bodies, the mechanisms associated ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-020-02261-4
更新日期：2021-01-25 00:00:00
abstract：:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE viru...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050626
更新日期：1997-04-01 00:00:00
abstract：:We present a case of progressive supranuclear palsy (PSP) with palatal myoclonus occurred in a 64-year-old man. The nucleus olivaris of the medulla oblongata showed high signal intensity on T2-weighted MR images, indicating brainstem tegmental atrophy, which were confirmed as hypertrophy of the nucleus inferior olivar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050706
更新日期：1997-09-01 00:00:00
abstract：:This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive con...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227818
更新日期：1992-01-01 00:00:00
abstract：:We present here an unusual case of papillary neuroepithelial tumor of the pineal region. The patient was a 29-year-old female who presented with headaches. A computed tomography scan revealed a tumorous lesion at the pineal region and hydrocephalus. The resected tumor was composed of columnar and cuboidal cells showin...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0898-z
更新日期：2004-10-01 00:00:00
abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050426
更新日期：1996-01-01 00:00:00
abstract：:The calcium-activated protease calpain cleaves a variety of biologically important proteins and serves, therefore, as a key regulator of many cellular functions. Activation of both main isoforms, calpain 1 and calpain 2, was demonstrated previously in Alzheimer's disease. In this report, antibodies specifically recogn...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0528-6
更新日期：2002-07-01 00:00:00
abstract：:Olfactory dysfunction is a frequent and early feature of patients with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) and is very uncommon in patients with frontotemporal dementia (FTD). Mechanisms underlying this clinical manifestation are poorly understood but the premature...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-011-0830-2
更新日期：2011-07-01 00:00:00
abstract：:Glioblastoma (GBM), the most common malignant brain tumor, is among the most lethal neoplasms, with a median survival of approximately 1 year. Prognosis is poor since GBMs possess a strong migratory and highly invasive potential, making complete surgical resection impossible. Reduced expression of carboxypeptidase E (...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-011-0940-x
更新日期：2012-07-01 00:00:00
abstract：:Insulin-dependent diabetes mellitus is a chronic metabolic disease that causes long-term secondary complications such as neuropathy. The occurrence of diabetic neuropathy has generally been thought of as being associated with hyperglycaemia. However, in a previous light microscopic examination of plantar nerves in dia...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050875
更新日期：1998-08-01 00:00:00
abstract：:α-Synuclein (αSyn) histopathology defines several neurodegenerative disorders, including Parkinson's disease, Lewy body dementia, and Alzheimer's disease (AD). However, the functional link between soluble αSyn and disease etiology remains elusive, especially in AD. We, therefore, genetically targeted αSyn in APP trans...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-018-1886-z
更新日期：2018-10-01 00:00:00
abstract：:The activities of three enzymes of the hexose monophosphate pathway (HMP) were measured in frozen samples of rat cerebral cortex and ethylnitrosourea-induced tumors of the rat nervous system. Results show that in most tumors, adequate amounts of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogena...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690440
更新日期：1978-03-15 00:00:00
abstract：:Striped skunks were inoculated intracerebrally with the scrapie agent (suspension of brain from a naturally infected Suffolk sheep) or intramuscularly with street rabies virus (suspension of salivary glands from naturally infected skunks). Those given the scrapie agent developed clinical signs of weakness, posterior a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687775
更新日期：1988-01-01 00:00:00
abstract：:Microglia are long-living resident immune cells of the brain, which secure a stable chemical and physical microenvironment necessary for the proper functioning of the central nervous system (CNS). These highly dynamic cells continuously scan their environment for pathogens and possess the ability to react to damage-in...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-015-1524-y
更新日期：2016-03-01 00:00:00
abstract：:The neuropathologic findings in the brain of a National Aeronautics and Space Administration (NASA) engineer, who died subsequent to nitrogen inhalation, are reported. Findings which are unusual in other forms of anoxia included relative preservation of neurons in the Sommer sector of the hippocampus and a pattern of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688632
更新日期：1985-01-01 00:00:00
abstract：:A total of 66 skin biopsies from persons with Alzheimer's disease (AD) or Down's syndrome (DS) and from persons without AD were used in this study. The age range was from 7 to 89 years. Positive immunoreactivity of skin biopsies to monoclonal antibody 4G8, which is reactive to amino acid residue 17-24 of synthetic amy...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293394
更新日期：1994-01-01 00:00:00
abstract：:Ectopic neurons have been detected in the hippocampus of postnatal hooded rats aged 5-24 days. These rats were exposed to methylazoxymethanol acetate (MAMac) during foetal development by injecting the mother rats with this neurotoxin. At birth, the hippocampus of rats exposed to MAMac showed a normal cytoarchitecture;...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688698
更新日期：1977-10-10 00:00:00
abstract：:We report a patient who showed pathological features of both multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) at autopsy. The clinical features included severe cerebellar ataxia, autonomic failure, and rigid-akinetic parkinsonism. The clinical diagnosis was MSA. Pathological examination showed se...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100433
更新日期：2002-01-01 00:00:00
abstract：:Monosodium-L-glutamate given subcutaneously to pregnant rats caused acute necrosis of the acetylcholinesterase-positive neurons in the area postrema. The same effect has been observed in the area postrema of fetal rats. The process of neuronal cell death and the elimination of debris by microglia cells proved to be si...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686787
更新日期：1987-01-01 00:00:00
abstract：:Tenascins (TNs) are a family of extracellular matrix glycoproteins. The first member of this family to be recognized, tenascin-C (TN-C), is known to be expressed in various tumors including human astrocytomas. Tenascin-X (TN-X) is the latest member of the TN family to be reported, and its expression in tumor tissues h...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050636
更新日期：1997-05-01 00:00:00
abstract：:A description is given of three cases of ganglioneuromas, which originated from ganglia of the sympathetic chain of hamsters. Other reports of such tumors in this species are reviewed and the literature relative to hamster ganglioneuromas presented. In addition, the possible genesis of origin from adult ganglion cells...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00696794
更新日期：1975-10-01 00:00:00
abstract：:Pregnant rats were administered a liquid diet containing 5% (w/v) ethanol between gestational days 10 and 21, and the brains of nine offspring were examined at 8 weeks of age. Two ethanol-treated offspring showed obvious hydrocephalus characterized by markedly enlarged lateral ventricles. Most of the other ethanol-tre...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0901-8
更新日期：2004-11-01 00:00:00
abstract：:The expression of glial fibrillary acidic protein (GFAP) in continuous glioma and non-glioma cell lines was evaluated by molecular hybridization and immunocytochemistry. RNA transcripts from the GFAP gene were detected in two of six cell lines by Northern blot analysis of cellular RNAs using a cloned mouse GFAP cDNA p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688264
更新日期：1987-01-01 00:00:00
abstract：:Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-morte...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1686-x
更新日期：2017-03-01 00:00:00
abstract：:Psammoma bodies at the perivascular area in five cases of meningioma were examined with the electron microscope. In general, meningocytic cells invest the outer aspect of blood vessels, which are constituted by multilayered basal laminae, collagen fibers, microfibrils, and pericytes. Remnants of degenerated cells are ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688693
更新日期：1985-01-01 00:00:00
abstract：:Immunohistochemical analysis of inflammatory cell density and infiltrate subpopulations in 42 meningiomas was performed. Evaluation of infiltrating cell density was carried out by cell counting. Meningothelial and fibroblastic meningiomas contained an average of 3% mononuclear cells; the few lymphocytes were localized...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294381
更新日期：1989-01-01 00:00:00
abstract：:A 65-year-old woman was admitted to our hospital for forgetfulness, depression and eccentric behavior that had been first noticed 2 years prior to admission. She showed memory impairment, perseveration and repeated violent actions, but no limb-kinetic apraxia. She died 12 years after the onset of symptoms. At autopsy,...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100460
更新日期：2002-03-01 00:00:00
abstract：:The growth potential of 65 pituitary adenomas was determined by histochemical analysis with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine (BrdUdR) labeling, and counts of argyrophilic nucleolar organizer regions (Ag-NORs). The mean proliferating cell indices (PCIs) determined by Ki-67 an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00311392
更新日期：1992-01-01 00:00:00
