Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion.

abstract：:The contribution of leukocyte apoptosis to the resolution of meningeal inflammation in bacterial meningitis was studied in the cerebrospinal fluid (CSF) and in meningeal infiltrates of humans and rabbits by in situ tailing, flow cytometry, agarose gel electrophoresis, and electron microscopy. In humans, the rate of ap...

journal_title：Acta neuropathologica

authors： Nau R,Zettl U,Gerber J,Trostdorf F,Michel U,Böttcher T,Schmidt H,Adler S,Brück W

更新日期：1998-11-01 00:00:00

abstract：:The presence of many neurofibrillary tangles (NFTs) in the central nervous system is a hallmark of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) in people living in the Kii peninsula of Japan and in the island of Guam. To determine whether or not ALS and PDC are on a spectrum of a single ...

journal_title：Acta neuropathologica

authors： Mimuro M,Kokubo Y,Kuzuhara S

更新日期：2007-06-01 00:00:00

abstract：:Investigations of the existence and distribution of muscle spindles and tendon organs in the human voluntary anal sphincter muscle in 53 cases of autopsy material from both female and male persons (age: 27th week of gestation to 81 years) brought forward the following results: Similar to animals, muscle spindles are f...

journal_title：Acta neuropathologica

authors： Lassmann G

更新日期：1984-01-01 00:00:00

abstract：:The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). However, the precise relationship between pathology and neurotoxicity and why these processes disproportionately affect certain neuron subp...

journal_title：Acta neuropathologica

authors： Luna E,Decker SC,Riddle DM,Caputo A,Zhang B,Cole T,Caswell C,Xie SX,Lee VMY,Luk KC

更新日期：2018-06-01 00:00:00

abstract：:We examined the effect of lactic acid on cultured human glioma cell lines expressing glial fibrillary acidic protein (GFAP), vimentin and neuron-specific enolase (NSE). The growth of the cells was inhibited by the lactic acid in a dose-dependent manner. At 56 mM of lactic acid, the surviving cells of the KNS-42-c2 cel...

journal_title：Acta neuropathologica

authors： Takeshita I,Sawa H,Nakamura T,Kuramitsu M,Kitamura K,Fukui M

更新日期：1990-01-01 00:00:00

abstract：:Neuropeptides have turned out to be promising new parameters, in addition to the routinely performed histochemical diagnosis, of Hirschsprung's disease (HD). Studies of the peptidergic innervation of the affected intestinal segment of patients with HD have demonstrated a marked reduction in the density of several neur...

journal_title：Acta neuropathologica

authors： Berger A,Kofler B,Santic R,Zipperer E,Sperl W,Hauser-Kronberger C

更新日期：2003-01-01 00:00:00

abstract：:Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic exami...

journal_title：Acta neuropathologica

authors： Pollanen MS,Onzivua S,Robertson J,McKeever PM,Olawa F,Kitara DL,Fong A

更新日期：2018-11-01 00:00:00

abstract：:Medulloblastoma comprises four distinct molecular variants with distinct genetics, transcriptomes, and outcomes. Subgroup affiliation has been previously shown to remain stable at the time of recurrence, which likely reflects their distinct cells of origin. However, a therapeutically relevant question that remains una...

journal_title：Acta neuropathologica

authors： Wang X,Dubuc AM,Ramaswamy V,Mack S,Gendoo DM,Remke M,Wu X,Garzia L,Luu B,Cavalli F,Peacock J,López B,Skowron P,Zagzag D,Lyden D,Hoffman C,Cho YJ,Eberhart C,MacDonald T,Li XN,Van Meter T,Northcott PA,Haibe-Kain

更新日期：2015-03-01 00:00:00

abstract：:We report the case of an elderly woman with a history of headache, vomiting and dizziness while walking. On CT scans a mass was identified in the right cerebellar hemisphere exhibiting radiological characteristics of lipomatous tissue. Surgery revealed a compact lesion consisting of whitish-yellow tissue with a fatty ...

journal_title：Acta neuropathologica

authors： Walter A,Dingemans KP,Weinstein HC,Troost D

更新日期：1994-01-01 00:00:00

abstract：:Two experiments were completed in which brains and spinal cords from lambs affected with spongy degeneration of the central nervous system (CNS) were analysed for water, sodium and potassium, as measures of cerebral oedema. In a third experiment, lambs with CNS spongy degeneration were tested for permeability of cereb...

journal_title：Acta neuropathologica

authors： Hooper PT

更新日期：1975-01-01 00:00:00

abstract：:Separation of pilocytic astrocytoma from diffuse astrocytomas frequently poses problems mostly related to small sample size. Precise classification and grading are essential due to different therapeutic strategies prompted by diagnoses of pilocytic astrocytoma WHO grade I, diffuse astrocytomas WHO grade II or anaplast...

journal_title：Acta neuropathologica

authors： Korshunov A,Meyer J,Capper D,Christians A,Remke M,Witt H,Pfister S,von Deimling A,Hartmann C

更新日期：2009-09-01 00:00:00

abstract：:We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...

journal_title：Acta neuropathologica

authors： Piao YS,Tan CF,Iwanaga K,Kakita A,Takano H,Nishizawa M,Lashley T,Revesz T,Lees A,de Silva R,Tsujihata M,Takahashi H

更新日期：2005-12-01 00:00:00

abstract：:Gliomatosis cerebri (GC), a rare and deadly CNS neoplasm characterized by involvement of at least three cerebral lobes, predominantly affects adults. While a few small series have reported its occurrence in children, little is known about the molecular characteristics of pediatric GC. We reviewed clinical, radiologica...

journal_title：Acta neuropathologica

authors： Broniscer A,Chamdine O,Hwang S,Lin T,Pounds S,Onar-Thomas A,Shurtleff S,Allen S,Gajjar A,Northcott P,Orr BA

更新日期：2016-02-01 00:00:00

abstract：:The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from four patients dying with cortical Lewy body disease (CLBD) all with Alzheimer-type pathology and compared to that in four other patients of similar age and gender dying with Alzheimer's disease (AD) alone....

journal_title：Acta neuropathologica

authors： Mann DM,Snowden JS

更新日期：1995-01-01 00:00:00

abstract：:Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...

journal_title：Acta neuropathologica

authors： Garruto RM,Shankar SK,Yanagihara R,Salazar AM,Amyx HL,Gajdusek DC

更新日期：1989-01-01 00:00:00

abstract：:It has been suggested that delayed development in either the peripheral or central nervous system could underlie the sudden infant death syndrome (SIDS). We studied the phrenic nerve in an attempt to find if maturation in this nerve was delayed in SIDS, and to see if fiber size differences could explain the paucity of...

journal_title：Acta neuropathologica

authors： Pamphlett R,Murray N,Louda C

更新日期：1996-01-01 00:00:00

abstract：:The distribution of apolipoprotein E (ApoE) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam, locally known as lytico bodig disease (LB), and compared with cases of Alzheimer's disease (AD) and normal brain tissue. In both LB and AD, strong ApoE immuno...

journal_title：Acta neuropathologica

authors： Schwab C,Steele JC,Akiyama H,McGeer PL

更新日期：1996-10-01 00:00:00

abstract：:Recent studies have documented carbonyl stress involvement in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The aim of the present study was to assess a role for carbonyl stress in motor neuron degeneration associated with superoxide dismutase-1 (SOD1) mutant familial ALS and its transgenic mouse m...

journal_title：Acta neuropathologica

authors： Shibata N,Hirano A,Hedley-Whyte ET,Dal Canto MC,Nagai R,Uchida K,Horiuchi S,Kawaguchi M,Yamamoto T,Kobayashi M

更新日期：2002-08-01 00:00:00

abstract：:Plaque-type deposition of prion protein (PrP) in the brain has been extremely rare in sporadic Creutzfeldt-Jakob disease patients with methionine homozygosity at polymorphic codon 129 of the PrP gene and type 1 abnormal isoform of PrP (sCJD-MM1). Here we report three sCJD-MM1 patients who showed prominent PrP-positive...

journal_title：Acta neuropathologica

authors： Kobayashi A,Arima K,Ogawa M,Murata M,Fukuda T,Kitamoto T

更新日期：2008-11-01 00:00:00

abstract：:A 17 year-old male, who was mentally and bodily retarded from the age of 7 years. At the age of 16 years, several neurological signs appeared. Pathologically, there was widespread myelin loss and tissue sponginess in the white matter of the cerebrum and cerebellum, bilaterally and symmetrically. A great many Alzheimer...

journal_title：Acta neuropathologica

authors： Miyakawa T,Murayama E

更新日期：1976-01-01 00:00:00

abstract：:Vascular smooth muscle cells are involved in deposition of amyloid in brain blood vessels. Accumulation of amyloid-beta peptide (Abeta) in cultured brain vascular smooth muscle cells that overexpress human amyloid-beta precursor protein (APP) Swedish, is strongly enhanced by exposure to iron ions. We studied cellular ...

journal_title：Acta neuropathologica

authors： Frackowiak J,Potempska A,Mazur-Kolecka B

更新日期：2009-05-01 00:00:00

abstract：:Psammoma bodies in meningocytic whorls were investigated by electron microscopy. In some whorls, connective tissue fibers were seen and membrane-bound vesicles were contiguous to degenerated cells. Some small vesicles, 0.1 to 0.5 micron in diameter, were outlined by plasma membrane (matrix vesicles), other larger ones...

journal_title：Acta neuropathologica

authors： Kubota T,Yamashima T,Hasegawa M,Kida S,Hayashi M,Yamamoto S

更新日期：1986-01-01 00:00:00

abstract：:Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy. Daily treatment with 0.5 g/kg of the drug for 26--46 days caused myopathic changes. ...

journal_title：Acta neuropathologica

authors： Teräväinen H,Larsen A,Hillbom M

更新日期：1977-08-16 00:00:00

abstract：:The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demon...

journal_title：Acta neuropathologica

authors： Schlegel J,Ullrich B,Stumm G,Gass P,Harwerth IM,Hynes NE,Kiessling M

更新日期：1993-01-01 00:00:00

abstract：:The central distal axonopathy induced in dogs by the administration of high doses of clioquinol is contrasted with the central-peripheral distal axonopathy precipitated by intoxication with 2,5-hexanedione. Mature, pure-bred Beagle dogs received a daily oral dose of 400 mg/kg of clioquinol for up to 7 months, or 1 ml ...

journal_title：Acta neuropathologica

authors： Krinke G,Schaumburg HH,Spencer PS,Thomann P,Hess R

更新日期：1979-08-01 00:00:00

abstract：:The suprascapular nerve from 14 horses, which had no clinical evidence of spinatus muscle atrophy, were obtained to determine whether the nerve was sub-clinically compressed at the scapular edge. The nerves were divided into three portions, proximal and distal to the scapular edge and as it reflected around it. In nin...

journal_title：Acta neuropathologica

authors： Duncan ID,Schneider RK,Hammang JP

更新日期：1987-01-01 00:00:00

abstract：:Motor dysfunction is frequently noted in human immunodeficiency virus type 1 (HIV-1)-infected patients. Until recently, neuropathological changes found in the basal ganglia were advanced as pathogenetic mechanisms. In the present study, further brain structures involved in motor control were analyzed morphometrically....

journal_title：Acta neuropathologica

authors： Abe H,Mehraein P,Weis S

更新日期：1996-08-01 00:00:00

abstract：:Gerstmann-Sträussler-Scheinker disease (GSS) is a hereditary transmissible spongiform encephalopathy associated with prion protein gene mutation P102L. The age of onset is roughly restricted to around the sixth decade; however, it is unclear whether the disease-specific pathology of GSS is already evident in the pre-c...

journal_title：Acta neuropathologica

authors： Sasaki K,Doh-ura K,Furuta A,Nakashima S,Morisada Y,Tateishi J,Iwaki T

更新日期：2003-07-01 00:00:00

abstract：:We studied three siblings and one unrelated patient with cerebrotendinous xanthomatosis (CTX). Of two unrelated patients, we examined biopsies of sural nerve, soleus muscle, and achilles tendon. We also performed neurophysiologic investigations. Another patient died, and a postmortem examination of both brain and spin...

journal_title：Acta neuropathologica

authors： Pop PH,Joosten E,van Spreeken A,Gabreëls-Festen A,Jaspar H,ter Laak H,Vos A

更新日期：1984-01-01 00:00:00

abstract：:A histochemical study is reported of regional differences of the lipid storage in a case of Niemann-Pick disease (NPD) type C. Besides tissues known to be affected (reticulo-endothelium, hepatocytes, nervous system), storage was demonstrated in adrenal cortical spongiocytes, sweat glands, renal glomerular and tubular ...

journal_title：Acta neuropathologica

authors： Elleder M,Jirásek A,Smíd F

更新日期：1975-12-19 00:00:00