Phrenic nerve maturation in the sudden infant death syndrome.

abstract：:We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mea...

journal_title：Acta neuropathologica

authors： Heinsen H,Rüb U,Bauer M,Ulmar G,Bethke B,Schüler M,Böcker F,Eisenmenger W,Götz M,Korr H,Schmitz C

更新日期：1999-06-01 00:00:00

abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...

journal_title：Acta neuropathologica

authors： Nonaka I,Ishiura S,Arahata K,Ishibashi-Ueda H,Maruyama T,Ii K

更新日期：1989-01-01 00:00:00

abstract：:The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic coun...

journal_title：Acta neuropathologica

authors： Dulai MS,Park CY,Howell WD,Smyth LT,Desai M,Carter DM,Vogel H

更新日期：2008-03-01 00:00:00

abstract：:Histopathological, immunocytochemical, and electron microscopical investigations were carried out in a man with a protracted history of spastic paraparesis, adrenal insufficiency and hypogonadism. Pathological findings were identical with those of the few previously reported cases of adrenomyeloneuropathy (AMN) includ...

journal_title：Acta neuropathologica

authors： Probst A,Ulrich J,Heitz PU,Herschkowitz N

更新日期：1980-01-01 00:00:00

abstract：:The extent of DNA fragmentation analysed using the TUNEL technique was evaluated in post-mortem human brain tissue. Twenty-four patients with clinical and histopathological diagnosis of Alzheimer's disease (AD) and a short post-mortem delay were analysed. We report an increase in the count of TUNEL-labelled cells as t...

journal_title：Acta neuropathologica

authors： Overmyer M,Kraszpulski M,Helisalmi S,Soininen H,Alafuzoff I

更新日期：2000-12-01 00:00:00

abstract：:We studied the distribution pattern of pathology and cholinergic deficits in the subnuclei of the amygdaloid complex (AC) in five patients with Alzheimer's disease (AD), eight with dementia with Lewy bodies (DLB) and five normal controls. In controls, the basal nucleus contained the highest choline acetyltransferase a...

journal_title：Acta neuropathologica

authors： Sahin HA,Emre M,Ziabreva I,Perry E,Celasun B,Perry R

更新日期：2006-02-01 00:00:00

abstract：:Paired helical filaments (PHF) were isolated from autopsied brain of cases of Alzheimer dementia, and their polypeptides were identified with monoclonal antibodies to PHF by Western blots. The PHF polypeptide profile consisted of several bands with a size difference of less than 5 kilodalton (kDa) between adjacent ban...

journal_title：Acta neuropathologica

authors： Grundke-Iqbal I,Wang GP,Iqbal K,Tung YC,Wisniewski HM

更新日期：1985-01-01 00:00:00

abstract：:The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demon...

journal_title：Acta neuropathologica

authors： Schlegel J,Ullrich B,Stumm G,Gass P,Harwerth IM,Hynes NE,Kiessling M

更新日期：1993-01-01 00:00:00

abstract：:Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were c...

journal_title：Acta neuropathologica

authors： Khuong-Quang DA,Buczkowicz P,Rakopoulos P,Liu XY,Fontebasso AM,Bouffet E,Bartels U,Albrecht S,Schwartzentruber J,Letourneau L,Bourgey M,Bourque G,Montpetit A,Bourret G,Lepage P,Fleming A,Lichter P,Kool M,von Deimling

更新日期：2012-09-01 00:00:00

abstract：:Activation of the MAPK signaling pathway has been shown to be a unifying molecular feature in pilocytic astrocytoma (PA). Genetically, tandem duplications at chromosome 7q34 resulting in KIAA1549-BRAF fusion genes constitute the most common mechanism identified to date. To elucidate alternative mechanisms of aberrant ...

journal_title：Acta neuropathologica

authors： Cin H,Meyer C,Herr R,Janzarik WG,Lambert S,Jones DT,Jacob K,Benner A,Witt H,Remke M,Bender S,Falkenstein F,Van Anh TN,Olbrich H,von Deimling A,Pekrun A,Kulozik AE,Gnekow A,Scheurlen W,Witt O,Omran H,Jabado N,C

更新日期：2011-06-01 00:00:00

abstract：:In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical ...

journal_title：Acta neuropathologica

authors： Vital A,Marchal C,Loiseau H,Rougier A,Pedespan JM,Rivel J,Vital C

更新日期：1994-01-01 00:00:00

abstract：:Aluminum was observed in the nucleolus, interchromatin granules, rough endoplasmic reticulum, free ribosomes, euchromatin, and the heterochromatin of the neuron. The association of aluminum with the first four r-RNA-containing cellular components and with the last two DNA-containing chromatins suggests the association...

journal_title：Acta neuropathologica

authors： Wen GY,Wisniewski HM

更新日期：1985-01-01 00:00:00

abstract：:APO2 ligand (APO2L)/TRAIL is a novel member of the tumor necrosis factor cytokine family and a potent inducer of apoptosis in tumor cell lines. We recently reported that APO2L is consistently expressed in low-grade astrocytomas, anaplastic astrocytomas, glioblastomas, and cell lines derived thereof, and that malignant...

journal_title：Acta neuropathologica

authors： Nakamura M,Rieger J,Weller M,Kim J,Kleihues P,Ohgaki H

更新日期：2000-01-01 00:00:00

abstract：:Massive GGGGCC repeat expansion in the first intron of the gene C9orf72 is the most common known cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Despite its intronic localization and lack of an ATG start codon, the repeat region is translated in all three reading fra...

journal_title：Acta neuropathologica

authors： Mori K,Arzberger T,Grässer FA,Gijselinck I,May S,Rentzsch K,Weng SM,Schludi MH,van der Zee J,Cruts M,Van Broeckhoven C,Kremmer E,Kretzschmar HA,Haass C,Edbauer D

更新日期：2013-12-01 00:00:00

abstract：:In G93A mice, the most popular model of amyotrophic lateral sclerosis (ALS), neuronal Lewy-body-like hyaline inclusions (LBHIs) and mitochondria-derived vacuoles are observed in addition to motor neuron loss. Although LBHIs are thought to be toxic, the significance of the mitochondria-derived vacuoles has not been ful...

journal_title：Acta neuropathologica

authors： Sumi H,Nagano S,Fujimura H,Kato S,Sakoda S

更新日期：2006-07-01 00:00:00

abstract：:A 79-year-old woman had a 10-year history of dementia, initially presenting as non-fluent aphasia. Magnetic resonance imaging showed frontal atrophy (left greater than right) and hyperintense foci within white matter. Neuropathologically, there was severe frontal atrophy due to cortical neuronal loss with spongy chang...

journal_title：Acta neuropathologica

authors： Powers JM,Byrne NP,Ito M,Takao M,Yankopoulou D,Spillantini MG,Ghetti B

更新日期：2003-08-01 00:00:00

abstract：:A 64-year-old woman developed septicemia and a generalized peripheral neuropathy while being ventilated postoperatively. No cause for the neuropathy could be found during life. At autopsy she was found to have infective endocarditis and multifocal inflammatory lesions in the central and peripheral nervous systems, con...

journal_title：Acta neuropathologica

authors： Pamphlett R,Walsh J

更新日期：1989-01-01 00:00:00

abstract：:The hemizygote of the macular mutant mice, which is clinically and neuropathologically considered to be a model of Menkes kinky hair disease (MKHD), were injected intraperitoneally four times with 10, 20, 20 and 30 micrograms of cupric chloride on days 4, 6, 8 and 10 after birth, respectively. Their cerebral and cereb...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Onaga A,Kawasaki H,Iwane S,Ono K,Nishimura M

更新日期：1988-01-01 00:00:00

abstract：:We evaluated by in situ nick end labeling the presence of apoptotic glial cells in the spinal cord of rats which have sustained a moderate and severe compression injury at the level of T8-9, resulting in a severe but reversible paraparesis and irreversible paraplegia, respectively. In a previous investigation we found...

journal_title：Acta neuropathologica

authors： Li GL,Farooque M,Holtz A,Olsson Y

更新日期：1999-11-01 00:00:00

abstract：:Following maternal chicken pox in the 14th week of pregnancy, a male infant was born with low birth weight, muscle wasting and limb contractures, hypotonia and areflexia. A rising titre of varicella-zoster-specific IgM (by enzyme-linked immunoabsorbent assay) confirmed congenital infection, and electromyogram showed w...

journal_title：Acta neuropathologica

authors： Harding B,Baumer JA

更新日期：1988-01-01 00:00:00

abstract：:Numerous families exhibiting both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have been described, and although many of these have been shown to harbour a repeat expansion in C9ORF72, several C9ORF72-negative FTD-ALS families remain. We performed neuropathological and genetic analysis of a la...

journal_title：Acta neuropathologica

authors： Dobson-Stone C,Luty AA,Thompson EM,Blumbergs P,Brooks WS,Short CL,Field CD,Panegyres PK,Hecker J,Solski JA,Blair IP,Fullerton JM,Halliday GM,Schofield PR,Kwok JB

更新日期：2013-04-01 00:00:00

abstract：:The quadriceps femoris muscles of experimental allergic myositis, in strain 13 guinea pigs immunised with rabbit myosin B fraction, were subjected to histochemical, immunohistochemical and electron microscopic studies. They demonstrated a variety of degenerative changes of muscle fibres, infiltration of lymphocytes an...

journal_title：Acta neuropathologica

authors： Matsubara S,Takamori M

更新日期：1987-01-01 00:00:00

abstract：:We examined the immunohistochemical localization of p35nck5a, the regulatory subunit of cyclin-dependent kinase 5 (cdk5), in brains obtained postmortem from patients with Parkinson's disease (PD) and controls. We found p35nck5a immunoreactivity in Lewy bodies (LB) in the substantia nigra, locus ceruleus, and neocortex...

journal_title：Acta neuropathologica

authors： Nakamura S,Kawamoto Y,Nakano S,Akiguchi I,Kimura J

更新日期：1997-08-01 00:00:00

abstract：:We have studied microtubule-associated protein 2 (MAP2) expression in anterior horn neurons in the cervical and lumbar spinal cords of 19 cases of adult-onset sporadic amyotrophic lateral sclerosis (ALS) using immunohistochemistry. Specimens from 7 patients without neurological disease served as controls. MAP2 express...

journal_title：Acta neuropathologica

authors： Kikuchi H,Doh-ura K,Kawashima T,Kira J,Iwaki T

更新日期：1999-01-01 00:00:00

abstract：:To identify antigenic differences between gliomas and normal brain, we have immunohistochemically studied the expression of lymphocyte adhesion molecules (ICAM-1, ICAM-2, ICAM-3, VCAM-1, E-selectin and CD58), epidermal growth factor receptor (EGFR) and extracellular matrix proteins (collagen IV, fibronectin, laminin, ...

journal_title：Acta neuropathologica

authors： Mäenpää A,Kovanen PE,Paetau A,Jäáskeläinen J,Timonen T

更新日期：1997-09-01 00:00:00

abstract：:To determine the role of advanced glycation endproducts (AGE) in the pathogenesis of familial amyotrophic lateral sclerosis (ALS) with superoxide dismutase-1 (SOD1) mutation, we investigated the immunohistochemical localization of N(epsilon)-carboxymethyl-lysine (CML), one of the major AGE structures, in spinal cords ...

journal_title：Acta neuropathologica

authors： Shibata N,Hirano A,Kato S,Nagai R,Horiuchi S,Komori T,Umahara T,Asayama K,Kobayashi M

更新日期：1999-03-01 00:00:00

abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...

journal_title：Acta neuropathologica

authors： Sasaki S,Warita H,Abe K,Iwata M

更新日期：2005-07-01 00:00:00

abstract：:The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...

journal_title：Acta neuropathologica

authors： Seilhean D,Kobayashi K,He Y,Uchihara T,Rosenblum O,Katlama C,Bricaire F,Duyckaerts C,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:We studied the muscle biopsy from an asymptomatic patient with high serum creatine kinase values. Subsarcolemmal and intermyofibrillar granular inclusions were seen at the light microscopy level. Ultrastructural observation showed clusters of cylindrical spirals (CS). CS are nonspecific, morphological finding, so far ...

journal_title：Acta neuropathologica

authors： Rapuzzi S,Prelle A,Moggio M,Rigoletto C,Ciscato P,Comi G,Francesca F,Scarlato G

更新日期：1995-01-01 00:00:00

abstract：:We studied a 27-year-old woman who died after a 6-year history of progressive dementia, dystonia, ataxia, apraxia, spasticity, choreoathetosis, visual and auditory hallucinations, and optic atrophy. Magnetic resonance imaging showed decreased intensity in the globus pallidus, substantia nigra, and dentate nuclei in T2...

journal_title：Acta neuropathologica

authors： Neumann M,Adler S,Schlüter O,Kremmer E,Benecke R,Kretzschmar HA

更新日期：2000-11-01 00:00:00