The origin, fate, and contribution of macrophages to spinal cord injury pathology.

Abstract:

:Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent effects have been largely attributed to environmental cues, such as specific cytokines, that influence the macrophage polarization state. In this review, we also consider the possibility that different macrophage origins, including the spleen, bone marrow, and local self-renewal, may also affect macrophage fate, and ultimately their function that contribute to the complex pathobiology of spinal cord injury.

journal_name

Acta Neuropathol

journal_title

Acta neuropathologica

authors

Milich LM,Ryan CB,Lee JK

doi

10.1007/s00401-019-01992-3

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

785-797

issue

5

eissn

0001-6322

issn

1432-0533

pii

10.1007/s00401-019-01992-3

journal_volume

137

pub_type

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