Abstract：
:Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focused on adult glioblastoma multiforme (GBM) with phase III trials targeting vascular endothelial growth factor continuing. In this study we investigated whether the degree of vascularity correlated with prognosis in a large cohort of pHGG (n = 150) and whether different vessel markers carried different prognostic value. We found that CD105 (endoglin) had a strongly significant association with poor prognosis on multivariate analysis (p = <0.001). Supervised hierarchical clustering of genome wide gene expression data identified 13 genes associated with differential degrees of vascularity in the cohort. The novel angiogenesis-associated genes identified in this analysis (including MIPOL-1 and ENPP5) were validated by realtime polymerase chain reaction. We also demonstrate that CD105 positive blood vessels associate with CD133 positive tumour cells and that a proportion of CD105 positive vessel cells demonstrates co-positivity for CD133, suggesting that the recently described phenomenon of vasculogenic mimicry occurs in pHGG. Together, the data suggest that targeting angiogenesis, and in particular CD105, is a valid therapeutic strategy for pHGG.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Smith SJ,Tilly H,Ward JH,Macarthur DC,Lowe J,Coyle B,Grundy RGdoi
10.1007/s00401-012-0952-1subject
Has Abstractpub_date
2012-07-01 00:00:00pages
99-110issue
1eissn
0001-6322issn
1432-0533journal_volume
124pub_type
杂志文章abstract：:Foetal rat brain reaggregate cultures have been employed to investigate the morphological changes associated with the neurotoxic action of ethylcholine mustard aziridinium (ECMA). In a companion study we provided evidence for apparent selective cholinergic neurotoxicity. Exposure of 9-day-old cultures to 12.5 microM E...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334882
更新日期：1993-01-01 00:00:00
abstract：:In the cytoplasm of Schwann cells of a sural nerve biopsy from a 21-year-old female patient with chronic neuropathy we noted numerous unique, usually double membrane-bound, osmiophilic, granular or globular inclusions, approximately 30-600 microm in diameter. Some of these membrane-bound vesicular or tubular structure...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051104
更新日期：1999-10-01 00:00:00
abstract：:A 64-year-old woman developed septicemia and a generalized peripheral neuropathy while being ventilated postoperatively. No cause for the neuropathy could be found during life. At autopsy she was found to have infective endocarditis and multifocal inflammatory lesions in the central and peripheral nervous systems, con...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687409
更新日期：1989-01-01 00:00:00
abstract：:This study reports the histological, ultrastructural, and immunocytochemical characteristics of intracytoplasmic eosinophilic inclusion bodies occurring in various types of neurons of the human central nervous system. By light microscopy, the inclusions were brightly eosinophilic, slightly birefringent, and sharply de...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308960
更新日期：1989-01-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide CAG repeat in the gene coding for huntingtin. Deregulation of chromatin remodeling is linked to the pathogenesis of HD but the mechanism remains elusive. To identify what genes are deregulated by trimethyla...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1103-z
更新日期：2013-05-01 00:00:00
abstract：:A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308813
更新日期：1991-01-01 00:00:00
abstract：:Acetylcholinesterase and butyrylcholinesterase have been associated with structures undergoing neurofibrillary degeneration, as well as with all types of senile plaques, in non-demented aged and Alzheimer's brains. At the electron microscope level, the reaction product of both enzymes, appeared to decorate paired heli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296744
更新日期：1994-01-01 00:00:00
abstract：:A complex neuropathological study of two cases of Niemann-Pick disease (NPD) type C (NPDC) revealed some novel features in the chemical pathology of the neuronal storage. Lipid histochemistry showed the presence of a lipid which met the criteria of a neuronal glycosphingolipid. Sphingomyelin (SM) was not detected in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690966
更新日期：1985-01-01 00:00:00
abstract：:Alpha-synuclein (αSyn) preformed fibrils (PFF) induce endogenous αSyn aggregation leading to reduced synaptic transmission. Neuronal activity modulates release of αSyn; however, whether neuronal activity regulates the spreading of αSyn pathology remains elusive. Here, we established a hippocampal slice culture system ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-020-02227-6
更新日期：2020-12-01 00:00:00
abstract：:The distribution of apolipoprotein E (ApoE) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam, locally known as lytico bodig disease (LB), and compared with cases of Alzheimer's disease (AD) and normal brain tissue. In both LB and AD, strong ApoE immuno...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050533
更新日期：1996-10-01 00:00:00
abstract：:Neurotrophins regulate the proliferation and differentiation of neurons in the central nervous system via a family of specialized receptors, including TrkA, TrkB, and TrkC. As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050906
更新日期：1998-10-01 00:00:00
abstract：:Brain metastases (BM) are common in cancer patients and are associated with high morbidity and poor prognosis, even after intensive multimodal therapy including resection, radiotherapy (stereotactic radiosurgery or whole brain radiotherapy) and chemotherapy. However, advances in the understanding of the pathobiology o...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-011-0933-9
更新日期：2012-02-01 00:00:00
abstract：:We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and duration of disease. Sections of middle frontal and inferior parie...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0162-9
更新日期：2007-01-01 00:00:00
abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308912
更新日期：1990-01-01 00:00:00
abstract：:The endothelial cells of three cases of cerebellar capillary hemangioblastoma were studied by means of electron microscopy. Crystalloid bodies, not previously described in the vessels of the central nervous system (CNS), were found in 5%-10% of the endothelial cells, more often in the capillaries with small irregular ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688686
更新日期：1985-01-01 00:00:00
abstract：:Immunohistochemical techniques were employed to examine the changes in free ubiquitin within the hippocampus 1, 3, 7, 14, and 30 days after a unilateral perforant pathway lesion occurred in the rat brain. Immunoreactivity for ubiquitin was remarkably decreased in the cell body and proximal dendrites of neurons through...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0489-1
更新日期：2002-05-01 00:00:00
abstract：:Ubiquitin-immunoreactive (ub-ir) neuronal cytoplasmic inclusions are characteristically found in the extramotor cortex in patients with motor neuron disease and dementia (MND-dementia) and a subset of patients with frontotemporal dementia without motor symptoms (FTD-MND type). Recently, ub-ir neuronal intranuclear inc...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0678-1
更新日期：2003-06-01 00:00:00
abstract：:Three cases of spontaneous olfactory neuroblastoma (ONB) in domestic cats were morphologically and immunocytochemically characterized. Diagnostic light microscopic features included Flexner and Homer-Wright rosettes, while ultrastructurally the cells had neuritic processes, intracellular intermediate filaments, and in...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294617
更新日期：1990-01-01 00:00:00
abstract：:Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density ge...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1165-y
更新日期：2013-10-01 00:00:00
abstract：:An ultrastructural study was performed on normal and Benzo(a)-pyrene(B(a)P)-transformed fetal mouse brain cells. Early subcultures of a strain initiated from whole brain presented three cell types in vitro: astroglial, poorly differentiated glial, and spongioblastic types. After B(a)P-treatment, there was an exclusive...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690548
更新日期：1979-08-01 00:00:00
abstract：:In almost all of the earlier reported cases of Kufs' disease, the adult form of ceroid lipofuscinosis, the diagnosis was ascertained by cerebral tissue examination, while peripheral biopsy examination revealed an apparent poor diffusion of specific lipofuscinic deposits, the finger print profiles (FPs). We report the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050866
更新日期：1998-07-01 00:00:00
abstract：:Eleven atypical teratoid/rhabdoid tumors (AT/RT) and 121 primitive neuroectodermal tumors/medulloblastomas (PNET/MB) were included in this study for evaluation of the histopathological features of AT/RT and comparison between AT/RT and PNET/MB. Histopathological studies of AT/RT showed that in addition to the commonly...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051149
更新日期：2000-05-01 00:00:00
abstract：:A system is presented for the classification of chronic herniations of the cerebellar tonsils in the absence of space-occupying intracranial lesions, based on a survey of the literature and 13 own cases. The Arnold-Chiari malformation in adults typically involves herniation of the cerebellar tonsils instead of herniat...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688677
更新日期：1976-03-30 00:00:00
abstract：:The neurone-centred view of the past disregarded or downplayed the role of astroglia as a primary component in the pathogenesis of neurological diseases. As this concept is changing, so is also the perceived role of astrocytes in the healthy and diseased brain and spinal cord. We have started to unravel the different ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-015-1513-1
更新日期：2016-03-01 00:00:00
abstract：:The brain of a 69-year-old man exhibited extensive granulomatous inflammation in the walls of arteries in the leptomeninges, associated with amyloid deposition in the media of the involved arteries. The extracranial arteries exhibited neither granulomatous inflammation nor amyloid deposition in their walls. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686094
更新日期：1986-01-01 00:00:00
abstract：:Data on the relationship between Parkinson's disease (PD) and stroke have been conflicting, some studies showing a reduced risk of stroke during life, and others indicating an increased risk of stroke-related death. Consecutive cases (n=617) of autopsy-proven idiopathic PD (Lewy body disease of the brain stem type) an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0676-3
更新日期：2003-05-01 00:00:00
abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687709
更新日期：1989-01-01 00:00:00
abstract：:The left and right recurrent laryngeal nerves and peroneal nerves from two groups of foals, one less than 1 month of age and the other 6 months of age, were examined by light and electron microscopy. While there was no evidence of fiber loss on light microscopy, occasional onion bulbs, regenerating clusters and swolle...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227825
更新日期：1992-01-01 00:00:00
abstract：:In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296190
更新日期：1994-01-01 00:00:00
abstract：:The mechanism of antibody-mediated central nervous system (CNS) demyelination in vivo was studied using rabbit eyes. Injection of anti-galactocerebroside (Gal C) antiserum alone into the normal rabbit vitreous body induced demyelination in the epiretinal myelinated fibers. This activity of the antiserum disappeared af...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687890
更新日期：1989-01-01 00:00:00
