Abstract：
:Electrophysiological studies in subjects with HIV/AIDS demonstrate subtle changes in the visual pathway even in the absence of visual symptoms. But the pathological correlate of the electrophysiological abnormalities is largely unknown. This study attempts to correlate pathological changes in the retina and intraorbital portion of optic nerve in four drug naïve patients of AIDS caused by HIV-1 clade C, who had abnormalities in the visual evoked potentials recorded antemortem. Three had no visual complaints and one patient had sudden loss of vision in the right eye. In all four patients, the visual evoked potentials disclosed variable prolongation of P100 latencies. Histologically axonal cytoskeletal breakdown and depletion in the optic nerves was the cardinal finding with variable myelin loss, even in the absence of overt visual dysfunction, or infective retinitis. The axonal loss was maximal in the symptomatic case. Retinal ganglion cell depletion was seen in only two patients. Sectoral infiltration of the optic nerve by cryptococci and Cryptococcal choroiditis was the only opportunistic infection to involve the eye. Axonal pathology in the optic nerve appears to be related to the abnormalities recorded in visual evoked potentials even in the absence of overt clinical symptoms. Opportunistic infections could be contributing to the axonal pathology in the optic nerve in patients with AIDS.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Mahadevan A,Satishchandra P,Prachet KK,Sidappa NB,Ranga U,Santosh V,Yasha TC,Desai A,Ravi V,Shankar SKdoi
10.1007/s00401-006-0089-1subject
Has Abstractpub_date
2006-10-01 00:00:00pages
461-9issue
4eissn
0001-6322issn
1432-0533journal_volume
112pub_type
杂志文章abstract：:A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00697397
更新日期：1983-01-01 00:00:00
abstract：:Paired helical filaments (PHF) were isolated from autopsied brain of cases of Alzheimer dementia, and their polypeptides were identified with monoclonal antibodies to PHF by Western blots. The PHF polypeptide profile consisted of several bands with a size difference of less than 5 kilodalton (kDa) between adjacent ban...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690830
更新日期：1985-01-01 00:00:00
abstract：:Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684802
更新日期：1979-04-12 00:00:00
abstract：:In this study we evaluated the relationship between polyglucosan bodies and peripheral nerve lesions. The biopsied sural nerve from a patient with late-onset chronic sensori-motor neuropathy showed many intra-axonal polyglucosan bodies and segmental demyelination/remyelination. The formation of Schwann cell hyperplasi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00454906
更新日期：1993-01-01 00:00:00
abstract：:Spinal cord of the rat was investigated immunohistochemically to detect signs of extravasation of fibronectin in animals in which the cord was subjected to different degrees of compression trauma. Immunohistochemistry was performed after survival periods of 4 and 24 h and parallel sections were incubated for albumin i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227738
更新日期：1992-01-01 00:00:00
abstract：:Morphometric observations have been made on the medial plantar division of the tibial nerve (MPD) and on the motor branches of the tibial nerve to the calf muscles (MBC) in rats ranging in age from weaning (3 weeks) to 12 months. Axon size, assessed by measurements of circumference and cross-sectional area, increased ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308712
更新日期：1990-01-01 00:00:00
abstract：:To clarify the significance of the constituents of canine senile plaques (SPs) or cerebrovascular amyloid deposits, paraffin and cryostat sections of canine brains were examined by immunohistochemistry using antibodies against cathepsin B (CB), cathepsin D (CD), cystatin C (CC), alpha-1-antichymotrypsin (ACT), heat sh...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050615
更新日期：1997-03-01 00:00:00
abstract：:Cerebrotendinous xanthomatosis (CTX), a rare autosomal-recessive lipid storage disease, has been well characterized clinically and biochemically, and recently also from the molecular biological aspect. However, only a very few publications deal with its neuropathology, and views on its pathogenesis vary. Based on a re...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294324
更新日期：1995-01-01 00:00:00
abstract：:Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether TDP-43 immunoreactivity is present in neuronal inclusions in familial ALS (FALS), we examined immunohistochemically the brains and spina...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0206-9
更新日期：2007-05-01 00:00:00
abstract：:Abuse of the club drugs Methamphetamine (Meth) and Ecstasy (MDMA) is an international problem. The seriousness of this problem is the result of what appears to be programmed cell death (PCD) occurring within the brain following their use. This follow up study focused on determining which cell types, neurons and/or gli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0259-9
更新日期：2007-09-01 00:00:00
abstract：:PICALM, a clathrin adaptor protein, plays important roles in clathrin-mediated endocytosis in all cell types. Recently, genome-wide association studies identified single nucleotide polymorphisms in PICALM gene as genetic risk factors for late-onset Alzheimer disease (LOAD). We analysed by western blotting with several...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1111-z
更新日期：2013-06-01 00:00:00
abstract：:Alpha-synuclein is known to play an important role in several neurodegenerative diseases. Moreover, it is expressed in central nervous system neuronal tumors, and another member of the synuclein family, gamma-synuclein, is overexpressed in breast and ovarian carcinomas. However, the expression of alpha-synuclein has n...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100443
更新日期：2002-02-01 00:00:00
abstract：:Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1800-0
更新日期：2018-02-01 00:00:00
abstract：:Alpha-synuclein (alphaS) and ubiquitin (Ub) are shared constituents of glial cytoplasmic inclusions (GCIs) and Lewy bodies (LBs), both composed of fibrillary structures. Staining profiles of GCIs were investigated with triple immunofluorescence involving immunostaining for alphaS and Ub, both amplified with catalyzed ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1066-9
更新日期：2005-10-01 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:It is conventionally accepted that during the early stages of Wallerian degeneration of myelinated peripheral nerve fibres Schmidt-Lanterman incisures represent the sites at which the myelin sheath, together with enclosed axoplasm, is segmented into myelin ovoids. This mechanism is considered by some authors to be fac...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demon...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00228582
更新日期：1993-01-01 00:00:00
abstract：:Pathways for drainage of interstitial fluid and cerebrospinal fluid from the rat brain were investigated by the injection of 2-5 microliters Indian ink into cerebral white and grey matter and into the subarachnoid space over the vertex of the left frontal lobe. Animals were killed by formalin or glutaraldehyde perfusi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296784
更新日期：1992-01-01 00:00:00
abstract：:Polyclonal antibodies directed towards synaptophysin were raised against a synthesised peptide corresponding to amino acids 246 to 260 of the human synaptophysin sequence. The antibodies, when applied for immunocytochemical staining, showed a staining pattern identical to that of the commercially available monoclonal ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293325
更新日期：1994-01-01 00:00:00
abstract：:The pattern of recovery of myelinated axons in the posterior tibial nerve after crushing was studied in rats chronically intoxicated with 2,5-hexanedione. It was given for 2 weeks before crushing (200 mg/kg i.p. 5 times a week) or additionally for two further weeks after the nerve crush. Two animals were examined from...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703206
更新日期：1983-01-01 00:00:00
abstract：:An ultrastructural study was performed on normal and Benzo(a)-pyrene(B(a)P)-transformed fetal mouse brain cells. Early subcultures of a strain initiated from whole brain presented three cell types in vitro: astroglial, poorly differentiated glial, and spongioblastic types. After B(a)P-treatment, there was an exclusive...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690548
更新日期：1979-08-01 00:00:00
abstract：:Most cases of frontotemporal lobar degeneration (FTLD) are characterized by abnormal intracellular accumulation of either tau or TDP-43 protein. However, in ~10% of cases, composed of a heterogenous collection of uncommon disorders, the molecular basis remains to be uncertain. We recently discovered that the pathologi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0764-0
更新日期：2011-02-01 00:00:00
abstract：:To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohistochemistry employing the monoclonal antibody 6E10, which is specific ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050735
更新日期：1997-11-01 00:00:00
abstract：:The cerebrovascular lesions of severe chronic hypertension were studied by light microscopy in perfusion-fixed, subserially sectioned brains from stroke-prone spontaneously hypertensive rats (SHRSP). The leakage and spread of plasma proteins were visualized by immunohistochemical detection of extravasated fibrinogen a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690831
更新日期：1985-01-01 00:00:00
abstract：:Plaque-type deposition of prion protein (PrP) in the brain has been extremely rare in sporadic Creutzfeldt-Jakob disease patients with methionine homozygosity at polymorphic codon 129 of the PrP gene and type 1 abnormal isoform of PrP (sCJD-MM1). Here we report three sCJD-MM1 patients who showed prominent PrP-positive...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-008-0425-8
更新日期：2008-11-01 00:00:00
abstract：:The neuropathologic findings in the brain of a National Aeronautics and Space Administration (NASA) engineer, who died subsequent to nitrogen inhalation, are reported. Findings which are unusual in other forms of anoxia included relative preservation of neurons in the Sommer sector of the hippocampus and a pattern of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688632
更新日期：1985-01-01 00:00:00
abstract：:Eleven atypical teratoid/rhabdoid tumors (AT/RT) and 121 primitive neuroectodermal tumors/medulloblastomas (PNET/MB) were included in this study for evaluation of the histopathological features of AT/RT and comparison between AT/RT and PNET/MB. Histopathological studies of AT/RT showed that in addition to the commonly...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051149
更新日期：2000-05-01 00:00:00
abstract：:The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). However, the precise relationship between pathology and neurotoxicity and why these processes disproportionately affect certain neuron subp...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-018-1829-8
更新日期：2018-06-01 00:00:00
abstract：:Six medulloblastomas were studied by electron microscopy. Two features were found which seem to be constant and essential characteristics of medulloblastoma. First, cell junctions are abundant between tumor cells. These are mostly desmosome-like but other, closer junctions, were also seen. Second, the capillary endoth...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685966
更新日期：1975-10-27 00:00:00
abstract：:A histochemical study is reported of regional differences of the lipid storage in a case of Niemann-Pick disease (NPD) type C. Besides tissues known to be affected (reticulo-endothelium, hepatocytes, nervous system), storage was demonstrated in adrenal cortical spongiocytes, sweat glands, renal glomerular and tubular ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688393
更新日期：1975-12-19 00:00:00
