Abstract：
:Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated human lymphocytes were used as diploid controls. With nonneoplastic tissue an average of 91% of the cells were diploid (presumably in G0 or G1 stage of the cell cycle). The cells of most benign tumors were mainly diploid (77-98%), nine specimens of pituitary adenomas had large numbers of aneuploid cells. In glioblastoma multiforme the proportion of diploid cells was significantly diminished and polyploid cells were frequently seen. Similar results were obtained in other malignant tumors, with metastatic tumors showing the greatest ploidy variation, which included triploid, tetraploid, and hypertetraploid cells. The analytical method used provides valuable information of significant clinical importance on the DNA distribution in brain tumor cells.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Kawamoto K,Herz F,Wolley RC,Hirano A,Kajikawa H,Koss LGdoi
10.1007/BF00684802subject
Has Abstractpub_date
1979-04-12 00:00:00pages
39-44issue
1-2eissn
0001-6322issn
1432-0533journal_volume
46pub_type
杂志文章abstract：:Surgical specimens of 4 intracranial saccular aneurysms were studied by scanning electron microscopy. The internal surface of the aneurysms showed crater-like defects and cytoplasmic bridges. In some areas the endothelium was preserved, but its longitudinal convolutions were higher and thicker than those found in unch...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691478
更新日期：1978-11-15 00:00:00
abstract：:The intracellular localization of myoglobin(Mb) mRNA in the skeletal muscles of normal subjects and patients with Duchenne muscular dystrophy(DMD) or amyotrophic lateral sclerosis(ALS) was examined by in situ hybridization using a biotin-labeled cDNA probe. In cross sections of normal muscles, Mb mRNA signals were dem...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00369442
更新日期：1993-01-01 00:00:00
abstract：:Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy. Daily treatment with 0.5 g/kg of the drug for 26--46 days caused myopathic changes. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703319
更新日期：1977-08-16 00:00:00
abstract：:The selective toxicity of silica dust for macrophages has been used to assess the role of these cells in experimental allergic neuritis (EAN). Inbred Lewis rats were inoculated with bovine dorsal roots in Freund's complete adjuvant (day 0). In two experiments, animals received 200 mg of silica dust in 1 cm3 of saline ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687614
更新日期：1984-01-01 00:00:00
abstract：:Widespread damage to axons in the white matter of the brain is a well-recognised consequence of non-missile head injury. This diffuse axonal injury is characterised by a gradual swelling of the axon associated with an accumulation of cellular organelles and proteins. We have investigated the relationship between the s...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051069
更新日期：1999-08-01 00:00:00
abstract：:Cerebral cortical lesions of tuberous sclerosis (TSC) and focal cortical dysplasia (FCD) show disturbances in laminar architecture and cellular differentiation. We immunohistochemically studied the expression of doublecortin, a fetal neuronal protein that regulates neuronal migration, in the surgical specimens of five...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0575-z
更新日期：2002-10-01 00:00:00
abstract：:A model of hypothermic circulatory arrest with recovery has been developed in the newborn dog. Eleven puppies were anesthetized with halothane, paralyzed and artificially ventilated with 70% nitrous oxide -30% oxygen to paO2 > 60 mm Hg, paCO2 = 33-42 mm Hg and pHa = 7.35-7.42. Animals were surface cooled to 20 degrees...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227767
更新日期：1993-01-01 00:00:00
abstract：:The neuropathologic findings in the brain of a National Aeronautics and Space Administration (NASA) engineer, who died subsequent to nitrogen inhalation, are reported. Findings which are unusual in other forms of anoxia included relative preservation of neurons in the Sommer sector of the hippocampus and a pattern of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688632
更新日期：1985-01-01 00:00:00
abstract：:Intracerebral C6 glioma xenografts spontaneously develop centrally located necrotic regions that are bordered by densely packed neoplastic cells. Proliferative and metabolic heterogeneity in these perinecrotic regions were assessed by bromodeoxyuridine (BrdU) incorporation, by immunocytological and by histochemical an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0803-1
更新日期：2004-03-01 00:00:00
abstract：:To identify antigenic differences between gliomas and normal brain, we have immunohistochemically studied the expression of lymphocyte adhesion molecules (ICAM-1, ICAM-2, ICAM-3, VCAM-1, E-selectin and CD58), epidermal growth factor receptor (EGFR) and extracellular matrix proteins (collagen IV, fibronectin, laminin, ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050696
更新日期：1997-09-01 00:00:00
abstract：:Damage to axons in acute multiple sclerosis (MS) lesions is now well established but the mechanisms of this damage remain obscure. Here we have applied a panel of antibodies that identify cell populations and proteins contained in them with a view to detecting those cells and proteins that are localised particularly c...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0045-0
更新日期：2006-04-01 00:00:00
abstract：:Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent aphasia, regardless of the underlying neuropathological features. Considerable progress has been made in recent years in our understanding of the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-007-0241-6
更新日期：2007-07-01 00:00:00
abstract：:A strong immunoreactivity for ferritin was observed in the neuritic (senile) plaques in Alzheimer's disease hippocampus. The ferritin accumulation was almost exclusively associated with the microglia, which appeared to have proliferated greatly. These cells were also positive for HLA-DR, a putative marker for reactive...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334497
更新日期：1990-01-01 00:00:00
abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/BF00293381
更新日期：1991-01-01 00:00:00
abstract：:Recent studies have documented carbonyl stress involvement in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The aim of the present study was to assess a role for carbonyl stress in motor neuron degeneration associated with superoxide dismutase-1 (SOD1) mutant familial ALS and its transgenic mouse m...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0537-5
更新日期：2002-08-01 00:00:00
abstract：:The number and nucleolar volume of nerve cells within the nucleus basalis of Meynert, locus caeruleus, substantia nigra and dorsal raphe were examined in five patients with Huntington's chorea. No significant changes in nerve cell number were noted in any area in any patient and, although nucleolar volume was reduced ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687718
更新日期：1989-01-01 00:00:00
abstract：:Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing rev...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100366
更新日期：2001-04-01 00:00:00
abstract：:The recently identified prolactin (PRL)-releasing peptide (PrRP) is the first hypothalamic peptide hormone found to operate as a ligand of an orphan receptor that specifically stimulates PRL production from the pituitary gland. However, its other biological functions remain unknown. Using immunohistochemistry, we exam...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0753-7
更新日期：2003-11-01 00:00:00
abstract：:Relatively little work has been done on the structural effects of organic lead in the central nervous system (CNS), although this form of lead may be a significant fraction of total brain lead. We tested a number of easily measured light-histological parameters of neuronal development in rats for sensitivity to (a) no...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687338
更新日期：1984-01-01 00:00:00
abstract：:Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294647
更新日期：1990-01-01 00:00:00
abstract：:The original version of this article unfortunately contained a typesetting error in Fig 3c. The corrected Fig. 3 is given in the following page. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00401-019-02115-8
更新日期：2020-02-01 00:00:00
abstract：:Both protein kinases and phosphoprotein phosphatases are important components of signal transduction systems in cells. Recent studies in Alzheimer's disease (AD) have shown abnormal protein phosphorylation in the cortex suggesting an alteration in these enzymes. In the present study, an antibody against CD45 was used ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294425
更新日期：1991-01-01 00:00:00
abstract：:Vasa vasorum are adventitial vessels that play a role in pathogenesis of atherosclerosis, aneurysm, vasculitides, and graft vascular disease. The existence of vasa vasorum in human intracranial arteries is not yet well defined. The specific aims of this study are to determine whether the human intracranial arteries ha...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050856
更新日期：1998-07-01 00:00:00
abstract：:A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227831
更新日期：1992-01-01 00:00:00
abstract：:Electron microscopy revealed the presence of cytoplasmic tubular aggregates in the capillary endothelium of a sparsely granulated growth hormone cell adenoma removed surgically from a 25-year-old female patient with acromegaly. To our knowledge, this is the second publication describing these structures in hypophysial...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684545
更新日期：1977-01-31 00:00:00
abstract：:Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris. However, the proteins in myelin debris that act as potent and selective inhibi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1521-1
更新日期：2016-02-01 00:00:00
abstract：:Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and 'adult-type' diffuse gliomas, are largely established, those of uncommon LGNTs remain to be define...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1539-z
更新日期：2016-06-01 00:00:00
abstract：:A case of classic medulloblastoma that metastasized, despite the absence of local recurrence, to extraneural sites 7 years after treatment is reported. The metastases were, in contrast to the primary tumor, of large cell type and displayed abortive myogenic and, in one site, also rhabdoid differentiation. The primary ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-0986-8
更新日期：2005-05-01 00:00:00
abstract：:The formation of oedema in peripheral nerves was studied in rats at intervals varying from 6 h to 14 days after transection of the right sciatic nerve. Samples were removed proximal and distal to the injury, and the degree of oedema was determined by a microgravimetric method and by measurements of the water content a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686069
更新日期：1986-01-01 00:00:00
abstract：:In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684561
更新日期：1975-01-01 00:00:00
