Abstract:
:Modern neuropathology serves a key function in the multidisciplinary management of brain tumor patients. Owing to the recent advancements in molecular neurooncology, the neuropathological assessment of brain tumors is no longer restricted to provide information on a tumor's histological type and malignancy grade, but may be complemented by a growing number of molecular tests for clinically relevant tissue-based biomarkers. This article provides an overview and critical appraisal of the types of genetic and epigenetic aberrations that have gained significance in the molecular diagnostics of gliomas, namely deletions of chromosome arms 1p and 19q, promoter hypermethylation of the O6-methylguanine-methyl-transferase (MGMT) gene, and the mutation status of the IDH1 and IDH2 genes. In addition, the frequent oncogenic aberration of BRAF in pilocytic astrocytomas may serve as a novel diagnostic marker and therapeutic target. Finally, this review will summarize recent mechanistic insights into the molecular alterations underlying treatment resistance in malignant gliomas and outline the potential of genome-wide profiling approaches for increasing our repertoire of clinically useful glioma markers.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Riemenschneider MJ,Jeuken JW,Wesseling P,Reifenberger Gdoi
10.1007/s00401-010-0736-4subject
Has Abstractpub_date
2010-11-01 00:00:00pages
567-84issue
5eissn
0001-6322issn
1432-0533journal_volume
120pub_type
杂志文章,评审abstract::An in vivo method for positively staining dead neurons was developed and compared with an in vitro staining method using acid fuchsin. Neurons previously killed by intracerebral injections of kainic acid were selectively stained by trypan blue within 15 min of its injection in vivo into the central nervous system of r...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687254
更新日期:1989-01-01 00:00:00
abstract::A case of 14-year-old girl is reported in whom an alveolar rhabdomyosarcoma occurred in the soft tissues of the left forearm 4 years prior to death. Despite extensive surgery as well as chemotherapy and radiotherapy the tumor recurred locally and produced extensive metastases including a metastasis to the brain. Cereb...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687824
更新日期:1985-01-01 00:00:00
abstract::To clarify the role of prostaglandins in peripheral nerve demyelination, we examined the expression of cyclooxygenase-2 (COX-2) using selected nerve specimens from patients with chronic inflammatory demyelinating polyneuropathy. COX-2 protein was up-regulated in macrophages causing active demyelination. In situ hybrid...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010000279
更新日期:2001-02-01 00:00:00
abstract::Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer's disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in the forms of extrace...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-016-1546-0
更新日期:2016-04-01 00:00:00
abstract::Axons of the peripheral nervous system (PNS) are reduced in caliber in response to the experimental diabetic state. The cause of this reduced axonal size is disputed. Various theories include (a) axonal dwindling, (b) inhibition of growth, and (c) shrinkage due to serum hyperosmolarity. This study was designed to dire...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688637
更新日期:1985-01-01 00:00:00
abstract::The identification of the alpha-synuclein gene on chromosome 4q as a locus for familial Lewy-body parkinsonism and of alpha-synuclein as a component of Lewy bodies has heralded a new era in the study of Parkinson's disease. We have identified a large family with Lewy body parkinsonism linked to a novel locus on chromo...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010051177
更新日期:2000-06-01 00:00:00
abstract::Excitotoxic stimulation of NMDA receptors results in the activation of a variety of cellular responses. The inducible transcription factor NF-kappaB is known to be involved in excitotoxic responses by neurons. Here, we show that NF-kappaB activation occurs in a biphasic manner in hippocampal slices following a 20-min ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-004-0876-5
更新日期:2004-09-01 00:00:00
abstract::The very existence of astroblastoma has been a question of considerable controversy, although there appears now to be sufficient documentation to establish it as a tenable entity. Due to the rarity of this tumor, little information exists in the literature as to its natural history, efficacy of therapy and its patholo...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00689508
更新日期:1986-01-01 00:00:00
abstract::We studied the microscopic features of 137 cases of human cerebral infarct. In each case, the age of the lesion was determined by measuring the time elapsed between initial clinical presentation and date of surgery or death. Multiple microscopic variables were analyzed on hematoxylin and eosin-stained sections. There ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-004-0918-z
更新日期:2004-12-01 00:00:00
abstract::Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conventionally subclassified into pure germinoma or non-germinomatous GCTs. Recent exhaustive genomic studies show...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-017-1673-2
更新日期:2017-03-01 00:00:00
abstract::Mutations in the sarcomeric protein titin, encoded by TTN, are emerging as a common cause of myopathies. The diagnosis of a TTN-related myopathy is, however, often not straightforward due to clinico-pathological overlap with other myopathies and the prevalence of TTN variants in control populations. Here, we present a...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-020-02257-0
更新日期:2021-01-15 00:00:00
abstract::The pattern of recovery of myelinated axons in the posterior tibial nerve after crushing was studied in rats chronically intoxicated with 2,5-hexanedione. It was given for 2 weeks before crushing (200 mg/kg i.p. 5 times a week) or additionally for two further weeks after the nerve crush. Two animals were examined from...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00703206
更新日期:1983-01-01 00:00:00
abstract::Adult rabbits were subjected to 4.5 Gy of whole-blody or brain alone gamma-irradiation, and their hippocampus was examined with the light and electron microscope. Pycnotic cells were found at the base of the granular layer of the dentate gyrus in the so-called subgranular zone, as soon as 3 h after irradiation, and we...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690520
更新日期:1979-12-01 00:00:00
abstract::Morphometric observations have been made on the medial plantar division of the tibial nerve (MPD) and on the motor branches of the tibial nerve to the calf muscles (MBC) in rats ranging in age from weaning (3 weeks) to 12 months. Axon size, assessed by measurements of circumference and cross-sectional area, increased ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00308712
更新日期:1990-01-01 00:00:00
abstract::3-Nitropropionic acid (NPA), a toxin which irreversibly inhibits the Krebs cycle enzyme succinate dehydrogenase, causes severe neurologic disease and a specific pattern of morphologic brain damage when given subcutaneously to rats. To determine whether hypotension or hypoxemia were necessary for development of morphol...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688340
更新日期:1987-01-01 00:00:00
abstract::A giant-cell glioblastoma was examined by electron microscopy and by the freeze-fracture technique. The cell membranes bordering the extensive extracellular space often showed complicated undulations and peripheral vacuoles as well as occasional microvilli or filopodia. The undulations were mainly composed of plasmale...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00689558
更新日期:1978-01-19 00:00:00
abstract::The deficiency of the cholinergic cortical projection system arising in the different basal forebrain structures collectively referred to as nucleus basalis of Meynert complex is a constant finding in Alzheimer's disease, a disorder which is neuro-pathologically characterised by the appearance of three intracerebral f...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690530
更新日期:1988-01-01 00:00:00
abstract::Human adenovirus type 12 (Ad 12) was inoculated intraperitoneally, intrapleurally, intramuscularly or subcutaneously into newborn rodents. Tumors developed preferentially in the peritoneal cavities in 93.9% of the hamsters and 82.6% of the mice, but none in rats; in contrast to the high incidence of brain tumors in ra...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687575
更新日期:1989-01-01 00:00:00
abstract::Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and mislocalization of muscle fiber nuclei. Genetically distinct forms exist, and mutations in BIN1 were recently identified in autosomal recessive cases (ARCNM). Amphiphysins have been implica...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-010-0754-2
更新日期:2011-02-01 00:00:00
abstract::Glycerol (an atoxic alcohol) and phenol (a toxic monohydroxybenzene) are currently used as neurolytic blocking agents to relieve pain or spasticity. In the present study we compared the endoneurial response of anhydrous glycerol and 7% phenol-aqua after intraneural injection into rat sciatic nerve, using electron micr...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010000349
更新日期:2001-07-01 00:00:00
abstract::Exercise intolerance associated with myalgias, muscle cramps or myoglobinuria may be associated with a dystrophinopathy. A search for abnormal dystrophin expression (using immunohistochemistry, immunoblot and DNA analysis) was carried out in a series of 15 patients. They were selected because they presented exercise i...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050671
更新日期:1997-07-01 00:00:00
abstract::A large series of central and peripheral nervous system tumors was studied for the presence of glial fibrillary acidic protein (GFAP) and gamma-enolase (neuron-specific enolase, NSE), using specific monoclonal antibodies (mAbs). Occurrence in and specificity of GFAP to glial and mixed tumors was confirmed and depended...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687791
更新日期:1988-01-01 00:00:00
abstract::Eleven atypical teratoid/rhabdoid tumors (AT/RT) and 121 primitive neuroectodermal tumors/medulloblastomas (PNET/MB) were included in this study for evaluation of the histopathological features of AT/RT and comparison between AT/RT and PNET/MB. Histopathological studies of AT/RT showed that in addition to the commonly...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010051149
更新日期:2000-05-01 00:00:00
abstract::A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294305
更新日期:1993-01-01 00:00:00
abstract::The relationship between diabetes and the size, density and area of the ventromedial hypothalamic nucleus (VMH) was studied in the genetically diabetic Chinese hamster. Matched diabetic and non-diabetic control chinese hamsters were perfused, the hypothalamus collected, sectioned and stained for light microscopy. The ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00691183
更新日期:1982-01-01 00:00:00
abstract::In an autopsy case of the sporadic juvenile ALS (a 17-year-old girl) intracytoplasmic inclusions are found in the upper and lower motor neurons and in nerve cells of the dentate nucleus, pontine nucleus, brain stem reticular formation, substantia nigra, thalamus, globus pallidus and others. Histochemically they contai...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00691069
更新日期:1978-12-15 00:00:00
abstract::The formation of oedema in peripheral nerves was studied in rats at intervals varying from 6 h to 14 days after transection of the right sciatic nerve. Samples were removed proximal and distal to the injury, and the degree of oedema was determined by a microgravimetric method and by measurements of the water content a...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686069
更新日期:1986-01-01 00:00:00
abstract::Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294647
更新日期:1990-01-01 00:00:00
abstract::Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688042
更新日期:1986-01-01 00:00:00
abstract::We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-005-1086-5
更新日期:2005-12-01 00:00:00