Abstract:
:Essential mixed cryoglobulinemia, which can cause hypersensitivity vasculitis, was observed in five patients with peripheral neuropathy. Three cases presented with multifocal neuropathies and two cases with symmetrical polyneuropathy. One had cryoglobulinemia with IgM monoclonal gammopathy IgG polyclonal gammopathy, and the other four had cryoglobulinemia with polyclonal gammopathy. Biopsies showed perivascular infiltration by mononuclear cells around medium, and mainly small-sized blood vessels. This was observed in the epineurium (five cases) and muscular fragments (three cases). At ultrastructural examination two cases showed severe damage of most myelinated fibers, which presented acute stages of Wallerian-like degeneration, and the three other cases showed a less widespread destruction of myelinated fibers. Most endoneurial capillaries showed swollen endoneurial cells. Myelino-axonal degeneration of myelinated fibers is probably due mainly to the vasculitis always present in the epineurium. This damage was probably worsened by the modifications of endoneurial capillaries. These lesions and their mechanisms are quite different from those observed in cases of cryoglobulinemia with an isolated monoclonal gammopathy.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Vital C,Deminière C,Lagueny A,Bergouignan FX,Pellegrin JL,Doutre MS,Clement A,Beylot Jdoi
10.1007/BF00686206subject
Has Abstractpub_date
1988-01-01 00:00:00pages
605-10issue
6eissn
0001-6322issn
1432-0533journal_volume
75pub_type
杂志文章abstract::Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated wi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-017-1737-3
更新日期:2017-11-01 00:00:00
abstract::Charcot-Marie-Tooth disease type 1 B (CMT1B) is a demyelinating neuropathy caused by mutations in the myelin protein zero (P0) gene (MPZ). A few cases of CMT1B were recently found to be characterized by focally folded myelin sheaths in nerve biopsy specimens; the significance of this association is unknown. Here, we d...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004019900175
更新日期:2000-09-01 00:00:00
abstract::Two cases out of a sample of 41 fetuses and infants with prosencephalic malformation, observed at the Institute of Pathology and Department of Neuropathology of the University of Heidelberg, are described here in detail. These cases presented grossly with microcephaly and missing forebrain, appearing to be cases of ap...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/pl00007438
更新日期:2000-03-01 00:00:00
abstract::We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and duration of disease. Sections of middle frontal and inferior parie...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-006-0162-9
更新日期:2007-01-01 00:00:00
abstract::We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mea...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010051037
更新日期:1999-06-01 00:00:00
abstract::The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly C...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00334513
更新日期:1990-01-01 00:00:00
abstract::The recently identified prolactin (PRL)-releasing peptide (PrRP) is the first hypothalamic peptide hormone found to operate as a ligand of an orphan receptor that specifically stimulates PRL production from the pituitary gland. However, its other biological functions remain unknown. Using immunohistochemistry, we exam...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-003-0753-7
更新日期:2003-11-01 00:00:00
abstract::Among the various mechanisms proposed to explain the pathogenesis of cerebral lesions in human immunodeficiency virus (HIV)-induced encephalitis, a cytokine-mediated action has found most favour. Indeed, elevated expression of cytokines such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha), thought to...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050457
更新日期:1996-01-01 00:00:00
abstract::There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-004-0934-z
更新日期:2005-02-01 00:00:00
abstract::Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer's disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in the forms of extrace...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-016-1546-0
更新日期:2016-04-01 00:00:00
abstract::The most common cause of familial frontotemporal lobar degeneration with TAR DNA-binding protein-43 pathology (FTLD-TDP) has been found to be an expansion of a hexanucleotide repeat (GGGGCC) in a noncoding region of the gene C9ORF72. Hippocampal sclerosis (HpScl) is a common finding in FTLD-TDP. Our objective was to s...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-013-1161-2
更新日期:2013-10-01 00:00:00
abstract::To elucidate whether the apolipoprotein E epsilon4 allele (APOE4) affects cortical neuropathology in Parkinson's disease (PD), we determined APOE genotypes and quantified the densities of cortical Lewy bodies (LBs), amyloid plaques and neurofibrillary tangles in 22 autopsy-proven PD cases (12 with dementia; 10 without...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050824
更新日期:1998-05-01 00:00:00
abstract::Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of intracellular lumina and pseudopsammoma bodies, expression of a distinct pattern of cytokeratins and clinically by pronounced perifocal brain edema. Here we descr...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-013-1093-x
更新日期:2013-03-01 00:00:00
abstract::Mineralization in the wall of central nervous system blood vessels is sporadically encountered in aged horses and cattle as in man, generally as an age-related change. This phenomenon has not to date been located in the meninges in dogs or cats. The present study reports a retrospective histological examination of 50 ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-002-0641-6
更新日期:2003-03-01 00:00:00
abstract::The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences in t...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-018-1859-2
更新日期:2018-07-01 00:00:00
abstract::Round granulated body (RGB) and eosinophilic hyaline droplets (EHDs) have been described as cytoplasmic inclusions of certain astrocytic tumors. In the previous literature, however, these inclusions have been described using various terms or regarded as nosologically the same entity. Light microscopically, RGB appeare...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00296486
更新日期:1994-01-01 00:00:00
abstract::The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the ne...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00334498
更新日期:1990-01-01 00:00:00
abstract::Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050559
更新日期:1996-12-01 00:00:00
abstract::In Alzheimer's disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several lines of evidence ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-018-1911-2
更新日期:2018-11-01 00:00:00
abstract::Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research ti...
journal_title:Acta neuropathologica
pub_type: 杂志文章,评审
doi:10.1007/s00401-008-0360-8
更新日期:2008-05-01 00:00:00
abstract::In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in Alzheimer's disease (AD). In this study, we used TR as a potential diagnostic marker of AD in frozen...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-008-0431-x
更新日期:2008-11-01 00:00:00
abstract::An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00304146
更新日期:1993-01-01 00:00:00
abstract::The E200K mutation is the most frequent prion protein gene (PRNP) mutation detected worldwide that is associated with Creutzfeldt-Jakob disease (CJD) and thought to have overlapping features with sporadic CJD, yet detailed neuropathological studies have not been reported. In addition to the prion protein, deposition o...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-010-0713-y
更新日期:2011-01-01 00:00:00
abstract::Neurotrophins regulate the proliferation and differentiation of neurons in the central nervous system via a family of specialized receptors, including TrkA, TrkB, and TrkC. As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050906
更新日期:1998-10-01 00:00:00
abstract::Hyper- and hypothyroidism repercussions on soma, nucleus and cytoplasm increases were studied by electron microscopy on 7-, 14-, 21-, and 35-day-old rats. Adult normal animals were compared with adult ones made hypothyroid until they were 35 days old. Also heat value restriction of food intake effects were compared wi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:
更新日期:1978-09-15 00:00:00
abstract::The dynamics of cell-associated Concanavalin A (Con A) in astrocytes of the newborn rat (RNA), the rat glioma (AC), and the human glioblastoma (GB) were studied in vitro by fluorescence and electron microscopy. Con A receptors on the cell surface were seen usually as a continuous thin layer, and Con A accumulations in...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690804
更新日期:1982-01-01 00:00:00
abstract::We studied three siblings and one unrelated patient with cerebrotendinous xanthomatosis (CTX). Of two unrelated patients, we examined biopsies of sural nerve, soleus muscle, and achilles tendon. We also performed neurophysiologic investigations. Another patient died, and a postmortem examination of both brain and spin...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688117
更新日期:1984-01-01 00:00:00
abstract::Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00684802
更新日期:1979-04-12 00:00:00
abstract::The authors present the case of a hypertensive patient with a thrombosis of a saccular microaneurysm (SMA) and underlying cerebral (pontine) lacunae. This SMA lay at the junction between the main vessel and two small feeding arteries penetrating into the necrotic territory. Microhemorrhages were observed in and outsid...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688313
更新日期:1986-01-01 00:00:00
abstract::Polyclonal antibodies directed towards synaptophysin were raised against a synthesised peptide corresponding to amino acids 246 to 260 of the human synaptophysin sequence. The antibodies, when applied for immunocytochemical staining, showed a staining pattern identical to that of the commercially available monoclonal ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00293325
更新日期:1994-01-01 00:00:00