Unilateral hemispheric cerebral changes similar to Creutzfeldt-Jakob disease in a case of hemiconvulsion.

abstract：:Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We hypothesized that the failu...

journal_title：Acta neuropathologica

authors： Nagano S,Jinno J,Abdelhamid RF,Jin Y,Shibata M,Watanabe S,Hirokawa S,Nishizawa M,Sakimura K,Onodera O,Okada H,Okada T,Saito Y,Takahashi-Fujigasaki J,Murayama S,Wakatsuki S,Mochizuki H,Araki T

更新日期：2020-11-01 00:00:00

abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...

journal_title：Acta neuropathologica

authors： Ingvar M,Morgan PF,Auer RN

更新日期：1988-01-01 00:00:00

abstract：:A case of cerebellar medullomyoblastoma in a young boy was investigated by electron microscopy. The neuroectodermal component shows the characteristics of a desmoplastic medulloblastoma. The mesodermal component consists of more or less differentiated cross-striated muscle cells. Undifferentiated muscle cells are very...

journal_title：Acta neuropathologica

authors： Walter GF,Brucher JM

更新日期：1979-12-01 00:00:00

abstract：:α-Synuclein (αSyn) histopathology defines several neurodegenerative disorders, including Parkinson's disease, Lewy body dementia, and Alzheimer's disease (AD). However, the functional link between soluble αSyn and disease etiology remains elusive, especially in AD. We, therefore, genetically targeted αSyn in APP trans...

journal_title：Acta neuropathologica

authors： Khan SS,LaCroix M,Boyle G,Sherman MA,Brown JL,Amar F,Aldaco J,Lee MK,Bloom GS,Lesné SE

更新日期：2018-10-01 00:00:00

abstract：:Mouse embryos were infected with murine cytomegalovirus (MCMV) by injecting the virus into the cerebral ventricles at the late gestation. After deliveries, offspring were fed by the mothers until 4 weeks. Cystic brain lesions, regarded as porencephaly or paraventricular cysts, were observed in about 20% of the MCMV-in...

journal_title：Acta neuropathologica

authors： Tsutsui Y,Kashiwai A,Kawamura N,Kadota C,Nagahama M

更新日期：1991-01-01 00:00:00

abstract：:In a study designed to identify the neuropathological features typical of chronic inflammatory demyelinating polyneuropathy (CIDP), we reviewed the sural nerve biopsy findings in 105 patients with this disorder. The patients' mean age at biopsy was 49 years. In 65% of patients the disease had a progressive and in 35% ...

journal_title：Acta neuropathologica

authors： Rizzuto N,Morbin M,Cavallaro T,Ferrari S,Fallahi M,Galiazzo Rizzuto S

更新日期：1998-12-01 00:00:00

abstract：:Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether TDP-43 immunoreactivity is present in neuronal inclusions in familial ALS (FALS), we examined immunohistochemically the brains and spina...

journal_title：Acta neuropathologica

authors： Tan CF,Eguchi H,Tagawa A,Onodera O,Iwasaki T,Tsujino A,Nishizawa M,Kakita A,Takahashi H

更新日期：2007-05-01 00:00:00

abstract：:In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we examined an associati...

journal_title：Acta neuropathologica

authors： Brand F,Förster A,Christians A,Bucher M,Thomé CM,Raab MS,Westphal M,Pietsch T,von Deimling A,Reifenberger G,Claus P,Hentschel B,Weller M,Weber RG

更新日期：2020-01-01 00:00:00

abstract：:With an incidence of approximately 350 in 100,000, stroke is the third leading cause of death and a major cause of disability in industrialized countries. At present, although progress has been made in understanding the molecular pathways that lead to ischemic cell death, the current clinical treatments remain poorly ...

journal_title：Acta neuropathologica

authors： Kriz J,Lalancette-Hébert M

更新日期：2009-05-01 00:00:00

abstract：:Histochemical and electron microscopic studies of the brains inclusive of the leptomeninges containing large blood vessels from 7 patients with mucopolysaccharidosis (MPS) I, II, IIIA and V showed marked increase in mesenchymal elements and the generalized presence of characteristic lesions around cerebral veins and a...

journal_title：Acta neuropathologica

authors： Dekaban AS,Constantopoulos G

更新日期：1977-07-15 00:00:00

abstract：:In the nerve tissue with proliferating macroglia cells were observed a lowered oxygen consumption, an increased aerobic glycolysis and alanine formation and a higher alanine aminotransferase and glutamate dehydrogenase activity than in the control tissue in the homogenates and in the cell sap fraction. The substrate s...

journal_title：Acta neuropathologica

authors： Ruscák M,Hager H,Orlický J

更新日期：1976-03-15 00:00:00

abstract：:Little information is available regarding the morphological changes in the mitochondria in amyotrophic lateral sclerosis (ALS). In particular, mitochondrial changes in dorsal root ganglion cells have not yet been examined. We therefore conducted an electron microscopic examination of the mitochondria in dorsal root ga...

journal_title：Acta neuropathologica

authors： Sasaki S,Horie Y,Iwata M

更新日期：2007-12-01 00:00:00

abstract：:We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient wit...

journal_title：Acta neuropathologica

authors： Crain BJ,McPhatter L,Croom DW 2nd,Hulette CM

更新日期：1995-01-01 00:00:00

abstract：:Thirty-one squirrel monkey fetuses were exposed to lead acetate given to the mothers perorally during the last three-fourths or two-thirds of pregnancy. The mean maternal blood lead concentration of the group was 37 micrograms/100 ml and the individual means ranged from 22-82 micrograms/100 ml. Examination of the cent...

journal_title：Acta neuropathologica

authors： Lögdberg B,Brun A,Berlin M,Schütz A

更新日期：1988-01-01 00:00:00

abstract：:We report the case of an 11-year-old male who developed subacute diffuse polyradiculoneuropathy, associated with digestive symptoms and Epstein-Barr virus infection. Parental consanguinity was present. The laboratory findings including bone marrow smear were consistent with hemophagocytic lymphohistiocytosis (HLH). El...

journal_title：Acta neuropathologica

authors： De Armas R,Sindou P,Gelot A,Routon MC,Ponsot G,Vallat JM

更新日期：2004-10-01 00:00:00

abstract：:Gelatinase A is an enzyme capable of cleaving soluble beta-amyloid protein (beta AP), and may function as an alpha-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (...

journal_title：Acta neuropathologica

authors： Yamada T,Miyazaki K,Koshikawa N,Takahashi M,Akatsu H,Yamamoto T

更新日期：1995-01-01 00:00:00

abstract：:Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic exami...

journal_title：Acta neuropathologica

authors： Pollanen MS,Onzivua S,Robertson J,McKeever PM,Olawa F,Kitara DL,Fong A

更新日期：2018-11-01 00:00:00

abstract：:This report presents the ultrastructural nerve study of a patient with sensorimotor neuropathy by a shoe glue containing an association of n-hexane and methylethylketone. Giant axons, distended by microfilamentous proliferation typical of such cases of neuropathy, were found in significant amounts. An unusual histolog...

journal_title：Acta neuropathologica

authors： Vallat JM,Leboutet MJ,Loubet A,Piva C,Dumas M

更新日期：1981-01-01 00:00:00

abstract：:The neurone-centred view of the past disregarded or downplayed the role of astroglia as a primary component in the pathogenesis of neurological diseases. As this concept is changing, so is also the perceived role of astrocytes in the healthy and diseased brain and spinal cord. We have started to unravel the different ...

journal_title：Acta neuropathologica

authors： Pekny M,Pekna M,Messing A,Steinhäuser C,Lee JM,Parpura V,Hol EM,Sofroniew MV,Verkhratsky A

更新日期：2016-03-01 00:00:00

abstract：:Accumulation of the tau protein in fibrillar intracellular aggregates is a defining feature of multiple neurodegenerative diseases collectively referred to as tauopathies. Despite intensive study of tau, there is limited information on the formation and clearance dynamics of tau inclusions. Using rAAV vectors to media...

journal_title：Acta neuropathologica

authors： Croft CL,Goodwin MS,Ryu DH,Lessard CB,Tejeda G,Marrero M,Vause AR,Paterno G,Cruz PE,Lewis J,Giasson BI,Golde TE

更新日期：2021-01-26 00:00:00

abstract：:Using a fluorescent antibody technique, sections of the brains of patients with senile dementia or Alzheimer's disease containing senile plaques were treated with rabbit antihuman immunoglobulins labelled with FITC (fluorescein isothiocyanate, BBL). The senile plaques and the cerebral amyloid angiopathy (drusige Entar...

journal_title：Acta neuropathologica

authors： Ishii T,Haga S

更新日期：1975-08-11 00:00:00

abstract：:A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...

journal_title：Acta neuropathologica

authors： Tagliavini F,Pilleri G,Gemignani F,Lechi A

更新日期：1983-01-01 00:00:00

abstract：:The intracellular localization of myoglobin(Mb) mRNA in the skeletal muscles of normal subjects and patients with Duchenne muscular dystrophy(DMD) or amyotrophic lateral sclerosis(ALS) was examined by in situ hybridization using a biotin-labeled cDNA probe. In cross sections of normal muscles, Mb mRNA signals were dem...

journal_title：Acta neuropathologica

authors： Mitsui T,Kawai H,Naruo T,Nishino H,Saito S

更新日期：1993-01-01 00:00:00

abstract：:Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer's disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in the forms of extrace...

journal_title：Acta neuropathologica

authors： Kumar S,Wirths O,Stüber K,Wunderlich P,Koch P,Theil S,Rezaei-Ghaleh N,Zweckstetter M,Bayer TA,Brüstle O,Thal DR,Walter J

更新日期：2016-04-01 00:00:00

abstract：:Circumscribed pink areas 0.3-1.0 cm in diameter seen in deeper parts of otherwise well-fixed brains are usually ascribed to inadequate fixation. Twenty-three patients with pink areas in their fixed brains had evidence of inflammation in at least one organ. Blood vessels in the pink areas contained bacteria. Postmortem...

journal_title：Acta neuropathologica

authors： Hedley-Whyte ET

更新日期：1985-01-01 00:00:00

abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...

journal_title：Acta neuropathologica

authors： Takahashi N,Iwatsubo T,Nakano I,Machinami R

更新日期：1992-01-01 00:00:00

abstract：:Structural proteins of cultured neurofibromatosis (NF) tumor and skin cells were studied with reference to control skin fibroblasts. In polyacrylamide gel electrophoresis (PAGE)/fluorography the banding patterns of the cell lysates were markedly similar. NF tumor cells, however, produced a 60 kD band with a stronger a...

journal_title：Acta neuropathologica

authors： Peltonen J,Näntö-Salonen K,Aho HJ,Kouri T,Virtanen I,Penttinen R

更新日期：1984-01-01 00:00:00

abstract：:Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined. DNA hypermethylation of the O (6) -methylguanine-DNA methyltransferase (MGMT) promoter is associated with an improved response to TMZ...

journal_title：Acta neuropathologica

authors： van Thuijl HF,Mazor T,Johnson BE,Fouse SD,Aihara K,Hong C,Malmström A,Hallbeck M,Heimans JJ,Kloezeman JJ,Stenmark-Askmalm M,Lamfers ML,Saito N,Aburatani H,Mukasa A,Berger MS,Söderkvist P,Taylor BS,Molinaro AM,Wessel

更新日期：2015-04-01 00:00:00

abstract：:The original version of this article unfortunately contained a typesetting error in Fig 3c. The corrected Fig. 3 is given in the following page. ...

journal_title：Acta neuropathologica

authors： Liu APY,Gudenas B,Lin T,Orr BA,Klimo P Jr,Kumar R,Bouffet E,Gururangan S,Crawford JR,Kellie SJ,Chintagumpala M,Fisher MJ,Bowers DC,Hassall T,Indelicato DJ,Onar-Thomas A,Ellison DW,Boop FA,Merchant TE,Robinson GW,N

更新日期：2020-02-01 00:00:00

abstract：:Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD is even considered to be a pre-NFT stage in the disease process of AD. Currently, the composition of GVD bodies, the mechanisms associated ...

journal_title：Acta neuropathologica

authors： Hondius DC,Koopmans F,Leistner C,Pita-Illobre D,Peferoen-Baert RM,Marbus F,Paliukhovich I,Li KW,Rozemuller AJM,Hoozemans JJM,Smit AB

更新日期：2021-01-25 00:00:00