Abstract：
:Thirty-one squirrel monkey fetuses were exposed to lead acetate given to the mothers perorally during the last three-fourths or two-thirds of pregnancy. The mean maternal blood lead concentration of the group was 37 micrograms/100 ml and the individual means ranged from 22-82 micrograms/100 ml. Examination of the central nervous system was performed in 15 of the offspring (one abortion, eight stillborns, three neonatal deaths, two killed fetuses and one killed newborn). The mean cerebral weight was reduced for the fetal age (about 10%). Three cerebra were paradoxically overweight for the fetal age as well as for the body weight, probably due to edema. Neurohistology revealed large numbers of characteristic perivascular, petechial hemorrhages in the white matter in six of the fifteen cerebra. In two of these cases, such hemorrhages were also found in the white matter of the cerebellum, brain stem and spinal cord. Examination of four recovered placentas (two after delivery and two at hysterotomies) indicated a lead dose-dependent weight reduction and revealed various pathological lesions. The extensive brain hemorrhages, as well as varying degrees of edema, were seen in stillborns and neonates, while prenatally sacrificed fetuses showed few or no petechial hemorrhages and no signs of edema. It is suggested that lead is involved in the parenchymal growth retardation and the endothelial changes in the prenatal brain, as well as the placental damage, and that prematurity, birth-associated mechanical stress and asphyxia contribute to or precipitate vascular lesions, which may form the basis of acute, or later apparent, neurobehavioral disturbances.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Lögdberg B,Brun A,Berlin M,Schütz Adoi
10.1007/BF00687421subject
Has Abstractpub_date
1988-01-01 00:00:00pages
120-7issue
2eissn
0001-6322issn
1432-0533journal_volume
77pub_type
杂志文章abstract：:A case of classic medulloblastoma that metastasized, despite the absence of local recurrence, to extraneural sites 7 years after treatment is reported. The metastases were, in contrast to the primary tumor, of large cell type and displayed abortive myogenic and, in one site, also rhabdoid differentiation. The primary ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-0986-8
更新日期：2005-05-01 00:00:00
abstract：:Proliferation indices and mean number of silver-stained nucleolar organizer region-associated proteins (Ag-NORs) are compared in 65 brain tumors, including 34 gliomas, 8 meningiomas, 17 metastatic tumors, and 6 other tumors. Immunocytochemical investigations include labeling with the monoclonal antibody Ki-67 which id...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308919
更新日期：1990-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) and adult onset X-linked recessive bulbospinal muscular atrophy (SPMA), constituting the category of adult onset form of motor neuron disease, were analyzed on motor nerve roots. The results of morphometric analysis on ventral spinal roots (VSR) of all spinal segments from ALS and S...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691322
更新日期：1981-01-01 00:00:00
abstract：:Interstitial cells are isolated neurons located in the infracortical white matter that are known to express neuropeptides. Twenty-four cases selected for the absence, slight (Braak stages I-II), moderate (Braak stages III-IV), or serious degree (Braak stages V-VI) of cortical neurofibrillary pathology were studied for...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0551-7
更新日期：2002-10-01 00:00:00
abstract：:A quantitative technique involving serial sectioning and semiautomatic morphometric analysis was used to assess the severity of the reduction in size of the major brain structures in cerebral hemispheres of children congenitally infected with HIV-1. Cerebral hemispheres from 12 children (18-48 months of age) who died ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050594
更新日期：1997-02-01 00:00:00
abstract：:Histomorphological and histochemical variability was studied in muscle specimens from 30 patients with congenital muscular dystrophy (CMD). We found involvement of the central nervous system in 8 patients (Fukuyama CMD, F-CMD), involvement of the brain and the eyes in 5 patients (muscle, eye and brain disease, MEB-D) ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00369452
更新日期：1993-01-01 00:00:00
abstract：:The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). However, the precise relationship between pathology and neurotoxicity and why these processes disproportionately affect certain neuron subp...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-018-1829-8
更新日期：2018-06-01 00:00:00
abstract：:Neurotrophins regulate the proliferation and differentiation of neurons in the central nervous system via a family of specialized receptors, including TrkA, TrkB, and TrkC. As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050906
更新日期：1998-10-01 00:00:00
abstract：:The expression of glial fibrillary acidic protein (GFAP), vimentin, S-100 protein (S-100), HNK-1, myelin basic protein (MBP) and fibronectin was investigated immunohistochemically in 51 ethylnitrosourea (ENU)-induced neurinomas of the rat. Additionally, 90 transplantation tumors derived from ENU-induced neurinomas and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310927
更新日期：1991-01-01 00:00:00
abstract：:Two experiments were completed in which brains and spinal cords from lambs affected with spongy degeneration of the central nervous system (CNS) were analysed for water, sodium and potassium, as measures of cerebral oedema. In a third experiment, lambs with CNS spongy degeneration were tested for permeability of cereb...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687928
更新日期：1975-01-01 00:00:00
abstract：:Focal cortical dysplasia (FCD) is a localized malformation of cortical development and is the commonest cause of severe childhood epilepsy in surgical practice. Children with FCD are severely disabled by their epilepsy, presenting with frequent seizures early in life. The commonest form of FCD in children is character...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1135-4
更新日期：2013-08-01 00:00:00
abstract：:The recently identified prolactin (PRL)-releasing peptide (PrRP) is the first hypothalamic peptide hormone found to operate as a ligand of an orphan receptor that specifically stimulates PRL production from the pituitary gland. However, its other biological functions remain unknown. Using immunohistochemistry, we exam...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0753-7
更新日期：2003-11-01 00:00:00
abstract：:Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294647
更新日期：1990-01-01 00:00:00
abstract：:Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684802
更新日期：1979-04-12 00:00:00
abstract：:Neuregulins belong to a family of multipotent growth-promoting proteins, and have been shown to have a crucial role in accumulating acetylcholine receptor at neuromuscular junctions. A functional role of neuregulins in muscle regeneration has not yet been identified. Using reverse transcription (RT)-PCR, Western blot ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0198-5
更新日期：2007-04-01 00:00:00
abstract：:Apoptosis of neurons and glial cells has been shown to occur in the brain of patients with the acquired immune deficiency syndrome (AIDS) and was postulated as contributing to brain atrophy and white matter damage in these patients. Since apoptotic events may be induced by the Fas-Fas ligand (FasL) system, we analyzed...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051094
更新日期：1999-10-01 00:00:00
abstract：:A woman of 36 was admitted to hospital because of griping abdominal pain which occurred especially during the night when turning in bed. She had a history of constipation and bloating since birth. Irrigoscopy revealed megacolon extending from the middle of the transverse colon to the rectum. A rectal biopsy excluded H...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688193
更新日期：1987-01-01 00:00:00
abstract：:The pattern of recovery of myelinated axons in the posterior tibial nerve after crushing was studied in rats chronically intoxicated with 2,5-hexanedione. It was given for 2 weeks before crushing (200 mg/kg i.p. 5 times a week) or additionally for two further weeks after the nerve crush. Two animals were examined from...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703206
更新日期：1983-01-01 00:00:00
abstract：:A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294305
更新日期：1993-01-01 00:00:00
abstract：:This study was undertaken to elucidate, using the Golgi method, the neuropathological change in the brain of the macular mutant mouse, whose hemizygote (Ml/y) is considered to be a model of Menkes kinky hair disease (MKHD). The hemizygote mice gradually lost weight after 10 days of age and died with emaciation and sei...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687266
更新日期：1987-01-01 00:00:00
abstract：:An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304146
更新日期：1993-01-01 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:A 77-year-old man suffered intermittent hemiconvulsions of unknown etiology on the left side for a period of about 5 weeks. At the autopsy, there was marked neuronal loss, severe proliferation of astrocytes and spongiform changes in the right cerebral cortex. The cerebral white matter showed loosening with astroglial ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687782
更新日期：1988-01-01 00:00:00
abstract：:It was demonstrated that New Zealand Albino rabbits sensitized to galactocerebroside had high levels of anti-galactocerebroside antibody and of immune complexes. The rabbits was high titers of immune complexes developed demyelination in the peripheral nerves. Lesion were produced in the peripheral nerves of mice by th...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690959
更新日期：1985-01-01 00:00:00
abstract：:To elucidate whether the apolipoprotein E epsilon4 allele (APOE4) affects cortical neuropathology in Parkinson's disease (PD), we determined APOE genotypes and quantified the densities of cortical Lewy bodies (LBs), amyloid plaques and neurofibrillary tangles in 22 autopsy-proven PD cases (12 with dementia; 10 without...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050824
更新日期：1998-05-01 00:00:00
abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0231-8
更新日期：2007-08-01 00:00:00
abstract：:We examined the immunohistochemical localization of p35nck5a, the regulatory subunit of cyclin-dependent kinase 5 (cdk5), in brains obtained postmortem from patients with Parkinson's disease (PD) and controls. We found p35nck5a immunoreactivity in Lewy bodies (LB) in the substantia nigra, locus ceruleus, and neocortex...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050687
更新日期：1997-08-01 00:00:00
abstract：:The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...
journal_title：Acta neuropathologica
pub_type： 临床试验,杂志文章
doi：10.1007/s004010050646
更新日期：1997-05-01 00:00:00
abstract：:The distribution of the calcium-binding protein calretinin was investigated by immunohistochemistry in the hippocampus, the subicular areas, and the entorhinal cortex in patients with Alzheimer's disease and in control subjects. By double immunolabelling, the calretinin immunoreactivity was compared to the immunoreact...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294357
更新日期：1994-01-01 00:00:00
abstract：:Previous investigators have suggested that proteolysis by calpain, a Ca2+-dependent protease, causes muscle fiber degradation in Duchenne and Becker muscular dystrophies (DMD/BMD). Recent evidence indicates that the nonlysosomal ATP-ubiquitin-dependent proteolytic complex (proteasomes) participates in muscle wasting d...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000229
更新日期：2000-12-01 00:00:00
