Presence of non-fibrillar amyloid beta protein in skin biopsies of Alzheimer's disease (AD), Down's syndrome and non-AD normal persons.

abstract：:Relatively little work has been done on the structural effects of organic lead in the central nervous system (CNS), although this form of lead may be a significant fraction of total brain lead. We tested a number of easily measured light-histological parameters of neuronal development in rats for sensitivity to (a) no...

journal_title：Acta neuropathologica

authors： Ferris NJ,Cragg BG

更新日期：1984-01-01 00:00:00

abstract：:A patient with mixed gonadal dysgenesis showed glove and stocking-type sensory impairment and slowing of motor and sensory nerve conduction. Sural nerve biopsy revealed minifascicular formation with decreased density of myelinated fibers. As far as we are aware, this is the first report of polyneuropathy with minifasc...

journal_title：Acta neuropathologica

authors： Umehara F,Yamaguchi N,Kodama D,Takenaga S,Kiwaki T,Sonoda Y,Arimura Y,Yamada H,Arimura K,Osame M

更新日期：1999-09-01 00:00:00

abstract：:We have recently shown that glioma cell lines, as well as cells of human malignant gliomas in situ, synthesize tropoelastin. In addition, glioma cells degrade tropoelastin using metalloproteinase(s), and the resulting peptides, incapable of assembling in the extracellular fibers, interact with the 67-kDa cell surface ...

journal_title：Acta neuropathologica

authors： Hinek A,Jung S,Rutka JT

更新日期：1999-04-01 00:00:00

abstract：:SNAP-25 (a synaptosomal-associated protein of 25 kDa) has been shown to be involved both in synaptic vesicle exocytosis and in axonal outgrowth. In the present study, we investigated the changes in SNAP-25 immunoreactivity in the hippocampus of the Mongolian gerbil (Meriones unguiculatus) at different time points afte...

journal_title：Acta neuropathologica

authors： Martí E,Ferrer I,Ballabriga J,Blasi J

更新日期：1998-03-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition (CARASIL) have emerged as important genetic model diseases for studying the molecular pathomechanisms of cerebral small vessel disease (SVD). CADASIL, the most frequent ...

journal_title：Acta neuropathologica

authors： Zellner A,Scharrer E,Arzberger T,Oka C,Domenga-Denier V,Joutel A,Lichtenthaler SF,Müller SA,Dichgans M,Haffner C

更新日期：2018-07-01 00:00:00

abstract：:In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease. This finding sparked interest in this member of the sialic acid-binding immunoglobulin-type lectin family which is linked to innate immunity. Subsequent studies found that CD33 is expressed in...

journal_title：Acta neuropathologica

authors： Estus S,Shaw BC,Devanney N,Katsumata Y,Press EE,Fardo DW

更新日期：2019-08-01 00:00:00

abstract：:Amplification of the epidermal growth factor receptor (EGFR) gene is found in about 40% of glioblastomas (GBMs) but is rarely detected in GBM cell lines. We confirmed that the exceptional SKMG-3 GBM cell line retained amplified EGFR genes in vitro, and found that these sequences were concentrated on extra-chromosomal ...

journal_title：Acta neuropathologica

authors： Thomas C,Ely G,James CD,Jenkins R,Kastan M,Jedlicka A,Burger P,Wharen R

更新日期：2001-06-01 00:00:00

abstract：:Circumscribed pink areas 0.3-1.0 cm in diameter seen in deeper parts of otherwise well-fixed brains are usually ascribed to inadequate fixation. Twenty-three patients with pink areas in their fixed brains had evidence of inflammation in at least one organ. Blood vessels in the pink areas contained bacteria. Postmortem...

journal_title：Acta neuropathologica

authors： Hedley-Whyte ET

更新日期：1985-01-01 00:00:00

abstract：:Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and p25α in the format...

journal_title：Acta neuropathologica

authors： Mavroeidi P,Arvanitaki F,Karakitsou AK,Vetsi M,Kloukina I,Zweckstetter M,Giller K,Becker S,Sorrentino ZA,Giasson BI,Jensen PH,Stefanis L,Xilouri M

更新日期：2019-09-01 00:00:00

abstract：:The choroid plexus is an epithelial-endothelial vascular convolute within the ventricular system of the vertebrate brain. It consists of epithelial cells, fenestrated blood vessels, and the stroma, dependent on various physiological or pathological conditions, which may contain fibroblasts, mast cells, macrophages, gr...

journal_title：Acta neuropathologica

authors： Wolburg H,Paulus W

更新日期：2010-01-01 00:00:00

abstract：:A case of cerebellar medullomyoblastoma in a young boy was investigated by electron microscopy. The neuroectodermal component shows the characteristics of a desmoplastic medulloblastoma. The mesodermal component consists of more or less differentiated cross-striated muscle cells. Undifferentiated muscle cells are very...

journal_title：Acta neuropathologica

authors： Walter GF,Brucher JM

更新日期：1979-12-01 00:00:00

abstract：:The occurrence of oligodendrocytes within astrocytes ("emperipolesis") has been described in demyelinating lesions in cases of multiple sclerosis and also in other non-demyelinating disorders. We found that this finding was common in the cerebral white matter of patients with Creutzfeldt-Jakob disease (CJD). Eight con...

journal_title：Acta neuropathologica

authors： Shintaku M,Yutani C

更新日期：2004-09-01 00:00:00

abstract：:Laminin alpha2 (merosin)-deficient congenital muscular dystrophy (CMD) patients show progressive muscle fiber necrosis and ineffective muscle regeneration. This is probably due to decreased formation of multi nucleated myotubes resulting from a myoblast fusion defect. When receiving a mechanical signal from muscle mem...

journal_title：Acta neuropathologica

authors： Sakuma K,Nakao R,Inashima S,Hirata M,Kubo T,Yasuhara M

更新日期：2004-09-01 00:00:00

abstract：:Motor dysfunction is frequently noted in human immunodeficiency virus type 1 (HIV-1)-infected patients. Until recently, neuropathological changes found in the basal ganglia were advanced as pathogenetic mechanisms. In the present study, further brain structures involved in motor control were analyzed morphometrically....

journal_title：Acta neuropathologica

authors： Abe H,Mehraein P,Weis S

更新日期：1996-08-01 00:00:00

abstract：:Synemin is a member of the intermediate protein superfamily. Previous studies in avian and rodent skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin. In the present study, the distribution of synemin was examined using immunohistochemi...

journal_title：Acta neuropathologica

authors： Olivé M,Goldfarb L,Dagvadorj A,Sambuughin N,Paulin D,Li Z,Goudeau B,Vicart P,Ferrer I

更新日期：2003-07-01 00:00:00

abstract：:The immunoreactivity to the free radical-related enzymes, nitric oxide synthase (NOS) and superoxide dismutase (SOD), was examined in brain tissue in progressive supranuclear palsy (PSP). To determine the relationship between the immunoexpression of these enzymes and tau-positive, argyrophilic cytoplasmic inclusions, ...

journal_title：Acta neuropathologica

authors： Komori T,Shibata N,Kobayashi M,Sasaki S,Iwata M

更新日期：1998-04-01 00:00:00

abstract：:Motor neuron disease (MND) may be complicated by frontotemporal dementia and/or an extrapyramidal movement disorder. Several studies have identified the pathological substrate for dementia in MND as being ubiquitin-immunoreactive inclusions and dystrophic neurites in the extramotor neocortex and hippocampus. Although ...

journal_title：Acta neuropathologica

authors： Mackenzie IR,Feldman H

更新日期：2004-04-01 00:00:00

abstract：:The pattern of recovery of myelinated axons in the posterior tibial nerve after crushing was studied in rats chronically intoxicated with 2,5-hexanedione. It was given for 2 weeks before crushing (200 mg/kg i.p. 5 times a week) or additionally for two further weeks after the nerve crush. Two animals were examined from...

journal_title：Acta neuropathologica

authors： Simonati A,Rizzuto N,Cavanagh JB

更新日期：1983-01-01 00:00:00

abstract：:The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...

journal_title：Acta neuropathologica

authors： Seilhean D,Kobayashi K,He Y,Uchihara T,Rosenblum O,Katlama C,Bricaire F,Duyckaerts C,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...

journal_title：Acta neuropathologica

authors： Nonaka I,Ishiura S,Arahata K,Ishibashi-Ueda H,Maruyama T,Ii K

更新日期：1989-01-01 00:00:00

abstract：:Changes in immature rats in motor neurones after axotomy were studied by enzyme-histochemical methods. Increased activity of dehydrogenases in these neurones demonstrates enhanced metabolism and there was also increase of acid phosphatases. Decreased activity of acetylcholinesterase and indoxylacetate esterase in the ...

journal_title：Acta neuropathologica

authors： Maślińska D,Thomas E

更新日期：1975-12-30 00:00:00

abstract：:We describe the clinical and neuropathological findings of three unrelated autopsy cases of MELAS harboring the A3243G transition in the mitochondrial DNA (mtDNA). Using immunohistochemical techniques, we studied the expression of several subunits of the respiratory chain in various brain regions from the same cases. ...

journal_title：Acta neuropathologica

authors： Sparaco M,Simonati A,Cavallaro T,Bartolomei L,Grauso M,Piscioli F,Morelli L,Rizzuto N

更新日期：2003-09-01 00:00:00

abstract：:A case of classic medulloblastoma that metastasized, despite the absence of local recurrence, to extraneural sites 7 years after treatment is reported. The metastases were, in contrast to the primary tumor, of large cell type and displayed abortive myogenic and, in one site, also rhabdoid differentiation. The primary ...

journal_title：Acta neuropathologica

authors： Donner LR

更新日期：2005-05-01 00:00:00

abstract：:Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...

journal_title：Acta neuropathologica

authors： Garruto RM,Shankar SK,Yanagihara R,Salazar AM,Amyx HL,Gajdusek DC

更新日期：1989-01-01 00:00:00

abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...

journal_title：Acta neuropathologica

authors： Ma KC,Chang ZH,Shih H,Zhu JH,Wu JY

更新日期：1991-01-01 00:00:00

abstract：:Data on the dural invasiveness of pituitary adenomas have been correlated to the expression of matrix metalloproteinases (e.g. MMP-9). Serine proteases have not yet been investigated in human pituitary adenomas. In this study, paraffin-embedded material from 84 human pituitary adenomas (acromegaly n=18, Cushing's dise...

journal_title：Acta neuropathologica

authors： Knappe UJ,Hagel C,Lisboa BW,Wilczak W,Lüdecke DK,Saeger W

更新日期：2003-11-01 00:00:00

abstract：:Neuronal and glial cytoplasmic inclusions (NCIs and GCIs), which contain alpha-synuclein as a major component, are characteristic cytopathological features of multiple system atrophy (MSA). We report MSA of 19 years' duration in a 73-year-old woman. Her initial symptom was parkinsonism, with dementia appearing about 8...

journal_title：Acta neuropathologica

authors： Piao YS,Hayashi S,Hasegawa M,Wakabayashi K,Yamada M,Yoshimoto M,Ishikawa A,Iwatsubo T,Takahashi H

更新日期：2001-03-01 00:00:00

abstract：:Modern neuropathology serves a key function in the multidisciplinary management of brain tumor patients. Owing to the recent advancements in molecular neurooncology, the neuropathological assessment of brain tumors is no longer restricted to provide information on a tumor's histological type and malignancy grade, but ...

journal_title：Acta neuropathologica

authors： Riemenschneider MJ,Jeuken JW,Wesseling P,Reifenberger G

更新日期：2010-11-01 00:00:00

abstract：:The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spi...

journal_title：Acta neuropathologica

authors： Kelly DF,Gaskell CJ

更新日期：1976-06-15 00:00:00

abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...

journal_title：Acta neuropathologica

authors： Sasaki S,Iwata M

更新日期：1996-01-01 00:00:00