Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells.

abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...

journal_title：Acta neuropathologica

authors： Sasaki S,Iwata M

更新日期：1996-01-01 00:00:00

abstract：:The very existence of astroblastoma has been a question of considerable controversy, although there appears now to be sufficient documentation to establish it as a tenable entity. Due to the rarity of this tumor, little information exists in the literature as to its natural history, efficacy of therapy and its patholo...

journal_title：Acta neuropathologica

authors： Hoag G,Sima AA,Rozdilsky B

更新日期：1986-01-01 00:00:00

abstract：:A description is given of three cases of ganglioneuromas, which originated from ganglia of the sympathetic chain of hamsters. Other reports of such tumors in this species are reviewed and the literature relative to hamster ganglioneuromas presented. In addition, the possible genesis of origin from adult ganglion cells...

journal_title：Acta neuropathologica

authors： Rustia M,Cardesa A

更新日期：1975-10-01 00:00:00

abstract：:The pro-inflammatory and blood-brain barrier (BBB) effects of intratumoral (IT) injection of human recombinant tumor necrosis factor-alpha (rTNF-alpha) were studied in the Fischer rat RT-2 glioma model. Animals received a single stereotaxic injection of either 6 x 10(4) U rTNF-alpha or excipient (vehicle) into the cen...

journal_title：Acta neuropathologica

authors： Wright JL,Merchant RE

更新日期：1997-01-01 00:00:00

abstract：:Histopathological, immunocytochemical, and electron microscopical investigations were carried out in a man with a protracted history of spastic paraparesis, adrenal insufficiency and hypogonadism. Pathological findings were identical with those of the few previously reported cases of adrenomyeloneuropathy (AMN) includ...

journal_title：Acta neuropathologica

authors： Probst A,Ulrich J,Heitz PU,Herschkowitz N

更新日期：1980-01-01 00:00:00

abstract：:We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according...

journal_title：Acta neuropathologica

authors： Fujita Y,Ohama E,Takatama M,Al-Sarraj S,Okamoto K

更新日期：2006-09-01 00:00:00

abstract：:Brain slices are used extensively for biochemical, electrophysiological and molecular investigations. However, only the time frame for electrophysiological and biochemical investigations has as yet been defined. The goal of the present study was to investigate the time course of nuclear structure in live brain slices....

journal_title：Acta neuropathologica

authors： Kasischke K,Büchner M,Ludolph AC,Riepe MW

更新日期：2001-05-01 00:00:00

abstract：:Keratan sulphate proteoglycan (KSPG) is a developmentally regulated barrier molecule, directing axonal growth during central nervous system (CNS) formation. The possible re-expression and functional significance of KSPG in preventing axon regeneration following spinal cord injury (SCI) is poorly understood. In the pre...

journal_title：Acta neuropathologica

authors： Krautstrunk M,Scholtes F,Martin D,Schoenen J,Schmitt AB,Plate D,Nacimiento W,Noth J,Brook GA

更新日期：2002-12-01 00:00:00

abstract：:Histochemical and electron microscopic studies were performed in an attempt to clarify the muscle pathology in an 18-year-old man with Fabry disease, showing proximal limb muscle atrophy, and his 52-year-old mother, who is a Fabry carrier with hypertrophic cardiomyopathy. Despite the relatively mild myopathic changes ...

journal_title：Acta neuropathologica

authors： Uchino M,Uyama E,Kawano H,Hokamaki J,Kugiyama K,Murakami Y,Yasue H,Ando M

更新日期：1995-01-01 00:00:00

abstract：:"Diffuse neurofibrillary tangles with calcification" (DNTC) is a rare form of slowly progressive dementia characterized by temporal or fronto-temporal atrophy with neuronal loss and astrocytosis, neurofibrillary tangles and Fahr-type calcification, but no senile plaques in the cerebral cortex. In patients with DNTC, w...

journal_title：Acta neuropathologica

authors： Terada S,Ishizu H,Tanabe Y,Takehisa Y,Haraguchi T,Hamaya K,Nose S,Sudo K,Kuroda S

更新日期：2001-12-01 00:00:00

abstract：:Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the internat...

journal_title：Acta neuropathologica

authors： Najm IM,Tassi L,Sarnat HB,Holthausen H,Russo GL

更新日期：2014-07-01 00:00:00

abstract：:Striped skunks were inoculated intracerebrally with the scrapie agent (suspension of brain from a naturally infected Suffolk sheep) or intramuscularly with street rabies virus (suspension of salivary glands from naturally infected skunks). Those given the scrapie agent developed clinical signs of weakness, posterior a...

journal_title：Acta neuropathologica

authors： Bundza A,Charlton KM

更新日期：1988-01-01 00:00:00

abstract：:An autopsy case of Nasu-Hakola's disease (membranous lipodystrophy) was reported. A 29-year-old Japanese woman whose younger sister had been affected with typical Nasu-Hakola's disease with skeletal and neuropsychiatric syndromes and membrano-cystic lesions in the bones developed forgetfulness and lack of initiative. ...

journal_title：Acta neuropathologica

authors： Matsushita M,Oyanagi S,Hanawa S,Shiraki H,Kosaka K

更新日期：1981-01-01 00:00:00

abstract：:Massive GGGGCC repeat expansion in the first intron of the gene C9orf72 is the most common known cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Despite its intronic localization and lack of an ATG start codon, the repeat region is translated in all three reading fra...

journal_title：Acta neuropathologica

authors： Mori K,Arzberger T,Grässer FA,Gijselinck I,May S,Rentzsch K,Weng SM,Schludi MH,van der Zee J,Cruts M,Van Broeckhoven C,Kremmer E,Kretzschmar HA,Haass C,Edbauer D

更新日期：2013-12-01 00:00:00

abstract：:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...

journal_title：Acta neuropathologica

authors： Nedergaard M,Diemer NH

更新日期：1987-01-01 00:00:00

abstract：:The nuclei for the nerves of a dorsal (m. splenius) and a ventral (m. longus capitis) neck muscle of the rat were retrogradely labeled by applying horseradish peroxidase (HRP) to the respective cut muscle nerves. Motoneurons of both muscles were analyzed for their localization, diameter of perikarya, and area of dendr...

journal_title：Acta neuropathologica

authors： Stillhard G

更新日期：1981-01-01 00:00:00

abstract：:Patients with von Hippel-Lindau disease carry a germline mutation of the Von Hippel-Lindau (VHL) tumor-suppressor gene. We discuss the molecular consequences of loss of VHL gene function and their impact on the nervous system. Dysfunction of the VHL protein causes accumulation and activation of hypoxia inducible facto...

journal_title：Acta neuropathologica

authors： Vortmeyer AO,Falke EA,Gläsker S,Li J,Oldfield EH

更新日期：2013-03-01 00:00:00

abstract：:Zitter mutant rats exhibit abnormal metabolism of superoxide species and demonstrate progressive degeneration of dopamine (DA) neurons in the substantia nigra (SN). Furthermore, long-term intake of vitamin E, an effective free radical scavenger, prevents the loss of DA neurons caused by free radicals. However, it is u...

journal_title：Acta neuropathologica

authors： Nakadate K,Noda T,Sakakibara S,Kumamoto K,Matsuura T,Joyce JN,Ueda S

更新日期：2006-07-01 00:00:00

abstract：:We investigated clinicopathologically pyramidal signs, including hyperreflexia, Babinski sign, and spasticity, and the involvement of the primary motor cortex and pyramidal tract, in eight Japanese autopsy cases of amyotrophic lateral sclerosis (ALS) with dementia. Pyramidal signs were observed in seven (88%) of the e...

journal_title：Acta neuropathologica

authors： Tsuchiya K,Ikeda K,Mimura M,Takahashi M,Miyazaki H,Anno M,Shiotsu H,Akabane H,Niizato K,Uchihara T,Tominaga I,Nakano I

更新日期：2002-09-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PS...

journal_title：Acta neuropathologica

authors： Kovacs GG,Lukic MJ,Irwin DJ,Arzberger T,Respondek G,Lee EB,Coughlin D,Giese A,Grossman M,Kurz C,McMillan CT,Gelpi E,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Roeber S,Xie SX,Lee VM,Trojan

更新日期：2020-08-01 00:00:00

abstract：:Three cases of spinal tanycytic ependymoma are reported, a man aged 45 years and two women aged 36 and 55 years. Each patient developed gradual paraparesis over a few months prior to admission. Magnetic resonance imaging showed an enhancing, well-circumscribed tumor in the spinal cord in each case. Histologically, the...

journal_title：Acta neuropathologica

authors： Kawano N,Yagishita S,Oka H,Utsuki S,Kobayashi I,Suzuki S,Tachibana S,Fujii K

更新日期：2001-01-01 00:00:00

abstract：:Hydrocephalic neonates were observed in a small breeding colony of rats. Normal rats from this colony were obtained and brother-sister mated for seven generations. The overall prevalence of hydrocephalics was approximately 23%; however, in one subline, the prevalence approached 50%. Breeding data suggested the trait t...

journal_title：Acta neuropathologica

authors： Kohn DF,Chinookoswong N,Chou SM

更新日期：1981-01-01 00:00:00

abstract：:Research efforts during the last decade have deciphered the basic molecular mechanisms governing mitochondrial fusion and fission. We now know that in mammalian cells mitochondrial fission is mediated by the large GTPase dynamin-related protein 1 (Drp1) acting in concert with outer mitochondrial membrane (OMM) protein...

journal_title：Acta neuropathologica

authors： Oettinghaus B,Licci M,Scorrano L,Frank S

更新日期：2012-02-01 00:00:00

abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...

journal_title：Acta neuropathologica

authors： Hinokuma K,Ohama E,Ikuta F,Tanimura K,Kameyama S

更新日期：1990-01-01 00:00:00

abstract：:Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explor...

journal_title：Acta neuropathologica

authors： Matosin N,Fernandez-Enright F,Fung SJ,Lum JS,Engel M,Andrews JL,Huang XF,Weickert CS,Newell KA

更新日期：2015-07-01 00:00:00

abstract：:In our recent ultrastructural studies on synapses of the nucleus dorsalis, central cervical nucleus, and anterior horn of the spinal cord of the normal cat we happened to find spheroids and several types of axonal alterations. These spheroids were up to 39 micrometer in diameter. They were found in myelinated and unmy...

journal_title：Acta neuropathologica

authors： Saito K

更新日期：1980-01-01 00:00:00

abstract：:The immunoreactivity to the free radical-related enzymes, nitric oxide synthase (NOS) and superoxide dismutase (SOD), was examined in brain tissue in progressive supranuclear palsy (PSP). To determine the relationship between the immunoexpression of these enzymes and tau-positive, argyrophilic cytoplasmic inclusions, ...

journal_title：Acta neuropathologica

authors： Komori T,Shibata N,Kobayashi M,Sasaki S,Iwata M

更新日期：1998-04-01 00:00:00

abstract：:Following maternal chicken pox in the 14th week of pregnancy, a male infant was born with low birth weight, muscle wasting and limb contractures, hypotonia and areflexia. A rising titre of varicella-zoster-specific IgM (by enzyme-linked immunoabsorbent assay) confirmed congenital infection, and electromyogram showed w...

journal_title：Acta neuropathologica

authors： Harding B,Baumer JA

更新日期：1988-01-01 00:00:00

abstract：:The mechanism of inflammatory demyelination in canine distemper encephalitis (CDE) is uncertain but macrophages are thought to play an important effector role in this lesion. Serum and cerebrospinal fluid (CSF), containing anti-canine distemper virus and anti-myelin antibodies from dogs with CDE were tested for their ...

journal_title：Acta neuropathologica

authors： Griot C,Bürge T,Vandevelde M,Peterhans E

更新日期：1989-01-01 00:00:00

abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...

journal_title：Acta neuropathologica

authors： Okeda R,Taki K,Ikari R,Funata N

更新日期：1995-01-01 00:00:00