Progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat.

abstract：:The formation of oedema in peripheral nerves was studied in rats at intervals varying from 6 h to 14 days after transection of the right sciatic nerve. Samples were removed proximal and distal to the injury, and the degree of oedema was determined by a microgravimetric method and by measurements of the water content a...

journal_title：Acta neuropathologica

authors： Pettersson CA,Tengvar C

更新日期：1986-01-01 00:00:00

abstract：:The recently identified prolactin (PRL)-releasing peptide (PrRP) is the first hypothalamic peptide hormone found to operate as a ligand of an orphan receptor that specifically stimulates PRL production from the pituitary gland. However, its other biological functions remain unknown. Using immunohistochemistry, we exam...

journal_title：Acta neuropathologica

authors： Abe T,Koga N,Tomita M,Tonoike T,Kushima M,Takahashi K,Sano Y,Taniyama M

更新日期：2003-11-01 00:00:00

abstract：:Medulloblastoma (MB) represents approximately 4% of adult brain tumours, and as such is a poorly studied disease. Although many adult MB are treated using paediatric MB protocols, the reported outcomes are inferior to those observed in children. It remains unclear whether biologic differences underlie these clinical o...

journal_title：Acta neuropathologica

authors： Al-Halabi H,Nantel A,Klekner A,Guiot MC,Albrecht S,Hauser P,Garami M,Bognar L,Kavan P,Gerges N,Shirinian M,Roberge D,Muanza T,Jabado N

更新日期：2011-02-01 00:00:00

abstract：:In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...

journal_title：Acta neuropathologica

authors： Hadfield MG,Ghatak NR,Laine FJ,Myer EC,Massie FS,Kramer WM

更新日期：1991-01-01 00:00:00

abstract：:A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...

journal_title：Acta neuropathologica

authors： Nochlin D,Mackenzie AP,Bryant EM,Norwood TH,Sumi SM

更新日期：1993-01-01 00:00:00

abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...

journal_title：Acta neuropathologica

authors： Mehling M,Simon P,Mittelbronn M,Meyermann R,Ferrone S,Weller M,Wiendl H

更新日期：2007-08-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition (CARASIL) have emerged as important genetic model diseases for studying the molecular pathomechanisms of cerebral small vessel disease (SVD). CADASIL, the most frequent ...

journal_title：Acta neuropathologica

authors： Zellner A,Scharrer E,Arzberger T,Oka C,Domenga-Denier V,Joutel A,Lichtenthaler SF,Müller SA,Dichgans M,Haffner C

更新日期：2018-07-01 00:00:00

abstract：:An unusual case of concurrent MS and anaplastic astrocytoma is presented. MS was diagnosed in a female patient at the age of 22 years. A left side thalamotomy was performed for relief of severe intention tremor at age 28 and at age 32 she received immunosuppressive therapy for 1 year. At the age of 36 after a severe e...

journal_title：Acta neuropathologica

authors： Kalimo H,Frey H,Raine CS,Törmä T,Röyttä M

更新日期：1979-05-15 00:00:00

abstract：:Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed pathological tau in Alzheimer's disease, and in frontotemporal lobar degeneration associated with tauopathy to include cases with Pick bodies, corticobasal degeneration, p...

journal_title：Acta neuropathologica

authors： Taniguchi-Watanabe S,Arai T,Kametani F,Nonaka T,Masuda-Suzukake M,Tarutani A,Murayama S,Saito Y,Arima K,Yoshida M,Akiyama H,Robinson A,Mann DMA,Iwatsubo T,Hasegawa M

更新日期：2016-02-01 00:00:00

abstract：:The thoracic sympathetic preganglionic outflow is important in the maintenance of postural normotension in man. Normative data on the intermediolateral column (ILC) neuron cell bodies is lacking. Counts and measurements on the right ILC cytons have been performed on the T6, T7 and T8 segments of 12 spinal cords of man...

journal_title：Acta neuropathologica

authors： Low PA,Okazaki H,Dyck PJ

更新日期：1977-09-26 00:00:00

abstract：:Seizures commonly occur in glioma patients, but their pathogenesis is poorly understood, in part due to a lack of valid and versatile experimental models. We have established a new model that enables comprehensive neuropathological and neurophysiological analysis on identical tissue preparations. Rat C6 glioma cells s...

journal_title：Acta neuropathologica

authors： Senner V,Köhling R,Püttmann-Cyrus S,Straub H,Paulus W,Speckmann EJ

更新日期：2004-01-01 00:00:00

abstract：:Both protein kinases and phosphoprotein phosphatases are important components of signal transduction systems in cells. Recent studies in Alzheimer's disease (AD) have shown abnormal protein phosphorylation in the cortex suggesting an alteration in these enzymes. In the present study, an antibody against CD45 was used ...

journal_title：Acta neuropathologica

authors： Masliah E,Mallory M,Hansen L,Alford M,Albright T,Terry R,Shapiro P,Sundsmo M,Saitoh T

更新日期：1991-01-01 00:00:00

abstract：:The original version of this article unfortunately contained a typesetting error in Fig 3c. The corrected Fig. 3 is given in the following page. ...

journal_title：Acta neuropathologica

authors： Liu APY,Gudenas B,Lin T,Orr BA,Klimo P Jr,Kumar R,Bouffet E,Gururangan S,Crawford JR,Kellie SJ,Chintagumpala M,Fisher MJ,Bowers DC,Hassall T,Indelicato DJ,Onar-Thomas A,Ellison DW,Boop FA,Merchant TE,Robinson GW,N

更新日期：2020-02-01 00:00:00

abstract：:A Schwann cell can form only one internode of myelin around an axon. However, we observed the formation by a single Schwann cell of myelin around two axons of different diameters in the sural nerve of a 45-year-old man with mononeuritis multiplex. Schwann cell processes spiraled in the same direction around each axon,...

journal_title：Acta neuropathologica

authors： Kusaka H,Imai T,Matsumoto S,Ito H,Yamasaki M

更新日期：1992-01-01 00:00:00

abstract：:Eleven atypical teratoid/rhabdoid tumors (AT/RT) and 121 primitive neuroectodermal tumors/medulloblastomas (PNET/MB) were included in this study for evaluation of the histopathological features of AT/RT and comparison between AT/RT and PNET/MB. Histopathological studies of AT/RT showed that in addition to the commonly...

journal_title：Acta neuropathologica

authors： Ho DM,Hsu CY,Wong TT,Ting LT,Chiang H

更新日期：2000-05-01 00:00:00

abstract：:We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mea...

journal_title：Acta neuropathologica

authors： Heinsen H,Rüb U,Bauer M,Ulmar G,Bethke B,Schüler M,Böcker F,Eisenmenger W,Götz M,Korr H,Schmitz C

更新日期：1999-06-01 00:00:00

abstract：:Glioblastoma (GBM), the most common malignant brain tumor, is among the most lethal neoplasms, with a median survival of approximately 1 year. Prognosis is poor since GBMs possess a strong migratory and highly invasive potential, making complete surgical resection impossible. Reduced expression of carboxypeptidase E (...

journal_title：Acta neuropathologica

authors： Höring E,Harter PN,Seznec J,Schittenhelm J,Bühring HJ,Bhattacharyya S,von Hattingen E,Zachskorn C,Mittelbronn M,Naumann U

更新日期：2012-07-01 00:00:00

abstract：:Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameter...

journal_title：Acta neuropathologica

authors： Martin H,Voss K

更新日期：1982-01-01 00:00:00

abstract：:Microglia are long-living resident immune cells of the brain, which secure a stable chemical and physical microenvironment necessary for the proper functioning of the central nervous system (CNS). These highly dynamic cells continuously scan their environment for pathogens and possess the ability to react to damage-in...

journal_title：Acta neuropathologica

authors： Dudvarski Stankovic N,Teodorczyk M,Ploen R,Zipp F,Schmidt MHH

更新日期：2016-03-01 00:00:00

abstract：:Accumulation of the tau protein in fibrillar intracellular aggregates is a defining feature of multiple neurodegenerative diseases collectively referred to as tauopathies. Despite intensive study of tau, there is limited information on the formation and clearance dynamics of tau inclusions. Using rAAV vectors to media...

journal_title：Acta neuropathologica

authors： Croft CL,Goodwin MS,Ryu DH,Lessard CB,Tejeda G,Marrero M,Vause AR,Paterno G,Cruz PE,Lewis J,Giasson BI,Golde TE

更新日期：2021-01-26 00:00:00

abstract：:Striped skunks were inoculated intracerebrally with the scrapie agent (suspension of brain from a naturally infected Suffolk sheep) or intramuscularly with street rabies virus (suspension of salivary glands from naturally infected skunks). Those given the scrapie agent developed clinical signs of weakness, posterior a...

journal_title：Acta neuropathologica

authors： Bundza A,Charlton KM

更新日期：1988-01-01 00:00:00

abstract：:Cystic necrosis in the cerebellar white matter was found in three premature infants. The necrosis was characteristically localized in the center of the white matter of the superficial cerebellar folia, sparing the overlying cortex. The patients were aged between 28 and 34 gestational weeks, and had a clinical history ...

journal_title：Acta neuropathologica

authors： Tsuru A,Mizuguchi M,Takashima S

更新日期：1995-01-01 00:00:00

abstract：:Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density ge...

journal_title：Acta neuropathologica

authors： Cama A,Verginelli F,Lotti LV,Napolitano F,Morgano A,D'Orazio A,Vacca M,Perconti S,Pepe F,Romani F,Vitullo F,di Lella F,Visone R,Mannelli M,Neumann HP,Raiconi G,Paties C,Moschetta A,Tagliaferri R,Veronese A,Sanna M

更新日期：2013-10-01 00:00:00

abstract：:Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and mislocalization of muscle fiber nuclei. Genetically distinct forms exist, and mutations in BIN1 were recently identified in autosomal recessive cases (ARCNM). Amphiphysins have been implica...

journal_title：Acta neuropathologica

authors： Toussaint A,Cowling BS,Hnia K,Mohr M,Oldfors A,Schwab Y,Yis U,Maisonobe T,Stojkovic T,Wallgren-Pettersson C,Laugel V,Echaniz-Laguna A,Mandel JL,Nishino I,Laporte J

更新日期：2011-02-01 00:00:00

abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...

journal_title：Acta neuropathologica

authors： Hinokuma K,Ohama E,Ikuta F,Tanimura K,Kameyama S

更新日期：1990-01-01 00:00:00

abstract：:Intracranial cartilaginous tumors are rare lesions, usually arising from the skull base in older individuals. We report the case of a 12-year-old girl with a low-grade type chondrosarcoma arising from the falx cerebri. To our knowledge this is the first such case reported in a child. She was treated with gross total s...

journal_title：Acta neuropathologica

authors： Gerszten PC,Pollack IF,Hamilton RL

更新日期：1998-01-01 00:00:00

abstract：:Specific pathological hallmarks have been described in amyotrophic lateral sclerosis (ALS), which include motor neuronal loss, Bunina bodies (BBs) and skein like inclusions (SLIs). We investigated the relation between these three lesions in the cervical and lumbar anterior horns and the hypoglossal nuclei of 20 ALS pa...

journal_title：Acta neuropathologica

authors： van Welsem ME,Hogenhuis JA,Meininger V,Metsaars WP,Hauw JJ,Seilhean D

更新日期：2002-06-01 00:00:00

abstract：:In this study, we used immunohistochemistry to screen for alpha-synuclein pathology in the brains of 241 individuals without clinical evidence of neurologic disease, and discovered 36 cases (15%) with incidental Lewy bodies (LBs) and one case, a 96-year-old woman (0.4%), with inclusions similar to those seen in multip...

journal_title：Acta neuropathologica

authors： Fujishiro H,Ahn TB,Frigerio R,DelleDonne A,Josephs KA,Parisi JE,Eric Ahlskog J,Dickson DW

更新日期：2008-09-01 00:00:00

abstract：:Dysferlin is a newly identified sarcolemmal protein related to Miyoshi myopathy and limb-girdle muscular dystrophy. Although its function is still unknown, it is inferred from the presence of C2 domains and a transmembrane domain in its sequence that dysferlin may be expressed or located not only at the sarcolemma but...

journal_title：Acta neuropathologica

authors： Ikezoe K,Furuya H,Ohyagi Y,Osoegawa M,Nishino I,Nonaka I,Kira J

更新日期：2003-06-01 00:00:00

abstract：:Six medulloblastomas were studied by electron microscopy. Two features were found which seem to be constant and essential characteristics of medulloblastoma. First, cell junctions are abundant between tumor cells. These are mostly desmosome-like but other, closer junctions, were also seen. Second, the capillary endoth...

journal_title：Acta neuropathologica

authors： Hassoun J,Hirano A,Zimmerman HM

更新日期：1975-10-27 00:00:00