Abstract：
:We examined the immunohistochemical localization of the proinflammatory cytokines tumor necrosis factor-alpha, lymphotoxin and interferon-gamma in 22 autopsy brains of patients with either cerebrovascular disease (CVD) or other neurological diseases as well as 2 non-neurological control brains. These cytokines were coexpressed mostly in the microglia/macrophages and in a few astroglia in the brains with acute cerebral infarction and cerebral hemorrhage. In cases with cerebral infarction, they were observed as early as 33 h after the onset of the illness and persisted for up to 40 days after the onset. In one patient with cerebral hemorrhage who survived for 4 h, the cytokine-immunoreactive glial cells were confined to the margins of the hematoma. In contrast, the cytokine-immunoreactive glia were distributed diffusely in one patient with cerebral hemorrhage who died 12 days after the onset of the illness. Labeling for these cytokines was weak in the glial cells of control brains and those with neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and multiple system atrophy, in so far as there were no concomitant acute CVD foci. The present results indicate that proinflammatory cytokines are up-regulated in the brains of patients with acute stroke, and suggest an early inflammatory response in human CVD.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Tomimoto H,Akiguchi I,Wakita H,Kinoshita A,Ikemoto A,Nakamura S,Kimura Jdoi
10.1007/s004010050519subject
Has Abstractpub_date
1996-09-01 00:00:00pages
281-7issue
3eissn
0001-6322issn
1432-0533journal_volume
92pub_type
杂志文章abstract：:Immunohistochemical techniques were employed to examine the changes in free ubiquitin within the hippocampus 1, 3, 7, 14, and 30 days after a unilateral perforant pathway lesion occurred in the rat brain. Immunoreactivity for ubiquitin was remarkably decreased in the cell body and proximal dendrites of neurons through...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0489-1
更新日期：2002-05-01 00:00:00
abstract：:Primary extradural ependymomas are rare neoplasms usually of the myxopapillary type. Reports on malignant primary extradural ependymal tumors are exceptionally rare. We here report on a 3-year-old boy with Schinzel-Giedion syndrome (SGS), who presented with lumbar spina bifida occulta and a progressive extraspinal les...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0179-0
更新日期：2007-03-01 00:00:00
abstract：:Focal cortical dysplasia (FCD) is a localized malformation of cortical development and is the commonest cause of severe childhood epilepsy in surgical practice. Children with FCD are severely disabled by their epilepsy, presenting with frequent seizures early in life. The commonest form of FCD in children is character...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1135-4
更新日期：2013-08-01 00:00:00
abstract：:A series of 50 human primary intracranial tumors were cultivated in vitro in an attempt to establish cell lines with the trypsinization technique. During the in vitro adaptation period, cultures were maintained at high cell density to avoid rapid over-growth by connective tissue. Five lines were established from 5 tum...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690383
更新日期：1977-07-15 00:00:00
abstract：:Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685251
更新日期：1984-01-01 00:00:00
abstract：:Mineralization in the wall of central nervous system blood vessels is sporadically encountered in aged horses and cattle as in man, generally as an age-related change. This phenomenon has not to date been located in the meninges in dogs or cats. The present study reports a retrospective histological examination of 50 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0641-6
更新日期：2003-03-01 00:00:00
abstract：:An in vivo method for positively staining dead neurons was developed and compared with an in vitro staining method using acid fuchsin. Neurons previously killed by intracerebral injections of kainic acid were selectively stained by trypan blue within 15 min of its injection in vivo into the central nervous system of r...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687254
更新日期：1989-01-01 00:00:00
abstract：:The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). We generated a human neuronal model and investigated the pathological phenotypes of human neurons containing G...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1149-y
更新日期：2013-09-01 00:00:00
abstract：:Histochemical and electron microscopic studies of the brains inclusive of the leptomeninges containing large blood vessels from 7 patients with mucopolysaccharidosis (MPS) I, II, IIIA and V showed marked increase in mesenchymal elements and the generalized presence of characteristic lesions around cerebral veins and a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690379
更新日期：1977-07-15 00:00:00
abstract：:Although clinical and electrophysiological evidence indicates that the amygdaloid body plays an important role in the pathogenesis of temporal lobe epilepsy, there are very few detailed data on histopathological changes in this nucleus in epilepsy patients. In the present study we have examined the lateral nucleus of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050658
更新日期：1997-06-01 00:00:00
abstract：:We studied the densities of utrophin and dystrophin at the motor end-plates of patients with myasthenia gravis (MG) using immunohistochemical analysis. The densities were compared with those found in patients with amyotrophic lateral sclerosis, Lambert-Eaton myasthenic syndrome and normal controls. Utrophin was reduce...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050483
更新日期：1996-07-01 00:00:00
abstract：:In an autopsy case of the sporadic juvenile ALS (a 17-year-old girl) intracytoplasmic inclusions are found in the upper and lower motor neurons and in nerve cells of the dentate nucleus, pontine nucleus, brain stem reticular formation, substantia nigra, thalamus, globus pallidus and others. Histochemically they contai...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691069
更新日期：1978-12-15 00:00:00
abstract：:Glycerol (an atoxic alcohol) and phenol (a toxic monohydroxybenzene) are currently used as neurolytic blocking agents to relieve pain or spasticity. In the present study we compared the endoneurial response of anhydrous glycerol and 7% phenol-aqua after intraneural injection into rat sciatic nerve, using electron micr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000349
更新日期：2001-07-01 00:00:00
abstract：:A 56-day-old infant with alpha-neuraminidase deficiency, whose clinical features included severe edema of extremities and ascites which resembled those in severe infantile sialidosis, was autopsied. Perforation, whose pathogenesis was unclear, was found on the descending portion of the duodenum. Light and electron mic...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688050
更新日期：1986-01-01 00:00:00
abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687402
更新日期：1989-01-01 00:00:00
abstract：:An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304146
更新日期：1993-01-01 00:00:00
abstract：:Cerebral cortical lesions of tuberous sclerosis (TSC) and focal cortical dysplasia (FCD) show disturbances in laminar architecture and cellular differentiation. We immunohistochemically studied the expression of doublecortin, a fetal neuronal protein that regulates neuronal migration, in the surgical specimens of five...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0575-z
更新日期：2002-10-01 00:00:00
abstract：:The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the ne...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334498
更新日期：1990-01-01 00:00:00
abstract：:Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688042
更新日期：1986-01-01 00:00:00
abstract：:The mechanisms underlying neurodegenerative diseases are the outcome of pathological alterations of evolutionary conserved molecular and cellular cascades. For this reason, Drosophila and C. elegans serve as useful model systems to study various aspects of neurodegenerative diseases. Here, we introduce the advantageou...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0689-7
更新日期：2010-08-01 00:00:00
abstract：:Mouse embryos were infected with murine cytomegalovirus (MCMV) by injecting the virus into the cerebral ventricles at the late gestation. After deliveries, offspring were fed by the mothers until 4 weeks. Cystic brain lesions, regarded as porencephaly or paraventricular cysts, were observed in about 20% of the MCMV-in...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293377
更新日期：1991-01-01 00:00:00
abstract：:Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1800-0
更新日期：2018-02-01 00:00:00
abstract：:Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin through...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685142
更新日期：1976-09-15 00:00:00
abstract：:The central distal axonopathy induced in dogs by the administration of high doses of clioquinol is contrasted with the central-peripheral distal axonopathy precipitated by intoxication with 2,5-hexanedione. Mature, pure-bred Beagle dogs received a daily oral dose of 400 mg/kg of clioquinol for up to 7 months, or 1 ml ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690549
更新日期：1979-08-01 00:00:00
abstract：:Chronic wasting disease (CWD), a progressive neurological disorder of captive mule deer, black-tailed deer, hybrids of mule deer and white-tailed deer and Rocky Mountain elk, is characterized neuropathologically by widespread spongiform change of the neuropil, intracytoplasmic vacuolation in neuronal perikarya and ast...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310125
更新日期：1991-01-01 00:00:00
abstract：:We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687396
更新日期：1989-01-01 00:00:00
abstract：:The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690561
更新日期：1976-06-15 00:00:00
abstract：:Gliomas induced in the rat by transplacental administration of ethylnitrosourea (ENU) are intensely immunoreactive for vimentin and scarcely for glial fibrillary acidic protein (GFAP). Since tumoral transformation takes place during the late fetal and early postnatal period, the sequential expression of the two glial ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227665
更新日期：1992-01-01 00:00:00
abstract：:The caudate nucleus and putamen belong to the selectively vulnerable brain regions which incur neuronal damage in clinical and experimental settings of both hypoglycemia and ischemia. We have previously documented the density and distribution of the hypoglycemic damage in rat caudoputamen, but the evolution of the inj...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688122
更新日期：1985-01-01 00:00:00
abstract：:Following maternal chicken pox in the 14th week of pregnancy, a male infant was born with low birth weight, muscle wasting and limb contractures, hypotonia and areflexia. A rising titre of varicella-zoster-specific IgM (by enzyme-linked immunoabsorbent assay) confirmed congenital infection, and electromyogram showed w...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687781
更新日期：1988-01-01 00:00:00
