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Premenstrual syndrome.

Abstract：

:The premenstrual syndrome (PMS) is a major clinical entity afflicting a large segment of the female population. Available information are descriptive in nature and the etiology of this syndrome remains unclear. In this review, both biochemical and psychosocial elements of the syndrome have been explored in an effort to redefine the pathophysiology of this seemingly multifactorial psychoneuroendocrine dysfunction. We propose that luteal phase sensitivity to and subsequent withdrawal from the central effects of the neuropeptides beta-endorphin and alpha-melanocyte-stimulating hormone result in a cascade of neuroendocrine changes within the brain-hypothalamus-pituitary complex. Modulation of neurotransmitter function by these peptides may produce alterations in mood and behavior as well as enhance pituitary release of prolactin and vasopressin. Variable gonadal steroid modulation of these responses from subject to subject likely accounts for the heterogeneous clinical manifestations of the PMS.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Reid RL,Yen SS

doi

10.1016/0002-9378(81)90417-8

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

85-104

issue

1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(81)90417-8

journal_volume

139

pub_type

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