Abstract：
:Neuropsychiatric symptoms are commonly related to interferon alpha treatment. The paper summarises the current knowledge about their aetiology, course, and treatment. Interferon alpha is a cytokine with antiviral and antineoplasmatic activity. It is commonly used in the treatment of chronic hepatitis C and B, malignant melanoma, Kaposi sarcoma, renal cancers, and some haematological malignancies. Treatment with interferon alpha is associated with depressive symptoms, cognitive disturbances, chronic fatigue syndrome, dysphoria, anxiety symptoms, anorexia, mania and psychotic states. Up to a half of the patients need psychiatric consultations, 10-25% of them need psychiatric treatment. Neuropsychiatric symptoms are the results of direct affection of CNS by interferon and induced cytokines. They increase hypothalamic-pituitary-adrenal (HPA) activity, alter thyroid function and lead to a behavioural syndrome called 'sickness behaviour'. Moreover interferon induces the activity of 2, 3 indoloamine dioxygenase, the enzyme which converts tryptophan into kynurenine, leads to a reduced level of tryptophan, and thus to a reduced level of central serotonin and to an increased level of neurotoxic kynurenine metabolites. Interferon also affects central opioid receptors and changes dopaminergic and noradrenergic neurotransmission. Serotonin selective reuptake inhibitors (SSRI), other antidepressants i.e. nortriptyline, benzodiazepines, naltrexone, and neuroleptics (for maniac and psychotic states) are used to treat interferon associated psychiatric symptoms. Psychological therapy may also be useful, as well as psychoeducation and behavioural interventions.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Małyszczak K,Inglot M,Pawłowski T,Czarnecki M,Rymer W,Kiejna Asubject
Has Abstractpub_date
2006-07-01 00:00:00pages
787-97issue
4eissn
0033-2674issn
2391-5854journal_volume
40pub_type
杂志文章,评审abstract：:The authors describe a new rehabilitation unit i.e. The Occupational Therapy Workshops, which were established on the basis of the Decree of Minister of Work and Social Politics. The paper consists of: 1) the law, regulations and rules; 2) experience gathered during one-year period of workshops functioning at the Inst...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:The authors present the review of basic knowledge about aetiological mechanisms of painful symptoms, especially chronic pain and give a detailed description of links between pain and depression (psychologic, biological). Depressive disorders and chronic pain often coexist. Data of studies show that 30-84% of patients ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:This article presents a review of the interactions between zinc and glutamate system in the pathophysiology and treatment of depression. ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2001-03-01 00:00:00
abstract：AIM:The purpose of the study was the estimation of comorbidity of depressive syndromes and anorexia nervosa (based on criteria of ICD-10 and DSM-IV). A group of 30 children (average age--13.5), 27 girls and 3 boys suffering from a first episode of anorexia nervosa was considered. METHOD:Anamnesis from patients and the...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:no summary. ...
journal_title：Psychiatria polska
pub_type： 社论
doi：10.12740/PP/74146
更新日期：2017-06-18 00:00:00
abstract：:Three cases of psychic disorders in the course of Lyme borreliosis were described. Two cases were connected with Lyme meningitis, one of them with chronic Lyme arthritis. These cases were described to discuss the possible occurrence of mental disturbances in the course of Lyme borreliosis, directly or indirectly conne...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:In recent years increased interest in the connection of intestinal microflora and the state of human health resulted in a great deal of research on the influence of intestinal microflora in particular on mental health, including works on affective functions of the central nervous system (CNS). Previous studies on anim...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/92392
更新日期：2019-04-30 00:00:00
abstract：:In this paper we review previous research, suggesting a link between depressive symptoms and poor prognosis in cancer patients. The possibility, to identify an association between depressed mood and poorer outcomes and survival in haematological malignancies seems to be very interesting. We shortly describe acute leuk...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：:Anorexia nervosa (AN) most often has its onset in adolescence, which is a crucial period to achieve peak bone mass. The hormonal abnormalities (hypoestrogenism, hypercortisolism, decreased secretion of dehydroepiandrosterone, testosterone, insulin-like growth factor) and malnutrition are associated with profound bone ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/59289
更新日期：2016-01-01 00:00:00
abstract：UNLABELLED:The clinicians agree to a point that mental retardation is a risk factor for the development of a mental disorder and that all kinds mental disorders are present in this population. AIM:The aim of this research was to find answers to two questions: 1. Was the intensity of depressiveness higher in adolescent...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The studies dealt with the relationships between negative and depressive symptomatology in the active phase of paranoid schizophrenia and were aimed at distinguishing the symptoms of the greatest power discriminating either category of symptoms. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Second generation antipsychotics share some similarities but display also differences in their action. The pharmacological profile as well as the clinical efficacy and tolerability of these drugs currently on the market in Poland have been described. The analysis of their properties reveals distinct differences betwee...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:The authors of this article on the basis "Uber die Klassifikation der Psychosen" analysis present the method of mental disorders' classification proposed by Carl Wernicke in 1899. Wernicke's classification was an alternative for other classification concepts existing in the 19th century. Carl Wernicke as one of the fi...
journal_title：Psychiatria polska
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：AIM:The paper aims to present the programme, the outcomes and the conclusions of a psychoeducational training series for families with schizophrenia carried out by the Babiński Specialist Hospital in Kraków, Poland. The paper sets out to describe an explorative project based on qualitative study methods. The programme ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/38934
更新日期：2015-01-01 00:00:00
abstract：:The paper presents the objectives and design of an ongoing multicenter randomized, controlled trial EDEN (European Day Hospital EvaluatioN). The EDEN-study aims to evaluate the efficacy of acute psychiatric treatment in a day hospital setting in five European centres: Dresden, London, Michalovce, Prague and Wroclaw. T...
journal_title：Psychiatria polska
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-11-01 00:00:00
abstract：:The cloze procedure was used to examine: predictability in speech samples from schizophrenics and their mothers as well as their ability to gain from the redundancy of language. Schizophrenic patients were found to be less predictable than normals, both schizophrenics and their mothers were less able to make use of th...
journal_title：Psychiatria polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-05-01 00:00:00
abstract：AIM:The evaluation of the activity of selected elements of the immune system in depression. METHOD:Lymphocyte subsets evaluation (CD3+, CD4+, CD8+, CD16+, CD19+, CD4/CD8) was performed in 32 patients with depression (21 women and 11 men in the age from 21 to 66 years) using the flow cytometry method. The cytokine eval...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：AIM:The aim of the study was to assess working memory and executive dysfunctions, as well as the intensity of depressive symptoms in hyperthyroid patients with Graves' disease compared to healthy persons. METHOD:Thirty (30) patients with Graves' disease (20 female, 10 male), aged 18-55, participated in the study. The ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：UNLABELLED:Transsexualism is one of the gender identity disorders where psychological sex is opposed to anatomical sex. This disorder leads to a discrepancy between the preferred social gender and the biological sex. AIM:The aim of this research is to compare knowledge and attitude toward transsexualism in student's o...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：AIM:The aim of our work was to assess qualitatively and quantatively emotional deficits in patients diagnosed with schizophrenia following ICD-10 criteria in early and late stages of the schizophrenic process and the evaluation of the relationship between genes polymorphism of enzymes influencing dopaminergic, serotoni...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:This review provides an overview of the concepts, methods and current status of the development of the Eleventh Revision of the Mental and Behavioural Disorders chapter of the International Classification of Diseases and Related Health Problems (ICD-11) by the World Health Organization (WHO). Given the global use of t...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/69660
更新日期：2017-04-30 00:00:00
abstract：UNLABELLED:Bulimia nervosa (BN) is a common and disabling psychiatric disorder, which affects mainly young females. The basic therapeutic modalities include pharmacotherapy with selective serotonin reuptake inhibitors, cognitive behavioural therapy and combined treatment. AIM:This 12-week open label study was performe...
journal_title：Psychiatria polska
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-01-01 00:00:00
abstract：AIM:The aim of the study is to assess the interrelation between three earlier described types of consent to inpatient treatment and compliance as well as some aspects of patients' autonomy. METHOD:200 inpatients admitted to four psychiatric hospitals were examined by means of a structured questionnaire. Persons with s...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:A group of 50 patients aged from 12 to 20 with anorexia nervosa was examined: 40 persons with a diagnosis of restricting type and 10 with binge-eating type according to DSM IV. The level of intelligence quotient (IQ) was estimated by using Wechsler Test, selfacceptation by SQ and aspiration by TAT and test of unfinish...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The position of selective mutism disorder - SM - has been modified in the last edition of the classification of mental disorders DSM-5. It was removed from "Disorders of childhood and adolescence" and placed in "Anxiety disorders". This caused two important changes in the interpretation of the symptoms of selective mu...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/76088
更新日期：2018-04-30 00:00:00
abstract：UNLABELLED:Drug addiction belongs to those phenomena of social pathology with complex canses, mechanisms and conditionings. Drug addiction mainly concerns young people, also those from the military environment despite the fact that recruitment boards consider detected drug addicts-conscripts to be completely or tempora...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：UNLABELLED:Central nervous system diseases are connected with the production of an increased amount of reactive oxygen species. Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia (TD) in schizophrenic patients in a prolonged neuroleptic treatment course. AIM:Evaluation of superoxid...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：AIM:This study investigated the relation between problem-solving strategies in the marital conflict and marital satisfaction. METHOD:Four problem-solving strategies (Dialogue, Loyalty, Escalation of conflict and Withdrawal) were measured by the Problem-Solving Strategies Inventory, in two versions: self-report and rep...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:It was proposed that the repetitive rapid-rate transcranial magnetic stimulation (TMS) induces the functional and structural changes analogous to those which are evoked during the electroconvulsive treatment. Presently, we compared the effects of 8 daily treatments with TMS (t = 5 min, B = 0.1 T, trise = 200 microseco...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：AIM:Qualitative analysis of acute psychiatric patients' subjective opinions on the conditions and effects of their hospital treatment. Presentation of patients' expectations in this respect and the follow up of the opinion changes taking place during hospital stay. METHOD:Patients' opinions were obtained in open quest...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
