Abstract:
:An intracellular signal transduction network constitutes an assembled machinery to control the dynamics of kinase-phosphatase cascade and gene expression. Spatio-temporal analyses of the cellular process can explain the biochemical role of the receptor tyrosine kinases in cancer development from a system point of view.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Hatakeyama Mdoi
10.1039/b612800asubject
Has Abstractpub_date
2007-02-01 00:00:00pages
111-6issue
2eissn
1742-206Xissn
1742-2051journal_volume
3pub_type
杂志文章,评审abstract::The molecular segmentation clock is a complex regulatory network that governs the periodic somite segmentation in vertebrate embryos. Underlying the rhythm of the segmentation clock is a single-cell level pace-making circuit, where inevitable molecular noise and time delay impose normal operating constraints to the pa...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70046a
更新日期:2013-06-01 00:00:00
abstract::Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Investigation of the hos...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c0mb00262c
更新日期:2011-05-01 00:00:00
abstract::The first fluorescent labeling technology, which can induce not only an increase in the fluorescence intensity but also a shift in the fluorescence spectrum, has been developed for "ratiometric" measurements for a protein by utilizing a newly designed "field-sensitive" fluorescent probe and its corresponding unique am...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b515777c
更新日期:2006-02-01 00:00:00
abstract::Breast cancer has been reported as one of the most frequently diagnosed malignant diseases and the leading cause of cancer death in women all around the world. Furthermore, this complicated cancer is divided into multiple subtypes which present different clinical symptoms and need correspondingly directed therapy. We ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c6mb00653a
更新日期:2017-05-02 00:00:00
abstract::The glutamate γ-carboxylation plays a pivotal part in a number of important human diseases. However, traditional protein γ-carboxylation site detection by experimental approaches are often laborious and time-consuming. In this study, we initiated an attempt for the computational prediction of protein γ-carboxylation s...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25185j
更新日期:2012-11-01 00:00:00
abstract::Fabry disease (FD) is an X-linked lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase α-galactosidase A (α-GalA) that leads to the intra-lysosomal accumulation of globotriaosylceramide (Gb3) in various organ systems. As a consequence, a multisystems disorder develops, culminating in stroke, pr...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00707g
更新日期:2015-06-01 00:00:00
abstract::Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that play key roles in cell signaling. Deregulation of PTP activity results in aberrant tyrosine phosphorylation, which has been linked to the etiology of several human diseases, including cancer. Since phosphate removal by the PTPs can both enh...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/b700704n
更新日期:2007-05-01 00:00:00
abstract::Understanding the molecular mechanism that underlies the differentiation of neural stem cells (NSCs) is vital to develop regenerative medicines for neurological disorders. In our previous work, Rho-GDI-γ was found to be able to prompt neuronal differentiation when it was down regulated. However, it is unclear how Rho-...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25147g
更新日期:2012-11-01 00:00:00
abstract::The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these pro...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00240k
更新日期:2015-08-01 00:00:00
abstract::One of the fundamental goals in cellular biochemistry is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. To realize this, it is indispensable to develop an automated method for fast and accurate identification of the subcellular locations of uncharac...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c7mb00267j
更新日期:2017-08-22 00:00:00
abstract::RNA-binding proteins (RBPs) are key regulators of gene expression. Some long non-coding RNAs (lncRNAs) affect gene expression by interacting with RBPs. However, whether this influences the biological characteristics of lncRNAs in diseases still remains unknown. Here, we classify lncRNAs into two categories, using the ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c7mb00144d
更新日期:2017-06-01 00:00:00
abstract::The biological processing - mechanism of cellular uptake, effects on the cytoplasmic and mitochondrial membranes, intracellular sites of localisation and induction of reactive oxygen species - of two dinuclear polypyridylruthenium(ii) complexes has been examined in three eukaryotic cells lines. Flow cytometry was used...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c6mb00431h
更新日期:2016-10-20 00:00:00
abstract::The effect of the glutathione transferase P1-1 (GSTP1-1) targeting has been investigated in both sensitive (U-2OS) and cisplatin-resistant (U-2OS/CDDP4 μg) human osteosarcoma cell lines. Despite the different enzyme's content, inhibition of GSTP1-1 by 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) causes the...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05295k
更新日期:2012-04-01 00:00:00
abstract::The use of Cyan Fluorescent Proteins, with a distinctive lifetime signature, opens up new alternatives to track and semi-quantify the relative expression of proteins in vivo using a single excitation source and emission channel. ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b815445g
更新日期:2009-02-01 00:00:00
abstract::Systematic screens for human disease genes have emerged in recent years, due to the wealth of information provided by genome sequences and large scale datasets. Here we review how integration of genomic data in yeast and human is helping to elucidate the genetic basis of mitochondrial diseases. The identification of n...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/b709494a
更新日期:2008-01-01 00:00:00
abstract::This paper describes a sensitive, non-destructive displacement assay, using a fluorescent peptide indicator, for real-time monitoring of the interactions between RNA and RNA binding proteins (RBPs). The developed fluorescent peptide indicators, each containing a mid-sequence fluorophore unit, allowed sensing of target...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25470k
更新日期:2013-05-01 00:00:00
abstract::Production of biofuels has been one of the promising efforts in biotechnology in the past few decades. The perspective of these efforts can be reduction of increasing demands for fossil fuels and consequently reducing environmental pollution. Nonetheless, most previous approaches did not succeed in obviating many big ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c6mb00119j
更新日期:2016-07-19 00:00:00
abstract::At the intersection between artificial intelligence and statistics, supervised learning allows algorithms to automatically build predictive models from just observations of a system. During the last twenty years, supervised learning has been a tool of choice to analyze the always increasing and complexifying data gene...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/b907946g
更新日期:2009-12-01 00:00:00
abstract::The chemical composition of the cervical mucus (CM), its physical characteristics and the volume of secretion change cyclically throughout the menstrual cycle. The aim of this study was to identify the constitutive protein composition of CM of fertile women and the changes in the CM proteome throughout the menstrual c...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00071h
更新日期:2015-06-01 00:00:00
abstract::α-Anomers of 2'-deoxyadenosine (αdA) are major products of deoxyadenosine damage when DNA is γ-irradiated under anoxic conditions. Such lesions are a threat to genomic stability and are known to be processed by human apurinic/apyrimidinic endonuclease 1 (APE1). The aim of this study was to determine whether the α-anom...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c6mb00511j
更新日期:2016-10-18 00:00:00
abstract::Recently, more and more research has shown that microRNAs (miRNAs) play critical roles in the development and progression of various diseases, but it is not easy to predict potential human miRNA-disease associations from the vast amount of biological data. Computational methods for predicting potential disease-miRNA a...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25180a
更新日期:2012-10-01 00:00:00
abstract::Drosophila cell culture is used as a model system with multiple applications including the identification of new therapeutic targets in screens, the study of conserved signal transduction pathway mechanisms, and as an expression system for recombinant proteins. However, in vitro methods for Drosophila cell and organ c...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00155a
更新日期:2014-10-01 00:00:00
abstract::Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate transcriptional networks in the form of recurrent circuits or motifs. A motif can be divided into a feedforward loop (FFL) and a feedback loop (FBL). Incoherent FFLs have been the recent focus due to their potential to dampen gene expression noise...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00526k
更新日期:2014-12-01 00:00:00
abstract::Predicting protein subcellular localization is a challenging problem, particularly when query proteins have multi-label features meaning that they may simultaneously exist at, or move between, two or more different subcellular location sites. Most of the existing methods can only be used to deal with the single-label ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25466f
更新日期:2013-04-05 00:00:00
abstract::α-Oxoaldehydes, which are produced in higher quantities in diabetes, uremia, oxidative stress, inflammation and aging, react with the amino, guanidine and thiol groups of proteins and cause the formation of advanced glycated end-products and protein cross-linking. To prevent these reactions, the efficiency of low mole...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00217b
更新日期:2014-08-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) are key signaling proteins that regulate how cells interact with their environment. Traditional signaling cascades involving GPCRs have been well described and are well established and very important clinical targets. With the development of more recent technologies, hints about the...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c2mb25429h
更新日期:2013-04-05 00:00:00
abstract::The heterogeneity of genetic alterations in human cancer genomes presents a major challenge to advancing our understanding of cancer mechanisms and identifying cancer driver genes. To tackle this heterogeneity problem, many approaches have been proposed to investigate genetic alterations and predict driver genes at th...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25528f
更新日期:2013-03-01 00:00:00
abstract::A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old r...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b816407j
更新日期:2009-10-01 00:00:00
abstract::Herein, we demonstrate that the bacterial signaling molecule, c-di-GMP, can enhance the peroxidation of hemin when proflavine is present. The c-di-GMP-proflavine-hemin nucleotidezyme can oxidize the colorless compound 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ABTS, to the colored radical cation ABTS˙(+) ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05430b
更新日期:2012-03-01 00:00:00
abstract::Rhein is a natural product purified from herbal plants such as Rheum palmatum, which has been shown to have anti-angiogenesis and anti-tumor metastasis properties. However, the biological effects of rhein on the behavior of breast cancers are not completely elucidated. To evaluate whether rhein might be useful in the ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00451e
更新日期:2014-12-01 00:00:00