A systems biology approach to reconcile metabolic network models with application to Synechocystis sp. PCC 6803 for biofuel production.

abstract：:Human mitogen-activated protein kinase (MAPK) family members JNK and p38 are two homologous protein-serine/threonine kinases but play distinct roles in the pathological process of neurological disorders. Selective targeting of JNK over p38 has been established as a potential therapeutic approach to epilepsy and other ...

journal_title：Molecular bioSystems

authors： Zhuo ZH,Sun YZ,Jin PN,Li FY,Zhang YL,Wang HL

更新日期：2016-07-19 00:00:00

abstract：:Induced hypoxia stress on cervical cancer derived cells (HeLa cells) leads to significant changes in their membrane lipid profiles. The lipidome of HeLa cells was characterized by a joint approach wherein liquid chromatography-mass spectrometry (LC-MS) analysis was followed by high resolution NMR measurements. Multiva...

journal_title：Molecular bioSystems

authors： Yu Y,Vidalino L,Anesi A,Macchi P,Guella G

更新日期：2014-04-01 00:00:00

abstract：:In the present study, we focused on the expression and biological functions of TMEM45B in pancreatic cancer tissues and cell lines. Real-time PCR and Western blotting were used to examine the expression levels of TMEM45B in pancreatic cancer tissues and cell lines. The functions of TMEM45B were evaluated using CCK-8, ...

journal_title：Molecular bioSystems

authors： Zhao LC,Shen BY,Deng XX,Chen H,Zhu ZG,Peng CH

更新日期：2016-05-24 00:00:00

abstract：:Protein methylation catalyzed by methyltransferases carries many important biological functions. Methylation and their regulatory enzymes are involved in a variety of human disease states, raising the possibility that abnormally methylated proteins can be disease markers and methyltransferases are potential therapeuti...

journal_title：Molecular bioSystems

authors： Shi SP,Xu HD,Wen PP,Qiu JD

更新日期：2015-10-01 00:00:00

abstract：:Unstable angina (UA) is one of the most dangerous types of coronary heart disease and has high mortality and morbidity rates worldwide. However, the diagnostic accuracy for UA is unsatisfactory in clinical practice. In this study, we investigated the application of plasma metabolomics in discovering potential biomarke...

journal_title：Molecular bioSystems

authors： Sun M,Gao X,Zhang D,Ke C,Hou Y,Fan L,Zhang R,Liu H,Li K,Yu B

更新日期：2013-12-01 00:00:00

abstract：:Enediyne natural product biosynthesis is characterized by a convergence of multiple pathways, generating unique peripheral moieties that are appended onto the distinctive enediyne core. Kedarcidin (KED) possesses two unique peripheral moieties, a (R)-2-aza-3-chloro-β-tyrosine and an iso-propoxy-bearing 2-naphthonate m...

journal_title：Molecular bioSystems

authors： Lohman JR,Huang SX,Horsman GP,Dilfer PE,Huang T,Chen Y,Wendt-Pienkowski E,Shen B

更新日期：2013-03-01 00:00:00

abstract：:Celastrol, isolated from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f. (Thunder God's Vine), has been used to treat cancer, chronic inflammatory, autoimmune and other human diseases. However, to date, the protein targets and the mechanism of action of celastrol have remained elusive. In this s...

journal_title：Molecular bioSystems

authors： Zhou Y,Li W,Wang M,Zhang X,Zhang H,Tong X,Xiao Y

更新日期：2016-12-20 00:00:00

abstract：:Asthma is a chronic inflammatory lung disease that leads to 250 000 deaths annually. There is a need to better understand asthma by identifying new pathogenic molecules. We conducted a liquid-chromatography time-of-flight mass spectrometry (LC-Q-TOF-MS)-based metabolomics study to test for asthma and investigate the i...

journal_title：Molecular bioSystems

authors： Su L,Shi L,Liu J,Huang L,Huang Y,Nie X

更新日期：2017-05-30 00:00:00

abstract：:Lung fibrosis is a progressive and often fatal lung disease characterized by fibroblast proliferation and excessive deposition of extracellular matrix in the lungs. The chemokine receptor CXCR7 has been shown to control cell adhesion, migration and proliferation by regulating the epithelial-to-mesenchymal transition (...

journal_title：Molecular bioSystems

authors： Guan S,Zhou J

更新日期：2017-09-26 00:00:00

abstract：:In order to elucidate the effect of flexible linker length on the catalytic efficiency of fusion proteins, two short flexible peptide linkers of various lengths were fused between Arabidopsis thaliana 4-coumaroyl-CoA ligase (4CL) and Polygonum cuspidatum stilbene synthase (STS) to generate fusion proteins 4CL-(GSG)n-S...

journal_title：Molecular bioSystems

authors： Guo H,Yang Y,Xue F,Zhang H,Huang T,Liu W,Liu H,Zhang F,Yang M,Liu C,Lu H,Zhang Y,Ma L

更新日期：2017-02-28 00:00:00

abstract：:Single molecule observation of fluorescence resonance energy transfer can be used to provide insight into the structure and dynamics of proteins. Using a straightforward triple-colour labelling strategy, we present a measurement and analysis scheme that can simultaneously study multiple regions within single intrinsic...

journal_title：Molecular bioSystems

authors： Milles S,Koehler C,Gambin Y,Deniz AA,Lemke EA

更新日期：2012-10-01 00:00:00

abstract：:Deciphering functional interactions between proteins is one of the great challenges in biology. Sequence-based homology-free encoding schemes have been increasingly applied to develop promising protein-protein interaction (PPI) predictors by means of statistical or machine learning methods. Here we analyze the relatio...

journal_title：Molecular bioSystems

authors： Zhou Y,Zhou YS,He F,Song J,Zhang Z

更新日期：2012-04-01 00:00:00

abstract：:As one of the most important trace elements within an organism, zinc has been shown to be involved in numerous biological processes and closely implicated in various diseases. The zinc ion is important for proteins to perform their functional roles. To provide in-depth functional annotation of zinc-binding proteins, a...

journal_title：Molecular bioSystems

authors： Chen Z,Wang Y,Zhai YF,Song J,Zhang Z

更新日期：2013-09-01 00:00:00

abstract：:Blockage of the interactions between immunologic checkpoint protein PD-1 and its ligand PD-L1 showed efficacy for cancer treatment. X-ray structures have captured static conformational snapshots of PD-1 and revealed that the CC' loop adopts an open conformation in the apo-protein but turns into a closed form and inter...

journal_title：Molecular bioSystems

authors： Liu W,Huang B,Kuang Y,Liu G

更新日期：2017-05-02 00:00:00

abstract：:The first fluorescent labeling technology, which can induce not only an increase in the fluorescence intensity but also a shift in the fluorescence spectrum, has been developed for "ratiometric" measurements for a protein by utilizing a newly designed "field-sensitive" fluorescent probe and its corresponding unique am...

journal_title：Molecular bioSystems

authors： Soh N,Seto D,Nakano K,Imato T

更新日期：2006-02-01 00:00:00

abstract：:Integrative pharmacology has been used to identify the key active constituents (KACs) of Buchang Naoxintong capsules (BNCs), a traditional Chinese medical preparation; this approach involves the evaluation of the content profiles and drug-like properties of the BNC constituents and development of an ingredient-target ...

journal_title：Molecular bioSystems

authors： Haiyu X,Yang S,Yanqiong Z,Qiang J,Defeng L,Yi Z,Feng L,Hongjun Y

更新日期：2016-01-01 00:00:00

abstract：:Upon entering biological systems, such as the blood stream, nanoparticles form molecular complexes with the proteins encountered called protein coronas, which shield the surface of the exogenous nanoparticle. The most abundant blood proteins, such as albumin, initially occupy the surface of the nanoparticle. Owing to ...

journal_title：Molecular bioSystems

authors： Ramezani F,Rafii-Tabar H

更新日期：2015-02-01 00:00:00

abstract：:When photoirradiated, an unnatural sialic acid analog can covalently capture the complex formed by ganglioside GM1 and cholera toxin subunit B. ...

journal_title：Molecular bioSystems

authors： Bond MR,Whitman CM,Kohler JJ

更新日期：2010-10-01 00:00:00

abstract：:The advent of large scale sequencing methods has enabled analyses of the protein-coding parts of cancer genomes to find the mutated genes that cause common human cancers. Unbiased mutation analyses of human tumors originating in the breast, colon, brain, and pancreas have revealed genomic landscapes composed of a few ...

journal_title：Molecular bioSystems

authors： Ali MA,Sjöblom T

更新日期：2009-09-01 00:00:00

abstract：:α-Alkylidene-γ-butyrolactones are quite common in nature and exhibit a broad spectrum of biological activities. We therefore synthesized a small library of xanthatine inspired α-alkylidene-γ-butyrolactones to screen non-pathogenic and uropathogenic E. coli strains by activity based protein profiling (ABPP). The identi...

journal_title：Molecular bioSystems

authors： Kunzmann MH,Sieber SA

更新日期：2012-11-01 00:00:00

abstract：:Precise quantification of endogenous protein-protein interactions across live cells would be a major boon to biology. Such precise measurement is theoretically possible with fluorescence lifetime imaging microscopy (FLIM) but requires first properly addressing multiple biological, instrumental, statistical, and photop...

journal_title：Molecular bioSystems

authors： Walther KA,Papke B,Sinn MB,Michel K,Kinkhabwala A

更新日期：2011-02-01 00:00:00

abstract：:Lamellipodin (Lpd) protein plays an important role in the formation of lamellipodial protrusion which is crucial in actin dynamics, cell polarity and motility. Lpd promotes actin polymerization with the help of members of the Ena/VASP family of actin regulators and tethering them to actin filaments. It is well documen...

journal_title：Molecular bioSystems

authors： Gorai S,Paul D,Haloi N,Borah R,Santra MK,Manna D

更新日期：2016-03-01 00:00:00

abstract：:At the intersection between artificial intelligence and statistics, supervised learning allows algorithms to automatically build predictive models from just observations of a system. During the last twenty years, supervised learning has been a tool of choice to analyze the always increasing and complexifying data gene...

journal_title：Molecular bioSystems

authors： Geurts P,Irrthum A,Wehenkel L

更新日期：2009-12-01 00:00:00

abstract：:Cell penetrating peptides (CPPs), TATp, in particular, has been used widely for intracellular delivery of various agents ranging from small molecules to proteins, peptides, range of pharmaceutical nanocarriers and imaging agents. This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous ex...

journal_title：Molecular bioSystems

authors： Sawant R,Torchilin V

更新日期：2010-04-01 00:00:00

abstract：:Cervical cancer is initiated by infection with high-risk human papillomavirus (HPV). The viral E6 and E7 oncogenes are required for the initiation of cervical epithelial cell immortalization, but do not suffice to cause cervical cancer. Human oncogenes and tumor suppressor genes with altered activity in cervical carci...

journal_title：Molecular bioSystems

authors： Kravchenko-Balasha N,Klein S,Safrai M,Levitzki A

更新日期：2011-05-01 00:00:00

abstract：:The chemical composition of the cervical mucus (CM), its physical characteristics and the volume of secretion change cyclically throughout the menstrual cycle. The aim of this study was to identify the constitutive protein composition of CM of fertile women and the changes in the CM proteome throughout the menstrual c...

journal_title：Molecular bioSystems

authors： Grande G,Milardi D,Vincenzoni F,Pompa G,Biscione A,Astorri AL,Fruscella E,De Luca A,Messana I,Castagnola M,Marana R

更新日期：2015-06-01 00:00:00

abstract：:A lipase substrate microarray was obtained by printing aliphatic C2-C12 monoesters of (5R)- and (5S)-3-(5,6-dihydroxyhexyloxy)benzaldehyde by reductive alkylation on amine-functionalized glass slides coated with bovine serum albumin and a short PEG linker. The microarray features 12 substrates and their 66 possible bi...

journal_title：Molecular bioSystems

authors： Grognux J,Reymond JL

更新日期：2006-10-01 00:00:00

abstract：:Breast cancer has been reported as one of the most frequently diagnosed malignant diseases and the leading cause of cancer death in women all around the world. Furthermore, this complicated cancer is divided into multiple subtypes which present different clinical symptoms and need correspondingly directed therapy. We ...

journal_title：Molecular bioSystems

authors： Chen Y,Wang X,Wang G,Li Z,Wang J,Huang L,Qin Z,Yuan X,Cheng Z,Zhang S,Yin Y,He J

更新日期：2017-05-02 00:00:00

abstract：:The investigation of the structure and dynamics of signal transduction systems through data-based mathematical models in ordinary differential equations or other paradigms has proven to be a successful approach in recent times. Extending this concept, we here analysed the use of kinetic models based on power-law terms...

journal_title：Molecular bioSystems

authors： Vera J,Rath O,Balsa-Canto E,Banga JR,Kolch W,Wolkenhauer O

更新日期：2010-11-01 00:00:00

abstract：:An intracellular signal transduction network constitutes an assembled machinery to control the dynamics of kinase-phosphatase cascade and gene expression. Spatio-temporal analyses of the cellular process can explain the biochemical role of the receptor tyrosine kinases in cancer development from a system point of view...

journal_title：Molecular bioSystems

authors： Hatakeyama M

更新日期：2007-02-01 00:00:00