Abstract:
:When photoirradiated, an unnatural sialic acid analog can covalently capture the complex formed by ganglioside GM1 and cholera toxin subunit B.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Bond MR,Whitman CM,Kohler JJdoi
10.1039/c0mb00069hsubject
Has Abstractpub_date
2010-10-01 00:00:00pages
1796-9issue
10eissn
1742-206Xissn
1742-2051journal_volume
6pub_type
杂志文章abstract::Information on extracellular signals and conditions is often transduced by biological systems using cascades of protein phosphorylation that affect the activity of enzymes, the localization of proteins and gene expression. A model to study signal transduction is the response of the yeast Saccharomyces cerevisiae to os...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b902256b
更新日期:2009-11-01 00:00:00
abstract::The multidrug resistance (MDR) system actively pumps antibiotics out of cells causing serious health problems. During the pumping, AcrB (one of the key components of MDR) undergoes a series of large-scale and proton-motive conformational changes. Capturing the conformational changes through all-atom simulations is cha...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c7mb00276a
更新日期:2017-09-26 00:00:00
abstract::Climatic change is an increasing challenge for agriculture that is driving the development of suitable crops in order to ensure supply for both human nutrition and animal feed. In this context, it is increasingly important to understand the biochemical responses of cells to environmental cues at the whole system level...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25056j
更新日期:2012-06-01 00:00:00
abstract::The identification of a suitable non-fluorescent molecule that can be oxidized by G-quadruplexes into a fluorescent product will be important for several fields such as bioanalyte sensing and cancer therapeutic discovery. Herein, we demonstrate that 2',7'-dichlorodihydrofluorescein diacetate is a superior reducing sub...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b916228c
更新日期:2010-01-01 00:00:00
abstract::Recently, the development of Src/Abl (c-Src/Bcr-Abl tyrosine kinases) dual inhibitors has attracted considerable attention from the research community for treatment of malignancies. In order to explore the different structural features impacting the Src and Abl inhibitory activities of N(9)-arenethenyl purines and to ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00350k
更新日期:2015-02-01 00:00:00
abstract::Lung fibrosis is a progressive and often fatal lung disease characterized by fibroblast proliferation and excessive deposition of extracellular matrix in the lungs. The chemokine receptor CXCR7 has been shown to control cell adhesion, migration and proliferation by regulating the epithelial-to-mesenchymal transition (...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c7mb00247e
更新日期:2017-09-26 00:00:00
abstract::Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their over expression is associated with many disease states and hence the interest in MMPs as drug targets. Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in t...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00003c
更新日期:2015-04-01 00:00:00
abstract::Differential gene expression governs the development, function and pathology of multicellular organisms. Transcription regulatory networks study differential gene expression at a systems level by mapping the interactions between regulatory proteins and target genes. While microarray transcription profiles are the most...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/B908108a
更新日期:2009-12-01 00:00:00
abstract::Intrinsically disordered regions in proteins are known to evolve rapidly while maintaining their function. However, given their lack of structure and sequence conservation, the means through which they stay functional is not clear. Poor sequence conservation also hampers the classification of these regions into functi...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25202c
更新日期:2012-10-30 00:00:00
abstract::A metabolomic study was performed to investigate the biochemical profiles of livers from male and female zebrafish (Danio rerio), using a multiple platform approach, incorporating 1H NMR, GC/MS and LC/MS. The reproducibility and reliability of the three methods were validated prior to the assays. Major biomolecules de...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b811850g
更新日期:2009-03-01 00:00:00
abstract::Protein-protein interactions are important biological processes and essential for a global understanding of cell functions. To date, little is known about the protein interactions and roles of the protein interacting networks and protein complexes in bacterial resistance to antibiotics. In the present study, we invest...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25090j
更新日期:2012-09-01 00:00:00
abstract::Inferring metabolic networks from metabolite concentration data is a central topic in systems biology. Mathematical techniques to extract information about the network from data have been proposed in the literature. This paper presents a critical assessment of the feasibility of reverse engineering of metabolic networ...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c0mb00083c
更新日期:2011-02-01 00:00:00
abstract::To identify an agent with specific activity against human lens epithelial cells (HLECs), we confirmed the presence of glucocorticoid receptors (GRs) and GR-α genes and evaluated whether GRs have a relationship with the apoptotic process in cultured HLECs. We also determined whether the inhibitor RU486 could rescue the...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05045a
更新日期:2011-06-01 00:00:00
abstract::Cycloserine (CS, 4-amino-3-isoxazolidone) is a cyclic amino acid mimic that is known to inhibit many essential pyridoxal 5'-phosphate (PLP)-dependent enzymes. Two CS enantiomers are known; D-cycloserine (DCS, also known as Seromycin) is a natural product that is used to treat resistant Mycobacterium tuberculosis infec...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c003743e
更新日期:2010-09-01 00:00:00
abstract::Rhein is a natural product purified from herbal plants such as Rheum palmatum, which has been shown to have anti-angiogenesis and anti-tumor metastasis properties. However, the biological effects of rhein on the behavior of breast cancers are not completely elucidated. To evaluate whether rhein might be useful in the ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c4mb00451e
更新日期:2014-12-01 00:00:00
abstract::The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these pro...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00240k
更新日期:2015-08-01 00:00:00
abstract::Insights into the structure and dynamics of modular polyketide synthases (PKS) are essential for understanding the mechanistic details of the biosynthesis of a large number of pharmaceutically important secondary metabolites. The crystal structures of the KS-AT di-domain from erythromycin synthase have revealed the re...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05425f
更新日期:2012-04-01 00:00:00
abstract::Histone deacetylases (HDACs) contribute to regulation of gene expression by mediating higher-order chromatin structures. They assemble into large multiprotein complexes that regulate activity and specificity. We report the development of small molecule probes with class IIa and pan-HDAC activity that contain photoreac...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c6mb00109b
更新日期:2016-05-24 00:00:00
abstract::Chronic inflammation can lead to the development of cancers and resolution of inflammation is an ongoing challenge. Inflammation can result from dysregulation of the epigenome and a number of compounds that modify the epigenome are in clinical use. In this study the anti-inflammatory and anti-cancer effects of a quina...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00554j
更新日期:2016-03-01 00:00:00
abstract::The identification of genetic markers (e.g. genes, pathways and subnetworks) for cancer has been one of the most challenging research areas in recent years. A subset of these studies attempt to analyze genome-wide expression profiles to identify markers with high reliability and reusability across independent whole-tr...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00684h
更新日期:2016-03-01 00:00:00
abstract::Biotin is an enzyme cofactor indispensable to metabolic fixation of carbon dioxide in all three domains of life. Although the catalytic and physiological roles of biotin have been well characterized, the biosynthesis of biotin remains to be fully elucidated. Studies in microbes suggest a two-stage biosynthetic pathway...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c1mb05022b
更新日期:2011-06-01 00:00:00
abstract::We demonstrate the expected preference of an immobilised oligosaccharide Man(9)(GlcNAc)(2) upon a 96-well photochemical array, for its known receptor, the cell-surface lectin Dendritic Cell-Specific ICAM3 Grabbing Nonintegrin (DC-SIGN) when compared to immobilised competing monosaccharides. ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c0mb00118j
更新日期:2011-01-01 00:00:00
abstract::The effect of aging and development in male Wistar-derived rats on the profile of endogenous metabolites excreted in the urine was investigated using both (1)H NMR spectroscopy and HPLC-TOF MS using electrospray ionisation (ESI). The endogenous metabolites were profiled in samples collected from male rats every two we...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b500852b
更新日期:2005-07-01 00:00:00
abstract::Many methods have been published by which combinatorial libraries may be screened for compounds capable of manipulating the function(s) of a target protein. One of the simplest approaches is to identify compounds in a library that bind the protein of interest, since these binding events usually occur on functionally i...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/b514349g
更新日期:2006-01-01 00:00:00
abstract::Tankyrases (TNKS), key transmitters in the Wnt signaling pathway which is very conservative in evolution, are vital targets as they are overexpressed widely in many cancers. In this work, 5 inhibitors with novel structures have been discovered and validated using the ligand-based (pharmacophore) virtual screening, doc...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c6mb00712k
更新日期:2017-01-31 00:00:00
abstract::Infectious diseases caused by bacterial pathogens pose a major concern to public health and, thus, greater attention must be given to providing insightful knowledge on host-pathogen interactions. There are several theories addressing the dynamics of complex mechanisms of host-pathogen interactions. The availability of...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c7mb00372b
更新日期:2017-11-21 00:00:00
abstract::Classical Hodgkin lymphoma (cHL) is a malignancy with complex pathogenesis. The hallmark of the disease is the presence of large mononucleated Hodgkin and bi- or multinucleated Reed/Sternberg (H/RS) cells. The origin of HRS cells in cHL is controversial as these cells show the coexpression of markers of several lineag...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00654f
更新日期:2016-01-01 00:00:00
abstract::Over the last few years important new insights into the process of long-range gene regulation have been obtained. Gene regulatory elements are found to engage in direct physical interactions with distant target genes and with loci on other chromosomes to modulate transcription. An overview of recently discovered long-...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/b803580f
更新日期:2008-11-01 00:00:00
abstract::Epigenetic regulation by histone methylation is crucial for proper programming of the genome during development. Homeostasis of histone methylation is balanced by the activities of histone methyltransferases and demethylases. Although these methyltransferases and demethylases represent logical targets for potential dr...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70413k
更新日期:2014-02-01 00:00:00
abstract::A recent model proposing that a barrier is raised against tumor evolution in pre-cancer tissues is investigated. For that we quantify expression alterations in genome maintenance pathways: DNA damage response, death pathways and cell cycle and also differentially expressed genes in transcriptomes of pre-cancerous and ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25242b
更新日期:2012-11-01 00:00:00