Abstract:
:Tankyrases (TNKS), key transmitters in the Wnt signaling pathway which is very conservative in evolution, are vital targets as they are overexpressed widely in many cancers. In this work, 5 inhibitors with novel structures have been discovered and validated using the ligand-based (pharmacophore) virtual screening, docking study, and Luciferase reporter assays for Wnt signaling. Among them, PYL-1, in particular, was the most potent inhibitor with an IC50 value of 9.56 μM against Wnt signaling. The analysis of binding modes was performed to further understand the vital interactions between inhibitors and TNKS 2, and the five hits belong to dual site inhibitors. This work could be helpful for the design and development of novel dual binders as TNKS inhibitors.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Pu Y,Zhang S,Chang Z,Zhang Y,Wang D,Zhang L,Li Y,Zuo Zdoi
10.1039/c6mb00712ksubject
Has Abstractpub_date
2017-01-31 00:00:00pages
363-370issue
2eissn
1742-206Xissn
1742-2051journal_volume
13pub_type
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