Abstract:
:Chronic inflammation can lead to the development of cancers and resolution of inflammation is an ongoing challenge. Inflammation can result from dysregulation of the epigenome and a number of compounds that modify the epigenome are in clinical use. In this study the anti-inflammatory and anti-cancer effects of a quinazoline epigenetic-modulator compound were determined in prostate cancer cell lines using a non-hypothesis driven transcriptomics strategy utilising the Affymetrix PrimeView® Human Gene Expression microarray. GATHER and IPA software were used to analyse the data and to provide information on significantly modified biological processes, pathways and networks. A number of genes were differentially expressed in both PC3 and DU145 prostate cancer cell lines. The top canonical pathways that frequently arose across both cell lines at a number of time points included cholesterol biosynthesis and metabolism, and the mevalonate pathway. Targeting of sterol and mevalonate pathways may be a powerful anticancer approach.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Lin Z,Bishop KS,Sutherland H,Marlow G,Murray P,Denny WA,Ferguson LRdoi
10.1039/c5mb00554jsubject
Has Abstractpub_date
2016-03-01 00:00:00pages
839-49issue
3eissn
1742-206Xissn
1742-2051journal_volume
12pub_type
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