Abstract:
:Larval serum protein-1 (LSP-1) and LSP-2 are the major proteins of Drosophila larval serum. The amount of LSP-1 synthesized is strictly proportional to the number of LSP-1 genes present within the range 1-10. The normal number in female flies is 6. Flies with extreme amounts of LSP-1 were, by our criteria, as fit as the wild type. The ratio of LSP-2:LSP-1 was analyzed in 169 different stocks and was constant in 164 of these. The significantly different ratios in five stocks were all due to the lack of one of the LSP-1 gene products.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Roberts DB,Blackwell SA,Loughlin SAdoi
10.1007/BF00499473subject
Has Abstractpub_date
1984-10-01 00:00:00pages
783-95issue
9-10eissn
0006-2928issn
1573-4927journal_volume
22pub_type
杂志文章abstract::Pancreatic cancer is the fourth leading cause of death in both males and females, with a 5-year relative survival rate of 8%. The Wnt signaling pathway has a significant role in the pathogenesis of many tumors, including those of pancreatic cancer. Hypermethylation of the Wnt inhibitory Factor-1 (WIF1) gene promoter h...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9895-0
更新日期:2019-08-01 00:00:00
abstract::In this study, we identified porcine single nucleotide polymorphisms (SNPs) by aligning eight sequences generated with two approaches: amplification of 665 intronic regions using one sample from each of eight breeds, including three East Asian pigs, and amplification of 289 3'-UTR regions using two samples from each o...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-011-9486-9
更新日期:2012-06-01 00:00:00
abstract::Studies have investigated the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and cardiometabolic risk factors (CMRFs), however with varying results, which could be due to ethnicity differences. Therefore, the present study was conducted among Bhil tribal population (...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9845-x
更新日期:2018-08-01 00:00:00
abstract::The molecular weight forms of kynurenine formamidase were studied both gentically and biochemically. Formamidase I (native molecular weight 60,000) was purified using (NH4)2SO4 and pH fractionation, DEAE-cellulose chromatography at two different pH's, hydroxylapatite chromatography, and Sephadex G-100 gel filtration. ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484718
更新日期:1978-08-01 00:00:00
abstract::Human PQBP-1 is known to interact with triplet repeat disease gene products such as ataxin and huntingtin through their poly-glutamine (poly-Q) tracts. The poly-Q tracts show extensive variation in both the number and the configuration of repeats among species. A surface plasmon resonance assay showed clear interactio...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-011-9473-1
更新日期:2012-04-01 00:00:00
abstract::For a number of decades, the lesser white-fronted goose (Anser erythropus) has been almost-absent from the Fennoscandian fauna and has a current population size of only about 60 breeding pairs, with fewer than 10 pairs in Sweden. During the period 1981-1991 more than 200 young have been reintroduced in northern Sweden...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Allelic frequencies at five polymorphic loci were determined in seven European and six Afrotropical populations of Drosophila melanogaster. African populations, which may be considered as ancestral for the species, showed a greater genetic diversity as measured by the number of alleles found. Within each geographic gr...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483971
更新日期:1982-08-01 00:00:00
abstract::Genetic diversity and differentiation of nine populations of Ginkgo biloba L. (Ginkgoaceae)from China were evaluated using RAPD. Of 47 clear and repeatable RAPD bands, 46 were polymorphic (overall polymorphism = 97.9%). A ranged from 1.57 to 1.83 with a mean of 1.75. Mean He was 0.3159 (0.2429-0.3603). The Shannon ind...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/b:bigi.0000034431.15308.57
更新日期:2004-08-01 00:00:00
abstract::A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00554618
更新日期:1994-06-01 00:00:00
abstract::The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice. After injection of hCG, hpg/hpg mice showed a decrease in LH receptor levels which was not ob...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484511
更新日期:1984-06-01 00:00:00
abstract::Using megagametophyte (maternal haploid) and embryo (diploid) tissues of incense-cedar seeds, the expression of one of three malate dehydrogenase (MDH) loci was found to be influenced by a second, unlinked, modifier locus. Whereas alleles of the affected structural locus are codominant, the modifier alleles show domin...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484435
更新日期:1983-06-01 00:00:00
abstract::The allele, genotype, and haplotype frequencies among 837 Polish Holstein-Friesian cattle were determined at two regulatory indel polymorphisms of the PRNP gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Alle...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-010-9408-2
更新日期:2011-06-01 00:00:00
abstract::Restriction endonuclease analyses of DNA from one Black G gamma A gamma-HPFH homozygote and four Black and one Indian G gamma A gamma-HPFH heterozygotes have identified three different HPFH types which are the result of large deletions including the delta and beta genes. Two of the types are comparable to those charac...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499284
更新日期:1984-02-01 00:00:00
abstract::We report a new enzyme xylose dehydrogenase, the structural locus for which is on chromosome 7 of the mouse, closely linked to Tam-1. Three alleles have been detected in both laboratory strains and wild populations. Two of these determine proteins differing in electrophoretic mobility and the third is a "null." This e...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483970
更新日期:1982-08-01 00:00:00
abstract::A novel cDNA fragment was identified from a human fetal brain cDNA library by using the coding sequence of human BRI3 gene (Accession No. NM015379) as bait in a yeast two-hybrid screening. Then by 5'-RACE (rapid amplification of cDNA end) and electronic hybridization, we obtained a 1.9 kb contig which consists of a no...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1013807518791
更新日期:2001-12-01 00:00:00
abstract::Phosphoglucomutase (PGM) of adult stage in Drosophilia melanogaster has been characterized by gel filtration, ion-exchange chromatography, and isoelectric focusing. The two common electrophoretic variants, PGMA and PGMB, differ with respect to their kinetic and stability parameters. PGMA is more thermostable than PGMB...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504306
更新日期:1979-10-01 00:00:00
abstract::Three distinct malathion carboxylesterase (MCE) phenotypes have been identified among strains of Lucilia cuprina. The high-activity phenotype shows 1.6- and 33-fold more MCE specific activity than the intermediate- and low-activity phenotypes, respectively. Flies with high MCE activity are 1000-fold more resistant to ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00566064
更新日期:1994-12-01 00:00:00
abstract::Neurospora crassa can utilize numerous compounds including certain amino acids as a sole nitrogen source. Mutants of the nit-2 locus, a regulatory gene which is postulated to mediate nitrogen catabolite repression, are deficient in the ability to utilize several amino acids as well as other nitrogen sources used by wi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484090
更新日期:1978-04-01 00:00:00
abstract::We have isolated the Drosophila melanogaster locus coding for L-glutamate dehydrogenase (EC 1.4.1.3) by virtue of its similarity to the corresponding human gene. There is only one copy of this gene in the fruit fly genome, located on the right arm of chromosome 3 (95D1-4). The transcript includes at least one large in...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::This study deals with the characterization of 10 populations of M. musculus from different geographical locations in India. The genetics of Indian wild mice has been completely obscure and this is the first report on allozyme variations in the natural population. We have used a set of 24 biochemical genetic markers to...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1018781026170
更新日期:1998-08-01 00:00:00
abstract::The segregation of human lysosomal arylsulfatase A (ARS-A) has been evaluated in 50 primary hybrid clones derived from four separate fusions involving WBCs from two unrelated individuals and three hamster cell lines. ARS-A was expressed in the hybrids as a dimeric molecule of very similar or identical subunits. The ex...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504344
更新日期:1979-12-01 00:00:00
abstract::Stable reciprocal hybrids between Flaveria pringlei (C3) and F. brownii (C4-like) have been produced by standard breeding techniques. There are no differences in the isoelectric focusing patterns of the catalytic subunits of the ribulose-1,5-bisphosphate carboxylase/oxygenase from F. pringlei, F. brownii, or the recip...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF02396147
更新日期:1989-10-01 00:00:00
abstract::The alpha-amylase in Drosophila melanogaster is a highly polymorphic enzyme, at both the allozyme level and the specific activity level. This enzyme changes its specific activity drastically depending on both food conditions and developmental stages, and it has been suggested that the ability to change its activity de...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1018715528413
更新日期:1999-12-01 00:00:00
abstract::Arylsulfatase A (ASA) activity was studied from five blood fractions, leukocytes plus platelets (LKPL), leukocytes (LK), neutrophils (N), lymphocytes (LYM), and platelets (PL). No significant difference was found among the mean ASA specific activity values for the fractions. Electrophoretic examination revealed four d...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484068
更新日期:1982-10-01 00:00:00
abstract::A restriction map has been constructed for Anastrepha suspensa mitochondrial DNA. One HaeIII site was found to be polymorphic among individuals in highly inbred colonies and a feral population. Based on mapping information, the polymorphic site was determined to be in the ATPase 6 gene. Primers TK-J-3804 and C3-N-5460...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1019839102099
更新日期:2002-08-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia associated with insulin resistance and relative insulin deficiency. T2DM is believed to be attributable to the combined effect of genetic and environmental factors. Peroxisome proliferator-activated receptor gamma 2 (PPARγ2) is one of the main c...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9765-6
更新日期:2017-02-01 00:00:00
abstract::A slow-migrating beta-esterase (S-esterase) is described which has been detected in Drosophila montana, Drosophila imeretensis, and some stocks of Drosophila virilis when mixtures of alpha- and beta-naphthyl acetate are used as substrates in histochemical reactions after electrophoresis. Sexual dimorphism for S-estera...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484882
更新日期:1976-02-01 00:00:00
abstract::Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9848-7
更新日期:2018-08-01 00:00:00
abstract::Environmentally induced flax genotrophs L and S show heritable shifts in the relative mobilities of peroxidase, esterase, and acid phosphatase isozymes, plus a number of nonspecific glycoproteins. All L isozymes migrated faster than corresponding S isozymes in 10% acrylamide gels. Various aspects of these shifts are r...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499290
更新日期:1984-02-01 00:00:00
abstract::The retinal pigment epithelium (RPE) plays a key role in the maintenance of the normal functions of the retina. Tissue engineering using amniotic membrane as a substrate to culture RPE cells may provide a promising new strategy to replace damaged RPE. We established a method of culturing RPE cells over the amniotic me...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-010-9409-1
更新日期:2011-06-01 00:00:00