Mapping of adrenergic receptors in the trachea by autoradiography.

abstract：:ABSTRACT During fetal development physiological stretching helps drive lung growth and maturation. At birth, the α-subunit of the alveolar epithelial sodium channel (α-ENaC) is a critical factor in helping to facilitate clearance of lung fluid during the perinatal period. The effects of stretch, however, on α-ENaC exp...

journal_title：Experimental lung research

authors： Mustafa SB,Isaac J,Seidner SR,Dixon PS,Henson BM,DiGeronimo RJ

更新日期：2014-10-01 00:00:00

abstract：:Purpose: Mechanical ventilation (MV) is an essential life support tool for patients with acute respiratory distress syndrome (ARDS). However, MV for ARDS can result in ventilator-induced lung injury (VILI). This study aimed to assess whether alpha 1-antitrypsin (AAT) can reduce VILI in ARDS rats. Materials and Methods...

journal_title：Experimental lung research

authors： Wang X,Gong J,Zhu J,Jin Z,Gao W

更新日期：2019-09-01 00:00:00

abstract：:Chymase is a chymotrypsin-like serine protease that is present in mast cells. Its activities include various effects associated with inflammatory responses. But little is known about the effects of chymase in pulmonary fibrosis. The mouse silicosis model was induced by intratracheal injection of 10 mg silica. The Ashc...

journal_title：Experimental lung research

authors： Takato H,Yasui M,Ichikawa Y,Waseda Y,Inuzuka K,Nishizawa Y,Tagami A,Fujimura M,Nakao S

更新日期：2011-03-01 00:00:00

abstract：:Confluent cultures of primary hamster tracheal surface epithelial cells are highly enriched with secretory cells resembling airway goblet cells. The cultures secrete lipids, most of which appear to be associated with high-molecular-weight mucinlike glycoproteins (HMW MLGP). In the present communication, we examined th...

journal_title：Experimental lung research

authors： Kim KC,Singh BN

更新日期：1990-05-01 00:00:00

abstract：:Lung injury and inflammation are associated with exposure to various types of particulate air pollutants. The present study was used to determine whether metalloproteinases (MMPs) are secreted after instilling dust samples into the lung, and to relate levels of specific MMPs to different fractions of the ambient air p...

journal_title：Experimental lung research

authors： Adamson IY,Vincent R,Bakowska J

更新日期：2003-09-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00

abstract：:A small subpopulation of pulmonary epithelial cells (PE) proliferates in low-density primary culture of alveolar type II cells and forms colonies of cells that could be passaged for several generations and that in some respects maintain a differentiated phenotype of the alveolar type II cells. At this time it is not k...

journal_title：Experimental lung research

authors： Kalina M,Riklis S,Blau H

更新日期：1993-03-01 00:00:00

abstract：AIM OF THE STUDY:Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in vivo delivery remains a challenge. Here we examined the feasibility of using electrospray to deliver nucleic acids to both porcine tracheal tissue sections and wh...

journal_title：Experimental lung research

authors： Riddell P,Gilbert JL,Molloy EL,Finnegan S,Egan JJ,O'Dea S

更新日期：2018-01-01 00:00:00

abstract：:The objective of this study was to assess the radioprotective effects of amifostine in the rat model of radiation-induced lung injury using fractionated doses of radiation, to determine whether amifostine given before irradiation protects tumor from radiation cytotoxicity, and to determine whether changes in plasma le...

journal_title：Experimental lung research

authors： Vujaskovic Z,Feng QF,Rabbani ZN,Samulski TV,Anscher MS,Brizel DM

更新日期：2002-10-01 00:00:00

abstract：:Purpose/Aim of Study: Studies of pulmonary fibrosis (PF) have resulted in DNA damage, inflammatory response, and cellular senescence being widely hypothesized to play a role in the progression of the disease. Utilizing these aforementioned terms, genomics databases were interrogated along with the term, "pulmonary fib...

journal_title：Experimental lung research

authors： Beach TA,Johnston CJ,Groves AM,Williams JP,Finkelstein JN

更新日期：2017-04-01 00:00:00

abstract：:Lung disorders such as asthma, acute respiratory distress syndrome (ARDS), chronic obstructive lung disease (COPD), and interstitial lung disease (ILD) show a few common threads of pathogenic mechanisms: inflammation, aberrant immune activity, infection, and fibrosis. Currently no modes of effective treatment are avai...

journal_title：Experimental lung research

authors： Inamdar AC,Inamdar AA

更新日期：2013-10-01 00:00:00

abstract：:The inhalation of inorganic dust can lead to the development of interstitial pulmonary fibrosis, characterized by the accumulation of fibroblasts and connective tissue matrix in the lung interstitium. The fibrosis causes alterations in the architecture of the lung parenchyma, resulting in abnormal gas exchange and hyp...

journal_title：Experimental lung research

authors： Schapira RM,Osornio-Vargas AR,Brody AR

更新日期：1991-11-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:Prostaglandins (PGs) synthesized by fetal and neonatal lungs play pivotal roles in pulmonary physiology, especially during the transition from uterine to independent life. One regulator of prostaglandin synthesis at this time may be oxygen. We examined the effects of 1% O2, 21% O2 and 50% O2 in 5% CO2, balance N2 (PO2...

journal_title：Experimental lung research

authors： Olson DM,Tanswell AK

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD) is a main chronic lung disease commonly occurs in preterm infants. BPD is characterized by impaired alveolarization and vascularization of the developing lung. Transforming growth factor-β (TGF-β) signaling pathway is known to play an important role during lung vascular devel...

journal_title：Experimental lung research

authors： Jin M,Lee J,Lee KY,Jin Z,Pak JH,Kim HS

更新日期：2016-09-01 00:00:00

abstract：:Investigations on leukocyte populations in the lung have shown that lymphocytes are found in different anatomical compartments. Lymphocytes can be seen to a different extent in the lung interstitium, the epithelium and lamina propria of the bronchi, the bronchoalveolar space, and the marginal lung vascular bed. Previo...

journal_title：Experimental lung research

authors： Fliegert FG,Tschernig T,Pabst R

更新日期：1996-11-01 00:00:00

abstract：:Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibros...

journal_title：Experimental lung research

authors： Yu J,Deng Y,Han M

更新日期：2020-09-01 00:00:00

abstract：:The role of bombesin was investigated in the course of the pulmonary inflammation and fibrosis (PF) elicited by the intratracheal (IT) or intravenous (i.v.) administration of bleomycin in mice. Bleomycin-induced alveolitis was associated with an accumulation of cells, presumably macrophages, containing bombesin, as ev...

journal_title：Experimental lung research

authors： Piguet PF,Vesin C,Thomas F

更新日期：1995-03-01 00:00:00

abstract：:Neutrophilic inflammation is responsible for much of the tissue damage seen in many lung diseases. For resolution of inflammation to occur, neutrophils must die by apoptosis, allowing their recognition and removal by macrophages. The molecular events controlling this important regulatory step are poorly understood, in...

journal_title：Experimental lung research

authors： Renshaw SA,Loynes CA,Elworthy S,Ingham PW,Whyte MK

更新日期：2007-12-01 00:00:00

abstract：:Aims:Bronchopulmonary dysplasia (BPD) is characterized by alveolarization arrest. During alveolarization, alveolar myofibroblasts are thought to migrate into the septal tips and elongate secondary septa. Lipopolysaccharide (LPS) exposure has been reported to disrupt directional migration and final location of alveolar...

journal_title：Experimental lung research

authors： Li J,Gong X

更新日期：2020-01-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the airway that is mediated by T-helper 2(TH2) cells. Thymic stromal lymphopoietin (TSLP) can aggravate asthmatic lung inflammation by activating dendritic cells (DCs) to promote TH2 differentiation. TSLP promoter polymorphisms are associated with susceptibility to...

journal_title：Experimental lung research

authors： Liu W,Xu LS,Liu QJ,Dong FZ,Qiu RF,Wen MC,Han YL,Tang NB,Kang LJ,Wu JX,Liu F,Zhao JP,Yang MM,Wang JF,Ding MJ,Sun YM,Fei WJ,Dong L

更新日期：2012-10-01 00:00:00

abstract：:This report describes the protocol for the strain A mouse lung tumor bioassay and summarizes results on selected chemicals that have been tested for carcinogenicity in the assay. The assay is of 6 months duration and can distinguish 2-fold differences in carcinogenic potential of compounds from several chemical classe...

journal_title：Experimental lung research

authors： Stoner GD

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

journal_title：Experimental lung research

authors： Dolkart O,E A,S S,S M,P G,Aa W

更新日期：2014-02-01 00:00:00

abstract：:Sex-related differences may be present during fetal lung growth and at the onset of surfactant synthesis. In this study we investigated the role of dihydrotestosterone (DHT) and estrogen (EST) on cell division and on labeled palmitate incorporation into disaturated phosphatidylcholine (DSPC) at various times of gestat...

journal_title：Experimental lung research

authors： McMillan EM,King GM,Adamson IY

更新日期：1989-03-01 00:00:00

abstract：:Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a m...

journal_title：Experimental lung research

authors： Dufresne A,Sébastien P,Michaud D,Perrault G,Bégin R

更新日期：1994-03-01 00:00:00

abstract：:Lung cancer is the leading cause of death of both men and women across the world. Overexpression and activating mutations of the epidermal growth factor receptor-1 (EGFR1) are frequently observed and associated with poor prognosis. To inhibit the function of EGFR1, multiple antibodies and small-molecule tyrosine kinas...

journal_title：Experimental lung research

authors： Gorgisen G,Ozes D,Pehlivanoglu S,Erdogan A,Dertsiz L,Ozbilim G,Ozbudak IH,Savas B,Ozes ON

更新日期：2013-11-01 00:00:00

abstract：:Alveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor...

journal_title：Experimental lung research

authors： da Hora K,Valença SS,Porto LC

更新日期：2005-10-01 00:00:00

abstract：:Previous studies have indicated increased plasma levels of inducible nitric oxide synthase in lung. This study further examines the pulmonary expression of nitric oxide synthase (NOS) isoforms in an ovine model of acute lung injury induced by smoke inhalation and burn injury (S+B injury). Female range bred sheep (4 pe...

journal_title：Experimental lung research

authors： Cox RA,Jacob S,Oliveras G,Murakami K,Enkhbaatar P,Traber L,Schmalstieg FC,Herndon DN,Traber DL,Hawkins HK

更新日期：2009-03-01 00:00:00

abstract：:Studies demonstrated that pathophysiological abnormalities of airway smooth muscle (ASM) contribute significantly to chronic obstructive pulmonary disease (COPD) pathogenesis, the aim of this study is to investigate heat shock protein 70 (Hsp70) in ASM in COPD. ASM from 8 COPD patients and 6 controls were isolated for...

journal_title：Experimental lung research

authors： Xie J,Zhao J,Xiao C,Xu Y,Yang S,Ni W

更新日期：2010-05-01 00:00:00