Mechanisms of increase in amylase activity in rat submandibular and sublingual glands after administration of pilocarpine.

Abstract:

:The increase in parotid rather than pancreatic-type amylase activity in the submandibular and sublingual glands of rats caused by administration of pilocarpine was abolished or diminished when pilocarpine was injected into rats which had been parotidectomized, sympathectomized by superior cervical ganglionectomy or pretreated with reserpine. These results suggest that the increases in amylase activity in the submandibular and sublingual glands by pilocarpine are not due to increase in enzyme synthesis, but to uptake of enzyme released into the blood in large quantities from the parotid gland and that the release from the parotid gland by pilocarpine is primarily mediated by sympathetic nerves.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Ikeno T,Nasu J,Hashimoto S,Kuzuya H

doi

10.1016/0003-9969(82)90076-0

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

597-601

issue

7

eissn

0003-9969

issn

1879-1506

journal_volume

27

pub_type

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