The secretory characteristics of epidermal growth factor in human saliva.

Abstract:

:A series of unstimulated and stimulated saliva samples from healthy volunteers was tested for EGF by radioimmunoassay. Salivary EGF, like other salivary constituents, was secreted in a diurnal pattern. On stimulation the rate of EGF secretion doubled but the concentration fell by 70% because of dilution by salivary fluid. EGF secretion was positively related to saliva flow (p = 0.00001) but the coefficient of correlation was low (r = 0.47). Over a period of 30 min continual salivary stimulation, EGF was released in a bimodal pattern with peaks occurring at 3 and 12 min. Subsequently, EGF secretion remained stable at a rate of release that was approx. 80% of the initial peak value (7.4 ng/min). Chromatography indicated that both high and low molecular-weight forms of EGF were present in unstimulated and stimulated saliva and that the low-weight form predominated. However, the proportion of high molecular-weight EGF increased from 18 to 38% of the total on short-term (3 min) stimulation.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

McGurk M,Hanford L,Justice S,Metcalfe RA

doi

10.1016/0003-9969(90)90032-6

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

653-9

issue

8

eissn

0003-9969

issn

1879-1506

pii

0003-9969(90)90032-6

journal_volume

35

pub_type

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