The effect of fluorhydroxyapatite in experimental human dental plaque on its pH, acid production and soluble calcium, phosphate and fluoride levels following glucose challenge.

Abstract:

:Plaque grown on terylene gauze in the mouths of 5 volunteers was treated with a mineralizing solution intermittently for 4 days to deposit fluorhydroxyapatite. Control plaque grown simultaneously was not treated. Sixteen hours after the last treatment, plaque gauzes were incubated in 0.28 M glucose under N2 at 37 degrees C. The mean pH, reached by the 5 mineralized plaques after 30 min, (4.78) was significantly higher than the mean pH reached by control plaques (4.13), a difference that was due neither to unequal microbial mass nor to unequal acid concentrations. Acid neutralization following the dissolution of apatite was probably mainly responsible for the pH differences although a small antiglycolytic effect from leached F could not be ruled out. Mineralized plaque lost on average 24 per cent of its Ca, 25 per cent of its P and 16 per cent of its F, resulting in 0.868 mM Ca, 0.676 mM P and 0.075 mM F in the supernatant. Test plaque fluid was saturated with respect to fluorapatite and only moderately undersaturated with respect to hydroxyapatite at the end of the incubation period; this could explain the pronounced caries-protective effect of plaque fluorhydroxyapatite shown previously.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Pearce EI,Hancock EM,Gallagher IH

doi

10.1016/0003-9969(84)90073-6

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

521-7

issue

7

eissn

0003-9969

issn

1879-1506

journal_volume

29

pub_type

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