In vitro migration of human mononuclear cells towards a psoriatic scale extract.

Abstract:

:Extracts of psoriatic scales from patients with chronic plaque psoriasis and of normal human post-mortem skin were tested for their effects on the migration of healthy human mononuclear cells in a modified Boyden chamber. A preparation of cells containing 12-32% monocytes was obtained from whole blood by a density gradient technique. The cells were allowed to migrate through a polycarbonate filter towards various dilutions of the two types of extract, a known chemoattractant or towards buffer alone. There was enhancement of migration towards psoriasis scale extract, with significant differences only at the stronger concentrations tested. The results suggest that scales taken from stable plaque psoriasis contain an extractable water-soluble factor which stimulates the movement of peripheral blood mononuclear cells.

journal_name

Acta Derm Venereol

authors

Sterling JC,Lidén S

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

543-6

issue

6

eissn

0001-5555

issn

1651-2057

journal_volume

64

pub_type

杂志文章
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