Abstract:
:Facial melanoma is difficult to diagnose and dermatoscopic features are often subtle. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value. In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas. Lesions were evaluated for the prevalence (> 50% of lesional surface) of 7 dermatoscopic non-melanoma features: scales, white follicles, erythema/reticular vessels, reticular and/or curved lines/fingerprints, structureless brown colour, sharp demarcation, and classic criteria of seborrhoeic keratosis. Melanomas had a lower number of non-melanoma patterns (p< 0.001). Scoring a lesion suspicious when no prevalent non-melanoma pattern is found resulted in a sensitivity of 88.5% and a specificity of 66.9% for the diagnosis of melanoma. Specificity was higher for solar lentigo (78.8%) and seborrhoeic keratosis (74.3%) and lower for actinic keratosis (61.4%) and lichenoid keratosis (25.6%). Evaluation of prevalent non-melanoma patterns can provide slightly lower sensitivity and higher specificity in detecting facial melanoma compared with already known malignant features.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Tschandl P,Gambardella A,Boespflug A,Deinlein T,de Giorgi V,Kittler H,Lallas A,Malvehy J,Moscarella E,Puig S,Scalvenzi M,Thomas L,Zalaudek I,Alfano R,Argenziano Gdoi
10.2340/00015555-2759subject
Has Abstractpub_date
2017-11-15 00:00:00pages
1219-1224issue
10eissn
0001-5555issn
1651-2057journal_volume
97pub_type
杂志文章abstract::The ultrastructure of oral lesions in 6 patients with erythema multiforme (EM) and of one apparently clinically healthy oral mucosa in one patient with recurrent EM during remission is described. Alterations were observed in epithelium, basal lamina and lamina propria. Both intercellular and intracellular oedema, intr...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570199203
更新日期:1990-01-01 00:00:00
abstract::Fifteen patients with nodular prurigo were treated with a trioxsalen bath (50 mg/150 l of water) and UVA given in an ordinary PUVA cabin. Good results were observed in 8 and moderate in 7 patients in the initial phase. The result was good or excellent in 13 of the 15 patients during maintenance treatment. The good res...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The combination of hydroxyzine and cimetidine is reported to be more effective than hydroxyzine alone in chronic urticaria. The plasma concentration of hydroxyzine was studied in seven patients treated both with the hydroxyzine 25 mg t.i.d. and the combinations of hydroxyzine 25 mg and cimetidine 200 mg t.i.d. Hydroxy...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Localized heat urticaria is a rare disorder, in which the nature of the mediator is not fully established. We report the case of a 41-year-old woman with the condition, dependent upon mast cell integrity, in which histamine was demonstrated as the dominant, if not sole mediator. Non-sedative antihistamines conferred s...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Generalized normolipemic plane xanthomatosis is a rare cutaneous disorder, frequently associated with reticuloendothelial diseases and some disorders with inflammation. Relapsing polychondritis is also a rare disease that shows an association with various immune-mediated diseases. We report a case of generalized normo...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555574221223
更新日期:1994-05-01 00:00:00
abstract::Aryl hydrocarbon hydroxylase (AHH) and glutathione S-transferase (GST) (EC 2.5.1.18) activity were measured in human lymphocytes of peripheral blood from 8 patients with irritant or allergic contact dermatitis of the hands, and compared with data from a control group. Both AHH and GST activity was found to be signific...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. The aim of this study was to clarify the pathogenesi...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3519
更新日期:2020-06-15 00:00:00
abstract::Confounding from comorbidity and socioeconomic status may have biased earlier findings of all-cause mortality among patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We therefore examined all-cause mortality among 72,295 Danish patients with BCC, 11,601 with SCC, and 383,714 age- and gender-m...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0899
更新日期:2010-07-01 00:00:00
abstract::Previous studies have shown that magnetic resonance imaging is more sensitive in assessing soft tissue and bone involvement in inflammatory arthritis than conventional radiography. Therefore the main objects of this study were to evaluate the frequency of hand involvement in psoriatic patients free from arthritic symp...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155598442809
更新日期:1998-11-01 00:00:00
abstract::A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision. Ca2+ channel blocking activity of verapamil in keloid cells was explored. One keloid was excised per subject and each w...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,随机对照试验
doi:10.2340/00015555-2384
更新日期:2016-08-23 00:00:00
abstract::The validity of Laser Doppler Flowmetry for measurements of changes in skin blood flow rates during orthostatic manoeuvres was evaluated. Fifteen healthy subjects were investigated. Relative skin blood flow rates on the dorsum of the hand were measured during stepwise raising and lowering of the arm in 10 cm increment...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570144147
更新日期:1990-01-01 00:00:00
abstract::Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-trigg...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/000155557213
更新日期:1992-01-01 00:00:00
abstract::Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation o...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2235
更新日期:2016-03-01 00:00:00
abstract::A series of agents with alleged photosensitizing properties has been studied in mice by a quantitative in vivo method for acute drug phototoxicity. The method, originally developed for phenothiazine studies, was found suitable for several drug groups with varying mechanism of action, such as tetracyclines, protoporphy...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Stratum corneum chymotryptic enzyme (SCCE) may be involved in desquamation, a process necessary for maintaining a normal anatomy at all sites where there is continuous turnover of cornified epithelia. Using immunohistochemistry and in situ hybridization, we have, in this work, analysed SCCE expression in the sebaceous...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155598443015
更新日期:1998-09-01 00:00:00
abstract::The area of UV erythema produced by a small beam head was found to increase with increasing doses. The aim was to investigate whether measurement of the area could be a more useful indicator of UV-induced damage than classic visual grading. Topical pretreatment with all-trans retinoic acid (tretinoin) and betamethason...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555573273275
更新日期:1993-08-01 00:00:00
abstract::Monocytes form a significant component of the inflammatory reaction taking place in the skin of atopic dermatitis and psoriasis. Chemokines are pivotal in mediating the attraction of leucocytes to sites of inflammation. The CC-chemokine, monocyte chemotactic protein 1 (MCP-1/CCL2), is expressed by keratinocytes in bot...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550410034444
更新日期:2004-01-01 00:00:00
abstract::In this article, the results of 3 studies on 2 hand cleansers (products A and B) are analysed. Three different test models (the patch test, the forearm wash test and the use test) are used to obtain information on the skin irritancy of these 2 products. Test reactivity was assessed by clinical scores and bioengineerin...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155502753600812
更新日期:2002-01-01 00:00:00
abstract::Eosinophilic pustular folliculitis is an inflammatory skin disease characterized by pruritic follicular papulopustules. It is usually resistant to topical and/or systemic corticosteroids, but it responds well to systemic indomethacin. We report here two patients with classical-type disease who were treated with system...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0759
更新日期:2010-01-01 00:00:00
abstract::Basal cell carcinoma (BCC) is the most common form of cancer worldwide. Exposure of the skin to ultraviolet (UV) radiation, from sunlight and other sources, is the most important risk factor. The aim of this large-scale case-control study was to determine which occupations are associated with increased risk of BCC in ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2660
更新日期:2017-07-06 00:00:00
abstract::Intraepidermal collections of neutrophils and lymphocytes are unique features of the inflammatory reaction of psoriasis. Migration of leukocytes from dermis to the epidermis suggests a role for chemotactic agent(s). In recent years, increased levels of chemokines such as IL-8 , GRO-a and MCP-1 have been reported in th...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750011615
更新日期:1999-01-01 00:00:00
abstract::To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750011336
更新日期:1999-03-01 00:00:00
abstract::The initiation of the antihistamine effect of a single dose of acrivastine (8 mg) or cetirizine (10 mg) on wheals and itch induced by histamine dihydrochloride (10 mg/ml) in the prick test was studied in a randomized cross-over design employing 20 healthy medical students. The prick test was performed before ingestion...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2340/0001555573350351
更新日期:1993-10-01 00:00:00
abstract::The treatment and relapse rate of genital warts are significant problems. The aim of this observational study was to assess the efficacy of holmium laser treatment of genital warts. A total of 1500 outpatients with genital human papillomavirus-induced lesions presenting from August 2002 to June 2005 were treated with ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0354
更新日期:2008-01-01 00:00:00
abstract::Heavy external pressure, caused by the weight of the body when lying on a hard transparent surface during UVA irradiation, prevents pigmentation in pressure exposed skin areas. After percutaneous H2O2 administration a delayed pigmentation appeared on the pressure sites. This finding provides evidence for the role of o...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The hair root status (trichogram) was studied in eleven patients with primary and eight with secondary syphilis. Variables studied in addition to the hair roots were absence or presence of hair root sheaths, deformities and hair roots with angulations exceeding 20 degrees. A decrease in the number of anagen hair roots...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Anorexia nervosa and bulimia nervosa are common yet occult eating disorders which each affect between 1 and 2% of young adult women in the UK (1). Cutaneous signs may provide valuable clues allowing earlier diagnosis. Eating disorders may both imitate (Table I) and complicate other medical illnesses, resulting in unne...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555746869
更新日期:1994-01-01 00:00:00
abstract::Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen i...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Inflammatory cells in 15 specimens of normal human epidermis were selectively stained by a monoclonal antibody immunoperoxidase technique. The quantitative assessment using an interactive image analysis system revealed OKT 11 positive cells (T lymphocytes) and Leu 2a positive cells (suppressor/cytotoxic cells). As the...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00