Cell populations in pagetoid reticulosis: an immunological study using cell activation associated monoclonal antibodies.

Abstract:

:The nature of the epidermal cellular infiltrate in pagetoid reticulosis is still subject to intense controversies. Using a panel of recently developed monoclonal antibodies against cell activation and proliferation associated antigens it was possible to demonstrate the activated state of numerous T cells within the lesional epidermis. Moreover approximately 10% of these T cells reacted with proliferation associated antigens. In addition macrophages and Langerhans' cells were found to represent a regular constituent of the epidermal infiltrate with a density clearly exceeding that of unaffected adjacent epidermis. The close apposition of activated T cells and monocytic cells suggests an intensive interaction of both cell types in the development of the pagetoid reticulosis lesion.

journal_name

Acta Derm Venereol

authors

Kaudewitz P,Burg G,Majiewski G,Gerdes J,Schwarting R,Braun-Falco O

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

24-9

issue

1

eissn

0001-5555

issn

1651-2057

journal_volume

67

pub_type

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