Rosacea: a cutaneous marker of Helicobacter pylori infection? Results of a pilot study.

Abstract:

:Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the potential association between severity of rosacea and direct and serological evidence of H. pylori infection. Patients were classified by severity into non-inflammatory erythematotelangiectatic or inflammatory/papulopustular rosacea and were tested for current H. pylori infection and evidence of previous exposure. Positive 13C-urea breath test and ELISA tests were more likely to be observed in patients with inflammatory rosacea, although not statistically significantly so (OR = 3.0, p = 0.15 and OR = 2.9, p = 0.16, respectively). However, the proportion of patients who tested positive in both assays (versus negative in at least one) was even higher in the inflammatory rosacea group and neared statistical significance (OR = 4.5, p = 0.06). This pilot study provides sufficient evidence suggestive of a positive association between the severity of rosacea and the presence of H. pylori to warrant further research.

journal_name

Acta Derm Venereol

authors

Diaz C,O'Callaghan CJ,Khan A,Ilchyshyn A

doi

10.1080/00015550310016544

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

282-6

issue

4

eissn

0001-5555

issn

1651-2057

journal_volume

83

pub_type

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