Erythema multiforme during GM-CSF therapy.

Abstract:

:A 52-year-old Caucasian man treated with granulocyte-macrophage colonystimulating factor (GM-CSF) developed a cutaneous eruption on legs and ankles with clinical and histologic features of erythema multiforme. Laboratory studies indicated that the eruption occurred at the time of peripheral blood lymphocyte recovery and that it was coincidental with serum peaks of interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6) and tumour necrosis factor-alpha. We postulate that GM-CSF provoked erythema multiforme in a predisposed individual as a consequence of either an inappropriate cytokine secretion or of an abnormal amplification mechanism following lymphocyte recovery.

journal_name

Acta Derm Venereol

authors

Stasi R,Gatti S,Perrotti A,Orlandi A,Spagnoli LG,Papa G

doi

10.2340/0001555574132134

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

132-4

issue

2

eissn

0001-5555

issn

1651-2057

journal_volume

74

pub_type

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