Abstract：
:Penicillin concentration in serum and cerebrospinal fluid (CSF) were estimated in 19 syphilitic patients given three different regimens: Penicillin G, 10 MIU i.v. three times a day (3 patients); procaine penicillin, 600 000 IU i.m. (11 patients); and penicillin V, 1.2 MIU by mouth four times a day (5 patients). Intravenous administration of penicillin G resulted in a penicillin concentration in CSF of 0.3-0.5 micrograms/ml; In contrast, procaine penicillin, i.m. and penicillin V by mouth did not result in any measurable CSF concentration, even in the presence of pleocytosis and/or barrier lesion. Penicillin V by mouth gave considerably higher serum concentrations than procaine penicillin intramuscular, however. In the light of these results, and reported treatment failures in neurosyphilis and demonstration of viable Treponema pallidum after treatment, we propose that neurosyphilis should be treated with high intravenous doses of penicillin to ensure treponemicidal concentrations in the central nervous system.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Löwhagen GB,Brorson JE,Kaijser Bsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
53-7issue
1eissn
0001-5555issn
1651-2057journal_volume
63pub_type
杂志文章abstract：:Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances. At present, the underlying mechanisms responsible for night-time itching are not well understood. Nocturnal pruritus may be related to the circadian rh...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.2340/00015555-0280
更新日期：2007-01-01 00:00:00
abstract：:Twenty-one patients with Behçet's disease were typed for HLA antigens. The controls were 50 subjects randomly chosen from a local population and 24 apparently healthy subjects of the same ethnic groupings as those of the patients. The study revealed significant differences in the frequencies of various antigens in the...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:The identification of mononuclear cells extracted from 12 basal cell carcinomas has been carried out by means of various assays such as the E rosette test, FITC anti-Ig conjugates and peroxidase conjugates viewed at an ultrastructural level. The relative quantities of B and T cells have been determined as well as the ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The main aims of this cross-sectional study were: (i) to assess the frequency of genital (vulval) lichen planus (VLP) and vulval lichen sclerosus (VLS) in women affected with oral lichen planus (OLP), regardless of the genital symptoms reported; and (ii) to verify whether any demographic, clinical, or histological fea...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0116
更新日期：2006-01-01 00:00:00
abstract：:The prevalence of melanocytic naevi in children correlates with sun exposure and may serve as an objective population risk indicator of future melanoma incidence. The aim was to investigate if mobile teledermatology could offer a valid methodology compared with standard manual, face-to-face counting of naevi on the ba...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1950
更新日期：2015-03-01 00:00:00
abstract：:We report 3 cases of pruriginous papular eruption of HIV disease, in which demodectic mites were found in the pilosebaceous follicles which were surrounded by a granulomatous inflammatory infiltrate. Papular eruption of HIV disease is a distinctive clinicopathological entity, whose pathogenicity is not known. Our obse...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574320322
更新日期：1994-07-01 00:00:00
abstract：:Twelve patients with cutaneous and/or eye symptoms caused by practolol have been studied. The morphological appearance of the skin eruptions was psoriasiform in 5, vesiculo-papular in one, and exfoliating dermatitis was seen in 2 patients. Keratoconjunctivitis sicca was the only adverse reaction to practolol in one an...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:We present a young male patient referred to our hospital with leg ulcers on both legs that were more than 3 years refractory to standard treatment with compression therapy. By thrombophilia screening factor V Leiden mutation, hyperhomocysteinemia and evidence for impaired fibrinolysis were found. Treatment with folic ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155502753600902
更新日期：2002-01-01 00:00:00
abstract：:Prevalence and severity of seborrhoeic dermatitis were studied in 150 patients with psychiatric disorders, including schizophrenia, mood disorders, anxiety and organic mental illness. As a control group, we examined 150 patients waiting for surgery and regarded as obviously anxious. Thirty-eight psychiatric patients w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570432434
更新日期：1990-01-01 00:00:00
abstract：:Some confusion exists in the literature about which criteria should be used to define familial melanoma. This could explain the different reported frequencies of mutations in predisposing genes, mostly CDKN2A, in these patients. This study evaluated the human leucocyte antigen (HLA) class II genotype and the presence ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155500300012936
更新日期：2000-11-01 00:00:00
abstract：:The initiation of the antihistamine effect of a single dose of acrivastine (8 mg) or cetirizine (10 mg) on wheals and itch induced by histamine dihydrochloride (10 mg/ml) in the prick test was studied in a randomized cross-over design employing 20 healthy medical students. The prick test was performed before ingestion...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2340/0001555573350351
更新日期：1993-10-01 00:00:00
abstract：:A review of a variety of cutaneous paraneoplastic conditions is presented. Although the conditions discussed appear in only 7-15% of cancer patients, they are considered indicators of possible underlying malignancy. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.2340/0001555573161170
更新日期：1993-06-01 00:00:00
abstract：:Vulvar vestibulitis, as defined by Friedrich, is considered to be inflammatory, despite the fact that the normal histology of this specific area has previously not been characterized. The aim of the present study was to compare the normal histology of the vulvar vestibulum with findings in localized vulvar vestibuliti...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555577319322
更新日期：1997-07-01 00:00:00
abstract：:The aims of this study were to compare the performance characteristics and cost-effectiveness of pooling endocervical samples for screening and diagnosis of Chlamydia trachomatis, and to investigate the prevalence of C. trachomatis infection in women in Leningrad Oblast, Russia. A total of 1500 endocervical samples we...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0196
更新日期：2007-01-01 00:00:00
abstract：:Aryl hydrocarbon hydroxylase (AHH) and glutathione S-transferase (GST) (EC 2.5.1.18) activity were measured in human lymphocytes of peripheral blood from 8 patients with irritant or allergic contact dermatitis of the hands, and compared with data from a control group. Both AHH and GST activity was found to be signific...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:is missing (Short communication). ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2725
更新日期：2017-10-02 00:00:00
abstract：:Normal skin and psoriatic lesions from 35 patients were investigated immunohistochemically with regard to the CD1a+ cell population (Langerhans' cells and indeterminate cells) in the epidermis as well as in the dermal infiltrate. In the normal-appearing skin, we found the regularly typical pattern of CD1a+ dendritic c...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Two cases of subacute cutaneous lupus erythematosus are described. Features which delayed diagnosis are discussed. The potential clinical and histopathological overlap between this condition and erythema multiforme is emphasized, drawing attention to the histological features which allow distinction. The possibility t...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015559850135869
更新日期：1998-01-01 00:00:00
abstract：:Studies on hydroxyproline and hydroxylysine, the two amino acids characteristic of collagen and related glycoproteins, were undertaken on biopsies of pathologic and clinically normal human skin. No statistically significant differences between clinically normal skin of mamma, thorax, axilla, femur, hip and sacral area...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Biopsies obtained from both the perilesional areas and clinically uninvolved skin of patients with pemphigus vulgaris (PV) were studied for antigen-presenting cell and lymphocyte phenotype and/or activation phenotype using monoclonal antibodies in avidin-biotin-peroxidase complex staining. Perilesional PV skin contain...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the pot...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310016544
更新日期：2003-01-01 00:00:00
abstract：:Apoptosis is a form of cellular suicide and is activated in various cells, including keratinocytes, in response to physiological and pathological stimuli. A current hypothesis holds that apoptotic cells in a concerted manner express characteristic phenotypic features comprising cytoplasmic budding, pyknosis, chromatin...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155598441800
更新日期：1998-07-01 00:00:00
abstract：:The hypothesis that zinc pyrithione, a highly active anti-dandruff agent, exerts an anti-biosynthetic effect and reduces the epidermal turnover has been tested using guinea pig and hairless mouse skins. It has been found that enhanced mitosis caused by both stripping off the horny layers and sodium dodecyl sulphate, c...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:In Behçet's disease, severe pathological changes are observed in the post-capillary venules, indicating that the venous side of the circulation is generally involved. It is proposed that one of the initial pathological changes is multiplication of the basal lamina surrounding the post-capillary venule. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The anti-inflammatory mechanisms of minocycline, an antibiotic used in the treatment of the inflammatory component of acne, are only partially understood. In addition to inflammation due to cytokines (IL-1, IL-6, TNF-alpha, etc.), recent studies have shown that neuropeptide-mediated neurogenic inflammation may play an...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155599750010625
更新日期：1999-07-01 00:00:00
abstract：:Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3121
更新日期：2019-04-01 00:00:00
abstract：:A dermatitis occurring during the treatment of mycosis fungoides with A vitamin analogues (13-cis-retinoic acid and etretinate) and mimicking a progression of the disease is described. It is considered to be a skin reaction due to the treatment. Its benign nature is revealed by histology showing a lymphocytic infiltra...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:BRAF and NRAS genetic analyses are time-consuming and can delay treatment choices in patients with metastatic melanomas presenting with acute deterioration. We compared the rapid, real-time, fully automated molecular diagnosis platform Idylla™ with next-generation sequencing (NGS) and immunohistochemistry for detectio...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2738
更新日期：2018-01-12 00:00:00
abstract：:Oxidation of 5-S-cysteinyldopa by mushroom tyrosinase was studied by measuring 5-S-cysteinyldopa consumption with HPLC. 5-S-cysteinyldopa was found to be a substrate for tyrosinase, but our results suggests that a self-catalysed oxidation induced by enzymatically formed 5-S-cysteinyl dopaquinone also takes place. Dopa...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with or without P. aeruginosa bacteremia were analysed. Patients whose lesions originated in the skin were in the majority (14 patients). Skin lesions were located at the site of entry of bacteria (apocrine areas in 12 pat...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
