[Surgical management and outcomes of lung cancer in women - results from the Epithor database].

Abstract:

INTRODUCTION:Rates of lung cancer in women have been increasing continually for several years. The basic surgical management of this condition is the same in both sexes but a number of differences are apparent. METHODS:We analysed data entered onto the Epithor database between June 2002 and June 2006 concerning 8535 surgical resections performed in primary lung cancer. RESULTS:22.5 percent of patients were women. They were significantly younger (59.6 years vs 62.7 years) and had a lower BMI (24.7 kg x m(-2) vs 25.5 kg x m(-2)). They were in a better physical condition in terms of American Society of Anaesthesiology score and performance status, with better preserved lung function and fewer co-morbidities (1.8 vs 2.1) compared to men. The percentage of adenocarcinomas was higher in women and a higher proportion had early stage disease. 30 day mortality was three times as high in men who also experienced much greater post-operative morbidity. Multivariate analysis revealed an odds ratio of 0.49 (95% CI 0.3-0.8) for mortality and 0.54 (95% CI 0.4-0.6) for morbidity in women compared to men. CONCLUSION:Women with lung cancer have less risk of post-operative morbidity and mortality than men. These data suggest that they might be able to benefit from more aggressive perioperative therapy.

journal_name

Rev Mal Respir

authors

Brouchet L,Mazieres J,Bauvin E,Bigay-Game L,Renaud C,Berjaud J,Dahan M

doi

10.1016/s0761-8425(07)91390-x

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

877-82

issue

7

eissn

0761-8425

issn

1776-2588

pii

MDOI-RMR-09-2007-24-7-0761-8425-101019-200720093

journal_volume

24

pub_type

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