[Respiratory dysfunction in burned patients].

Abstract:

INTRODUCTION:Smoke inhalation and respiratory complications are still the major causes of mortality in severely burned patients. STATE OF THE ART:The diagnosis is suspected clinically on the basis of history and physical examination and can be confirmed bronchoscopically. Respiratory failure in burned patients occurs through a number of associated mechanisms. Pneumonitis and adult respiratory distress syndrome (ARDS) are common early complications. New pulmonary treatments and advances in ventilation have reduced the incidence of both barotrauma and infectious complications. Tracheal stenosis can occur as a late complication of prolonged mechanical ventilation. PERSPECTIVES:Clinical and experimental studies have shown that damage to the mucosal barrier and the release of inflammatory mediators are the most important pathophysiological events following smoke inhalation. Manipulation of the inflammatory response following inhalation may be a treatment option in the distant future. CONCLUSION:Inhalation injury occurring in burned patients can produce severe respiratory and systemic complications.

journal_name

Rev Mal Respir

authors

Bargues L,Vaylet F,Le Bever H,L'Her P,Carsin H

doi

10.1016/s0761-8425(05)85572-x

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

449-60

issue

3

eissn

0761-8425

issn

1776-2588

pii

MDOI-RMR-06-2005-22-3-0761-8425-101019-200530021

journal_volume

22

pub_type

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