[Epidermoid bronchial cancer induced by radiotherapy].

Abstract:

:The occurrence is reported of a bronchial epidermoid cancer appearing 13 years after irradiation for an intra-thoracic paraganglioma. Four criteria are required when considering the carcinogenic effects of radiation: a documented history or irradiation, a latent period of 8 to 20 years, histological evidence of the development of a malign tumor within the irradiated zone and a different histological type from that of the primary tumor. All these criteria are satisfied in this case. The occurrence of post radiation fibrosis and the knowledge of a cancer developing in primary or secondary pulmonary fibrosis are considered in discussing carcinogenesis. Radiation induces fibrous and an oncogenic mutation which by the secretion of certain proteins, notably a growth factor, favours the development of a cancer.

journal_name

Rev Mal Respir

authors

Courty G,Laylavoix F,Martre P,Pierchon MS

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

111-3

issue

2

eissn

0761-8425

issn

1776-2588

journal_volume

3

pub_type

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  • [Is atopy a risk factor of occupational asthma?].

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    doi:

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