The principle of interval constraints: a generalization of the symmetric Dirichlet distribution.

Abstract:

:A structure for representing problems in decision analysis and in expert systems, which reason under uncertainty, is the influence diagram or causal network. A causal network consists of an underlying joint probability distribution and a directed acyclic graph in which a propositional variable that represents a marginal distribution is stored at each vertex in the graph. This paper is concerned with two of the problems in applications that use causal networks. The first problem is the determination of the conditional probabilities of the values of remaining propositional variables in the network given that certain variables are instantiated for particular values. This is called probability propagation. The second problem is the determination of the most probable, second most probable, third most probable, and so on sets of values of a particular set of variables (called the explanation set) given that certain variables are instantiated for particular values. This problem is called abductive inference. There exists a class of causal networks in which each variable has only two parents, for which the time is required, by any known method, for probability propagation is exponential relative to the number of vertices in the network. The determination of a new method that would be efficient for all causal networks appears unlikely, because probability propagation has been shown to be #P-complete. In many medical applications, networks are often large and not sparsely connected. Therefore a method for the exact determination of probability values appears unlikely for such applications, and the development of approximation methods seems to be the best solution. The current approximation methods obtain interval bounds for the probability values. When such intervals are obtained, it is not possible in general to rank the alternatives. In this paper, a method is developed for obtaining expected values for the point probabilities from interval constraints on the probabilities. The method is based on an application of the principle of indifference to the probability values themselves. The distributions obtained with the principle of indifference are a generalization of the symmetric Dirichlet distribution in which prior ignorance is assumed.

journal_name

Math Biosci

journal_title

Mathematical biosciences

authors

Neapolitan RE

doi

10.1016/0025-5564(91)90089-2

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

33-44

issue

1

eissn

0025-5564

issn

1879-3134

pii

0025-5564(91)90089-2

journal_volume

103

pub_type

杂志文章
  • Multiscale modelling of saliva secretion.

    abstract::We review a multiscale model of saliva secretion, describing in brief how the model is constructed and what we have so far learned from it. The model begins at the level of inositol trisphosphate receptors (IPR), and proceeds through the cellular level (with a model of acinar cell calcium dynamics) to the multicellula...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2014.06.017

    authors: Sneyd J,Crampin E,Yule D

    更新日期:2014-11-01 00:00:00

  • CXCR4 and CCR5 regulation and expression patterns on T- and monocyte-macrophage cell lineages: implications for susceptibility to infection by HIV-1.

    abstract::Chemokine receptor expression may vary dramatically among cell subsets. Therefore, the stage of differentiation and the lineage of CD4 cells may profoundly affect their susceptibility to infection by human immunodeficiency virus type 1 (HIV-1). However, the mechanisms of coreceptor competition for association with HIV...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2005.01.002

    authors: Joly M,Pinto JM

    更新日期:2005-05-01 00:00:00

  • Controlling emerging infectious diseases like SARS.

    abstract::To control emerging infectious diseases like SARS, it is necessary to resort to basic control measures that limit exposures to infectious individuals. These measures include isolating cases at diagnosis, quarantining household members and tracing contacts of diagnosed cases, providing the community with advice on how ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2004.07.006

    authors: Becker NG,Glass K,Li Z,Aldis GK

    更新日期:2005-02-01 00:00:00

  • Biological growth on a surface.

    abstract::A new biological growth model is introduced. After random selection of possible growth sites, cells are added in an allowable random direction. Unlike the Eden model, the current model is grid independent and can be adapted to any curved surface. Growths of colonies of as many as 10(5) cells are simulated on planar, c...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(97)00012-6

    authors: Wang CY,Bassingthwaighte JB

    更新日期:1997-06-01 00:00:00

  • To switch or taper off: the dynamics of saturation.

    abstract::Many situations in population biology involve a rate--typically a contact or recruitment rate--which increases linearly for small populations but reaches a maximum value (saturates) for large populations. Models for populations of variable size need to incorporate both characteristics to predict behavior accurately. T...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2004.11.001

    authors: Kribs-Zaleta CM

    更新日期:2004-12-01 00:00:00

  • Dynamics of a predator-prey model with generalized Holling type functional response and mutual interference.

    abstract::Mutual interference and prey refuge are important drivers of predator-prey dynamics. The "exponent" or degree of mutual interference has been under much debate in theoretical ecology. In the present work, we investigate the interplay of the mutual interference exponent, and prey refuge, on the behavior of a predator-p...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2020.108407

    authors: Antwi-Fordjour K,Parshad RD,Beauregard MA

    更新日期:2020-08-01 00:00:00

  • Pathway-level disease data mining through hyper-box principles.

    abstract::In microarray data analysis, traditional methods that focus on single genes are increasingly replaced by methods that analyse functional units corresponding to biochemical pathways, as these are considered to offer more insight into gene expression and disease associations. However, the development of robust pipelines...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2014.09.005

    authors: Yang L,Ainali C,Kittas A,Nestle FO,Papageorgiou LG,Tsoka S

    更新日期:2015-02-01 00:00:00

  • Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus?

    abstract::Recent experimental data have shown that HIV-specific CD4 T cells provide a very important target for HIV replication. We use mathematical models to explore the effect of specific CD4 T cell infection on the dynamics of virus spread and immune responses. Infected CD4 T cells can provide antigen for their own stimulati...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2007.01.007

    authors: Wodarz D,Hamer DH

    更新日期:2007-09-01 00:00:00

  • What can trigger the onset of Parkinson's disease - A modeling study based on a compartmental model of α-synuclein transport and aggregation in neurons.

    abstract::The aim of this paper is to develop a minimal model describing events leading to the onset of Parkinson's disease (PD). The model accounts for α-synuclein (α-syn) production in the soma, transport toward the synapse, misfolding, and aggregation. The production and aggregation of polymeric α-syn is simulated using a mi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2016.05.002

    authors: Kuznetsov IA,Kuznetsov AV

    更新日期:2016-08-01 00:00:00

  • A diversity of responses displayed by a stochastic model of radiation carcinogenesis allowing for cell death.

    abstract::A stochastic model is presented of carcinogenesis induced by irradiation with arbitrary time-dependent dose rate. The key feature of the model is that it allows for radiation-induced cell killing to compete with the process of tumor promotion. Two versions of the model arise when considering target tissues with slow a...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0025-5564(95)00047-x

    authors: Yakovlev A,Polig E

    更新日期:1996-02-01 00:00:00

  • Evaluating spread of invaders from gravity scores--a way of using gravity models in ecology.

    abstract::This study is a theoretical excursion into gravity models and their usability in evaluating importance of spatial structure and population development for the spread of colonizing organisms. A so called "gravity score" for sites is deduced, and such a score could be used for predicting risk of colonization once one si...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2009.08.008

    authors: Järemo J

    更新日期:2009-11-01 00:00:00

  • Permanence of sparse catalytic networks.

    abstract::Some global dynamical properties of catalytic networks, in particular permanence, are closely related with a directed graph representing the differential equation. It can be shown that for every directed graph with a Hamiltonian circuit there is a choice of rate constants such that the system is permanent. On the othe...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(95)00033-x

    authors: Stadler PF,Schuster P

    更新日期:1996-01-15 00:00:00

  • Delay equation analysis of human respiratory stability.

    abstract::A mathematical analysis of the stability in human respiration, based on the tau-decomposition method, is conducted on a simple, but realistic CO2 model of the respiratory system. This model incorporates a two-compartment representation (lungs and tissues) for the plant and a very general class of controller. By derivi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(98)10028-7

    authors: Vielle B,Chauvet G

    更新日期:1998-09-01 00:00:00

  • Mathematical models for the effects of hypertension and stress on kidney and their uncertainty.

    abstract::Determining the future state of individual patients, with regard to the susceptibility to life-threatening condition is a crucial problem in the public health. Chronic Kidney Disease (CKD) is a perilous disease, which is characterized by gradual loss of kidney function. This paper presents a set of mathematical models...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2018.08.013

    authors: Waezizadeh T,Mehrpooya A,Rezaeizadeh M,Yarahmadian S

    更新日期:2018-11-01 00:00:00

  • The influence of concurrent partnerships on the dynamics of HIV/AIDS.

    abstract::Most models of the spread of HIV/AIDS assume that the probability of transmission from an infected individual to a susceptible partner has some constant value per sexual act, compounding independently randomly (so that ten acts with one person chosen from a particular group has, on average, the same risk as one act wi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(92)90006-i

    authors: Watts CH,May RM

    更新日期:1992-02-01 00:00:00

  • A mechanoreceptor model for rapidly and slowly adapting afferents subjected to periodic vibratory stimuli.

    abstract::A simple model of Freeman and Johnson on cutaneous mechanoreceptors is modified by introducing mechanisms for hyperexcitation and refractoriness. These lead to significant improvements in the match between the neural and model data. ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(94)00083-c

    authors: Slavík P,Bell J

    更新日期:1995-11-01 00:00:00

  • Robust model matching design methodology for a stochastic synthetic gene network.

    abstract::Synthetic biology has shown its potential and promising applications in the last decade. However, many synthetic gene networks cannot work properly and maintain their desired behaviors due to intrinsic parameter variations and extrinsic disturbances. In this study, the intrinsic parameter uncertainties and external di...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2010.12.007

    authors: Chen BS,Chang CH,Wang YC,Wu CH,Lee HC

    更新日期:2011-03-01 00:00:00

  • On the effect of a therapy able to modify both the growth rates in a Gompertz stochastic model.

    abstract::A Gompertz-type diffusion process characterized by the presence of exogenous factors in the drift term is considered. Such a process is able to describe the dynamics of populations in which both the intrinsic rates are modified by means of time-dependent terms. In order to quantify the effect of such terms the evaluat...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2013.01.001

    authors: Albano G,Giorno V,Román-Román P,Torres-Ruiz F

    更新日期:2013-09-01 00:00:00

  • Chemotherapy for tumors: an analysis of the dynamics and a study of quadratic and linear optimal controls.

    abstract::We investigate a mathematical model of tumor-immune interactions with chemotherapy, and strategies for optimally administering treatment. In this paper we analyze the dynamics of this model, characterize the optimal controls related to drug therapy, and discuss numerical results of the optimal strategies. The form of ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2006.05.003

    authors: de Pillis LG,Gu W,Fister KR,Head T,Maples K,Murugan A,Neal T,Yoshida K

    更新日期:2007-09-01 00:00:00

  • Analysis of logistic growth models.

    abstract::A variety of growth curves have been developed to model both unpredated, intraspecific population dynamics and more general biological growth. Most predictive models are shown to be based on variations of the classical Verhulst logistic growth equation. We review and compare several such models and analyse properties ...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(02)00096-2

    authors: Tsoularis A,Wallace J

    更新日期:2002-07-01 00:00:00

  • Global stability for a 2n+1 dimensional HIV/AIDS epidemic model with treatments.

    abstract::In this work, we derive and analyze a 2n+1-dimensional deterministic differential equation modeling the transmission and treatment of HIV (Human Immunodeficiency Virus) disease. The model is extended to a stochastic differential equation by introducing noise in the transmission rate of the disease. A theoretical treat...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2018.03.013

    authors: Otunuga OM

    更新日期:2018-05-01 00:00:00

  • Controlling the number of HIV infectives in a mobile population.

    abstract::The spread of the human immunodeficiency virus (HIV) depends prominently on the migration of people between different regions. An important consequence of this population mobility is that HIV control strategies that are optimal in a regional sense may not be optimal in a national sense. We formulate various mathematic...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2008.03.003

    authors: Sani A,Kroese DP

    更新日期:2008-06-01 00:00:00

  • A stochastic model for the spread of a sexually transmitted disease which results in a scale-free network.

    abstract::A stochastic model for the spread of a sexually transmitted disease (STD) is presented. To reflect varying degrees of promiscuity among individuals it is assumed that the infectivity of any infected individual is proportional to the number of previous contacts the individual has had with other infected individuals. In...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2005.12.016

    authors: Reed WJ

    更新日期:2006-05-01 00:00:00

  • Time delay in physiological systems: analyzing and modeling its impact.

    abstract::This article examines the functional and clinical impact of time delays that arise in human physiological systems, especially control systems. An overview of the mathematical and physiological contexts for considering time delays will be illustrated, from the system level to cell level, by examining models that incorp...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.mbs.2011.08.006

    authors: Batzel JJ,Kappel F

    更新日期:2011-12-01 00:00:00

  • A model of HIV/AIDS with staged progression and amelioration.

    abstract::An epidemic model with multiple stages of infection is studied. The model allows for infected individuals to move from advanced stages of infection back to less advanced stages of infection. A threshold parameter which determines the local stability of the disease free equilibrium is found and interpreted. Under condi...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(02)00149-9

    authors: McCluskey CC

    更新日期:2003-01-01 00:00:00

  • Deterministic epidemic models with explicit household structure.

    abstract::For a wide range of airborne infectious diseases, transmission within the family or household is a key mechanism for the spread and persistence of infection. In general, household-based transmission is relatively strong but only involves a limited number of individuals in contact with each infectious person. In contra...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2008.01.011

    authors: House T,Keeling MJ

    更新日期:2008-05-01 00:00:00

  • A competition model for viral inhibition of host cell proliferation.

    abstract::Some viruses encode proteins that promote cell proliferation while others, such as the human immunodeficiency virus (HIV), encode proteins that prevent cell division. It has been hypothesized that the selective advantage determining which strategy evolves depends on the ability of the virus to induce a cellular enviro...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/s0025-5564(00)00020-1

    authors: Holtea S,Emerman M

    更新日期:2000-07-01 00:00:00

  • Investigation of the performance of fermentation processes using a mathematical model including effects of metabolic bottleneck and toxic product on cells.

    abstract::A number of recent research studies have focused on theoretical and experimental investigation of a bottleneck in a metabolic reaction network. However, there is no study on how the bottleneck affects the performance of a fermentation process when a product is highly toxic and remarkably influences the growth and deat...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2010.08.001

    authors: Sriyudthsak K,Shiraishi F

    更新日期:2010-11-01 00:00:00

  • A new necessary condition for Turing instabilities.

    abstract::Reactivity (a.k.a initial growth) is necessary for diffusion driven instability (Turing instability). Using a notion of common Lyapunov function we show that this necessary condition is a special case of a more powerful (i.e. tighter) necessary condition. Specifically, we show that if the linearised reaction matrix an...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/j.mbs.2012.04.006

    authors: Elragig A,Townley S

    更新日期:2012-09-01 00:00:00

  • Four-state models and regulation of contraction of smooth muscle. I. Physical considerations, stability, and solutions.

    abstract::Cyclic four-state models are frequently used in biology to represent a variety of molecular behaviors. A common experimental strategy to test such models is to follow the behavior of the real system after some of the rate constants are changed in a stepwise manner. We analyze the mathematical behavior of a simple exam...

    journal_title:Mathematical biosciences

    pub_type: 杂志文章

    doi:10.1016/0025-5564(92)90086-c

    authors: Lazalde CA,Barr L

    更新日期:1992-11-01 00:00:00