Abstract：
:The spread of the human immunodeficiency virus (HIV) depends prominently on the migration of people between different regions. An important consequence of this population mobility is that HIV control strategies that are optimal in a regional sense may not be optimal in a national sense. We formulate various mathematical control problems for HIV spread in mobile heterosexual populations, and show how optimal regional control strategies can be obtained that minimize the national spread of HIV. We apply the cross-entropy method to solve these highly multi-modal and non-linear optimization problems. We demonstrate the effectiveness of the method via a range of experiments and illustrate how the form of the optimal control function depends on the mathematical model used for the HIV spread.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Sani A,Kroese DPdoi
10.1016/j.mbs.2008.03.003subject
Has Abstractpub_date
2008-06-01 00:00:00pages
103-12issue
2eissn
0025-5564issn
1879-3134pii
S0025-5564(08)00043-6journal_volume
213pub_type
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